Published in J Biol Chem on December 03, 1999
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci U S A (2000) 5.53
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc Natl Acad Sci U S A (2004) 3.86
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem (2000) 3.02
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci U S A (2002) 2.69
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. J Clin Invest (2001) 2.00
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70
Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol (2013) 1.70
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol (2005) 1.66
Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat. PLoS One (2010) 1.29
Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol (2004) 1.26
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell Mol Life Sci (2010) 1.25
Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome. Mol Cell Biol (2002) 1.24
Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity. J Virol (2001) 1.16
Effects of histone acetylation and DNA methylation on p21( WAF1) regulation. World J Gastroenterol (2002) 1.15
p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP). Mol Cell Biol (2004) 1.14
The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Mol Cell Biol (2002) 1.13
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition. Arterioscler Thromb Vasc Biol (2011) 1.12
Nutrient regulation of gene expression by the sterol regulatory element binding proteins: increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo. Proc Natl Acad Sci U S A (2000) 1.09
Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene. Mol Cell Biol (2001) 1.06
Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. J Virol (2002) 1.05
Targeting histone deacetyalses in the treatment of B- and T-cell malignancies. Invest New Drugs (2010) 1.05
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04
A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. J Biol Chem (2010) 1.02
Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. Mol Cell Biol (2003) 1.01
Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs. J Mol Cell Cardiol (2014) 1.00
Epigenetic regulation of caloric restriction in aging. BMC Med (2011) 0.99
Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. J Biol Chem (2007) 0.99
Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae. Mol Cell Biol (2003) 0.99
Novel therapeutic agents for cutaneous T-Cell lymphoma. J Hematol Oncol (2012) 0.98
ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors. Oncogene (2006) 0.97
Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications. Int J Biol Sci (2014) 0.96
Chromatin modification and disease. J Med Genet (2000) 0.96
Targeting histone deacetylases for the treatment of disease. J Cell Mol Med (2008) 0.94
Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. Oncogene (2009) 0.93
Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Proc Natl Acad Sci U S A (2004) 0.92
Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells. BMC Cancer (2012) 0.91
The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol (2005) 0.90
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. ACS Chem Biol (2012) 0.89
Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. J Nat Prod (2010) 0.88
A Phase II Clinical Trial of Oral Valproic Acid in Patients with Castration-Resistant Prostate Cancers Using an Intensive Biomarker Sampling Strategy. Transl Oncol (2008) 0.88
Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function. Pulm Pharmacol Ther (2012) 0.85
Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53. PLoS One (2013) 0.85
Mechanism of growth inhibition of prostate cancer xenografts by valproic acid. J Biomed Biotechnol (2012) 0.85
Gene-selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol. Alcohol Alcohol (2012) 0.84
Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. Invest New Drugs (2005) 0.84
Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01. Br J Cancer (2006) 0.84
Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth. Cancer Res (2012) 0.84
Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer (2013) 0.83
Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. PLoS One (2009) 0.83
Boron chemicals in diagnosis and therapeutics. Future Med Chem (2013) 0.82
Histone Deacetylase Inhibitor M344 Inhibits Cell Proliferation and Induces Apoptosis in Human THP-1 Leukemia Cells. Am J Biomed Sci (2009) 0.82
Customized targeted therapy in Hodgkin lymphoma: hype or hope? Hematol Oncol Clin North Am (2014) 0.82
Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells. Int J Oncol (2012) 0.80
PLK1 inhibitors synergistically potentiate HDAC inhibitor lethality in imatinib mesylate-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clin Cancer Res (2012) 0.79
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Endocr Relat Cancer (2015) 0.78
Therapy of thyroid carcinoma with the histone deacetylase inhibitor MS-275. Eur J Nucl Med Mol Imaging (2010) 0.78
Epigenetic histone acetylation modifiers in vascular remodelling - new targets for therapy in cardiovascular disease. Neth Heart J (2008) 0.78
CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy. Horm Cancer (2016) 0.78
Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. J Cell Mol Med (2009) 0.78
Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. Biomol Ther (Seoul) (2012) 0.77
Nuclear Smad7 Overexpressed in Mesenchymal Cells Acts as a Transcriptional Corepressor by Interacting with HDAC-1 and E2F to Regulate Cell Cycle. Biol Open (2012) 0.77
Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer Prev Res (Phila) (2015) 0.76
The histone deacetylase inhibitor Entinostat enhances polymer-mediated transgene expression in cancer cell lines. Biotechnol Bioeng (2015) 0.75
Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia. J Med Chem (2016) 0.75
Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science (2001) 24.48
Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics (1990) 13.23
The HIV 'A' (sor) gene product is essential for virus infectivity. Nature (1987) 7.51
Relationships between Leaf Water Status, Abscisic Acid Levels, and Stomatal Resistance in Maize and Sorghum. Plant Physiol (1975) 6.38
Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol (1982) 6.05
Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res (2001) 5.78
Optimizing reproduction in a randomly varying environment. J Theor Biol (1966) 5.69
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science (1999) 5.53
The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis. Nature (2008) 5.42
Single-particle electron cryo-microscopy: towards atomic resolution. Q Rev Biophys (2000) 4.86
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet (1993) 4.78
On population growth in a randomly varying environment. Proc Natl Acad Sci U S A (1969) 4.62
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
A prokaryotic voltage-gated sodium channel. Science (2001) 4.56
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
