Published in Mol Biol Evol on April 01, 2000
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47
Predicting protein function and binding profile via matching of local evolutionary and geometric surface patterns. J Mol Biol (2009) 1.26
Amino-acid solvation structure in transmembrane helices from molecular dynamics simulations. Biophys J (2006) 1.24
Integrated assessment of genomic correlates of protein evolutionary rate. PLoS Comput Biol (2009) 1.20
Phylogenomic reconstruction of lactic acid bacteria: an update. BMC Evol Biol (2011) 1.13
Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms. Nucleic Acids Res (2005) 1.12
Improved detection of homologous membrane proteins by inclusion of information from topology predictions. Protein Sci (2002) 1.10
Structural imperatives impose diverse evolutionary constraints on helical membrane proteins. Proc Natl Acad Sci U S A (2009) 1.08
Accumulation of amino acid substitutions promotes irreversible structural changes in the hemagglutinin of human influenza AH3 virus during evolution. J Virol (2005) 1.04
Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithorax. J Biol Chem (2008) 1.00
Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance. BMC Evol Biol (2009) 0.97
Evaluating evolutionary constraint on the rapidly evolving gene matK using protein composition. J Mol Evol (2007) 0.89
Pattern of amino acid substitutions in transmembrane domains of β-barrel membrane proteins for detecting remote homologs in bacteria and mitochondria. PLoS One (2011) 0.87
Evolutionary approach to predicting the binding site residues of a protein from its primary sequence. Proc Natl Acad Sci U S A (2011) 0.87
A collection of amino acid replacement matrices derived from clusters of orthologs. J Mol Evol (2005) 0.87
The complete mitochondrial genome of the Asiatic cavity-nesting honeybee Apis cerana (Hymenoptera: Apidae). PLoS One (2011) 0.86
On the relevance of the Met-turn methionine in metzincins. J Biol Chem (2010) 0.86
Membrane environment imposes unique selection pressures on transmembrane domains of G protein-coupled receptors. J Mol Evol (2013) 0.85
Model of the whole rat AT1 receptor and the ligand-binding site. J Mol Model (2006) 0.84
Deep ultraviolet mapping of intracellular protein and nucleic acid in femtograms per pixel. Cytometry A (2011) 0.84
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. BMC Evol Biol (2011) 0.84
Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoire. BMC Immunol (2012) 0.84
Classification of protein functional surfaces using structural characteristics. Proc Natl Acad Sci U S A (2012) 0.83
Biocomputational characterization and evolutionary analysis of bubaline dicer1 enzyme. Asian-Australas J Anim Sci (2015) 0.83
Rapid evolution of the sequences and gene repertoires of secreted proteins in bacteria. PLoS One (2012) 0.83
GFT projection NMR based resonance assignment of membrane proteins: application to subunit C of E. coli F(1)F (0) ATP synthase in LPPG micelles. J Biomol NMR (2008) 0.82
Functional bias in molecular evolution rate of Arabidopsis thaliana. BMC Evol Biol (2010) 0.81
Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3. Biochemistry (2009) 0.81
Filling the Void: Proximity-Based Labeling of Proteins in Living Cells. Trends Cell Biol (2016) 0.80
13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1. J Biomol NMR (2015) 0.80
Mutations in Escherichia coli ExbB transmembrane domains identify scaffolding and signal transduction functions and exclude participation in a proton pathway. J Bacteriol (2013) 0.80
Comprehensive, structurally-informed alignment and phylogeny of vertebrate biogenic amine receptors. PeerJ (2015) 0.78
PSC: protein surface classification. Nucleic Acids Res (2012) 0.78
Nonrandom intragenic variations in patterns of codon bias implicate a sequential interplay between transitional genetic drift and functional amino acid selection. J Mol Evol (2003) 0.78
Quantitative residue-level structure-evolution relationships in the yeast membrane proteome. Genome Biol Evol (2013) 0.78
Enhancing ubiquitin crystallization through surface-entropy reduction. Acta Crystallogr F Struct Biol Commun (2014) 0.78
Genome wide exploration of the origin and evolution of amino acids. BMC Evol Biol (2010) 0.77
Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life. Mol Biol Evol (2016) 0.75
Machine learning classifier for identification of damaging missense mutations exclusive to human mitochondrial DNA-encoded polypeptides. BMC Bioinformatics (2017) 0.75
CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation. Cell Chem Biol (2016) 0.75
Tridimensional model structure and patterns of molecular evolution of Pepino mosaic virus TGBp3 protein. Virol J (2011) 0.75
Contrasting patterns of nucleotide polymorphism suggest different selective regimes within different parts of the PgiC1 gene in Festuca ovina L. Hereditas (2017) 0.75
Proximity-dependent labeling methods for proteomic profiling in living cells. Wiley Interdiscip Rev Dev Biol (2017) 0.75
Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc Natl Acad Sci U S A (1979) 41.08
The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res (1987) 26.51
Statistical tests of neutrality of mutations. Genetics (1993) 24.94
Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs. Proc Natl Acad Sci U S A (1987) 10.66
Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J Mol Evol (1993) 9.43
Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees. Am J Hum Genet (2001) 9.35
Evidence for higher rates of nucleotide substitution in rodents than in man. Proc Natl Acad Sci U S A (1985) 8.18
Mutation rates differ among regions of the mammalian genome. Nature (1989) 7.63
Date of the monocot-dicot divergence estimated from chloroplast DNA sequence data. Proc Natl Acad Sci U S A (1989) 6.99
Codon usage in regulatory genes in Escherichia coli does not reflect selection for 'rare' codons. Nucleic Acids Res (1986) 5.68
Linkage disequilibrium in subdivided populations. Genetics (1973) 5.22
Distribution of nucleotide differences between two randomly chosen cistrons in a finite population. Genetics (1977) 5.22
An evolutionary perspective on synonymous codon usage in unicellular organisms. J Mol Evol (1986) 5.05
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites. Mol Biol Evol (1995) 4.88
Drift variances of heterozygosity and genetic distance in transient states. Genet Res (1975) 4.45
Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications. J Mol Evol (1984) 4.42
Rates of nucleotide substitution in angiosperm mitochondrial DNA sequences and dates of divergence between Brassica and other angiosperm lineages. J Mol Evol (1999) 4.37
Pseudogenes as a paradigm of neutral evolution. Nature (1981) 4.33
Statistical properties of bootstrap estimation of phylogenetic variability from nucleotide sequences. I. Four taxa with a molecular clock. Mol Biol Evol (1992) 4.31
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias. Mol Biol Evol (1987) 4.30
Is the guinea-pig a rodent? Nature (1991) 4.25
Transposable elements are found in a large number of human protein-coding genes. Trends Genet (2001) 3.89
Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase. J Biol Chem (1988) 3.74
On the rate of DNA sequence evolution in Drosophila. J Mol Evol (1989) 3.74
Non-random association between electromorphs and inversion chromosomes in finite populations. Genet Res (1980) 3.69
Patterns of nucleotide substitution in pseudogenes and functional genes. J Mol Evol (1982) 3.43
The molecular clock runs more slowly in man than in apes and monkeys. Nature (1987) 3.42
Simple method for constructing phylogenetic trees from distance matrices. Proc Natl Acad Sci U S A (1981) 3.09
Probability of identical monomorphism in related species. Genet Res (1975) 2.91
Male-driven evolution of DNA sequences. Nature (1993) 2.86
The size distribution of insertions and deletions in human and rodent pseudogenes suggests the logarithmic gap penalty for sequence alignment. J Mol Evol (1995) 2.77
Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67
Estimating the age of the common ancestor of a sample of DNA sequences. Mol Biol Evol (1997) 2.64
Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. Mol Biol Evol (2001) 2.64
Coalescing into the 21st century: An overview and prospects of coalescent theory. Theor Popul Biol (1999) 2.38
Accumulation of mutations in sexual and asexual populations. Genet Res (1987) 2.30
Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons. J Mol Evol (1987) 2.27
Maximum likelihood estimation of population parameters. Genetics (1993) 2.01
Total number of individuals affected by a single deleterious mutation in a finite population. Am J Hum Genet (1972) 1.98
High polymorphism at the human melanocortin 1 receptor locus. Genetics (1999) 1.94
Stable linkage disequilibrium without epistasis in subdivided populations. Theor Popul Biol (1974) 1.93
Distribution of nucleotide differences between two randomly chosen cistrons in a subdivided population: the finite island model. Theor Popul Biol (1976) 1.86
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100. Nature (1986) 1.85
Molecular phylogeny of extant gymnosperms and seed plant evolution: analysis of nuclear 18S rRNA sequences. Mol Biol Evol (1997) 1.85
Molecular phylogeny of the kingdoms Animalia, Plantae, and Fungi. Mol Biol Evol (1989) 1.83
Deletions in processed pseudogenes accumulate faster in rodents than in humans. J Mol Evol (1989) 1.73
The transient distribution of allele frequencies under mutation pressure. Genet Res (1976) 1.70
Chromosomal location and evolutionary rate variation in enterobacterial genes. Science (1989) 1.67
The molecular clock ticks regularly in muroid rodents and hamsters. J Mol Evol (1992) 1.66
Neuroendocrine differentiation in 32 cases of so-called sclerosing hemangioma of the lung: identified by immunohistochemical and ultrastructural study. Am J Surg Pathol (1997) 1.64
Genomic divergence between human and chimpanzee estimated from large-scale alignments of genomic sequences. J Hered (2002) 1.63
