Published in Genetics on March 01, 1993
Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Genetics (1997) 20.93
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78
The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics (1995) 9.53
Properties of statistical tests of neutrality for DNA polymorphism data. Genetics (1995) 7.62
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet (1998) 7.56
Estimation of past demographic parameters from the distribution of pairwise differences when the mutation rates vary among sites: application to human mitochondrial DNA. Genetics (1999) 7.12
Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol (2004) 7.11
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations. Genetics (2004) 7.00
Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A (2002) 6.95
The degeneration of Y chromosomes. Philos Trans R Soc Lond B Biol Sci (2000) 5.22
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci U S A (2005) 5.21
Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. Genetics (1994) 5.05
The pattern of neutral molecular variation under the background selection model. Genetics (1995) 5.03
Genomic regions exhibiting positive selection identified from dense genotype data. Genome Res (2005) 4.81
Estimating ancestral population parameters. Genetics (1997) 4.42
Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus. Am J Hum Genet (2000) 4.39
How reliable are empirical genomic scans for selective sweeps? Genome Res (2006) 4.14
The population genetics of dN/dS. PLoS Genet (2008) 3.88
Estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of DNA sequences. Genetics (1994) 3.82
Global landscape of recent inferred Darwinian selection for Homo sapiens. Proc Natl Acad Sci U S A (2005) 3.77
New statistical tests of neutrality for DNA samples from a population. Genetics (1996) 3.75
The discovery of single-nucleotide polymorphisms--and inferences about human demographic history. Am J Hum Genet (2001) 3.50
A phylogenetic estimator of effective population size or mutation rate. Genetics (1994) 3.39
Approximate Bayesian inference reveals evidence for a recent, severe bottleneck in a Netherlands population of Drosophila melanogaster. Genetics (2005) 3.31
The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation. Genetics (2000) 3.24
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A (1995) 3.20
A test of neutrality based on interlocus associations. Genetics (1997) 3.09
DNA variability and recombination rates at X-linked loci in humans. Genetics (1998) 3.01
Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet (2006) 3.00
A multilocus sequence survey in Arabidopsis thaliana reveals a genome-wide departure from a neutral model of DNA sequence polymorphism. Genetics (2005) 2.97
Inferences about human demography based on multilocus analyses of noncoding sequences. Genetics (2002) 2.95
When did the human population size start increasing? Genetics (2000) 2.94
Nonequilibrium migration in human history. Genetics (1999) 2.93
Inferring the fitness effects of DNA mutations from polymorphism and divergence data: statistical power to detect directional selection under stationarity and free recombination. Genetics (1999) 2.89
Evidence on the origin of cassava: phylogeography of Manihot esculenta. Proc Natl Acad Sci U S A (1999) 2.89
Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene. Genetics (2001) 2.89
Inferring the demographic history and rate of adaptive substitution in Drosophila. PLoS Genet (2006) 2.88
Pattern of diversity in the genomic region near the maize domestication gene tb1. Proc Natl Acad Sci U S A (2003) 2.85
Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster. Proc Natl Acad Sci U S A (2002) 2.81
The amount of DNA polymorphism maintained in a finite population when the neutral mutation rate varies among sites. Genetics (1996) 2.69
Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67
Distinguishing between selective sweeps and demography using DNA polymorphism data. Genetics (2005) 2.65
Selectionism and neutralism in molecular evolution. Mol Biol Evol (2005) 2.64
Estimation of nucleotide diversity, disequilibrium coefficients, and mutation rates from high-coverage genome-sequencing projects. Mol Biol Evol (2008) 2.64
A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs. Am J Hum Genet (2009) 2.62
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet (2000) 2.62
Host switching in Lyssavirus history from the Chiroptera to the Carnivora orders. J Virol (2001) 2.61
Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet (2008) 2.58
The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus. Proc Natl Acad Sci U S A (2000) 2.52
A test of the background selection hypothesis based on nucleotide data from Drosophila ananassae. Proc Natl Acad Sci U S A (1998) 2.49
Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques. PLoS Pathog (2011) 2.45
Statistical tests for detecting positive selection by utilizing high-frequency variants. Genetics (2006) 2.43
Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. Proc Natl Acad Sci U S A (2007) 2.41
Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection. J Mol Evol (2003) 2.39
Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection? Genetics (1994) 2.38
A practical genome scan for population-specific strong selective sweeps that have reached fixation. PLoS One (2007) 2.35
Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster. Genetics (2001) 2.34
Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet (2004) 2.33
Effects of inbreeding on the genetic diversity of populations. Philos Trans R Soc Lond B Biol Sci (2003) 2.26
A monkey's tale: the origin of Plasmodium vivax as a human malaria parasite. Proc Natl Acad Sci U S A (2005) 2.25
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet (2004) 2.21
The causes of phylogenetic conflict in a classic Drosophila species group. Proc Biol Sci (2003) 2.14
Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. Genome Res (2003) 2.12
Nucleotide polymorphism and linkage disequilibrium in wild populations of the partial selfer Caenorhabditis elegans. Genetics (2005) 2.11
Population differentiation as a test for selective sweeps. Genome Res (2010) 2.08
Evidence for inversion polymorphism related to sympatric host race formation in the apple maggot fly, Rhagoletis pomonella. Genetics (2003) 2.07
Different forces drive the evolution of the Acp26Aa and Acp26Ab accessory gland genes in the Drosophila melanogaster species complex. Genetics (1998) 2.07
Genetic analysis of lice supports direct contact between modern and archaic humans. PLoS Biol (2004) 2.06
Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1. Infect Immun (2003) 2.02
Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data. Genetics (2007) 2.00
Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J Exp Med (2009) 2.00
On the meaning and existence of an effective population size. Genetics (2004) 1.98
Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection. Genetics (2004) 1.98
Molecular characterization of two natural hotspots in the Drosophila buzzatii genome induced by transposon insertions. Genome Res (2001) 1.98
Detecting selective sweeps in naturally occurring Escherichia coli. Genetics (1994) 1.96
Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes. Mol Ecol (2008) 1.96
A 454 multiplex sequencing method for rapid and reliable genotyping of highly polymorphic genes in large-scale studies. BMC Genomics (2010) 1.95
Contingency tests of neutrality using intra/interspecific gene trees: the rejection of neutrality for the evolution of the mitochondrial cytochrome oxidase II gene in the hominoid primates. Genetics (1996) 1.94
Intragenic recombination in the Adh locus of the wild plant Arabidopsis thaliana. Genetics (1996) 1.93
Genealogical evidence for positive selection in the nef gene of HIV-1. Genetics (1999) 1.93
Estimation of allele frequency and association mapping using next-generation sequencing data. BMC Bioinformatics (2011) 1.93
De novo origination of a new protein-coding gene in Saccharomyces cerevisiae. Genetics (2008) 1.87
Nucleotide variation at the CHALCONE ISOMERASE locus in Arabidopsis thaliana. Genetics (2000) 1.85
Haplotype test reveals departure from neutrality in a segment of the white gene of Drosophila melanogaster. Genetics (1995) 1.85
A novel DNA sequence database for analyzing human demographic history. Genome Res (2008) 1.85
Critical review of host specificity and its coevolutionary implications in the fig/fig-wasp mutualism. Proc Natl Acad Sci U S A (2005) 1.84
Genome-wide scans for footprints of natural selection. Philos Trans R Soc Lond B Biol Sci (2010) 1.84
Population genetics of polymorphism and divergence for diploid selection models with arbitrary dominance. Genetics (2004) 1.83
Molecular population genetics of floral homeotic loci. Departures from the equilibrium-neutral model at the APETALA3 and PISTILLATA genes of Arabidopsis thaliana. Genetics (1999) 1.82
Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen. Genetics (2003) 1.82
Molecular population genetics of the Arabidopsis CAULIFLOWER regulatory gene: nonneutral evolution and naturally occurring variation in floral homeotic function. Proc Natl Acad Sci U S A (1998) 1.82
Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. Genetics (2004) 1.81
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet (2007) 1.79
Multiple origins of knockdown resistance mutations in the Afrotropical mosquito vector Anopheles gambiae. PLoS One (2007) 1.79
Detecting ancient admixture and estimating demographic parameters in multiple human populations. Mol Biol Evol (2009) 1.78
Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans. Genetics (2000) 1.78
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration. PLoS Pathog (2006) 1.76
The structure of linkage disequilibrium around a selective sweep. Genetics (2006) 1.75
The confounding effects of population structure, genetic diversity and the sampling scheme on the detection and quantification of population size changes. Genetics (2010) 1.72
The impact of sampling schemes on the site frequency spectrum in nonequilibrium subdivided populations. Genetics (2009) 1.71
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics (1989) 73.50
