A molecular basis for nitric oxide sensing by soluble guanylate cyclase.

PubWeight™: 1.86‹?› | Rank: Top 3%

🔗 View Article (PMC 24720)

Published in Proc Natl Acad Sci U S A on December 21, 1999

Authors

Y Zhao1, P E Brandish, D P Ballou, M A Marletta

Author Affiliations

1: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA.

Articles citing this

Concepts of neural nitric oxide-mediated transmission. Eur J Neurosci (2008) 3.08

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov (2006) 2.84

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41

What is the real physiological NO concentration in vivo? Nitric Oxide (2009) 1.88

Quantitative vibrational dynamics of iron in nitrosyl porphyrins. J Am Chem Soc (2004) 1.69

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol Ther (2009) 1.66

Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology. Antioxid Redox Signal (2010) 1.63

NO activation of guanylyl cyclase. EMBO J (2004) 1.50

Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase. EMBO J (2000) 1.44

Subcellular targeting and trafficking of nitric oxide synthases. Biochem J (2006) 1.37

Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. Free Radic Biol Med (2006) 1.36

CO-sensing mechanisms. Microbiol Mol Biol Rev (2004) 1.30

Spectroscopic characterization of heme iron-nitrosyl species and their role in NO reductase mechanisms in diiron proteins. Nat Prod Rep (2007) 1.26

Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP. Proc Natl Acad Sci U S A (2005) 1.24

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Curr Opin Chem Biol (2012) 1.19

Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal (2008) 1.16

A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc Natl Acad Sci U S A (2009) 1.14

A functional nitric oxide reductase model. Proc Natl Acad Sci U S A (2008) 1.14

Temperature-dependent studies of NO recombination to heme and heme proteins. J Am Chem Soc (2005) 1.13

H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila. Mol Microbiol (2010) 1.13

Direct probe of iron vibrations elucidates NO activation of heme proteins. J Am Chem Soc (2005) 1.12

On the activation of soluble guanylyl cyclase by nitric oxide. Proc Natl Acad Sci U S A (2001) 1.12

A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation. Proc Natl Acad Sci U S A (2003) 1.08

In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis. Biophys J (2001) 1.06

Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme. Am J Physiol Heart Circ Physiol (2011) 1.04

Mechanism of binding of NO to soluble guanylyl cyclase: implication for the second NO binding to the heme proximal site. Biochemistry (2012) 1.01

Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization. J Biol Chem (2011) 1.01

Allostery in recombinant soluble guanylyl cyclase from Manduca sexta. J Biol Chem (2008) 1.01

Oriented single-crystal nuclear resonance vibrational spectroscopy of [Fe(TPP)(MI)(NO)]: quantitative assessment of the trans effect of NO. Inorg Chem (2010) 1.01

Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. Biochemistry (2008) 1.01

Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking. Biochemistry (2013) 0.99

Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase. Br J Pharmacol (2010) 0.97

A "sliding scale rule" for selectivity among NO, CO, and O₂ by heme protein sensors. Biochemistry (2011) 0.95

Ultrafast ligand rebinding in the heme domain of the oxygen sensors FixL and Dos: general regulatory implications for heme-based sensors. Proc Natl Acad Sci U S A (2002) 0.93

Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect. Proc Natl Acad Sci U S A (2002) 0.93

Is Nostoc H-NOX a NO sensor or redox switch? Biochemistry (2010) 0.92

Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics. J Biol Chem (2010) 0.92

Analysis of nitric oxide-cyclic guanosine monophosphate signaling during metamorphosis of the nudibranch Phestilla sibogae Bergh (Gastropoda: Opisthobranchia). Evol Dev (2008) 0.90

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc Natl Acad Sci U S A (2014) 0.89

How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase. Antioxid Redox Signal (2012) 0.89

Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues. J Biol Inorg Chem (2008) 0.89

