Published in J Biol Chem on March 17, 2000
Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol (2006) 2.21
Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol (2012) 1.67
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell (2003) 1.67
Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer. Br J Cancer (2004) 1.17
Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A (2009) 1.10
TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae. Am J Physiol Renal Physiol (2008) 1.06
Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation. J Cell Biol (2012) 1.03
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen. Mol Cancer Res (2009) 0.89
Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. Br J Pharmacol (2010) 0.85
Caveolin-1 as a promoter of tumour spreading: when, how, where and why. J Cell Mol Med (2013) 0.84
Modulation of integrin-linked kinase (ILK) expression in human oesophageal squamous cell carcinoma cell lines by the EGF and TGFbeta1 growth factors. Cancer Cell Int (2006) 0.81
Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants. Oncotarget (2015) 0.76
Role of caveolae in high glucose and TGF-β₁ induced fibronectin production in rat mesangial cells. Int J Clin Exp Pathol (2014) 0.75
Liquid crystal droplet-based amplification of microvesicles that are shed by mammalian cells. Analyst (2014) 0.75
Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway. Cell Death Dis (2017) 0.75
Membrane-mediated regulation of vascular identity. Birth Defects Res C Embryo Today (2016) 0.75
Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation. J Biol Chem (1984) 1.80
Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor. J Biol Chem (1985) 1.80
Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol (2001) 1.37
Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. J Biol Chem (1998) 1.17
Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection. Clin Exp Allergy (2010) 1.14
Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. J Biol Chem (1996) 1.12
Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells. Mol Endocrinol (2000) 1.10
Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor. J Biol Chem (1999) 1.06
ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. J Biol Chem (2000) 1.06
Epidermal growth factor and its receptor. Mol Cell Endocrinol (1987) 1.04
Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro. Proc Natl Acad Sci U S A (1991) 1.00
Kinetics of phosphorylation of Na+/K(+)-ATPase by protein kinase C. Biochim Biophys Acta (1990) 1.00
Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteins. J Biol Chem (1992) 1.00
A three-step purification procedure for protein kinase C: characterization of the purified enzyme. Anal Biochem (1987) 1.00
Platelet-derived growth factor-stimulated migration of murine fibroblasts is associated with epidermal growth factor receptor expression and tyrosine phosphorylation. J Biol Chem (2000) 0.99
Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase. J Biol Chem (1999) 0.98
Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brain. J Steroid Biochem Mol Biol (1997) 0.96
Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma. Clin Exp Allergy (2013) 0.96
The juxtamembrane, cytosolic region of the epidermal growth factor receptor is involved in association with alpha-subunit of Gs. J Biol Chem (1997) 0.95
Modulation of the protein tyrosine kinase activity and autophosphorylation of the epidermal growth factor receptor by its juxtamembrane region. Arch Biochem Biophys (1999) 0.93
Modulation of epidermal growth factor receptor interaction with the detergent-insoluble cytoskeleton and its effects on receptor tyrosine kinase activity. Endocrinology (1995) 0.91
Evidence for the potentiation of epidermal growth factor receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton: analysis of intact and carboxy-terminally truncated receptors. Endocrinology (1993) 0.89
Regulation of the epidermal growth factor receptor by phosphorylation. J Cell Biochem (1985) 0.87
Calcium and phosphatidylserine stimulate the self-association of conventional protein kinase C isoforms. Biochemistry (1999) 0.87
Protection of mice from endotoxic death by 2-methylthio-ATP. Proc Natl Acad Sci U S A (1994) 0.86
Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors. J Biol Chem (1996) 0.86
Interleukin 5 signals through Shc and Grb2 in human eosinophils. Am J Respir Cell Mol Biol (1998) 0.85
Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442A fibroblasts. J Biol Chem (1999) 0.84
The juxtamembrane region of the epidermal growth factor receptor is required for phosphorylation of Galpha(s). Arch Biochem Biophys (2000) 0.82