On the number of segregating sites in genetical models without recombination. Theor Popul Biol (1975) 60.96
Evolutionary relationship of DNA sequences in finite populations. Genetics (1983) 40.67
Evolutionary rate at the molecular level. Nature (1968) 33.15
Adaptive protein evolution at the Adh locus in Drosophila. Nature (1991) 31.65
A test of neutral molecular evolution based on nucleotide data. Genetics (1987) 24.44
Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc Natl Acad Sci U S A (1979) 41.08
The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res (1987) 26.51
Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs. Proc Natl Acad Sci U S A (1987) 10.66
Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J Mol Evol (1993) 9.43
Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees. Am J Hum Genet (2001) 9.35
Evidence for higher rates of nucleotide substitution in rodents than in man. Proc Natl Acad Sci U S A (1985) 8.18
Mutation rates differ among regions of the mammalian genome. Nature (1989) 7.63
Date of the monocot-dicot divergence estimated from chloroplast DNA sequence data. Proc Natl Acad Sci U S A (1989) 6.99
Codon usage in regulatory genes in Escherichia coli does not reflect selection for 'rare' codons. Nucleic Acids Res (1986) 5.68
Linkage disequilibrium in subdivided populations. Genetics (1973) 5.22
Distribution of nucleotide differences between two randomly chosen cistrons in a finite population. Genetics (1977) 5.22
An evolutionary perspective on synonymous codon usage in unicellular organisms. J Mol Evol (1986) 5.05
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites. Mol Biol Evol (1995) 4.88
Drift variances of heterozygosity and genetic distance in transient states. Genet Res (1975) 4.45
Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications. J Mol Evol (1984) 4.42
Rates of nucleotide substitution in angiosperm mitochondrial DNA sequences and dates of divergence between Brassica and other angiosperm lineages. J Mol Evol (1999) 4.37
Pseudogenes as a paradigm of neutral evolution. Nature (1981) 4.33
Statistical properties of bootstrap estimation of phylogenetic variability from nucleotide sequences. I. Four taxa with a molecular clock. Mol Biol Evol (1992) 4.31
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias. Mol Biol Evol (1987) 4.30
Is the guinea-pig a rodent? Nature (1991) 4.25
Transposable elements are found in a large number of human protein-coding genes. Trends Genet (2001) 3.89
Estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of DNA sequences. Genetics (1994) 3.82
Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase. J Biol Chem (1988) 3.74
On the rate of DNA sequence evolution in Drosophila. J Mol Evol (1989) 3.74
Non-random association between electromorphs and inversion chromosomes in finite populations. Genet Res (1980) 3.69
Patterns of nucleotide substitution in pseudogenes and functional genes. J Mol Evol (1982) 3.43
The molecular clock runs more slowly in man than in apes and monkeys. Nature (1987) 3.42
A phylogenetic estimator of effective population size or mutation rate. Genetics (1994) 3.39
Simple method for constructing phylogenetic trees from distance matrices. Proc Natl Acad Sci U S A (1981) 3.09
Probability of identical monomorphism in related species. Genet Res (1975) 2.91
Male-driven evolution of DNA sequences. Nature (1993) 2.86
The size distribution of insertions and deletions in human and rodent pseudogenes suggests the logarithmic gap penalty for sequence alignment. J Mol Evol (1995) 2.77
Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67
Estimating the age of the common ancestor of a sample of DNA sequences. Mol Biol Evol (1997) 2.64
Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. Mol Biol Evol (2001) 2.64
Coalescing into the 21st century: An overview and prospects of coalescent theory. Theor Popul Biol (1999) 2.38
Accumulation of mutations in sexual and asexual populations. Genet Res (1987) 2.30
Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons. J Mol Evol (1987) 2.27
Maximum likelihood estimation of population parameters. Genetics (1993) 2.01
Total number of individuals affected by a single deleterious mutation in a finite population. Am J Hum Genet (1972) 1.98
High polymorphism at the human melanocortin 1 receptor locus. Genetics (1999) 1.94
Stable linkage disequilibrium without epistasis in subdivided populations. Theor Popul Biol (1974) 1.93
Distribution of nucleotide differences between two randomly chosen cistrons in a subdivided population: the finite island model. Theor Popul Biol (1976) 1.86
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100. Nature (1986) 1.85
Molecular phylogeny of extant gymnosperms and seed plant evolution: analysis of nuclear 18S rRNA sequences. Mol Biol Evol (1997) 1.85
Molecular phylogeny of the kingdoms Animalia, Plantae, and Fungi. Mol Biol Evol (1989) 1.83
Deletions in processed pseudogenes accumulate faster in rodents than in humans. J Mol Evol (1989) 1.73
The transient distribution of allele frequencies under mutation pressure. Genet Res (1976) 1.70
Chromosomal location and evolutionary rate variation in enterobacterial genes. Science (1989) 1.67
