Published in Antimicrob Agents Chemother on March 17, 2008
Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Nucleic Acids Res (2011) 0.98
Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology (2013) 0.95
Aptamers in virology: recent advances and challenges. Front Microbiol (2012) 0.95
Aptamer-based therapeutics: new approaches to combat human viral diseases. Pharmaceuticals (Basel) (2013) 0.86
Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. J Virol (2013) 0.84
The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers. Viruses (2015) 0.82
Single-Stranded DNA Aptamers against Pathogens and Toxins: Identification and Biosensing Applications. Biomed Res Int (2015) 0.81
Aptamers in diagnostics and treatment of viral infections. Viruses (2015) 0.80
Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses. Pharmaceuticals (Basel) (2016) 0.79
An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation. J Virol (2015) 0.77
Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein. Mol Ther Nucleic Acids (2015) 0.76
Prospects for nucleic acid-based therapeutics against hepatitis C virus. World J Gastroenterol (2013) 0.76
Oligonucleotide aptamers: potential novel molecules against viral hepatitis. Res Pharm Sci (2017) 0.75
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet (2001) 35.17
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. Proc Natl Acad Sci U S A (1998) 24.28
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science (1985) 10.97
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 6.96
Course and outcome of hepatitis C. Hepatology (2002) 6.51
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin Chem (1999) 5.22
Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol (1999) 4.99
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37
Aptamers: an emerging class of therapeutics. Annu Rev Med (2005) 4.15
Following G-quartet formation by UV-spectroscopy. FEBS Lett (1998) 4.08
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A (1999) 3.77
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04
Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin-2. J Virol (2003) 2.86
De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus. J Virol (2000) 2.65
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. J Virol (2003) 2.63
Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. J Virol (1995) 2.38
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology (2001) 2.21
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 2.19
Thermal difference spectra: a specific signature for nucleic acid structures. Nucleic Acids Res (2005) 1.91
Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase. J Virol (2000) 1.91
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2002) 1.89
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem (2005) 1.87
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc Natl Acad Sci U S A (2005) 1.71
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. J Virol (2004) 1.71
Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proc Natl Acad Sci U S A (2003) 1.55
RNA replication by Q beta replicase: a working model. Proc Natl Acad Sci U S A (1996) 1.28
HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA. Eur J Biochem (2001) 1.24
DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes. J Biol Chem (1999) 1.17
Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction. Biochemistry (2006) 1.15
Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives. J Biol Chem (2003) 1.15
Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase. J Virol (2002) 1.15
Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs. Nat Struct Mol Biol (2005) 1.14
A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J Biol Chem (2004) 1.13
Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture. Virology (2002) 1.00
Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication. J Virol (2002) 0.99
Identification of RNA ligands that bind hepatitis C virus polymerase selectively and inhibit its RNA synthesis from the natural viral RNA templates. Virology (2003) 0.94
Single-stranded DNA aptamer RT1t49 inhibits RT polymerase and RNase H functions of HIV type 1, HIV type 2, and SIVCPZ RTs. AIDS Res Hum Retroviruses (2007) 0.94
Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase. Mini Rev Med Chem (2005) 0.93
Cross-linking localization of a HIV-1 reverse transcriptase peptide involved in the binding of primer tRNALys3. J Mol Biol (1999) 0.92
High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA. J Biol Chem (2007) 0.91
RNA-dependent RNA polymerase activity encoded by GB virus-B non-structural protein 5B. J Viral Hepat (2000) 0.91
High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity. Antimicrob Agents Chemother (2006) 0.88
Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3'-end of virus minus-strand RNA. FEBS J (2005) 0.87
Aptamers: selected oligonucleotides for therapy. Curr Opin Mol Ther (2000) 0.86
Aptamers to Escherichia coli core RNA polymerase that sense its interaction with rifampicin, sigma-subunit and GreB. Eur J Biochem (2004) 0.86
Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro. Oligonucleotides (2003) 0.82
The hepatitis C virus minigenome: a new cellular model for studying viral replication. J Virol Methods (2007) 0.79
HIV-1 integrase crosslinked oligomers are active in vitro. Nucleic Acids Res (2005) 1.96
Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. Int J Cancer (2002) 1.53
alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene (2003) 1.36
Altered adhesion properties and alphav integrin expression in a cisplatin-resistant human ovarian carcinoma cell line. Int J Cancer (2002) 1.16
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14
A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5' UTR. Nucleic Acids Res (2003) 1.11
Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsids. PLoS Pathog (2009) 1.10
Antisense oligonucleotides targeted to the domain IIId of the hepatitis C virus IRES compete with 40S ribosomal subunit binding and prevent in vitro translation. Nucleic Acids Res (2003) 1.06
The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. PLoS One (2010) 1.04
Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes. PLoS Pathog (2011) 1.00
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression. Silence (2011) 0.98
Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A (2014) 0.98
Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells. J Antimicrob Chemother (2010) 0.97
Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion. Hepatology (2012) 0.97
Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate. J Biol Chem (2003) 0.95
Selective inhibitory DNA aptamers of the human RNase H1. Nucleic Acids Res (2003) 0.95
Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development. J Am Chem Soc (2014) 0.93
Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules. ACS Chem Biol (2014) 0.90
The lethal phenotype observed after HIV-1 integrase expression in yeast cells is related to DNA repair and recombination events. Gene (2003) 0.89
Small-angle X-ray characterization of the nucleoprotein complexes resulting from DNA-induced oligomerization of HIV-1 integrase. Nucleic Acids Res (2007) 0.89
Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors. Biochemistry (2005) 0.88
Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells. PLoS One (2013) 0.87
Endogenous expression of an anti-TAR aptamer reduces HIV-1 replication. RNA Biol (2006) 0.87
Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3'-end of virus minus-strand RNA. FEBS J (2005) 0.87
Modulating viral gene expression by aptamers to RNA structures. Biol Cell (2003) 0.87
Dynamic, thermodynamic, and kinetic basis for recognition and transformation of DNA by human immunodeficiency virus type 1 integrase. Biochemistry (2003) 0.87
Cellular uptake of ODNs in HIV-1 human-infected cells: a role for viral particles in DNA delivery? Oligonucleotides (2007) 0.87
Hepatitis C virus genetic variability in 52 human immunodeficiency virus-coinfected patients. J Med Virol (2003) 0.86
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405. J Virol (2012) 0.86
Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains. Front Microbiol (2013) 0.86
Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation. Cell Microbiol (2010) 0.85
HIV-1 integrase interacts with yeast microtubule-associated proteins. Biochim Biophys Acta (2002) 0.85
Identification by phage display selection of a short peptide able to inhibit only the strand transfer reaction catalyzed by human immunodeficiency virus type 1 integrase. Biochemistry (2004) 0.84
Intasome architecture and chromatin density modulate retroviral integration into nucleosome. Retrovirology (2015) 0.83
Development and biological assessment of fully water-soluble helical aromatic amide foldamers. Angew Chem Int Ed Engl (2007) 0.83
Glycosyl-nucleoside-lipid based supramolecular assembly as a nanostructured material with nucleic acid delivery capabilities. Chem Commun (Camb) (2009) 0.83
Direct evidence for RNA-RNA interactions at the 3' end of the Hepatitis C virus genome using surface plasmon resonance. RNA (2013) 0.83
Lipid-conjugated oligonucleotides via "click chemistry" efficiently inhibit hepatitis C virus translation. J Med Chem (2008) 0.83
Seven nucleotide changes characteristic of the hepatitis C virus genotype 3 5' untranslated region: correlation with reduced in vitro replication. J Gen Virol (2008) 0.82
Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro. Oligonucleotides (2003) 0.82
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity. Oligonucleotides (2007) 0.82
A functional selection of viral genetic elements in cultured cells to identify hepatitis C virus RNA translation inhibitors. Nucleic Acids Res (2008) 0.81
Identification of a structural element of the hepatitis C virus minus strand RNA involved in the initiation of RNA synthesis. Nucleic Acids Res (2010) 0.80
In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins. Methods Mol Biol (2005) 0.79
Targeting HIV-1 integrase with aptamers selected against the purified RNase H domain of HIV-1 RT. Biochimie (2005) 0.79
The cyclin-dependent kinase inhibitor p21(cip1/waf1) enhances the cytotoxicity of ganciclovir in HSV-tk transfected ovarian carcinoma cells. Cancer Lett (2004) 0.79
HIV-1 integrase-hydrolyzing IgM antibodies from sera of HIV-infected patients. Int Immunol (2010) 0.79
Cellular internalization of water-soluble helical aromatic amide foldamers. Chembiochem (2010) 0.78
Mutations of the SL2 dimerization sequence of the hepatitis C genome abrogate viral replication. Cell Mol Life Sci (2015) 0.78
Natural stilbenoids isolated from grapevine exhibiting inhibitory effects against HIV-1 integrase and eukaryote MOS1 transposase in vitro activities. PLoS One (2013) 0.78
Antibodies to HIV integrase catalyze site-specific degradation of their antigen. Int Immunol (2011) 0.78
Anti-integrase abzymes from the sera of HIV-infected patients specifically hydrolyze integrase but nonspecifically cleave short oligopeptides. J Mol Recognit (2012) 0.78
A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase. J Mol Biol (2002) 0.78
The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration. Antivir Ther (2011) 0.78
HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients. Biochimie (2009) 0.77
Yeast system as a model to study Moloney murine leukemia virus integrase: expression, mutagenesis and search for eukaryotic partners. J Gen Virol (2005) 0.76
[Integrins, cell response to anti-tumor agents and chemoresistance]. Bull Cancer (2002) 0.76
An oligonucleotide complementary to the SL-B1 domain in the 3'-end of the minus-strand RNA of the hepatitis C virus inhibits in vitro initiation of RNA synthesis by the viral polymerase. Virology (2003) 0.76
Activation of GCN2 upon HIV-1 infection and inhibition of translation. Cell Mol Life Sci (2013) 0.76
Regulating mRNA translation with a kiss. Nucleic Acids Symp Ser (Oxf) (2008) 0.76
Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression. Nucleosides Nucleotides Nucleic Acids (2007) 0.75
Catalytic antibodies from HIV-infected patients specifically hydrolyzing viral integrase suppress the enzyme catalytic activities. J Mol Recognit (2011) 0.75
Encapsidation of RNA-polyelectrolyte complexes with amphiphilic block copolymers: toward a new self-assembly route. J Am Chem Soc (2012) 0.75
Cell surface overexpression of alphavbeta5 integrin impedes alphavbeta3-mediated migration of the human ovarian adenocarcinoma cell line IGROV1. Cell Biol Int (2006) 0.75
Hijacking hepatitis C viral replication with a non-coding replicative RNA. Antiviral Res (2010) 0.75