Published in Biochemistry on December 21, 1999
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol (2001) 2.39
The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol Biol Cell (2009) 2.09
Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol (2001) 1.96
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. J Physiol (2003) 1.86
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem (2009) 1.45
Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction. J Biol Chem (2009) 1.32
Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proc Natl Acad Sci U S A (2004) 1.30
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J (2002) 1.29
Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. Biochem J (2006) 1.14
Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development (2009) 1.03
Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure (2007) 1.02
Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem J (2006) 0.99
CPI-17-deficient smooth muscle of chicken. J Physiol (2004) 0.99
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol (2007) 0.97
GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Biochem J (2004) 0.87
Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders. Pharmacol Rev (2016) 0.87
Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Genetics (2008) 0.85
Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Neuroscience (2009) 0.84
PHI-1 interacts with the catalytic subunit of myosin light chain phosphatase to produce a Ca(2+) independent increase in MLC(20) phosphorylation and force in avian smooth muscle. FEBS Lett (2006) 0.83
A bioinformatic and computational study of myosin phosphatase subunit diversity. Am J Physiol Regul Integr Comp Physiol (2014) 0.81
Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells. Histochem Cell Biol (2004) 0.79
Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. Br J Pharmacol (2008) 0.79
Diversity and plasticity in signaling pathways that regulate smooth muscle responsiveness: Paradigms and paradoxes for the myosin phosphatase, the master regulator of smooth muscle contraction. J Smooth Muscle Res (2017) 0.77
Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles. J Neurogastroenterol Motil (2016) 0.77
Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal (2016) 0.76
Role of myosin light chain phosphatase in cardiac physiology and pathophysiology. J Mol Cell Cardiol (2016) 0.75
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell (1990) 6.12
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun (1989) 4.63
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science (1992) 3.64
Mitochondrial cytochrome c: preparation and activity of native and chemically modified cytochromes c. Methods Enzymol (1978) 2.87
B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc Natl Acad Sci U S A (1997) 2.30
Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase. J Biol Chem (1976) 2.25
Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit. J Cell Biol (1992) 2.16
Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. J Pediatr (1982) 2.03
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem (2000) 2.00
Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol (2001) 1.96
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn. J Biol Chem (1981) 1.95
Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A. J Neurosci (1991) 1.90
Definition of cytochrome c binding domains by chemical modification. III. Kinetics of reaction of carboxydinitrophenyl cytochromes c with cytochrome c oxidase. J Biol Chem (1978) 1.79
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J Biol Chem (1994) 1.79
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. J Biol Chem (2001) 1.77
Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells. J Cell Biol (1990) 1.68
Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish. J Cell Biol (1989) 1.66
Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase. J Biol Chem (1978) 1.64
Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol Endocrinol (1991) 1.59
Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods. Neuron (1992) 1.54
Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. J Biol Chem (1990) 1.49
Cytosolic protein phosphotyrosine phosphatases from rabbit kidney. Purification of two distinct enzymes that bind to Zn2+-iminodiacetate agarose. J Biol Chem (1984) 1.37
Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. Proc Natl Acad Sci U S A (1988) 1.37
Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry (1999) 1.36
Cytoskeletal integrity in interphase cells requires protein phosphatase activity. Proc Natl Acad Sci U S A (1992) 1.36
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature (1994) 1.34
Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation. J Biol Chem (2001) 1.31
Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau. J Biol Chem (1998) 1.30
Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts. Mol Biol Cell (1997) 1.30
Multiple low spin forms of the cytochrome c ferrihemochrome. EPR spectra of various eukaryotic and prokaryotic cytochromes c. J Biol Chem (1977) 1.25
Methods to distinguish various types of protein phosphatase activity. Methods Enzymol (1988) 1.24
Molecular basis for substrate specificity of protein kinases and phosphatases. Int J Biochem (1986) 1.16
Definition of cytochrome c binding domains by chemical modification. I. Reaction with 4-chloro-3,5-dinitrobenzoate and chromatographic separation of singly substituted derivatives. J Biol Chem (1978) 1.13
Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. Proc Natl Acad Sci U S A (2001) 1.13
Preparation of cytochrome c2 from Rhodospirillum rubrum. Anal Biochem (1976) 1.13
Phosphorylase phosphatase catalytic subunit. Evidence that the Mr = 33,000 enzyme fragment is derived from a native protein of Mr = 70,000. J Biol Chem (1985) 1.11
Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. FEBS Lett (2001) 1.11
