Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.
PubWeight™: 0.83‹?›
Published in J Am Coll Cardiol on February 21, 2017
Authors
Thomas R Webb1, Jeanette Erdmann2, Kathleen E Stirrups3, Nathan O Stitziel4, Nicholas G D Masca1, Henning Jansen5, Stavroula Kanoni6, Christopher P Nelson1, Paola G Ferrario7, Inke R König7, John D Eicher8, Andrew D Johnson8, Stephen E Hamby1, Christer Betsholtz9, Arno Ruusalepp10, Oscar Franzén11, Eric E Schadt12, Johan L M Björkegren13, Peter E Weeke14, Paul L Auer15, Ursula M Schick16, Yingchang Lu17, He Zhang18, Marie-Pierre Dube19, Anuj Goel20, Martin Farrall20, Gina M Peloso21, Hong-Hee Won22, Ron Do23, Erik van Iperen24, Jochen Kruppa25, Anubha Mahajan26, Robert A Scott27, Christina Willenborg28, Peter S Braund1, Julian C van Capelleveen29, Alex S F Doney30, Louise A Donnelly30, Rosanna Asselta31, Pier A Merlini32, Stefano Duga31, Nicola Marziliano33, Josh C Denny34, Christian Shaffer35, Nour Eddine El-Mokhtari36, Andre Franke37, Stefanie Heilmann38, Christian Hengstenberg39, Per Hoffmann40, Oddgeir L Holmen41, Kristian Hveem42, Jan-Håkan Jansson43, Karl-Heinz Jöckel44, Thorsten Kessler5, Jennifer Kriebel45, Karl L Laugwitz46, Eirini Marouli6, Nicola Martinelli47, Mark I McCarthy48, Natalie R Van Zuydam49, Christa Meisinger50, Tõnu Esko51, Evelin Mihailov52, Stefan A Escher53, Maris Alver54, Susanne Moebus44, Andrew D Morris55, Jarma Virtamo56, Majid Nikpay57, Oliviero Olivieri47, Sylvie Provost58, Alaa AlQarawi59, Neil R Robertson60, Karen O Akinsansya61, Dermot F Reilly61, Thomas F Vogt61, Wu Yin61, Folkert W Asselbergs62, Charles Kooperberg63, Rebecca D Jackson64, Eli Stahl65, Martina Müller-Nurasyid66, Konstantin Strauch67, Tibor V Varga53, Melanie Waldenberger68, Wellcome Trust Case Control Consortium, Lingyao Zeng5, Rajiv Chowdhury69, Veikko Salomaa56, Ian Ford70, J Wouter Jukema71, Philippe Amouyel72, Jukka Kontto56, MORGAM Investigators, Børge G Nordestgaard73, Jean Ferrières74, Danish Saleheen75, Naveed Sattar76, Praveen Surendran77, Aline Wagner78, Robin Young69, Joanna M M Howson69, Adam S Butterworth79, John Danesh80, Diego Ardissino81, Erwin P Bottinger82, Raimund Erbel44, Paul W Franks83, Domenico Girelli47, Alistair S Hall84, G Kees Hovingh29, Adnan Kastrati85, Wolfgang Lieb86, Thomas Meitinger87, William E Kraus88, Svati H Shah88, Ruth McPherson57, Marju Orho-Melander89, Olle Melander90, Andres Metspalu54, Colin N A Palmer30, Annette Peters91, Daniel J Rader92, Muredach P Reilly93, Ruth J F Loos94, Alex P Reiner95, Dan M Roden96, Jean-Claude Tardif19, John R Thompson97, Nicholas J Wareham27, Hugh Watkins20, Cristen J Willer98, Nilesh J Samani99, Heribert Schunkert5, Panos Deloukas100, Sekar Kathiresan101, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
Author Affiliations
1: Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
2: Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany; DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany; University Heart Center Luebeck, Lübeck, Germany.
3: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
4: Cardiovascular Division, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri; McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri.
5: Deutsches Herzzentrum München, Technische Universität München, München, Germany; DZHK, Partner Site Munich Heart Alliance, Munich, Germany.
6: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
7: DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany; Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Germany.
8: Center for Population Studies, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, Massachusetts.
9: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden; Department of Medical Biochemistry and Biophysics, Vascular Biology Unit, Karolinska Institutet, Stockholm, Sweden.
10: Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia; Clinical Gene Networks AB, Stockholm, Sweden.
11: Clinical Gene Networks AB, Stockholm, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
12: Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
13: Department of Medical Biochemistry and Biophysics, Vascular Biology Unit, Karolinska Institutet, Stockholm, Sweden; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia; Clinical Gene Networks AB, Stockholm, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
14: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
15: School of Public Heath, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
16: Fred Hutchinson Cancer Research Center, Seattle, Washington; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York.
17: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York.
18: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
19: Université de Montréal, Faculté de médecine, Département de médecine, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada.
20: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
21: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.
22: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.
23: The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York; The Center for Statistical Genetics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; The Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; The Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
24: Department of Biostatistics, Academic Medical Center, Amsterdam, the Netherlands.
25: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.
26: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
27: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
28: Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
29: Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
30: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom.
31: Department of Biomedical Sciences, Humanitas University, Milan, Italy; Humanitas Clinical and Research Center, Milan, Italy.
