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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 1984 17.70
2 Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 1984 14.21
3 Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 1986 7.90
4 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 1999 6.79
5 c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 1998 5.31
6 A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996 4.47
7 Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 1996 4.26
8 Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry 1987 3.94
9 The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 1997 3.23
10 ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J 1996 3.22
11 Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry 1987 3.20
12 Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 2000 3.12
13 Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 2000 3.06
14 Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem 1983 2.94
15 Expression of epidermal growth factor receptors in human brain tumors. Cancer Res 1984 2.83
16 Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell 1992 2.62
17 Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000 2.47
18 The avian beta-adrenergic receptor: primary structure and membrane topology. Proc Natl Acad Sci U S A 1986 2.45
19 Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv Cancer Res 2000 2.33
20 Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 1997 2.33
21 A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol Cell Biol 1991 2.27
22 The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci U S A 1999 2.22
23 Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 1991 2.16
24 Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett 2001 2.15
25 The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem 1999 2.13
26 Regulation of cell proliferation by epidermal growth factor. CRC Crit Rev Biochem 1983 2.09
27 Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res 2000 2.07
28 Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J 1998 2.04
29 Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 1995 2.02
30 Neu and its ligands: from an oncogene to neural factors. Bioessays 1993 2.00
31 Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development 1990 1.99
32 The basic biology of HER2. Ann Oncol 2001 1.97
33 Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts. J Biol Chem 1982 1.96
34 Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001 1.95
35 A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold. EMBO J 1992 1.93
36 Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor. Proc Natl Acad Sci U S A 1981 1.87
37 Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem 1998 1.81
38 Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry 1990 1.81
39 Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 2007 1.79
40 Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth. Proc Natl Acad Sci U S A 1991 1.78
41 Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships. EMBO J 1993 1.74
42 Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors. Proc Natl Acad Sci U S A 1981 1.72
43 A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J 1994 1.68
44 A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors. Oncogene 1997 1.64
45 Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2. Mol Cell Biol 1995 1.63
46 Alternative intracellular routing of ErbB receptors may determine signaling potency. J Biol Chem 1998 1.62
47 Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies. J Biol Chem 1985 1.61
48 Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J 1997 1.58
49 Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J Biol Chem 2000 1.54
50 The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. Biochim Biophys Acta 1998 1.51
51 c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol Biol Cell 1992 1.50
52 Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J Biol Chem 2001 1.50
53 Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network. EMBO J 1998 1.49
54 Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene 1996 1.48
55 An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. J Biol Chem 1996 1.43
56 A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J 1991 1.39
57 Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J Biol Chem 1996 1.38
58 Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 1999 1.34
59 Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. EMBO J 1991 1.33
60 Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc Natl Acad Sci U S A 1995 1.32
61 EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism. Oncogene 2010 1.30
62 KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993 1.30
63 ERG30, a VAP-33-related protein, functions in protein transport mediated by COPI vesicles. J Cell Biol 1999 1.29
64 Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A 1993 1.28
65 Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem 1996 1.24
66 Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells. Cancer Res 1992 1.24
67 ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling. J Mammary Gland Biol Neoplasia 1997 1.20
68 Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. J Biol Chem 1992 1.20
69 Steel factor and c-kit protooncogene: genetic lessons in signal transduction. Crit Rev Oncog 1994 1.20
70 ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol Cell Biol 1998 1.19
71 Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. J Biol Chem 1995 1.19
72 Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains. Oncogene 2007 1.18
73 The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell 1995 1.17
74 Roles for a cytoplasmic tyrosine and tyrosine kinase activity in the interactions of Neu receptors with coated pits. J Biol Chem 1995 1.17
75 The murine flg gene encodes a receptor for fibroblast growth factor. Oncogene 1990 1.17
76 Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain. Proc Natl Acad Sci U S A 1998 1.17
77 Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase. Proc Natl Acad Sci U S A 1992 1.17
78 Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers. J Biol Chem 1992 1.15
79 Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation. J Biol Chem 1992 1.15
80 Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. Am J Pathol 1996 1.12
81 A non-mitogenic analogue of epidermal growth factor enhances the phosphorylation of endogenous membrane proteins. Biochem Biophys Res Commun 1981 1.12
82 Microaggregation of hormone-occupied epidermal growth factor receptors on plasma membrane preparations. EMBO J 1986 1.08
83 Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells. Mol Endocrinol 1995 1.08
84 ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene 1995 1.06