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells. Proc Natl Acad Sci U S A (1981) 1.11
Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments. Biochem J (1987) 1.10
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem (1991) 1.08
Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors. Biochem J (1988) 1.06
Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression. Cell Signal (1999) 1.02
Do evolutionary changes in cytochrome c structure reflect functional adaptations? Fed Proc (1976) 1.02
Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. J Biol Chem (2001) 1.00
Protein phosphatase type-1 and glycogen bind to a domain in the skeletal muscle regulatory subunit containing conserved hydrophobic sequence motif. Biochemistry (1996) 1.00
Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins. J Biol Chem (1986) 0.99
Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling. J Biol Chem (2000) 0.97
Inhibition of myosin/moesin phosphatase by expression of the phosphoinhibitor protein CPI-17 alters microfilament organization and retards cell spreading. Cell Motil Cytoskeleton (2000) 0.96
Uterine estrogen receptor in vivo: phosphorylation of nuclear specific forms on serine residues. Mol Endocrinol (1991) 0.96
Subunit structure and activation of inactive phosphorylase phosphatase. Biochemistry (1983) 0.96
Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000. J Biol Chem (1985) 0.96
Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes. J Biol Chem (1991) 0.95
Specificity of protein phosphotyrosine phosphatases. Comparison with mammalian alkaline phosphatase using polypeptide substrates. J Biol Chem (1985) 0.95
Definition of cytochrome c binding domains by chemical modification. II. Identification and properties of singly substituted carboxydinitrophenyl cytochromes c at lysines 8, 13, 22, 27, 39, 60, 72, 87, and 99. J Biol Chem (1978) 0.93
Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c. J Biol Chem (1980) 0.92
A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Lett (1998) 0.92
Separate intramolecular pathways for reduction and oxidation of cytochrome c in electron transport chain reactions. Proc Natl Acad Sci U S A (1973) 0.92
Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. J Clin Invest (1992) 0.92
Hepatic protein tyrosine phosphatases in the rat. Biochem J (1991) 0.91
Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. J Clin Invest (1990) 0.89
Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. Biochem J (2000) 0.89
Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J Biol Chem (2000) 0.88
Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells. Biochemistry (1982) 0.88
Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates. FEBS Lett (1994) 0.87
Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits. J Biol Chem (1996) 0.87
PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. Oncogene (2012) 0.86
Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM. J Biol Chem (1999) 0.86
Induction of hepatic glycogenesis in the fetal rat. Am J Physiol (1989) 0.84
Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation. J Biol Chem (1992) 0.83
Adenosine's role in regulating basal coronary arteriolar tone. Am J Physiol (1986) 0.82
Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle. J Biol Chem (1997) 0.82
Dephosphorylation of skeletal muscle phosphorylase, glycogen synthase, and phosphorylase kinase beta-subunit by a Mn2+-activated protein phosphatase. Arch Biochem Biophys (1982) 0.82
Regulation of an epithelial chloride channel by direct phosphorylation and dephosphorylation. Am J Physiol (1992) 0.82
Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines. Cancer Res (1992) 0.82
Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues. Proc Natl Acad Sci U S A (1980) 0.82
Interleukin 2 stimulates serine phosphorylation of CD45 in CTLL-2.4 cells. Eur J Immunol (1991) 0.81
Sequence homologies between type 1 and type 2A protein phosphatases. Mol Endocrinol (1987) 0.81
Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects. J Clin Invest (1991) 0.81
Concurrent purification of type-1 and type-2A protein phosphatase catalytic subunits. Protein Expr Purif (1994) 0.80
Meeting report: targeting protein phosphatases-medicines for the new millenium. Sci STKE (2000) 0.80
Low-temperature studies of electron transfer between different cytochromes c and cytochrome c oxidase. Biochemistry (1978) 0.80
Metal chelate affinity chromatography of Zn2+-inhibited protein Tyr(P) phosphatases. J Biochem Biophys Methods (1987) 0.78
Modulation of type-1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus. FEBS Lett (1991) 0.78
Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. Biochem J (1996) 0.78
Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. Biol Trace Elem Res (1998) 0.77
Latent forms of type-1 protein phosphatase in rabbit skeletal muscle. Biochem Biophys Res Commun (1987) 0.77
Tyrosine phosphorylation of phosphatase inhibitor 2. J Cell Biochem (1995) 0.77
Phosphorylase phosphatase complex from skeletal muscle. Activation of one of two catalytic subunits by manganese ions. Biochemistry (1980) 0.77
Activation of skeletal muscle phosphorylase phosphatase. Effects of proteolysis and divalent cations. Biochemistry (1982) 0.77
Compartmentalized protein phosphorylation/dephosphorylation in glycogen particles from rabbit skeletal muscle. Biochem Int (1988) 0.77
Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers. Proc Natl Acad Sci U S A (1980) 0.75
Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells. Lipids (1985) 0.75
Focus on women. Science (1996) 0.75
Role of adenosine in the maintenance of coronary vasodilation distal to a severe coronary artery stenosis. Observations in conscious domestic swine. Circ Res (1983) 0.75
Chromatographic isolation of PP2A from Limulus lateral eyes. Conventional and small scale methods. Methods Mol Biol (1998) 0.75