Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 10700516)

Published in Stroke on March 01, 2000

Authors

S P Didion1, C D Sigmund, F M Faraci

Author Affiliations

1: Departments of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242-1081, USA.

Articles citing this

Hypertension and cerebrovascular dysfunction. Cell Metab (2008) 2.30

Protecting against vascular disease in brain. Am J Physiol Heart Circ Physiol (2011) 1.66

Hypertension: a harbinger of stroke and dementia. Hypertension (2013) 1.30

Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice. J Neurochem (2012) 0.93

Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. Am J Physiol Regul Integr Comp Physiol (2009) 0.91

Angiotensin II-induced endothelial dysfunction is temporally linked with increases in interleukin-6 and vascular macrophage accumulation. Front Physiol (2014) 0.90

Roles of Brain Angiotensin II in Cognitive Function and Dementia. Int J Hypertens (2012) 0.84

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci (2017) 0.82

Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage. Br J Pharmacol (2011) 0.80

Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice. Am J Physiol Regul Integr Comp Physiol (2013) 0.77

Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? Front Pharmacol (2016) 0.76

Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm. Pflugers Arch (2014) 0.76

Angiotensinogen polymorphism and ischemic stroke risk. Int J Clin Exp Med (2015) 0.75

Articles by these authors

Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94

Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol (1988) 3.60

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51

Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest (1996) 2.30

Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol (1994) 1.91

RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int (2006) 1.88

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87

The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem (1997) 1.78

Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. Stroke (1997) 1.74

Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.73

The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res (1998) 1.73

Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem (2001) 1.72

Effects of lipopolysaccharide priming on acute ischemic brain injury. Stroke (2000) 1.70

Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics (1999) 1.60

Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest (2000) 1.59

Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest (1996) 1.59

Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol (1998) 1.57

NO-dependent vasorelaxation is impaired after gene transfer of inducible NO-synthase. Arterioscler Thromb Vasc Biol (2001) 1.53

Gene transfer of calcitonin gene-related peptide prevents vasoconstriction after subarachnoid hemorrhage. Circ Res (2000) 1.51

Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res (2001) 1.50

Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens (1999) 1.42

Differential requirement for SLP-76 domains in T cell development and function. Immunity (2001) 1.36

Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest (1997) 1.29

Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice. Arterioscler Thromb Vasc Biol (1997) 1.29

Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem (1999) 1.28

Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem (2000) 1.25

Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem (1996) 1.22

Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res (2001) 1.22

Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem (1994) 1.22

Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol (2001) 1.19

Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol (2000) 1.18

Subarachnoid haemorrhage: what happens to the cerebral arteries? Clin Exp Pharmacol Physiol (1998) 1.18

Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels. Stroke (1997) 1.15

Role of potassium channels in cerebral blood vessels. Stroke (1995) 1.14

IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation. Am J Physiol Heart Circ Physiol (2000) 1.14

Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol (1999) 1.12

Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. J Bacteriol (1983) 1.11

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics (2000) 1.11

Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. J Biol Chem (1999) 1.09

Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res (2000) 1.08

M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system. Receptors Channels (2003) 1.05

Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem (2000) 1.05

Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem (2000) 1.04

Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. J Thromb Haemost (2003) 1.02

Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction. Arterioscler Thromb Vasc Biol (2005) 1.02

Flow-mediated dilatation of the basilar artery in vivo. Circ Res (1991) 1.02

Altered vascular function after adenovirus-mediated overexpression of endothelial nitric oxide synthase. Am J Physiol (1997) 1.02

Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol Heart Circ Physiol (2001) 1.02

Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol (1993) 1.01

Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol (2010) 1.01

Segmental vascular responses to acute hypertension in cerebrum and brain stem. Am J Physiol (1987) 1.00

ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. Circ Res (1994) 1.00

Role of Ca(2+)-dependent K+ channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat. Stroke (1996) 1.00

Role of sex differences and effects of endothelial NO synthase deficiency in responses of carotid arteries to serotonin. Arterioscler Thromb Vasc Biol (2001) 1.00

Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem (1997) 0.99

Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits. Circulation (2000) 0.98

Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice. Stroke (1999) 0.98

Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice. Am J Physiol Heart Circ Physiol (2000) 0.98

The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res (1999) 0.98

Expression of murine renin genes during fetal development. Mol Endocrinol (1990) 0.97

NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension (2001) 0.97

Responses of cerebral arteries after ischemia and reperfusion in cats. Am J Physiol (1988) 0.97

Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Biotechniques (2001) 0.96

Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. Am J Physiol (1987) 0.96

Effects of aging on responses of cerebral arterioles. Am J Physiol (1990) 0.95

Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol (2001) 0.95

Vasomotion of basilar arteries in vivo. Am J Physiol (1990) 0.94

Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo. J Pharmacol Exp Ther (1995) 0.94

Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res (1999) 0.94

sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion. Stroke (2000) 0.93

Effect of carbon monoxide on rabbit cerebral arteries. Stroke (1994) 0.93

Vascular effects of LPS in mice deficient in expression of the gene for inducible nitric oxide synthase. Am J Physiol (1998) 0.93

Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivo. Am J Physiol Heart Circ Physiol (2000) 0.93

Tumor necrosis factor-alpha-induced dilatation of cerebral arterioles. Stroke (1998) 0.93

Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res (1997) 0.92

Effect of norepinephrine on rat basilar artery in vivo. Am J Physiol (1993) 0.92

Attenuated pulmonary pressor response to hypoxia in bar-headed geese. Am J Physiol (1984) 0.91

Allele-specific expression of the murine Ren-1 genes. J Biol Chem (1989) 0.91

Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension (1995) 0.91

Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels. Am J Physiol (1993) 0.91

Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction. Hypertension (2000) 0.91

Disruption of the blood-brain barrier in cerebrum and brain stem during acute hypertension. Am J Physiol (1986) 0.90

Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circ Res (2000) 0.89

Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. J Biol Chem (2000) 0.89

Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate. Am J Physiol (1998) 0.89

Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. EMBO J (1989) 0.88

Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol (1998) 0.88

Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter. Am J Physiol (1997) 0.88

Oxygen delivery to the heart and brain during hypoxia: Pekin duck vs. bar-headed goose. Am J Physiol (1984) 0.88

COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin. Am J Physiol Heart Circ Physiol (2001) 0.87

JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol (1999) 0.87

Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem (1997) 0.87

Regional circulatory responses to hypocapnia and hypercapnia in bar-headed geese. Am J Physiol (1986) 0.87

Recent insights into the regulation of cerebral circulation. Clin Exp Pharmacol Physiol (1996) 0.87

Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca(2+)-dependent K+ channels. Circ Res (1995) 0.87

Potassium channels modulate cerebral autoregulation during acute hypertension. Am J Physiol Heart Circ Physiol (2000) 0.86

Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway. Stroke (1999) 0.86

Mechanisms of protection of the blood-brain barrier during acute hypertension in chronically hypertensive rats. Hypertension (1987) 0.86