Published in Nucleic Acids Res on January 25, 1993
CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J (2002) 6.83
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol Cell Biol (1997) 3.70
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. J Clin Invest (1997) 2.56
Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol (2011) 2.14
The effects of IL-6 on CD4 T cell responses. Clin Immunol (2008) 1.90
Regulation of serum amyloid A protein expression during the acute-phase response. Biochem J (1998) 1.83
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61
Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1. Mol Cell Biol (1998) 1.52
NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line. EMBO J (1995) 1.45
Multiple forms of C/EBP beta bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol Cell Biol (1994) 1.10
Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein delta and CREB-binding protein. Mol Biol Cell (2005) 1.07
Separation of C/EBPalpha-mediated proliferation arrest and differentiation pathways. Proc Natl Acad Sci U S A (1999) 1.06
Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochem J (2000) 1.05
Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor. Mol Cell Biol (1994) 1.05
Glucocorticoids enhance or spare innate immunity: effects in airway epithelium are mediated by CCAAT/enhancer binding proteins. J Immunol (2007) 1.04
Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response. Mol Cell Biol (2006) 1.04
Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease. J Clin Pathol (2006) 1.02
The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level. Biochem J (1995) 1.02
C5a-regulated CCAAT/enhancer-binding proteins β and δ are essential in Fcγ receptor-mediated inflammatory cytokine and chemokine production in macrophages. J Biol Chem (2011) 1.01
Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis. PLoS One (2012) 0.99
C/EBPalpha is critical for the neonatal acute-phase response to inflammation. Mol Cell Biol (1998) 0.98
Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo. Biochem J (1997) 0.97
Role of transcription factors in peripheral nerve regeneration. Front Mol Neurosci (2012) 0.94
Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution. Biochem J (1998) 0.92
Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha. J Immunol (2010) 0.89
The DAS28-ESR cutoff value necessary to achieve remission under the new Boolean-based remission criteria in patients receiving tocilizumab. Clin Rheumatol (2012) 0.85
Oncostatin M induced alpha1-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer. Biochem J (2002) 0.85
Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter. Mol Immunol (2012) 0.84
Analysis of the Xenopus laevis CCAAT-enhancer binding protein alpha gene promoter demonstrates species-specific differences in the mechanisms for both auto-activation and regulation by Sp1. Nucleic Acids Res (2001) 0.83
Interleukin-6 represses the transcription of the CCAAT/enhancer binding protein-alpha gene in hepatoma cells by inhibiting its ability to autoactivate the proximal promoter region. Nucleic Acids Res (2003) 0.81
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. Int J Biochem Cell Biol (2009) 0.79
C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells. J Cell Mol Med (2014) 0.78
Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ. PLoS One (2014) 0.78
Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. Br J Pharmacol (2001) 0.78
Interleukin-6 expands homeostatic space for peripheral T cells. Cytokine (2013) 0.77
Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a. Mol Neurobiol (2015) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry (1977) 38.82
Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci U S A (1982) 20.55
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev (1991) 11.10
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci U S A (1987) 9.26
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J (1990) 9.17
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev (1992) 7.66
Interleukin-6: an overview. Annu Rev Immunol (1990) 7.48
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science (1989) 6.46
The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell (1987) 6.14
Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface. EMBO J (1986) 5.60
Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06
LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev (1990) 4.98
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science (1988) 4.93
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev (1991) 4.50
A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal Tech (1989) 3.95
Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol (1986) 3.20
cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev (1991) 2.75
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A (1992) 2.55
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem (1988) 2.40
Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev (1990) 2.31
The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J (1989) 2.04
Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol (1987) 1.97
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89
Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med (1990) 1.88
Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor. J Immunol (1989) 1.87
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression. New Biol (1991) 1.70
Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein. Proc Natl Acad Sci U S A (1990) 1.54
Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J (1990) 1.53
Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma. Mol Cell Biol (1991) 1.49
Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. J Immunol (1992) 1.40
Transcriptional activation and repression by cellular DNA-binding protein C/EBP. J Virol (1990) 1.35
Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias. Int J Cell Cloning (1991) 1.27
Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells. J Biol Chem (1987) 1.22
Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor. J Biol Chem (1991) 1.13
Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6. FEBS Lett (1991) 1.10
Post-transcriptional control of negative acute phase genes by transforming growth factor beta. EMBO J (1989) 1.02
pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 7.78
A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13. J Mol Biol (1979) 7.73
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70
Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science (2000) 6.55
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 4.19
A general method to select for M13 clones carrying base pair substitution mutants constructed in vitro. Nucleic Acids Res (1983) 4.14
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol (1972) 3.57
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell (1989) 3.51
Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med (1998) 3.20
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. EMBO J (1988) 3.14
Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature (1980) 3.07
Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell (1985) 2.99
Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell (1983) 2.94
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest (1998) 2.74
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. EMBO J (1987) 2.69
Elevated levels of interleukin-6 in unstable angina. Circulation (1996) 2.66
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J (1988) 2.60
Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res (1985) 2.59
Hepatocyte-specific expression of Cre recombinase. Genesis (2000) 2.52
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem (1988) 2.40
Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J (1988) 2.36
Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem (1974) 2.36
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Cloning of the gene coding for human L apoferritin. Nucleic Acids Res (1986) 2.31
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology (2000) 2.24
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. J Clin Invest (1997) 2.11
Structure and expression of the human haptoglobin locus. EMBO J (1985) 2.09
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem (2001) 2.09
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell (1990) 2.09
Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J (1987) 2.08
Transcription signals in embryonic Xenopus laevis U1 RNA genes. EMBO J (1985) 2.07
Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J (1985) 2.05
The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J (1989) 2.04
Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J (1989) 1.98
Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J (1990) 1.95
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood (1998) 1.93
The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev (1999) 1.92
Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res (1986) 1.91
Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res (1996) 1.91
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell (1979) 1.91
Suppression of defective RAS1 and RAS2 functions in yeast by an adenylate cyclase activated by a single amino acid change. EMBO J (1986) 1.90
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J (1994) 1.90
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89
The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J (1987) 1.85
Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J (1987) 1.85
The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J (1987) 1.82
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J Virol (2000) 1.70
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol (1977) 1.69
Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites. EMBO J (1990) 1.63
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription. EMBO J (1992) 1.62
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J (1991) 1.60
Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res (1987) 1.59
Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J (1990) 1.53
Formation of the 3' end on U snRNAs requires at least three sequence elements. EMBO J (1986) 1.52
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J (1998) 1.50
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Ther (2004) 1.50
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci U S A (1991) 1.48
Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene (1993) 1.47
Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol (1997) 1.47
CD4+CD25+ regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge. Cancer Gene Ther (2006) 1.45
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood (1994) 1.45
Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucleic Acids Res (1988) 1.44
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J Mol Biol (1999) 1.44
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut (2004) 1.42
Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family. EMBO J (1984) 1.42
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling. EMBO J (1995) 1.39
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci U S A (1999) 1.38
Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc Natl Acad Sci U S A (1982) 1.38
Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol (2001) 1.37
Inducible site-specific recombination in the brain. J Mol Biol (1999) 1.37