Structural insights into the molecular mechanism of H-NOX activation. Protein Sci (2010) 0.88

Nitric oxide signaling in the microcirculation. Crit Rev Biomed Eng (2011) 0.88

Reductive coupling of nitrogen monoxide (*NO) facilitated by heme/copper complexes. Inorg Chem (2010) 0.88

Deciphering cGMP signatures and cGMP-dependent pathways in plant defence. Plant Signal Behav (2009) 0.86

Plant nucleotide cyclases: an increasingly complex and growing family. Plant Signal Behav (2007) 0.86

Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases. Biochemistry (2013) 0.85

The production of nitrous oxide by the heme/nonheme diiron center of engineered myoglobins (Fe(B)Mbs) proceeds through a trans-iron-nitrosyl dimer. J Am Chem Soc (2014) 0.84

Lead neurotoxicity: effects on brain nitric oxide synthase. J Mol Histol (2012) 0.84

Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. J Biol Chem (2012) 0.84

The case of CO signaling: why the jury is still out. J Clin Invest (2001) 0.83

Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry (2012) 0.83

A twist on heme signaling. ACS Chem Biol (2008) 0.80

Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase. Proc Natl Acad Sci U S A (2015) 0.79

Probing the local electronic and geometric properties of the heme iron center in a H-NOX domain. J Inorg Biochem (2011) 0.78

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow. Front Physiol (2014) 0.78

Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways. Nitric Oxide (2014) 0.77

Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia. Pediatr Res (2010) 0.77

The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: ROLE OF THE PSEUDOSYMMETRIC SITE. J Biol Chem (2015) 0.76

Effect of Outer-Sphere Side Chain Substitutions on the Fate of the trans Iron-Nitrosyl Dimer in Heme/Nonheme Engineered Myoglobins (FeBMbs): Insights into the Mechanism of Denitrifying NO Reductases. Biochemistry (2016) 0.76

Nitric Oxide Regulation of H-NOX Signaling Pathways in Bacteria. Biochemistry (2016) 0.75

Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor. Antioxid Redox Signal (2016) 0.75

Is histidine dissociation a critical component of the NO/H-NOX signaling mechanism? Insights from X-ray absorption spectroscopy. Dalton Trans (2012) 0.75

Binding of O2 and NO to heme in heme-nitric oxide/oxygen-binding (H-NOX) proteins. A theoretical study. J Phys Chem B (2013) 0.75

Profile of Michael A. Marletta. Proc Natl Acad Sci U S A (2010) 0.75

Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization. J Biol Inorg Chem (2016) 0.75

Thrombospondins: A Role in Cardiovascular Disease. Int J Mol Sci (2017) 0.75

Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex. Nat Chem Biol (2017) 0.75

Articles cited by this

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther (1981) 6.71

Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science (1997) 4.29

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature (1990) 4.28

Control of coronary vascular tone by nitric oxide. Circ Res (1990) 3.64

"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol (1996) 3.34

Reactions between nitric oxide and haemoglobin under physiological conditions. Nature (1998) 3.13

Guanylate cyclase and the .NO/cGMP signaling pathway. Biochim Biophys Acta (1999) 3.01

Nitric oxide synthase: aspects concerning structure and catalysis. Cell (1994) 2.84

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins. J Inorg Biochem (1981) 2.77

Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol (1991) 2.72

Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry (1994) 2.65

Mechanism of nitric oxide release from S-nitrosothiols. J Biol Chem (1996) 2.02

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms. J Biol Chem (1986) 1.86

Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. Biochemistry (1987) 1.76

Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. Biochemistry (1996) 1.75

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. Biochim Biophys Acta (1980) 1.74

Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol (1983) 1.68

Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc Natl Acad Sci U S A (1982) 1.64

Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett (1981) 1.55

Cooperativity in the dissociation of nitric oxide from hemoglobin. J Biol Chem (1976) 1.55

Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand. Biochemistry (1998) 1.47