The molecular clock ticks regularly in muroid rodents and hamsters. J Mol Evol (1992) 1.66
Neuroendocrine differentiation in 32 cases of so-called sclerosing hemangioma of the lung: identified by immunohistochemical and ultrastructural study. Am J Surg Pathol (1997) 1.64
Selective constraints, amino acid composition, and the rate of protein evolution. Mol Biol Evol (2000) 1.63
Genomic divergence between human and chimpanzee estimated from large-scale alignments of genomic sequences. J Hered (2002) 1.63
Higher rates of amino acid substitution in rodents than in humans. Mol Phylogenet Evol (1992) 1.61
Persistence of common alleles in two related populations or species. Genetics (1977) 1.54
A rapid heuristic algorithm for finding minimum evolution trees. Mol Phylogenet Evol (2000) 1.50
Rate of gene silencing at duplicate loci: a theoretical study and interpretation of data from tetraploid fishes. Genetics (1980) 1.49
Estimation of confidence in phylogeny: the complete-and-partial bootstrap technique. Mol Phylogenet Evol (1995) 1.49
Ubiquitin genes as a paradigm of concerted evolution of tandem repeats. J Mol Evol (1987) 1.47
Simulating allele frequencies in a population and the genetic differentiation of populations under mutation pressure. Theor Popul Biol (1983) 1.44
Assessment of compositional heterogeneity within and between eukaryotic genomes. Genome Res (2000) 1.43
What amino acid properties affect protein evolution? J Mol Evol (1998) 1.42
Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria. Genetica (1998) 1.42
Maintenance of genetic variability under mutation and selection pressures in a finite population. Proc Natl Acad Sci U S A (1977) 1.41
Weak male-driven molecular evolution in rodents. Proc Natl Acad Sci U S A (1994) 1.40
The complete cDNA and amino acid sequence of human apolipoprotein B-100. J Biol Chem (1986) 1.39
Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree. Nature (1989) 1.37
Molecular cloning and expression of partial cDNAs and deduced amino acid sequence of a carboxyl-terminal fragment of human apolipoprotein B-100. Proc Natl Acad Sci U S A (1985) 1.35
Contrasting rates of nucleotide substitution in the X-linked and Y-linked zinc finger genes. J Mol Evol (1994) 1.28
Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. J Lipid Res (1989) 1.27
Statistical tests of molecular phylogenies. Methods Enzymol (1990) 1.26
Trichromatic vision in prosimians. Nature (1999) 1.25
Structure of apolipoprotein B-100 of human low density lipoproteins. Arteriosclerosis (1989) 1.24
Structure and evolution of the apolipoprotein multigene family. J Mol Biol (1986) 1.21
Human DNA sequence variation in a 6.6-kb region containing the melanocortin 1 receptor promoter. Genetics (2001) 1.20
Maintenance of genetic variability under the pressure of neutral and deleterious mutations in a finite population. Genetics (1979) 1.20
Origins and antiquity of X-linked triallelic color vision systems in New World monkeys. Proc Natl Acad Sci U S A (1998) 1.18
Molecular evolution of trichromacy in primates. Vision Res (1998) 1.17
Understanding the origins of AIDS viruses. Nature (1988) 1.15
Stem cells from deciduous tooth repair mandibular defect in swine. J Dent Res (2009) 1.14
Estimating the age of the common ancestor of men from the ZFY intron. Science (1996) 1.13
Structure and evolution of the lipase superfamily. J Lipid Res (1992) 1.13
Molecular genetics of spectral tuning in New World monkey color vision. J Mol Evol (1998) 1.13
Adaptive evolution of color vision genes in higher primates. Science (1995) 1.12
Molecular phylogenetic studies of Brassica, rorippa, arabidopsis and allied genera based on the internal transcribed spacer region of 18S-25S rDNA. Mol Phylogenet Evol (1999) 1.12
Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates. Mol Biol Evol (1996) 1.10
Apobec-1 and apolipoprotein B mRNA editing. Biochim Biophys Acta (1997) 1.09
High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions. J Med Virol (1999) 1.08
Total number of individuals affected by a single sex-linked deleterious mutation in a finite population. Am J Hum Genet (1973) 1.08
Structure and expression of dog apolipoprotein A-I, E, and C-I mRNAs: implications for the evolution and functional constraints of apolipoprotein structure. J Lipid Res (1989) 1.08
Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Mol Biol Evol (1992) 1.04
Evolutionary change of restriction cleavage sites and phylogenetic inference. Genetics (1986) 1.04
Molecular systematics of pikas (genus Ochotona) inferred from mitochondrial DNA sequences. Mol Phylogenet Evol (2000) 1.03
Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina. Proc Natl Acad Sci U S A (1999) 1.02
No severe bottleneck during human evolution: evidence from two apolipoprotein C-II deficiency alleles. Am J Hum Genet (1991) 1.02
Gene admixture in the silk road region of China: evidence from mtDNA and melanocortin 1 receptor polymorphism. Genes Genet Syst (2000) 1.02
Evolution of protein inhibitors of serine proteinases: positive Darwinian selection or compositional effects? J Mol Evol (1989) 1.02