Granulocyte macrophage colony-stimulating factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils. Am J Respir Cell Mol Biol (2001) 0.82
Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain. Oncogene (2009) 0.82
Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes. Biochem J (1991) 0.81
CD14(+) cells are necessary for increased survival of eosinophils in response to lipopolysaccharide. Am J Respir Cell Mol Biol (2000) 0.81
Potentiation of epidermal growth factor receptor protein-tyrosine kinase activity by sulfate. Biochim Biophys Acta (1992) 0.81
Reversibility of the epidermal growth factor receptor self-phosphorylation reaction. Evidence for formation of a high energy phosphotyrosine bond. J Biol Chem (1989) 0.81
Alteration of the kinetic properties of the epidermal growth factor receptor tyrosine kinase by basic proteins. Biochem J (1992) 0.81
Regulatory features of the epidermal growth factor receptor. J Cell Physiol Suppl (1987) 0.80
Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations. Clin Exp Allergy (2014) 0.80
Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages. J Leukoc Biol (2013) 0.80
Partial characterization of the microsomal and solubilized hypothalamic progesterone 5 alpha-reductase. J Steroid Biochem (1984) 0.79
Down-regulation of epidermal growth factor receptor-dependent signaling by Porphyromonas gingivalis lipopolysaccharide in life-expanded human gingival fibroblasts. J Periodontal Res (2008) 0.79
Kinetic analysis of protein kinase C: product and dead-end inhibition studies using ADP, poly(L-lysine), nonhydrolyzable ATP analogues, and diadenosine oligophosphates. Biochemistry (1991) 0.78
Growth hormone attenuation of epidermal growth factor-induced mitogenesis. J Cell Physiol (1997) 0.78
Activation of protein kinase C by selective binding of arginine-rich polypeptides. J Biol Chem (1993) 0.78
Nuclear translocation of NF-kappaB in lipopolysaccharide-treated macrophages fails to correspond to endotoxicity: evidence suggesting a requirement for a gamma interferon-like signal. Infect Immun (1998) 0.78
IL-5 activates a 45-kilodalton mitogen-activated protein (MAP) kinase and Jak-2 tyrosine kinase in human eosinophils. J Immunol (1996) 0.77
Pituitary progesterone 5 alpha-reductase: solubilization and partial characterization. J Steroid Biochem (1985) 0.77
The kinetic mechanism of the anterior pituitary progesterone 5 alpha-reductase. J Steroid Biochem (1986) 0.77
Increased protein kinase C activity in low density eosinophils. J Immunol (1993) 0.76
Laminin responsiveness is associated with changes in fibroblast morphology, motility, and anchorage-independent growth: cell system for examining the interaction between laminin and EGF signaling pathways. J Cell Physiol (1995) 0.76
Inhibition of epidermal growth factor/transforming growth factor-alpha-stimulated cell growth by a synthetic peptide. J Cell Physiol (1989) 0.76
Insights into modulation of (and by) growth hormone signaling. J Lab Clin Med (2000) 0.76
Cellular regulation of corpus luteum function during maternal recognition of pregnancy. Reprod Fertil Dev (1992) 0.75
Ontogeny of the epidermal growth factor receptor during development of the fetal bovine mesonephros and associated organs of the urogenital tract. Biol Reprod (1993) 0.75
Distribution and ovarian control of progestin-metabolizing enzymes in various rat hypothalamic regions. J Steroid Biochem (1987) 0.75
Chronic exposure to lead acetate affects the development of protein kinase C activity and the distribution of the PKCgamma isozyme in the rat hippocampus. Neurotoxicology (1999) 0.75
Analysis of functional domains in the epidermal growth factor receptor using site-directed mutagenesis. Adv Exp Med Biol (1988) 0.75
Localization of epidermal growth factor receptors in first- and third-trimester human placentas. J Histochem Cytochem (1994) 0.75
Binding of epidermal growth factor and transforming growth factor-alpha in mammalian preimplantation embryos. Theriogenology (1994) 0.75
Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors. Bioorg Med Chem Lett (1999) 0.75
Ovarian regulation of hypothalamic and pituitary progestin-metabolizing enzyme activities. Endocrinology (1981) 0.75
A high affinity inhibitor of pituitary progesterone 5 alpha-reductase. Endocrinology (1984) 0.75
Proteins secreted from the early ovine conceptus block the action of prostaglandin F2 alpha on large luteal cells. Biol Reprod (1992) 0.75
Potent inhibition of the hypothalamic progesterone 5 alpha-reductase by a 5 alpha-dihydroprogesterone analog. J Biol Chem (1984) 0.75