Purification and properties of protocatechuate 3,4-dioxygenase from Pseudomonas putida. A new iron to subunit stoichiometry. J Biol Chem (1981) 1.34

Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobin. Biochemistry (1998) 1.32

Localization of the heme binding region in soluble guanylate cyclase. Biochemistry (1997) 1.26

Spectroscopic studies and bonding model for nitric oxide complexes of iron porphyrins. J Am Chem Soc (1974) 1.26

The chemical mechanism of microbial denitrification. FEBS Lett (1982) 1.26

S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther (1998) 1.25

EPR characterization of axial bond in metal center of native and cobalt-substituted guanylate cyclase. J Biol Chem (1999) 1.21

Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclase. Biochemistry (1997) 1.11

Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 1.06

Nitrosyliron(III) hemoglobin: autoreduction and spectroscopy. Biochemistry (1986) 1.01

Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase. Biochem Biophys Res Commun (1995) 1.01

Resonance raman characterization of the heme domain of soluble guanylate cyclase. Biochemistry (1998) 0.97

The role of diffusion in limiting the rate of ligand binding to hemoglobin. J Biol Chem (1980) 0.96

Evidence for N-acetylcysteine-sensitive nitric oxide storage as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta. Br J Pharmacol (1996) 0.94

Synthesis and Structural Characterization of Several Ruthenium Porphyrin Nitrosyl Complexes. Inorg Chem (1997) 0.91

Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase. Biochem Pharmacol (1997) 0.85

Spectroscopic properties of the nitric oxide derivative of ferrous man, horse, and ruminant hemoglobins: a comparative study. J Inorg Biochem (1992) 0.83

Molecular cloning of membrane forms of guanylyl cyclase. Methods Enzymol (1991) 0.80

Articles by these authors

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1985) 7.36

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci U S A (1987) 5.69

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. J Immunol (1987) 5.00

Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem (1989) 3.42

Oxidative protein folding is driven by the electron transport system. Cell (1999) 3.09

Guanylate cyclase and the .NO/cGMP signaling pathway. Biochim Biophys Acta (1999) 3.01

Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res (1987) 2.69

Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry (1994) 2.65

Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry (1992) 2.65

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. J Biol Chem (1991) 2.58

Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci (1989) 2.51

Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A (1991) 2.49

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate. Biochemistry (1986) 2.20

Nitric-oxide synthase assays. Methods Enzymol (1994) 2.19

Phthalate dioxygenase reductase: a modular structure for electron transfer from pyridine nucleotides to [2Fe-2S]. Science (1992) 2.12

The mechanism of action of xanthine oxidase. J Biol Chem (1974) 2.07

Cloning, expression, and regulation of the Pseudomonas cepacia protocatechuate 3,4-dioxygenase genes. J Bacteriol (1989) 2.04

Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia. J Biol Chem (1987) 1.79

Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. Biochemistry (1996) 1.75

Mechanistic studies of cyclohexanone monooxygenase: chemical properties of intermediates involved in catalysis. Biochemistry (2001) 1.67

Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. Biochemistry (1999) 1.65

Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. Biochemistry (2000) 1.64

The use of protocatechuate dioxygenase for maintaining anaerobic conditions in biochemical experiments. Anal Biochem (2000) 1.61

Flavin-oxygen derivatives involved in hydroxylation by p-hydroxybenzoate hydroxylase. J Biol Chem (1976) 1.61

Nitrosation of amines by stimulated macrophages. Carcinogenesis (1987) 1.59

Inhibition of soluble guanylate cyclase by ODQ. Biochemistry (2000) 1.58

Electron-nuclear double resonance spectroscopy of 15N-enriched phthalate dioxygenase from Pseudomonas cepacia proves that two histidines are coordinated to the [2Fe-2S] Rieske-type clusters. Biochemistry (1989) 1.56

Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1981) 1.56

The mobile flavin of 4-OH benzoate hydroxylase. Science (1994) 1.55

Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens. Immunol Lett (1994) 1.54

Mechanistic studies on cyclohexanone oxygenase. Biochemistry (1982) 1.54

Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem (1997) 1.52

From peptidoglycan to glycoproteins: common features of lipid-linked oligosaccharide biosynthesis. FEMS Microbiol Lett (1994) 1.50

Analytical and preparative high-performance liquid chromatography separation of flavin and flavin analog coenzymes. Anal Biochem (1980) 1.49

Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand. Biochemistry (1998) 1.47

Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase. Biochemistry (1995) 1.44

Fluoride elimination from substrates in hydroxylation reactions catalyzed by p-hydroxybenzoate hydroxylase. J Biol Chem (1980) 1.41

Coupling of cobalt-carbon bond homolysis and hydrogen atom abstraction in adenosylcobalamin-dependent glutamate mutase. Biochemistry (1998) 1.40

Inactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine. Biochem Biophys Res Commun (1991) 1.40

Purification and properties of protocatechuate 3,4-dioxygenase from Pseudomonas putida. A new iron to subunit stoichiometry. J Biol Chem (1981) 1.34

Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobin. Biochemistry (1998) 1.32

Spectroscopic characterization of the heme-binding sites in Plasmodium falciparum histidine-rich protein 2. Biochemistry (1999) 1.30

Peroxidases depolymerize lignin in organic media but not in water. Proc Natl Acad Sci U S A (1986) 1.27

Localization of the heme binding region in soluble guanylate cyclase. Biochemistry (1997) 1.26

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. Biochemistry (1998) 1.26

Characterization of neuronal nitric oxide synthase and a C415H mutant, purified from a baculovirus overexpression system. Biochemistry (1994) 1.25

Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with Resonance raman spectroscopy. Biochemistry (1996) 1.23

Genetic organization and sequence of the Pseudomonas cepacia genes for the alpha and beta subunits of protocatechuate 3,4-dioxygenase. J Bacteriol (1989) 1.22

Halogenated protocatechuates as substrates for protocatechuate dioxygenase from Pseudomonas cepacia. J Biol Chem (1983) 1.21

Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide. Chem Biol (1998) 1.18

The oxidative half-reaction of liver microsomal FAD-containing monooxygenase. J Biol Chem (1981) 1.17

Lung sources and cytokine requirements for in vivo expression of inducible nitric oxide synthase. Am J Respir Cell Mol Biol (1995) 1.16

Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studies. Biochemistry (2000) 1.14

Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites. J Immunol (1995) 1.12

Structure and mechanism of the iron-sulfur flavoprotein phthalate dioxygenase reductase. FASEB J (1995) 1.12

Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase. Biochemistry (1989) 1.12

Kinetic isotope effects as probes of the mechanism of galactose oxidase. Biochemistry (1998) 1.11

Magnetic circular dichroism studies on the mononuclear ferrous active site of phthalate dioxygenase from Pseudomonas cepacia show a change of ligation state on substrate binding. Biochemistry (1993) 1.08

pH-dependent structural changes in the active site of p-hydroxybenzoate hydroxylase point to the importance of proton and water movements during catalysis. Biochemistry (1996) 1.07

Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates. J Biol Chem (1986) 1.06

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity. Biochemistry (1992) 1.06

Nitric oxide complexes of inducible nitric oxide synthase: spectral characterization and effect on catalytic activity. Biochemistry (1995) 1.04

Substrate recognition by "password" in p-hydroxybenzoate hydroxylase. Biochemistry (1999) 1.04

Cloning and expression of the catA and catBC gene clusters from Pseudomonas aeruginosa PAO. J Bacteriol (1988) 1.04

Evidence for N coordination to Fe in the [2Fe-2S] clusters of Thermus Rieske protein and phthalate dioxygenase from Pseudomonas. J Biol Chem (1985) 1.04

Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism. FASEB J (1988) 1.04

NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase. Biochemistry (1993) 1.03

Resonance Raman studies of Rieske-type proteins. Biochim Biophys Acta (1992) 1.03

Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase. Biochem Biophys Res Commun (1995) 1.01

Participation of cob(I) alamin in the reaction catalyzed by methionine synthase from Escherichia coli: a steady-state and rapid reaction kinetic analysis. Biochemistry (1990) 1.00

The reductive half-reaction of liver microsomal FAD-containing monooxygenase. J Biol Chem (1981) 1.00

Determination of the dead time of a stopped-flow fluorometer. Anal Biochem (1989) 0.99

Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry (2001) 0.99

Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center. Biochemistry (1996) 0.99

Synthesis and action of nitric oxide in rat glomerular mesangial cells. Am J Physiol (1991) 0.99

Use of free energy relationships to probe the individual steps of hydroxylation of p-hydroxybenzoate hydroxylase: studies with a series of 8-substituted flavins. Biochemistry (1999) 0.99

Properties of anthranilate hydroxylase (deaminating), a flavoprotein from Trichosporon cutaneum. J Biol Chem (1987) 0.98

Kinetic analysis of the catalytic domain of human cdc25B. J Biol Chem (1996) 0.98

X-ray absorption spectroscopy of the [2Fe-2S] Rieske cluster in Pseudomonas cepacia phthalate dioxygenase. Determination of core dimensions and iron ligation. Biochemistry (1989) 0.97

Resonance raman characterization of the heme domain of soluble guanylate cyclase. Biochemistry (1998) 0.97

Thermodynamics and reduction kinetics properties of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase. Biochemistry (1997) 0.97

Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase. Biochemistry (1996) 0.96

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450. Biochem Biophys Res Commun (1976) 0.95

Catalytic function of tyrosine residues in para-hydroxybenzoate hydroxylase as determined by the study of site-directed mutants. J Biol Chem (1991) 0.95

Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin. Arch Biochem Biophys (1985) 0.94

Ion pair formation in pig heart lipoamide dehydrogenase: rationalization of pH profiles for reactivity of oxidized enzyme with dihydrolipoamide and 2-electron-reduced enzyme with lipoamide and iodoacetamide. J Biol Chem (1977) 0.94

Equilibrium and transient state spectrophotometric studies of the mechanism of reduction of the flavoprotein domain of P450BM-3. Biochemistry (1996) 0.94

Oxygen reactivity of p-hydroxybenzoate hydroxylase containing 1-deaza-FAD. J Biol Chem (1980) 0.94

Heme stoichiometry of heterodimeric soluble guanylate cyclase. Biochemistry (1995) 0.93

Kinetic characterization of an organic radical in the ascarylose biosynthetic pathway. Biochemistry (1996) 0.92

Unusual mechanism of oxygen atom transfer and product rearrangement in the catalytic reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase. Biochemistry (1997) 0.92

Interflavin oxidation-reduction reactions between pig kidney general acyl-CoA dehydrogenase and electron-transferring flavoprotein. Biochemistry (1985) 0.92

Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase. Biochemistry (1998) 0.91

Polymerization of phenols catalyzed by peroxidase in nonaqueous media. Biotechnol Bioeng (1987) 0.91

Stereochemical outcome of processing of fluorinated substrates by ATP citrate lyase and malate synthase. Biochemistry (1981) 0.91

Reaction of phthalate dioxygenase reductase with NADH and NAD: kinetic and spectral characterization of intermediates. Biochemistry (1994) 0.91

Mechanistic studies of 9-ethynylphenanthrene-inactivated cytochrome P450 2B1. Arch Biochem Biophys (1995) 0.91

Flavin conformational changes in the catalytic cycle of p-hydroxybenzoate hydroxylase substituted with 6-azido- and 6-aminoflavin adenine dinucleotide. Biochemistry (1997) 0.91