Higher rates of amino acid substitution in rodents than in humans. Mol Phylogenet Evol (1992) 1.61
Persistence of common alleles in two related populations or species. Genetics (1977) 1.54
A rapid heuristic algorithm for finding minimum evolution trees. Mol Phylogenet Evol (2000) 1.50
Rate of gene silencing at duplicate loci: a theoretical study and interpretation of data from tetraploid fishes. Genetics (1980) 1.49
Estimation of confidence in phylogeny: the complete-and-partial bootstrap technique. Mol Phylogenet Evol (1995) 1.49
Ubiquitin genes as a paradigm of concerted evolution of tandem repeats. J Mol Evol (1987) 1.47
Simulating allele frequencies in a population and the genetic differentiation of populations under mutation pressure. Theor Popul Biol (1983) 1.44
Assessment of compositional heterogeneity within and between eukaryotic genomes. Genome Res (2000) 1.43
What amino acid properties affect protein evolution? J Mol Evol (1998) 1.42
Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria. Genetica (1998) 1.42
Maintenance of genetic variability under mutation and selection pressures in a finite population. Proc Natl Acad Sci U S A (1977) 1.41
Weak male-driven molecular evolution in rodents. Proc Natl Acad Sci U S A (1994) 1.40
The complete cDNA and amino acid sequence of human apolipoprotein B-100. J Biol Chem (1986) 1.39
Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree. Nature (1989) 1.37
Molecular cloning and expression of partial cDNAs and deduced amino acid sequence of a carboxyl-terminal fragment of human apolipoprotein B-100. Proc Natl Acad Sci U S A (1985) 1.35
Contrasting rates of nucleotide substitution in the X-linked and Y-linked zinc finger genes. J Mol Evol (1994) 1.28
Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. J Lipid Res (1989) 1.27
Statistical tests of molecular phylogenies. Methods Enzymol (1990) 1.26
Trichromatic vision in prosimians. Nature (1999) 1.25
Structure of apolipoprotein B-100 of human low density lipoproteins. Arteriosclerosis (1989) 1.24
Structure and evolution of the apolipoprotein multigene family. J Mol Biol (1986) 1.21
Human DNA sequence variation in a 6.6-kb region containing the melanocortin 1 receptor promoter. Genetics (2001) 1.20
Maintenance of genetic variability under the pressure of neutral and deleterious mutations in a finite population. Genetics (1979) 1.20
Origins and antiquity of X-linked triallelic color vision systems in New World monkeys. Proc Natl Acad Sci U S A (1998) 1.18
Molecular evolution of trichromacy in primates. Vision Res (1998) 1.17
Understanding the origins of AIDS viruses. Nature (1988) 1.15
Stem cells from deciduous tooth repair mandibular defect in swine. J Dent Res (2009) 1.14
Estimating the age of the common ancestor of men from the ZFY intron. Science (1996) 1.13
Structure and evolution of the lipase superfamily. J Lipid Res (1992) 1.13
Molecular genetics of spectral tuning in New World monkey color vision. J Mol Evol (1998) 1.13
Adaptive evolution of color vision genes in higher primates. Science (1995) 1.12
Molecular phylogenetic studies of Brassica, rorippa, arabidopsis and allied genera based on the internal transcribed spacer region of 18S-25S rDNA. Mol Phylogenet Evol (1999) 1.12
Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates. Mol Biol Evol (1996) 1.10
Apobec-1 and apolipoprotein B mRNA editing. Biochim Biophys Acta (1997) 1.09
High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions. J Med Virol (1999) 1.08
Total number of individuals affected by a single sex-linked deleterious mutation in a finite population. Am J Hum Genet (1973) 1.08
Structure and expression of dog apolipoprotein A-I, E, and C-I mRNAs: implications for the evolution and functional constraints of apolipoprotein structure. J Lipid Res (1989) 1.08
Evolutionary change of restriction cleavage sites and phylogenetic inference. Genetics (1986) 1.04
Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Mol Biol Evol (1992) 1.04
Molecular systematics of pikas (genus Ochotona) inferred from mitochondrial DNA sequences. Mol Phylogenet Evol (2000) 1.03
Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina. Proc Natl Acad Sci U S A (1999) 1.02
Evolution of protein inhibitors of serine proteinases: positive Darwinian selection or compositional effects? J Mol Evol (1989) 1.02
No severe bottleneck during human evolution: evidence from two apolipoprotein C-II deficiency alleles. Am J Hum Genet (1991) 1.02
Gene admixture in the silk road region of China: evidence from mtDNA and melanocortin 1 receptor polymorphism. Genes Genet Syst (2000) 1.02
A model for the correlation of mutation rate with GC content and the origin of GC-rich isochores. J Mol Evol (1994) 1.01
Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. J Immunol (2000) 1.00
Apolipoprotein B mRNA editing. Validation of a sensitive assay and developmental biology of RNA editing in the rat. J Biol Chem (1990) 0.99