Published in Proc Natl Acad Sci U S A on April 25, 2000
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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
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Hypoxic preconditioning protects against ischemic brain injury. NeuroRx (2004) 1.44
Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2004) 1.33
MicroRNAs: new players in cardiac injury and protection. Mol Pharmacol (2011) 1.26
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. EMBO J (2003) 1.24
Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. BMC Cancer (2009) 1.23
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Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol (2009) 0.89
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Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS One (2013) 0.86
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Prognostic Significance of Hypoxia-Inducible Factor Expression in Renal Cell Carcinoma: A PRISMA-compliant Systematic Review and Meta-Analysis. Medicine (Baltimore) (2015) 0.83
Constitutive HIF-1α expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance. J Cardiovasc Transl Res (2011) 0.82
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Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg Med Chem Lett (2011) 0.79
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget (2016) 0.78
Vascular endothelial growth factor-dependent spinogenesis underlies antidepressant-like effects of enriched environment. J Biol Chem (2012) 0.77
Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies. BMC Cancer (2014) 0.77
Overexpression of extracellular superoxide dismutase protects against brain injury induced by chronic hypoxia. PLoS One (2014) 0.76
The twisted survivin connection to angiogenesis. Mol Cancer (2015) 0.76
Neurodevelopmental implications of the general anesthesia in neonate and infants. Exp Neurol (2015) 0.76
Human activated macrophages and hypoxia: a comprehensive review of the literature. Iran J Basic Med Sci (2014) 0.75
Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes (2016) 0.75
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha. Clin Diagn Lab Immunol (2005) 0.75
Significance of duon mutations in cancer genomes. Sci Rep (2016) 0.75
William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award. J Clin Invest (2016) 0.75
Telomerase activity in pregnancy complications (Review). Mol Med Rep (2016) 0.75
Foxp3 enhances HIF-1α target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation. Oncotarget (2016) 0.75
Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma. PLoS Pathog (2017) 0.75
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev (1998) 12.48
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Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem (1996) 4.72
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev (1998) 12.48
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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev (2001) 6.35
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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol (1996) 5.52
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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene (2011) 2.42
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