Published in Proc Natl Acad Sci U S A on February 11, 2005
Phytochrome structure and signaling mechanisms. Annu Rev Plant Biol (2006) 5.31
Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biol (2008) 2.99
The structure of a complete phytochrome sensory module in the Pr ground state. Proc Natl Acad Sci U S A (2008) 2.65
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Multiple roles of a conserved GAF domain tyrosine residue in cyanobacterial and plant phytochromes. Biochemistry (2005) 1.48
The signaling helix: a common functional theme in diverse signaling proteins. Biol Direct (2006) 1.46
Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent. Plant Physiol (2006) 1.34
Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function. Proc Natl Acad Sci U S A (2007) 1.31
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci U S A (2009) 1.30
2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry (2008) 1.26
The structure of phytochrome: a picture is worth a thousand spectra. Plant Cell (2006) 1.25
The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. J Biol Chem (2008) 1.15
Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis. J Biol Chem (2009) 1.13
O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis. J Bacteriol (2008) 1.07
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
Structural and biochemical characterization of free methionine-R-sulfoxide reductase from Neisseria meningitidis. J Biol Chem (2010) 1.06
Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. J Biol Chem (2008) 1.01
Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis. J Mol Biol (2009) 0.99
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights. Structure (2009) 0.96
Integration of rotation and piston motions in coiled-coil signal transduction. J Bacteriol (2007) 0.93
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc Natl Acad Sci U S A (2005) 0.90
Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola. J Bacteriol (2013) 0.89
Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis. Front Plant Sci (2014) 0.88
Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. J Biol Chem (2010) 0.86
Structures of the PelD cyclic diguanylate effector involved in pellicle formation in Pseudomonas aeruginosa PAO1. J Biol Chem (2012) 0.85
Structural interface parameters are discriminatory in recognising near-native poses of protein-protein interactions. PLoS One (2014) 0.83
Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria. J Mol Evol (2008) 0.79
Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2. PeerJ (2015) 0.76
Crystallization and preliminary crystallographic analysis of the second GAF domain of DevS from Mycobacterium smegmatis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
Maximum-likelihood density modification. Acta Crystallogr D Biol Crystallogr (2000) 20.67
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng (1995) 19.22
Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr D Biol Crystallogr (1994) 17.44
The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem Sci (1997) 4.10
Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol (2001) 2.68
Swiss-PDB Viewer (Deep View). Brief Bioinform (2001) 2.48
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A (1999) 2.10
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A (2002) 2.10
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci U S A (2000) 1.86
Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proc Natl Acad Sci U S A (1990) 1.55
Isolation and characterization of multiple adenylate cyclase genes from the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol (1997) 1.32
A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. EMBO J (2002) 1.28
Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding. J Biol Chem (1996) 1.26
Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase. J Biol Chem (1998) 1.20
Molecular organization of bovine rod cGMP-phosphodiesterase 6. J Mol Biol (2001) 1.16
Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase. J Biol Chem (2004) 1.16
Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A. J Biol Chem (2004) 1.12
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J Biol Chem (1995) 1.08
Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. Cell Signal (2002) 1.00
Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms. J Struct Biol (2002) 0.95
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc Natl Acad Sci U S A (2005) 0.90
Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5. FEBS Lett (2003) 0.89
Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 9.48
Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature (2007) 8.21
The crystal structure of a voltage-gated sodium channel. Nature (2011) 7.82
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev (2006) 6.75
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science (2002) 6.32
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (2007) 5.08
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature (2006) 4.96
The HAMP domain structure implies helix rotation in transmembrane signaling. Cell (2006) 4.34
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol (2006) 3.22
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell (2004) 3.07
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature (2012) 2.78
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Nature (2012) 2.76
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res (2003) 2.39
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell (2006) 2.31
Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure (2009) 2.30
A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin. Nat Chem Biol (2012) 2.18
Structural assembly of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2010) 2.17
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell (2013) 2.14
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A (2002) 2.10
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons. Proc Natl Acad Sci U S A (2006) 2.02
Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell (2006) 1.92
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell (2005) 1.90
Structural regulation of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2011) 1.89
Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods (2008) 1.84
A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem (2001) 1.83
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
The class III adenylyl cyclases: multi-purpose signalling modules. Cell Signal (2003) 1.75
Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circ Res (2007) 1.74
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71
Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc Natl Acad Sci U S A (2008) 1.67
Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell (2010) 1.66
A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat Struct Mol Biol (2009) 1.58
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J (2003) 1.56
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme. Science (2005) 1.52
Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2010) 1.48
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res (2009) 1.47
SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature (2013) 1.41
Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. J Biol Chem (2001) 1.35
Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proc Natl Acad Sci U S A (2006) 1.34
Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc Natl Acad Sci U S A (2004) 1.34
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci U S A (2010) 1.33
JAZ8 lacks a canonical degron and has an EAR motif that mediates transcriptional repression of jasmonate responses in Arabidopsis. Plant Cell (2012) 1.32
The mechanisms of HAMP-mediated signaling in transmembrane receptors. Structure (2011) 1.30
GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides. Mol Interv (2002) 1.29
A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. EMBO J (2002) 1.28
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol (2006) 1.27
Auxin perception--structural insights. Cold Spring Harb Perspect Biol (2010) 1.27
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. Circ Res (2007) 1.27
Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J Pathol (2012) 1.26
The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts. J Biol Chem (2004) 1.25
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc Natl Acad Sci U S A (2006) 1.23
Exploring the functional complexity of cellular proteins by protein knockout. Proc Natl Acad Sci U S A (2003) 1.21
mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain. J Comp Neurol (2003) 1.17
Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase. J Biol Chem (2004) 1.16
The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. J Biol Chem (2008) 1.15
Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Circ Res (2002) 1.15
A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins. Mol Cell (2006) 1.14
Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol Microbiol (2006) 1.13
Mechanism of regulation of receptor histidine kinases. Structure (2012) 1.13
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol (2010) 1.13
Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A. J Biol Chem (2004) 1.12
High-level expression and purification of recombinant SCF ubiquitin ligases. Methods Enzymol (2005) 1.11
Catalysis of Na+ permeation in the bacterial sodium channel Na(V)Ab. Proc Natl Acad Sci U S A (2013) 1.09
Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). Plant Cell (2011) 1.09
Cyclic nucleotides promote monocyte differentiation toward a DC-SIGN+ (CD209) intermediate cell and impair differentiation into dendritic cells. J Immunol (2003) 1.06
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain. J Biol Chem (2002) 1.05
Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev (2013) 1.05
Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. J Mol Cell Cardiol (2010) 1.04
Aquaporin-mediated fluid regulation in the inner ear. Cell Mol Neurobiol (2003) 1.04
cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J Biol Chem (2005) 1.04
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. Cell Signal (2004) 1.03
A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. J Immunol (2004) 1.01
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res (2013) 1.01
Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. J Biol Chem (2008) 1.01
Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents. Mol Interv (2007) 1.00
Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A (2009) 1.00
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. Proc Natl Acad Sci U S A (2002) 1.00
The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis. Eur J Biochem (2004) 0.99
A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS Lett (2003) 0.98
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell Signal (2004) 0.97
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages. Neurochem Int (2004) 0.97
The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization. J Biol Chem (2003) 0.97
Retracted Escherichia coli exports cyclic AMP via TolC. J Bacteriol (2010) 0.95
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem (2012) 0.95
Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res (2013) 0.95