32: Niguarda Hospital, Milan, Italy.
33: Azienda Sanitaria Locale 3 San Francesco, Nuoro, Italy 3, Nuoro, Italy.
34: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
35: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
36: Klinik für Kardiologie, Pneumologie und Innere Medizin, Imland Klinik Rendsburg, Rendsburg, Germany.
37: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
38: Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
39: McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri; Deutsches Herzzentrum München, Technische Universität München, München, Germany.
40: Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany; Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
41: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
42: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway; Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
43: Department of Public Health and Clinical Medicine, Research Unit Skellefteå, Umeå University, Sweden.
44: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
45: Research unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research, Neuherberg, Germany.
46: DZHK, Partner Site Munich Heart Alliance, Munich, Germany; Institute Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
47: Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy.
48: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford, Oxford, United Kingdom.
49: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
50: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
51: Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts; Department of Genetics, Harvard Medical School, Boston, Massachusetts; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts.
52: Estonian Genome Center, University of Tartu, Tartu, Estonia.
53: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.
54: Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, Tartu, Estonia.
55: School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, Scotland, United Kingdom.
56: National Institute for Health and Welfare (THL), Helsinki, Finland.
57: Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
58: Montreal Heart Institute, Montreal, Quebec, Canada.
59: Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
60: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
61: Merck Sharp & Dohme, Rahway, New Jersey.
62: Department of Cardiology, Division Heart & Lungs, UMC Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom.
63: Fred Hutchinson Cancer Research Center, Seattle, Washington.
64: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Ohio State University, Columbus, Ohio.
65: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
66: DZHK, Partner Site Munich Heart Alliance, Munich, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.
67: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
68: Research unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
69: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
70: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.
71: Department of Cardiology, Leiden University Medical Center, Leiden and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands.
72: Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE, Lille, France.
73: Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
74: Toulouse University School of Medicine, Toulouse, France.
75: Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Noncommunicable Diseases, Karachi, Pakistan.
76: British Heart Foundation, Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
77: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
78: Department of Epîdemiology and Public Health, University of Strasbourg, Strasbourg, France.
79: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute of Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.
80: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute of Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
81: Parma University Hospital, Parma, Italy.
82: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York.
83: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Department of Public Health & Clinical Medicine, Umeå University Hospital, Umeå, Sweden.
84: Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom.
85: Deutsches Herzzentrum München, Technische Universität München, München, Germany.
86: Institute of Epidemiology and Biobank popgen, Christian-Albrechts-University Kiel, Kiel, Germany.
87: DZHK, Partner Site Munich Heart Alliance, Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany.
88: Duke Molecular Physiology Institute, Duke University, Durham, North Carolina; Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina.
89: Department of Clinical Sciences in Malmo, Lund University, Clinical Research Center, Malmo, Sweden.
90: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden.
91: DZHK, Partner Site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
92: Department of Genetics, Cardiovascular Institute and Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
93: Division of Cardiology, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University, New York, New York.
94: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York.
95: Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington.
96: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
97: NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom; Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
98: Université de Montréal, Faculté de médecine, Département de médecine, Montreal, Quebec, Canada; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan.
99: Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom. Electronic address: njs@le.ac.uk.
100: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: p.deloukas@qmul.ac.uk.
101: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.
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Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol (2012) 2.15
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry (2010) 2.11
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort. Eur Heart J (2013) 1.85
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med (2014) 1.81
Pathophysiology of LV Remodeling in Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis. JACC Cardiovasc Imaging (2015) 1.69
Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia. J Am Coll Cardiol (2014) 1.64
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project. PLoS One (2014) 1.54
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet (2015) 1.52
Genomic analyses inform on migration events during the peopling of Eurasia. Nature (2016) 1.47
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. Br J Psychiatry (2009) 1.45
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci. Arthritis Rheum (2011) 1.44
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet (2009) 1.41
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One (2009) 1.28
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet (2015) 1.27
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet (2016) 1.24
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
XIAP variants in male Crohn's disease. Gut (2014) 1.22
Evidence that duplications of 22q11.2 protect against schizophrenia. Mol Psychiatry (2013) 1.20
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies. PLoS Genet (2015) 1.20
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet (2016) 1.20
A robust clustering algorithm for identifying problematic samples in genome-wide association studies. Bioinformatics (2011) 1.19
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol (2016) 1.15
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Hum Mol Genet (2013) 1.14
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet (2014) 1.08
No evidence from genome-wide data of a Khazar origin for the Ashkenazi Jews. Hum Biol (2013) 1.07
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis. Hum Mol Genet (2012) 1.06
Association of persistent or worsened echocardiographic dyssynchrony with unfavourable clinical outcomes in heart failure patients with narrow QRS width: a subgroup analysis of the EchoCRT trial. Eur Heart J (2015) 1.04
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet (2015) 1.02
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet (2014) 0.97
Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy. PLoS Genet (2015) 0.93
Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array. Genet Epidemiol (2011) 0.93
Genome-wide association study of kidney function decline in individuals of European descent. Kidney Int (2014) 0.91
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut (2014) 0.90
Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet (2012) 0.88
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One (2012) 0.86
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genet (2014) 0.86
Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun (2015) 0.86
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol (2015) 0.85