Genetic associations with human longevity at the APOE and ACE loci. Nat Genet (1994) 4.17
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol (2004) 4.12
Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83
TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem (1997) 3.81
The CIC library: a large insert YAC library for genome mapping in Arabidopsis thaliana. Plant J (1995) 3.79
Function of GATA transcription factors in preadipocyte-adipocyte transition. Science (2000) 3.60
The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell (1991) 3.59
PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol (1996) 3.38
A comparison of characteristics of Kevorkian euthanasia cases and physician-assisted suicides in Oregon. Gerontologist (2001) 3.31
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin Pharmacol Ther (2012) 3.16
Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents. Proc Natl Acad Sci U S A (1990) 3.09
Barley endosperm bioassay for gibberellins. I. Parameters of the response system. Plant Physiol (1967) 3.05
The emerging role of electronic medical records in pharmacogenomics. Clin Pharmacol Ther (2011) 2.93
Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. J Biol Chem (2000) 2.88
Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res (1998) 2.48
Alcohol availability and homicide in New Orleans: conceptual considerations for small area analysis of the effect of alcohol outlet density. J Stud Alcohol (1999) 2.46
Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci U S A (2001) 2.46
CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J Biol Chem (1992) 2.41
Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nat Genet (1993) 2.40
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev (1997) 2.38
Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol (2001) 2.37
Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther (2011) 2.36
Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit. Science (1991) 2.34
Cellular and ultrastructural changes in mesophyll and bundle sheath cells of maize in response to water stress. Plant Physiol (1974) 2.32
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31
Age differences in immunity against wild and vaccine strains of poliovirus prior to the 1988 outbreak in Israel and response to booster immunization. Vaccine (1993) 2.30
Scaffold proteins of MAP-kinase modules. Oncogene (2007) 2.30
Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. Proc Natl Acad Sci U S A (2001) 2.24
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol (1998) 2.18
The future of genetic case-control studies. Adv Genet (2001) 2.11
Autologous blood transfusion in total knee replacement surgery. Br J Anaesth (2001) 2.11
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res (2001) 2.10
A general method for the chromosomal amplification of genes in yeast. Science (1988) 2.07
Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells. J Cell Biol (1996) 2.06
Non-isotopic and sensitive method for diagnosis of maternally-inherited diabetes and deafness. Diabetologia (1994) 2.03
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem (2001) 2.02
cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network. EMBO J (2001) 2.00
Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial. Lancet (2002) 2.00
Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol (1999) 1.99
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A (1999) 1.99
Discrimination and imitation of facial expression by neonates. Science (1982) 1.98
Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res (2001) 1.98
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet (1992) 1.95
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci (2001) 1.95
Randomized trial of a specialist genetic assessment service for familial breast cancer. J Natl Cancer Inst (2000) 1.92
Taxol: mechanisms of action and resistance. J Natl Cancer Inst Monogr (1993) 1.88
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest (1994) 1.82
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab (2001) 1.82
Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island. Science (1991) 1.82
Barley Endosperm Bioassay for Gibberellins. II. Application of the Method. Plant Physiol (1967) 1.80
Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect Immun (1999) 1.80
Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A (1992) 1.79
Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex. Proc Natl Acad Sci U S A (1983) 1.78
Myosin II is involved in the production of constitutive transport vesicles from the TGN. J Cell Biol (1997) 1.78
On the founder effect and the evolution of altruistic traits. Theor Popul Biol (1976) 1.78
Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci (1992) 1.78
Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem (1999) 1.77
Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I. J Exp Med (1983) 1.71
Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors. Am J Transplant (2014) 1.70
A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1985) 1.69
An empirical evaluation of the Global Deterioration Scale for staging Alzheimer's disease. Am J Psychiatry (1992) 1.69
FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors. Mol Cell Biol (1999) 1.69
Antibiotic use in acute respiratory infections and the ways patients pressure physicians for a prescription. J Fam Pract (2001) 1.67
Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene (2001) 1.67
A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells. Dev Dyn (2001) 1.66
The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region. Vaccine (2007) 1.66
Psychiatric manifestations revealing inborn errors of metabolism in adolescents and adults. J Inherit Metab Dis (2007) 1.64
Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn Reson Med (2003) 1.64
Ferromagnetic contamination in the lungs and other organs of the human body. Science (1973) 1.62
Smoking impairs long-term dust clearance from the lung. Science (1979) 1.62
Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization. Acta Radiol (2008) 1.61
Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models. J Clin Invest (1998) 1.60
An evaluation of the TruView EVO2 laryngoscope. Anaesthesia (2007) 1.59
The environmental distribution of canine respiratory tract neoplasms. Arch Environ Health (1971) 1.59
Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: A systematic review of randomized, placebo controlled trials and guidelines for clinical practice. Eur Psychiatry (2011) 1.58
An extreme-sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet (1999) 1.56
"Retroposon" insertion into the cellular oncogene c-myc in canine transmissible venereal tumor. Proc Natl Acad Sci U S A (1985) 1.56
Magnetoencephalography: evidence of magnetic fields produced by alpha-rhythm currents. Science (1968) 1.56
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene. J Clin Invest (1993) 1.55
The development of sequence-tagged sites for human chromosome 4. Hum Mol Genet (1993) 1.55
Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem (1998) 1.55