Published in J Virol on February 01, 2000
Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. J Virol (2002) 2.62
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol (2002) 2.61
Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication. J Virol (2007) 2.15
Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase. J Virol (2000) 1.91
Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase. J Virol (2002) 1.72
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. J Virol (2004) 1.71
Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 1.63
Cell-free replication of the hepatitis C virus subgenomic replicon. J Virol (2002) 1.52
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proc Natl Acad Sci U S A (2011) 1.39
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells. J Virol (2003) 1.36
Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. J Virol (2003) 1.32
Significance in replication of the terminal nucleotides of the flavivirus genome. J Virol (2003) 1.30
De novo synthesis of negative-strand RNA by Dengue virus RNA-dependent RNA polymerase in vitro: nucleotide, primer, and template parameters. J Virol (2003) 1.28
Comparison of turnip crinkle virus RNA-dependent RNA polymerase preparations expressed in Escherichia coli or derived from infected plants. J Virol (2002) 1.27
cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome. J Virol (2004) 1.26
In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus. J Virol (2003) 1.20
Structural and functional analysis of hepatitis C virus strain JFH1 polymerase. J Virol (2009) 1.17
Recognition of the core RNA promoter for minus-strand RNA synthesis by the replicases of Brome mosaic virus and Cucumber mosaic virus. J Virol (2000) 1.17
Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase. J Virol (2002) 1.15
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother (2006) 1.15
Specific interaction of hepatitis C virus protease/helicase NS3 with the 3'-terminal sequences of viral positive- and negative-strand RNA. J Virol (2001) 1.15
Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor. Antimicrob Agents Chemother (2006) 1.14
Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell. J Virol (2004) 1.14
Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase. J Virol (2002) 1.13
Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase. EMBO J (2012) 1.12
Template nucleotide moieties required for de novo initiation of RNA synthesis by a recombinant viral RNA-dependent RNA polymerase. J Virol (2000) 1.07
A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes. J Virol (2011) 1.07
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses (2010) 1.07
Comparison of polymerase subunits from double-stranded RNA bacteriophages. J Virol (2001) 1.07
Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase. J Virol (2006) 1.03
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2007) 1.03
Hepatitis C virus NS5B polymerase exhibits distinct nucleotide requirements for initiation and elongation. J Biol Chem (2008) 1.03
Structural explanation for the role of Mn2+ in the activity of phi6 RNA-dependent RNA polymerase. Nucleic Acids Res (2008) 1.02
Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate. Nucleic Acids Res (2004) 1.01
Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex. J Biol Chem (2012) 1.01
De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase. J Virol (2007) 0.98
Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis. J Virol (2003) 0.98
Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion. Proc Natl Acad Sci U S A (2010) 0.97
Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A. Hepatology (2009) 0.95
Secondary structure of the 3' terminus of hepatitis C virus minus-strand RNA. J Virol (2002) 0.94
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity. J Biol Chem (2010) 0.94
Template requirements for de novo RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase on the viral X RNA. J Virol (2002) 0.93
Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase. J Virol (2005) 0.93
Secondary structure and hybridization accessibility of hepatitis C virus 3'-terminal sequences. J Virol (2002) 0.92
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance. Viruses (2015) 0.92
Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV. PLoS One (2012) 0.90
Inhibition of hepatitis C virus (HCV) RNA polymerase by DNA aptamers: mechanism of inhibition of in vitro RNA synthesis and effect on HCV-infected cells. Antimicrob Agents Chemother (2008) 0.90
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob Agents Chemother (2008) 0.90
Mycophenolate mofetil inhibits hepatitis C virus replication in human hepatic cells. Virus Res (2012) 0.86
Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2010) 0.86
Repair and polyadenylation of a naturally occurring hepatitis C virus 3' nontranslated region-shorter variant in selectable replicon cell lines. J Virol (2006) 0.86
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrob Agents Chemother (2009) 0.85
The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A. J Virol (2006) 0.81
De novo polymerase activity and oligomerization of hepatitis C virus RNA-dependent RNA-polymerases from genotypes 1 to 5. PLoS One (2011) 0.79
Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. J Biol Chem (2014) 0.76
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders. Antimicrob Agents Chemother (2014) 0.76
Three-dimensional structure of the 3'X-tail of hepatitis C virus RNA in monomeric and dimeric states. RNA (2017) 0.76
Dinucleotide analogues as novel inhibitors of RNA-dependent RNA polymerase of hepatitis C Virus. Antimicrob Agents Chemother (2003) 0.75
Flavivirus RNA synthesis in vitro. Methods (2015) 0.75
Combinations of siRNAs against La Autoantigen with NS5B or hVAP-A Have Additive Effect on Inhibition of HCV Replication. Hepat Res Treat (2016) 0.75
Evidence for a non-catalytic ion-binding site in multiple RNA-dependent RNA polymerases. PLoS One (2012) 0.75
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 6.96
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol (1997) 4.71
Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol (1996) 4.59
Structure of the 3' terminus of the hepatitis C virus genome. J Virol (1996) 3.40
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol (1999) 2.37
Genetic organization and diversity of the 3' noncoding region of the hepatitis C virus genome. Virology (1996) 2.04
De novo initiation of RNA synthesis by a recombinant flaviviridae RNA-dependent RNA polymerase. Virology (1999) 1.83
Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Virology (1998) 1.81
Identification and characterization of an RNA-dependent RNA polymerase activity within the nonstructural protein 5B region of bovine viral diarrhea virus. J Virol (1998) 1.75
Initiation of minus-strand RNA synthesis by the brome mosaicvirus RNA-dependent RNA polymerase: use of oligoribonucleotide primers. J Virol (1996) 1.70
Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. J Biol Chem (1999) 1.62
Expression of hepatitis C virus NS5B protein: characterization of its RNA polymerase activity and RNA binding. Hepatology (1999) 1.52
RNA-dependent RNA polymerase of hepatitis C virus. Methods Enzymol (1996) 1.28
Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli. Virus Res (1998) 1.11
Hepatitis C virus as a causative agent of hepatocellular carcinoma. Intervirology (1995) 0.99
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73
Replacement of the Bacillus subtilis subtilisin structural gene with an In vitro-derived deletion mutation. J Bacteriol (1984) 5.03
Characterization of the spo0A locus and its deduced product. Proc Natl Acad Sci U S A (1985) 4.86
Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37
Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med (2000) 4.33
Structure of the hepatitis C virus RNA helicase domain. Nat Struct Biol (1997) 3.80
Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtilisin in Bacillus subtilis. Nucleic Acids Res (1983) 3.70
Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation. J Bacteriol (1984) 3.41
The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol (1999) 3.25
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med (2001) 3.02
Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology (2000) 2.99
Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology (2000) 2.83
Chromosomal location of a Bacillus subtilis DNA fragment uniquely transcribed by sigma-28-containing RNA polymerase. J Bacteriol (1982) 2.82
New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78
Cloning structural gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis: expression of the gene in Escherichia coli. J Bacteriol (1983) 2.73
Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signalling systems. J Bacteriol (1988) 2.71
Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus. Virology (1991) 2.57
Studies of sigma D-dependent functions in Bacillus subtilis. J Bacteriol (1990) 2.53
Paternal concentrations of dioxin and sex ratio of offspring. Lancet (2000) 2.47
Isolation of Bacillus subtilis genes from a charon 4A library. J Bacteriol (1981) 2.45
Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology (2012) 2.45
Mutagenesis of the 3' nontranslated region of Sindbis virus RNA. J Virol (1990) 2.42
Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers. BMJ (1997) 2.42
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol (1999) 2.37
Identification of the pleiotropic sacQ gene of Bacillus subtilis. J Bacteriol (1986) 2.33
Effect of stage 0 sporulation mutations on subtilisin expression. J Bacteriol (1986) 2.31
Small-bowel perforations related to endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II gastrectomy. Endoscopy (1999) 2.24
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology (2001) 2.21
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. J Biol Chem (1991) 2.08
Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization. Biotechniques (1997) 2.01
Evidence that hepatitis D virus needs hepatitis B virus to cause hepatocellular damage. Am J Clin Pathol (1992) 1.98
A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. Tinzaparine ou Heparine Standard: Evaluations dans l'Embolie Pulmonaire. N Engl J Med (1997) 1.97
Clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy. AJNR Am J Neuroradiol (2008) 1.92
Factors predictive of a beneficial response to therapy of hepatitis C. Hepatology (1997) 1.90
Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J Biol Chem (2001) 1.85
Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurol (2006) 1.83
Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection. J Hepatol (1997) 1.82
Location of the targets of the hpr-97, sacU32(Hy), and sacQ36(Hy) mutations in upstream regions of the subtilisin promoter. J Bacteriol (1988) 1.74
Cloning and localization of the lepidopteran protoxin gene of Bacillus thuringiensis subsp. kurstaki. Proc Natl Acad Sci U S A (1982) 1.71
Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction. Clin Pharmacol Ther (2011) 1.67
Evaluation of a novel serotyping system for hepatitis C virus: strong correlation with standard genotyping methodologies. J Clin Microbiol (1995) 1.65
A longitudinal analysis of hepatitis C virus replication following liver transplantation. Gastroenterology (1996) 1.65
Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 1.63
The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J Immunol (1997) 1.63
High prevalence of Helicobacter pylori infection in duodenal ulcer perforations not caused by non-steroidal anti-inflammatory drugs. Br J Surg (1996) 1.62
Plant callose synthase complexes. Plant Mol Biol (2001) 1.61
Subcellular location of delta-pyrroline-5-carboxylate reductase in root/nodule and leaf of soybean. Plant Physiol (1992) 1.58
Characterization of the levanase gene of Bacillus subtilis which shows homology to yeast invertase. Mol Gen Genet (1987) 1.58
Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis. Lancet (1994) 1.55
Characterization and mapping of the Bacillus subtilis prtR gene. J Bacteriol (1987) 1.55
Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J Infect Dis (2000) 1.52
Comparison of two-dimensional vs three-dimensional camera systems in laparoscopic surgery. Surg Endosc (1997) 1.50
Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J Virol (2001) 1.50
Constrained evolution with respect to gene overlap of hepatitis B virus. J Mol Evol (1997) 1.49
Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. J Virol (2000) 1.47
A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology (1992) 1.44
Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection. Dig Dis Sci (1997) 1.44
Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia. J Hepatol (1995) 1.44
Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology (1996) 1.42
[Precaution in the thrombolytic treatment of myocardial infarction]. Presse Med (1989) 1.40
[Severe early pulmonary embolism after blockage of the vena cava]. Presse Med (1994) 1.39
Intrapericardial bronchogenic cyst: an unusual cause of CA 19-9 increase. Eur J Med (1992) 1.39
Two functional soybean genes encoding p34cdc2 protein kinases are regulated by different plant developmental pathways. Proc Natl Acad Sci U S A (1993) 1.39
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J Virol (1996) 1.38
Eradication of Helicobacter pylori prevents recurrence of ulcer after simple closure of duodenal ulcer perforation: randomized controlled trial. Ann Surg (2000) 1.37
Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase. J Virol (1999) 1.37
Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am J Pathol (1996) 1.35
p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. Cell Death Differ (2009) 1.30
Correlation between Bacillus subtilis scoC phenotype and gene expression determined using microarrays for transcriptome analysis. J Bacteriol (2001) 1.26
A unified nomenclature for Arabidopsis dynamin-related large GTPases based on homology and possible functions. Plant Mol Biol (2003) 1.23
Molecular cloning of the spo0B sporulation locus in bacteriophage lambda. J Bacteriol (1982) 1.23
Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents. FEBS Lett (1996) 1.23
Measurement of the cross section for prompt isolated diphoton production using the full CDF run II data sample. Phys Rev Lett (2013) 1.22
The X-ray structure of a recombinant major urinary protein at 1.75 A resolution. A comparative study of X-ray and NMR-derived structures. Acta Crystallogr D Biol Crystallogr (2001) 1.20
Clinical aspects of hepatitis B virus infection. Lancet (1993) 1.20
Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: relationship to genotype and level of viremia. Hepatology (1996) 1.19
Quantification of serum hepatitis C virus core protein level in patients chronically infected with different hepatitis C virus genotypes. Gut (1996) 1.18
Transforming growth factor-beta 1 in chronic hepatitis C. J Viral Hepat (1997) 1.18
Topology and phosphorylation of soybean nodulin-26, an intrinsic protein of the peribacteroid membrane. J Cell Biol (1992) 1.18
Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees. Virology (1999) 1.18
SCH 48973: a potent, broad-spectrum, antienterovirus compound. Antimicrob Agents Chemother (1997) 1.17
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription. Am J Respir Cell Mol Biol (2001) 1.17
Expression of c-Myc, c-Fos, and c-jun in hepatocellular carcinoma. Cancer (2001) 1.16
Genetic and enzymic studies on the recombination process in Bacillus subtilis. Mol Gen Genet (1975) 1.16
Mechanisms of action of ribavirin in antiviral therapies. Antivir Chem Chemother (2001) 1.16
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity. Protein Sci (1999) 1.15