Published in Nucleic Acids Res on June 25, 1983
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
The gapped duplex DNA approach to oligonucleotide-directed mutation construction. Nucleic Acids Res (1984) 8.30
Structure and expression of the human haptoglobin locus. EMBO J (1985) 2.09
The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA. Proc Natl Acad Sci U S A (1986) 1.27
Enzymatic techniques for the isolation of random single-base substitutions in vitro at high frequency. Proc Natl Acad Sci U S A (1984) 0.97
U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus. Proc Natl Acad Sci U S A (1996) 0.87
Transcription of multimeric tRNA genes. Nucleic Acids Res (1984) 0.80
Targeted mutagenesis in vitro: lac repressor mutations generated using AMV reverse transcriptase and dBrUTP. Nucleic Acids Res (1984) 0.78
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
Directed mutagenesis of DNA cloned in filamentous phage: influence of hemimethylated GATC sites on marker recovery from restriction fragments. Nucleic Acids Res (1982) 5.72
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
Site-specific mutagenesis by error-directed DNA synthesis. Nature (1982) 4.46
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Gap misrepair mutagenesis: efficient site-directed induction of transition, transversion, and frameshift mutations in vitro. Proc Natl Acad Sci U S A (1982) 2.78
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Induction and isolation of mutants in a specific region of gene A of bacteriophage phi chi 174. Virology (1976) 1.61
Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc Natl Acad Sci U S A (1982) 1.38
pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19
Novel bacteriophage lambda cloning vector. Proc Natl Acad Sci U S A (1980) 8.97
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 7.78
A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13. J Mol Biol (1979) 7.73
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70
Plasmids pEMBLY: new single-stranded shuttle vectors for the recovery and analysis of yeast DNA sequences. Gene (1985) 5.73
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 4.19
The yeast homologue of U3 snRNA. EMBO J (1987) 3.74
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol (1972) 3.57
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell (1989) 3.51
Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med (1998) 3.20
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. EMBO J (1988) 3.14
Base pairing of RNA I with its complementary sequence in the primer precursor inhibits ColE1 replication. Nature (1981) 3.11
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts. Nature (1991) 3.10
Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature (1980) 3.07
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01
Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell (1985) 2.99
Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell (1983) 2.94
Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem (2001) 2.93
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest (1998) 2.74
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. EMBO J (1987) 2.69
Elevated levels of interleukin-6 in unstable angina. Circulation (1996) 2.66
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J (1988) 2.60
Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res (1985) 2.59
Control of ColE1 DNA replication: the rop gene product negatively affects transcription from the replication primer promoter. Proc Natl Acad Sci U S A (1982) 2.56
The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth. Mol Cell Biol (1989) 2.55
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem (1988) 2.40
Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J (1988) 2.36
Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem (1974) 2.36
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Cloning of the gene coding for human L apoferritin. Nucleic Acids Res (1986) 2.31
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology (2000) 2.24
Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem (1998) 2.13
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. J Clin Invest (1997) 2.11
Structure and expression of the human haptoglobin locus. EMBO J (1985) 2.09
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem (2001) 2.09
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell (1990) 2.09
Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J (1987) 2.08
Transcription signals in embryonic Xenopus laevis U1 RNA genes. EMBO J (1985) 2.07
A novel leader peptide which allows efficient secretion of a fragment of human interleukin 1 beta in Saccharomyces cerevisiae. EMBO J (1987) 2.05
Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J (1985) 2.05
The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J (1989) 2.04
Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J (1989) 1.98
Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J (1990) 1.95
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood (1998) 1.93
Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res (1986) 1.91
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell (1979) 1.91
Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J Mol Biol (1991) 1.90
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J (1994) 1.90
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89
The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J (1987) 1.85
Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J (1987) 1.85
The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J (1987) 1.82
Identification of the ferroxidase centre in ferritin. FEBS Lett (1989) 1.78
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J Virol (2000) 1.70
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol (1977) 1.69
Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene (1998) 1.69
SH3-SPOT: an algorithm to predict preferred ligands to different members of the SH3 gene family. J Mol Biol (2000) 1.67
Antagonistic controls regulate copy number of the yeast 2 mu plasmid. EMBO J (1987) 1.66
Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites. EMBO J (1990) 1.63
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
A novel peptide-SH3 interaction. EMBO J (1999) 1.61
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J (1991) 1.60
Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res (1987) 1.59
Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J (1990) 1.53
Formation of the 3' end on U snRNAs requires at least three sequence elements. EMBO J (1986) 1.52
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J (1998) 1.50
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Ther (2004) 1.50
The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res (1993) 1.49
SnR30: a new, essential small nuclear RNA from Saccharomyces cerevisiae. Nucleic Acids Res (1988) 1.48
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci U S A (1991) 1.48
Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol (1997) 1.47
Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene (1993) 1.47