Published in Protein Sci on April 01, 2010
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Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins. BMC Genomics (2003) 1.76
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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature (2004) 5.09
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature (2004) 4.37
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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol (2006) 2.95
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa. ACS Chem Biol (2011) 2.76
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell (2007) 2.68
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell (2012) 2.67
Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. Nat Chem Biol (2005) 2.60
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A (2009) 2.55
Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases. Structure (2012) 2.51
Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49
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Structure of a sliding clamp on DNA. Cell (2008) 2.42
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
A molecular basis for NO selectivity in soluble guanylate cyclase. Nat Chem Biol (2005) 2.34
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci (2005) 2.32
Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A (2008) 2.18
Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa. Proc Natl Acad Sci U S A (2009) 2.17
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron (2009) 2.14
Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Chem Biol (2003) 2.11
The structure, regulation, and function of ZAP-70. Immunol Rev (2009) 2.01
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res (2006) 1.98
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure (2007) 1.87
Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
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Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry (2004) 1.80
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Clamp loaders and sliding clamps. Curr Opin Struct Biol (2002) 1.77
Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Anal Chem (2013) 1.76
Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol (2002) 1.74
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
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The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell (2009) 1.72
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Design and characterization of an active site selective caspase-3 transnitrosating agent. ACS Chem Biol (2006) 1.67
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res (2009) 1.64
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
How a DNA polymerase clamp loader opens a sliding clamp. Science (2011) 1.56
Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proc Natl Acad Sci U S A (2007) 1.52
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Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain. Biochemistry (2005) 1.48
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Probing the function of heme distortion in the H-NOX family. ACS Chem Biol (2008) 1.42
Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy. Chem Biol (2002) 1.42
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res (2002) 1.34
Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors. J Inorg Biochem (2005) 1.32
Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. J Biol Chem (2006) 1.32
Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection. Infect Immun (2004) 1.31
Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from Escherichia coli. Biochemistry (2005) 1.28
Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins. Curr Opin Chem Biol (2005) 1.28
DNA polymerase clamp loaders and DNA recognition. FEBS Lett (2005) 1.28
Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (2005) 1.27
Regulation of the catalytic activity of the EGF receptor. Curr Opin Struct Biol (2011) 1.26
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol (2008) 1.26
Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Mol Cell (2012) 1.25
Analysis of the role of PCNA-DNA contacts during clamp loading. BMC Struct Biol (2010) 1.25
Clamp loaders and replication initiation. Curr Opin Struct Biol (2006) 1.25
Quantitative proteomic approach for cellulose degradation by Neurospora crassa. J Proteome Res (2011) 1.25
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP. Proc Natl Acad Sci U S A (2005) 1.24
Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. J Am Chem Soc (2013) 1.23
The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem (2006) 1.22
A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation. Proc Natl Acad Sci U S A (2009) 1.22
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife (2013) 1.22
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol (2010) 1.21
Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry (2005) 1.21
Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex. Proc Natl Acad Sci U S A (2004) 1.20
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Curr Opin Chem Biol (2012) 1.19
Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxide. Biochemistry (2007) 1.18
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). BMC Struct Biol (2009) 1.18
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. J Biol Chem (2006) 1.16