Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

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Published in Proc Natl Acad Sci U S A on May 22, 2001

Authors

J Liu1, T D Prickett, E Elliott, G Meroni, D L Brautigan

Author Affiliations

1: Center for Cell Signaling, University of Virginia School of Medicine, P.O. Box 800577, Charlottesville, VA 22908-0577, USA.

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Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c. J Biol Chem (1980) 0.92

Separate intramolecular pathways for reduction and oxidation of cytochrome c in electron transport chain reactions. Proc Natl Acad Sci U S A (1973) 0.92

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Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. Biochem J (2000) 0.89

Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J Biol Chem (2000) 0.88

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Intestinal amoebiasis and giardiasis in southern Indian infants and children. Trans R Soc Trop Med Hyg (1991) 0.88

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Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM. J Biol Chem (1999) 0.86

Pattern of diaphragmatic activity during forced expiratory vital capacity. J Appl Physiol Respir Environ Exerc Physiol (1981) 0.86

Role of exposure databases in epidemiology. Arch Environ Health (1993) 0.85

Phototherapy for hyperbilirubinaemia in low birthweight infants. Arch Dis Child (1974) 0.85

Health beliefs as predictors of HIV-preventive behavior and ethnic differences in prediction. J Soc Psychol (1996) 0.85

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