Published in Nucleic Acids Res on May 11, 1981
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini. Nucleic Acids Res (1985) 7.18
Ubiquitous transposon-like repeats B1 and B2 of the mouse genome: B2 sequencing. Nucleic Acids Res (1982) 4.35
Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats. Nucleic Acids Res (1984) 3.15
Sequence of an expressed human beta-tubulin gene containing ten Alu family members. Nucleic Acids Res (1984) 3.08
Highly conserved sequences in the 3' untranslated region of mRNAs coding for homologous proteins in distantly related species. Nucleic Acids Res (1985) 2.83
Low molecular weight RNAs transcribed in vitro by RNA polymerase III from Alu-type dispersed repeats in Chinese hamster DNA are also found in vivo. Proc Natl Acad Sci U S A (1981) 2.60
Unusual evolutionary conservation and frequent DNA segment exchange in class I genes of the major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 2.21
Asymmetrical distribution of CpG in an 'average' mammalian gene. Nucleic Acids Res (1982) 2.04
The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor. Proc Natl Acad Sci U S A (1985) 2.03
Structural analysis of repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region. Nucleic Acids Res (1982) 1.99
Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98
Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proc Natl Acad Sci U S A (1987) 1.97
Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Nucleic Acids Res (1984) 1.93
Human U1 RNA pseudogenes may be generated by both DNA- and RNA-mediated mechanisms. Mol Cell Biol (1982) 1.89
A cluster of repetitive elements within a 700 base pair region in the mouse genome. Nucleic Acids Res (1983) 1.88
Isolation and characterization of human myosin heavy chain genes. Proc Natl Acad Sci U S A (1983) 1.72
A chicken middle-repetitive DNA sequence which shares homology with mammalian ubiquitous repeats. Nucleic Acids Res (1981) 1.70
The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res (1989) 1.60
Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53
Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element. Mol Cell Biol (1990) 1.51
A novel sequence segment and other nucleotide structural features in the long terminal repeat of a BALB/c mouse genomic leukemia virus-related DNA clone. Nucleic Acids Res (1983) 1.51
Rat beta casein cDNA: sequence analysis and evolutionary comparisons. Nucleic Acids Res (1982) 1.44
Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression. Proc Natl Acad Sci U S A (1982) 1.41
Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence. Nucleic Acids Res (1982) 1.40
The sequences homologous to major interspersed repeats B1 and B2 of mouse genome are present in mRNA and small cytoplasmic poly(A) + RNA. Nucleic Acids Res (1982) 1.40
Nucleotide sequence analysis of the spacer regions flanking the rat rRNA transcription unit and identification of repetitive elements. Nucleic Acids Res (1986) 1.39
DNA sequence analysis of a mouse pro alpha 1 (I) procollagen gene: evidence for a mouse B1 element within the gene. Mol Cell Biol (1982) 1.27
Isolation and characterization of the rat tryptophan oxygenase gene. EMBO J (1982) 1.26
Genomic organization of rat rDNA. Nucleic Acids Res (1983) 1.22
One gene and one pseudogene for the cytokeratin endo A. Proc Natl Acad Sci U S A (1985) 1.19
Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation. Proc Natl Acad Sci U S A (1982) 1.18
Isolation and characterization of the human prolactin gene. EMBO J (1984) 1.17
Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence. Proc Natl Acad Sci U S A (1984) 1.13
Transcription of two classes of rat growth hormone gene-associated repetitive DNA: differences in activity and effects of tandem repeat structure. Nucleic Acids Res (1984) 1.11
Nucleotide sequence of small polyadenylated B2 RNA. Nucleic Acids Res (1985) 1.03
The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells. Mol Cell Biol (1983) 1.03
Structure of a fish (rainbow trout) growth hormone gene and its evolutionary implications. Proc Natl Acad Sci U S A (1988) 0.94
Small RNA molecules related to the Alu family of repetitive DNA sequences. Mol Cell Biol (1982) 0.93
A generalized method of subcloning DNA fragments by restriction site reconstruction: application to sequencing the amino-terminal coding region of the transforming gene of Gazdar murine sarcoma virus. Nucleic Acids Res (1982) 0.89
Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J (1996) 0.88
Localization and characterization of members of a family of repetitive sequences in the goat beta globin locus. Nucleic Acids Res (1985) 0.83
Posttranscriptional regulation of rat growth hormone gene expression: increased message stability and nuclear polyadenylation accompany thyroid hormone depletion. Mol Cell Biol (1992) 0.81
