Published in Retrovirology on December 15, 2005
HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology (2007) 1.29
LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates. Blood (2015) 0.89
Telomerase and primary T cells: biology and immortalization for adoptive immunotherapy. Immunotherapy (2011) 0.80
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription. Sci Adv (2016) 0.76
Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res (2014) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Switching and signaling at the telomere. Cell (2001) 11.25
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature (1981) 9.25
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol (2003) 7.02
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43
Protection of mammalian telomeres. Oncogene (2002) 5.38
Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95
Homologous recombination generates T-loop-sized deletions at human telomeres. Cell (2004) 4.85
In situ analyses of genome instability in breast cancer. Nat Genet (2004) 4.32
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell (1998) 4.21
Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17
Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology (1983) 4.11
Telomeric localization of TRF2, a novel human telobox protein. Nat Genet (1997) 3.23
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci U S A (1983) 3.01
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92
T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor. Proc Natl Acad Sci U S A (1980) 2.89
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J (2001) 2.83
Telomeres in T and B cells. Nat Rev Immunol (2002) 2.76
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet (2000) 2.68
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell (1999) 2.46
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol (2004) 2.45
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J Virol (1992) 2.21
Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet (2002) 2.08
Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci U S A (2002) 2.03
A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev (2000) 1.88
Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood (2000) 1.87
Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene (2003) 1.66
High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood (2000) 1.63
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc Natl Acad Sci U S A (1999) 1.42
Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia (2003) 1.39
Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood (2004) 1.32
Mechanisms of T-cell activation by human T-cell lymphotropic virus type I. Microbiol Mol Biol Rev (1999) 1.27
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades. Oncogene (2003) 1.19
Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells. Blood (2000) 1.17
Telomerase: regulation, function and transformation. Crit Rev Oncol Hematol (2005) 1.03
Inactivation of hTERT transcription by Tax. Oncogene (2003) 1.01
Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax. J Virol (1997) 1.00
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines. Blood (2003) 0.93
TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts. Oncogene (2006) 0.86
Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix. Oncogene (2004) 0.86
Telomerase activity and telomere length as prognostic factors of adult T-cell leukemia. Leuk Lymphoma (2005) 0.86
Correlation of telomerase activity with development and progression of adult T-cell leukemia. Leuk Res (1999) 0.84
Infection of synoviocytes with HTLV-I induces telomerase activity. Rheumatol Int (2001) 0.80
Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol (2002) 3.16
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol (2006) 1.95
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep (2002) 1.79
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet (2003) 1.65
CST meets shelterin to keep telomeres in check. Mol Cell (2010) 1.63
Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie (2007) 1.57
A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol (2009) 1.51
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell (2010) 1.50
TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J (2009) 1.42
General regulatory factors (GRFs) as genome partitioners. J Biol Chem (2002) 1.39
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest (2007) 1.39
The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. PLoS Genet (2009) 1.37
The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. J Biol Chem (2005) 1.37
The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol (2009) 1.36
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology (2007) 1.29
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway. Nucleic Acids Res (2009) 1.29
Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood (2007) 1.28
Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Cell Res (2011) 1.25
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms. EMBO J (2003) 1.21
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A (2003) 1.20
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol (2013) 1.12
Insulator dynamics and the setting of chromatin domains. Bioessays (2004) 1.11
Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF. EMBO J (2009) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Subtelomeric proteins negatively regulate telomere elongation in budding yeast. EMBO J (2006) 1.11
Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells. Cancer Res (2009) 1.11
Protosilencers as building blocks for heterochromatin. Bioessays (2002) 1.09
A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells. Nucleic Acids Res (2009) 1.07
Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet (2010) 1.06
The vertebrate protein CTCF functions as an insulator in Saccharomyces cerevisiae. Nucleic Acids Res (2002) 1.05
The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA. Nucleic Acids Res (2011) 1.04
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells. Eur J Cancer (2006) 1.04
CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. J Biol Chem (2010) 1.00
Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation. EMBO J (2006) 1.00
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1. J Virol (2012) 0.99
Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Clin Cancer Res (2003) 0.98
The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation. Nat Struct Mol Biol (2006) 0.97
Chromatin domain boundaries delimited by a histone-binding protein in yeast. J Biol Chem (2004) 0.97
G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors. Clin Cancer Res (2008) 0.97
Telomeric RNA enters the game. Nat Cell Biol (2008) 0.97
Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol (2004) 0.96
HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice. PLoS Pathog (2011) 0.96
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Rep (2013) 0.95
Biology of cancer and aging: a complex association with cellular senescence. J Clin Oncol (2014) 0.95
Structural identity of telomeric complexes. FEBS Lett (2010) 0.94
D4Z4 as a prototype of CTCF and lamins-dependent insulator in human cells. Nucleus (2011) 0.93
Retracted Overexpression of caveolin-1 in adult T-cell leukemia. Blood (2010) 0.92
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood (2011) 0.92
One identity or more for telomeres? Front Oncol (2013) 0.91
Notch ligands potentiate IL-7-driven proliferation and survival of human thymocyte precursors. Eur J Immunol (2009) 0.91
The telomerase cycle: normal and pathological aspects. J Mol Med (Berl) (2005) 0.90
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis. Nucleic Acids Res (2013) 0.90
A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast. Mol Cell Biol (2003) 0.90
p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest (2012) 0.90
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle (2014) 0.89
Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes. Retrovirology (2005) 0.89
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner. PLoS One (2012) 0.89
Redox events in HTLV-1 Tax-induced apoptotic T-cell death. Antioxid Redox Signal (2002) 0.89
Global analysis of DNA methylation and transcription of human repetitive sequences. Epigenetics (2009) 0.89
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents. Clin Cancer Res (2011) 0.88
Brief report: musashi1-eGFP mice, a new tool for differential isolation of the intestinal stem cell populations. Stem Cells (2013) 0.86
Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells. J Biol Chem (2012) 0.86
Alzheimer's disease treatment: assessing caregiver preferences for mode of treatment delivery. Adv Ther (2009) 0.86
RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts. EMBO J (2012) 0.86
Patient-reported benefit of ReSTOR multi-focal intraocular lenses after cataract surgery: results of principal component analysis on clinical trial data. Health Qual Life Outcomes (2008) 0.85
Are aging biomarkers clinically relevant in oncogeriatrics? Crit Rev Oncol Hematol (2012) 0.85
Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias. Exp Hematol (2010) 0.84
Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae. Genetics (2006) 0.84
Dynamics of telomeric chromatin at the crossroads of aging and cancer. Essays Biochem (2010) 0.84
Corrected and uncorrected near and distance vision with ReSTOR compared to monofocal intraocular lens implantation after cataract surgery: a pooled analysis. Ophthalmologica (2008) 0.84
Telomere uncapping during in vitro T-lymphocyte senescence. Aging Cell (2008) 0.84
Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3' ends in Saccharomyces cerevisiae. J Biol Chem (2011) 0.83
Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation. Exp Dermatol (2014) 0.83
La sets the tone for telomerase assembly. Nat Struct Mol Biol (2007) 0.83
HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis (2013) 0.83
Length-dependent processing of telomeres in the absence of telomerase. Nucleic Acids Res (2014) 0.83
Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila. FASEB J (2009) 0.83
Histone H1 of Saccharomyces cerevisiae inhibits transcriptional silencing. Genetics (2006) 0.82
The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions. DNA Repair (Amst) (2008) 0.81
What we are learning on HTLV-1 pathogenesis from animal models. Front Microbiol (2012) 0.81
Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae. Mol Biol Cell (2008) 0.81
Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1. J Virol (2008) 0.81
Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element. J Biol Chem (2002) 0.81
Telomeric impact of conventional chemotherapy. Front Med (2013) 0.81
Platination of telomeric DNA by cisplatin disrupts recognition by TRF2 and TRF1. J Biol Inorg Chem (2010) 0.80