85 The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing. EMBO J 1999 1.06
86 Epiregulin is Up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth. Biochem Biophys Res Commun 2000 1.05
87 PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene 1991 1.05
88 Molecular requirements for the effect of neuregulin on cell spreading, motility and colony organization. Oncogene 2000 1.04
89 Structural organization of the murine c-kit proto-oncogene. Oncogene 1992 1.04
90 Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J Biol Chem 1994 1.03
91 Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes. Proc Natl Acad Sci U S A 1994 1.02
92 The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. Oncogene 1998 1.02
93 Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. Biochim Biophys Acta 1981 1.01
94 An oncogenic point mutation confers high affinity ligand binding to the neu receptor. Implications for the generation of site heterogeneity. J Biol Chem 1992 1.01
95 Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen. Biosci Rep 1983 1.01
96 Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J Immunol 1993 1.00
97 Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. Mol Cell Biol 1999 1.00
98 Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene 2011 1.00
99 Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene. Mol Cell Biol 1990 0.99
100 STAT protein recruitment and activation in c-Kit deletion mutants. J Biol Chem 1999 0.98
101 Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation. J Biol Chem 1998 0.98
102 c-Cbl is a suppressor of the neu oncogene. J Biol Chem 2000 0.98
103 Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies. Cancer Immunol Immunother 2000 0.97
104 Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies. Br J Cancer 1996 0.97
105 Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. Oncogene 2011 0.97
106 Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior. Am J Clin Pathol 1994 0.96
107 The EGF receptor kinase: evidence for allosteric activation and intramolecular self-phosphorylation. Ciba Found Symp 1985 0.96
108 Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene 2011 0.95
109 The ErbB/HER family of receptor tyrosine kinases: A potential target for chemoprevention of epithelial neoplasms. J Cell Biochem Suppl 2000 0.95
110 Cytoplasmic control of cell adhesion. Cold Spring Harb Symp Quant Biol 1992 0.94
111 A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor. J Cell Biol 1982 0.94
112 A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. J Biol Chem 1992 0.93
113 Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation. Oncogene 1997 0.92
114 Flg-2, a new member of the family of fibroblast growth factor receptors. Oncogene 1991 0.92
115 Neu differentiation factors: a family of alternatively spliced neuronal and mesenchymal factors. Proc Soc Exp Biol Med 1994 0.91
116 Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol Cell Biol 1993 0.91
117 Intracellular retention and degradation of the epidermal growth factor receptor, two distinct processes mediated by benzoquinone ansamycins. J Biol Chem 2000 0.91
118 Differences between phosphotyrosine accumulation and Neu/ErbB-2 receptor expression in astrocytic proliferative processes. Implications for glial oncogenesis. Cancer 1996 0.90
119 Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells. Oncogene 1996 0.90
120 Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. J Biol Chem 1993 0.90
121 Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells. Mol Biol Cell 1998 0.89
122 Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C. Cold Spring Harb Symp Quant Biol 1986 0.88
123 The murine vik gene (chromosome 9) encodes a putative receptor with unique protein kinase motifs. Oncogene 1993 0.88
124 Structure-function analyses of the kit receptor for the steel factor. Stem Cells 1993 0.87
125 Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth. Oncogene 2010 0.86
126 Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system. Proc Natl Acad Sci U S A 1984 0.86
127 Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase. Cancer Treat Res 1994 0.86
128 Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light. Ann N Y Acad Sci 1993 0.84
129 A cromoglycate binding protein from rat mast cells of a leukemia line is a nucleoside diphosphate kinase. Biochemistry 1992 0.84
130 The epidermal growth factor receptor as a substrate for a kinase-splitting membranal proteinase. J Biol Chem 1988 0.84
131 A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis. Oncogene 2011 0.84
132 Signal transduction by the neu/erbB-2 receptor: a potential target for anti-tumor therapy. J Steroid Biochem Mol Biol 1992 0.84
133 Expression of erbB receptors and their ligands in breast cancer: implications to biological behavior and therapeutic response. Breast Dis 2000 0.82
134 The Heregulin gene can be included in the 8p12 amplification unit in human breast cancer. Genes Chromosomes Cancer 1994 0.82
135 p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells. Oncogene 1996 0.81
136 Receptor tyrosine kinase expression in astrocytic lesions: similar features in gliosis and glioma. Neurosurgery 1993 0.80
137 Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behavior. Am J Pathol 1994 0.80
138 Protein kinase C-dependent release of a functional whole extracellular domain of the mast cell growth factor (MGF) receptor by MGF-dependent human myeloid cells. Oncogene 1994 0.79
139 Structural aspects of receptor dimerization. c-kit as an example. Ann N Y Acad Sci 1995 0.78
140 Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3). Proc Natl Acad Sci U S A 1983 0.77
141 Present and future breast cancer management--bench to bedside and back: a positioning paper of academia, regulatory authorities and pharmaceutical industry. Ann Oncol 2013 0.77
142 Specific inhibition of the reaction between a tumor-inhibitory antibody and the ErbB-2 receptor by a mimotope derived from a phage display library. Immunol Lett 2000 0.77
143 Enhanced expression of heregulin in c-erb B-2 and c-Ha-ras transformed mouse and human mammary epithelial cells. J Cell Biochem 1996 0.76
144 Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells. Int J Oncol 1993 0.76
145 Activation of a transfected FGFR-1 receptor in Madin-Darby epithelial cells results in a reversible loss of epithelial properties. J Cell Physiol 1995 0.75
146 The gene encoding sarcoplasmic reticulum calcium ATPase-1 (Atp2a1) maps to distal mouse chromosome 7. Mamm Genome 1996 0.75
147 Biochemistry of HER2 oncogenesis in breast cancer. Breast Dis 2000 0.75
148 Molecular steps in the action and regulation of epidermal growth factor: a cellular mitogen. Prog Clin Biol Res 1982 0.75
149 Receptor tyrosine kinases: the emerging tip of systems control. IET Syst Biol 2008 0.75