Polymorphism in an androgen-regulated mouse gene is the result of the insertion of a B1 repetitive element into the transcription unit. Mol Cell Biol (1986) 0.81
Cloning and nucleotide sequence of a cDNA encoding the mink growth hormone. Nucleic Acids Res (1990) 0.80
Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences. Nucleic Acids Res (1989) 0.78
G-repeats: a novel hamster sine family. Nucleic Acids Res (1989) 0.77
Rat prostatic steroid binding protein: characterisation of the Alu element upstream of the C3 genes. Nucleic Acids Res (1984) 0.76
In vitro transcription of RU, a middle repetitive element of the rat genome. Nucleic Acids Res (1986) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. Science (1977) 13.24
Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit. Cell (1978) 9.60
Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30
Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites. Nature (1978) 8.54
Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections. Science (1978) 8.24
Accurate transcription initiation on a purified mouse beta-globin DNA fragment in a cell-free system. Cell (1980) 8.02
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Improved separation of transfer RNA's on polychlorotrifuoroethylene-supported reversed-phase chromatography columns. Biochim Biophys Acta (1971) 6.49
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
BKV splice sequences based on analysis of preferred donor and acceptor sites. Nucleic Acids Res (1979) 4.86
Cloning of influenza cDNA ino M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucleic Acids Res (1980) 4.75
Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology (1968) 4.12
Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones. Proc Natl Acad Sci U S A (1977) 2.47
Mutagenesis in vitro by DNA polymerase from an RNA tumour virus. Nature (1979) 2.00
Preparative fractionation of DNA restriction fragments by reversed phase column chromatography. Proc Natl Acad Sci U S A (1976) 1.77
Structure of genes for human growth hormone and chorionic somatomammotropin. Proc Natl Acad Sci U S A (1979) 1.71
Biogenesis, structures, and sites of encoding of the 5' termini of adenovirus-2 mRNAs. Cold Spring Harb Symp Quant Biol (1980) 1.52
Genomic organization of rat prolactin and growth hormone genes. Proc Natl Acad Sci U S A (1980) 1.27
Comparison of potential nuclear precursors for prolactin and growth hormone messenger RNA. J Biol Chem (1980) 1.18
High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04
A global optimisation method for robust affine registration of brain images. Med Image Anal (2001) 27.87
Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging (2001) 25.22
Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis. J Virol (1974) 23.54
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
DNA nucleotide sequence restricted by the RI endonuclease. Proc Natl Acad Sci U S A (1972) 15.71
Entropic elasticity of lambda-phage DNA. Science (1994) 15.40
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Specificity of substrate recognition by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1975) 11.07
Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64
Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ (1995) 9.26
Large-scale temporal gene expression mapping of central nervous system development. Proc Natl Acad Sci U S A (1998) 9.06
Nopaline synthase: transcript mapping and DNA sequence. J Mol Appl Genet (1982) 8.73
Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell (1992) 8.36
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol Cell Biol (1986) 7.11
Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures. J Mol Biol (1975) 6.95
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
DNA substrate site for the EcoRII restriction endonuclease and modification methylase. Nat New Biol (1973) 5.90
Sequence of the human insulin gene. Nature (1980) 5.76
Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation (1999) 5.62
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell (1992) 5.16
Nucleotide sequences at the cleavage sites of two restriction endonucleases from Hemophilus parainfluenzae. Biochem Biophys Res Commun (1974) 5.14
The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell (1998) 4.92
Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. Plant J (1995) 4.87
Isolation of the Arabidopsis GA4 locus. Plant Cell (1995) 4.86
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase. Biochemistry (1974) 4.58
Molecular cloning and sequence analysis of adult chicken betal globin cDNA. Nucleic Acids Res (1979) 4.49
Tumor DNA structure in plant cells transformed by A. tumefaciens. Science (1980) 4.36
Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate. J Mol Biol (1975) 4.21
Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res (1981) 4.03
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90
Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA (2000) 3.87
Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomato. Proc Natl Acad Sci U S A (1990) 3.85
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities. Clin Genet (1975) 3.81
Human growth hormone: complementary DNA cloning and expression in bacteria. Science (1979) 3.67
Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62
A number of different nuclear genes for the small subunit of RuBPCase are transcribed in petunia. Nucleic Acids Res (1983) 3.56
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res (1990) 3.46
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature (1991) 3.43
RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32
Tumor induction by Agrobacterium tumefaciens: analysis of the boundaries of T-DNA. J Mol Appl Genet (1982) 3.28
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13
Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
The next ten years of health spending: what does the future hold? The Health Expenditures Projection Team. Health Aff (Millwood) (1998) 3.04
Stigmatization of AIDS patients by physicians. Am J Public Health (1987) 3.03
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res (1993) 2.99
Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (1968) 2.98
Molecular cloning of the avian myelocytomatosis virus genome and recovery of infectious virus by transfection of chicken cells. J Virol (1981) 2.95
Respiratory epithelial cell invasion by group B streptococci. Infect Immun (1992) 2.86
A randomised controlled trial of stress reduction for hypertension in older African Americans. Hypertension (1995) 2.85
TOPS: an internet-based system to prevent healthy subjects from over-volunteering for clinical trials. Eur J Clin Pharmacol (2012) 2.80
Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet (2005) 2.78
Health spending growth up in 1999; faster growth expected in the future. Health Aff (Millwood) (2001) 2.77
Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile. J Hosp Infect (2009) 2.76
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76
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Comparison of CT scan muscle measurements and isokinetic trunk strength in postoperative patients. Spine (Phila Pa 1976) (1989) 2.70
The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice. Biochem J (1938) 2.69
Determining the common medical presenting problems to an accident and emergency department. Arch Dis Child (2001) 2.67
Nucleotide sequence at the 5' terminus of the avian sarcoma virus genome. Proc Natl Acad Sci U S A (1977) 2.66
TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
Map-based cloning of a gene controlling omega-3 fatty acid desaturation in Arabidopsis. Science (1992) 2.59
Structure and function of phage RNA. Annu Rev Biochem (1973) 2.50
The gene encoding the common alpha subunit of the four human glycoprotein hormones. J Mol Appl Genet (1981) 2.48
Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones. Proc Natl Acad Sci U S A (1977) 2.47
A new locus (NIA 1) in Arabidopsis thaliana encoding nitrate reductase. EMBO J (1988) 2.46
The Arabidopsis photomorphogenic mutant hy1 is deficient in phytochrome chromophore biosynthesis as a result of a mutation in a plastid heme oxygenase. Plant Cell (1999) 2.38
Resolution of simian virus 40 proteins in whole cell extracts by two-dimensional electrophoresis: heterogeneity of the major capsid protein. Cell (1976) 2.37
Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. Nature (1979) 2.36
The care of HIV-infected adults in rural areas of the United States. J Acquir Immune Defic Syndr (2001) 2.34
Structure and processing of yeast precursor tRNAs containing intervening sequences. Nature (1978) 2.31
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Nucleotide sequence that binds primer for DNA synthesis to the avian sarcoma virus genome. J Virol (1976) 2.28
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Assessing operative skill. Needs to become more objective. BMJ (1999) 2.19
Identification and map position of YAC clones comprising one-third of the Arabidopsis genome. Plant J (1991) 2.17
Cloning and nitrate induction of nitrate reductase mRNA. Proc Natl Acad Sci U S A (1986) 2.17
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. Virology (1977) 2.16
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J (1988) 2.15
Interaction of bacteriophage T4 RNA and DNA ligases in joining of duplex DNA at base-paired ends. J Biol Chem (1977) 2.13
The nucleotide sequences of tyrosine transfer RNAs of Escherichia coli. Eur J Biochem (1970) 2.13
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A (1987) 2.12