Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit.

PubWeight™: 5.15‹?› | Rank: Top 1%

🔗 View Article (PMID 8943284)

Published in J Biol Chem on December 13, 1996

Authors

L E Huang1, Z Arany, D M Livingston, H F Bunn

Author Affiliations

1: Hematology-Oncology Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. Bunn@calvin.bwh.harvard.edu

Articles citing this

(truncated to the top 100)

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol (2000) 5.21

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J (2001) 5.20

Radical-free biology of oxidative stress. Am J Physiol Cell Physiol (2008) 4.33

Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33

The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J (2004) 4.26

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J (1999) 3.70

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J (1998) 3.63

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell (2008) 3.41

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J (1998) 3.13

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer (2001) 3.10

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest (2003) 3.02

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61

Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol (2000) 2.61

Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell (2002) 2.61

The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal (2009) 2.43

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation (2010) 2.06

HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest (2003) 1.99

Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin (2010) 1.98

Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest (2002) 1.95

Repression of gene expression by oxidative stress. Biochem J (1999) 1.85

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci U S A (2000) 1.82

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal (2009) 1.81

Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res (2012) 1.81

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol (1998) 1.80

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol Cell Biol (2002) 1.67

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem (2003) 1.66

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J (2000) 1.66

[(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging (2003) 1.62

Exercise acts as a drug; the pharmacological benefits of exercise. Br J Pharmacol (2012) 1.61

High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia (2008) 1.56

Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1. J Biol Chem (2005) 1.54

Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett (2008) 1.53

Reactive oxygen species and cellular oxygen sensing. Free Radic Biol Med (2007) 1.49

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease. Mutat Res (2008) 1.47

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep (2006) 1.43

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol (2013) 1.42

The human side of hypoxia-inducible factor. Br J Haematol (2008) 1.41

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol (2002) 1.38

Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr (2007) 1.37

Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal (2013) 1.34

Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1). Curr Drug Targets (2006) 1.33

Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut (2001) 1.32

Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31

Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxid Redox Signal (2010) 1.31

The EPAS1 gene influences the aerobic-anaerobic contribution in elite endurance athletes. Hum Genet (2005) 1.29

Erythropoietin. Cold Spring Harb Perspect Med (2013) 1.28

A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol (2011) 1.26

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26

Going ape as an approach to cancer therapeutics. Antioxid Redox Signal (2009) 1.25

The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia. Nucleic Acids Res (2005) 1.25

Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res (1998) 1.25

Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. BMC Cancer (2009) 1.23

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res (2007) 1.22

A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res (2008) 1.22

Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression. J Biol Chem (2009) 1.21

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis. Mol Cancer (2009) 1.19

Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ (2013) 1.19

Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Proc Natl Acad Sci U S A (2004) 1.17

Erythropoietin: a model system for studying oxygen-dependent gene regulation. J Exp Biol (1998) 1.17

Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Biochem J (2001) 1.16

Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation. Nucleic Acids Res (2001) 1.14

Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease. Clin Exp Nephrol (2008) 1.14

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc Natl Acad Sci U S A (2003) 1.13

Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer (2009) 1.12

Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem (2009) 1.12

Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding. Mol Cell Biol (2003) 1.11

APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Curr Mol Pharmacol (2012) 1.10

An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation. Nucleic Acids Res (2000) 1.09

Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke. Curr Med Chem (2009) 1.08

Oxygen sensing and signaling: impact on the regulation of physiologically important genes. Respir Physiol (1999) 1.07

HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat (2004) 1.06

Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro. Neoplasia (2001) 1.06

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. Am J Pathol (1998) 1.06

Redox systems of the cell: possible links and implications. Proc Natl Acad Sci U S A (2002) 1.06

Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Res (2011) 1.06

Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res (2004) 1.06

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics? J Cereb Blood Flow Metab (2012) 1.05

Hypoxia imaging-directed radiation treatment planning. Eur J Nucl Med Mol Imaging (2006) 1.04

Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8. J Cereb Blood Flow Metab (2011) 1.04

Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. Br J Cancer (2007) 1.04

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions. PLoS One (2012) 1.01

Hypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases. Curr Drug Targets (2013) 1.01

HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol (2010) 1.01

Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons. Neurosci Lett (2008) 1.01

Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99

Influence of hypoxia in inflammatory synovitis. Ann Rheum Dis (1998) 0.98

Genetic causes of erythrocytosis and the oxygen-sensing pathway. Blood Rev (2008) 0.97

Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer. BMC Med (2010) 0.97

Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma. BMC Cancer (2010) 0.97

Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists. J Leukoc Biol (2009) 0.96

HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol (2007) 0.96

Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells. Biochem J (1998) 0.95

Articles by these authors

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 10.01

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92

Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73

Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell (1991) 6.55

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell (1989) 6.43

Immunoaffinity chromatography of proteins. Methods Enzymol (1974) 6.40

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science (1988) 5.71

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58

E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26

Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell (1992) 5.05

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05

T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83

An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57

Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40

In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01

Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet (1994) 3.89

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell (1989) 3.88

The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell (1998) 3.86

Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83

Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med (2000) 3.72

Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell (1980) 3.62

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell (1991) 3.47

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A (1996) 3.43

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43

Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39

lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33

Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32

Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29

p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev (1996) 3.24

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24

E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24

Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol (1972) 3.23

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell (1990) 3.19

Exchange of heme among hemoglobins and between hemoglobin and albumin. J Biol Chem (1968) 3.09

The p400 complex is an essential E1A transformation target. Cell (2001) 3.05

E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev (1995) 3.02

The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00

Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84

An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell (1989) 2.78

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell (1995) 2.70

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science (1993) 2.70

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev (1996) 2.58

TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell (1993) 2.57

Control of Saccharomyces cerevisiae 2microN DNA replication by cell division cycle genes that control nuclear DNA replication. J Mol Biol (1977) 2.55

BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1997) 2.55

The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A (1987) 2.51

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev (1999) 2.51

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48

Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites. Cell (1976) 2.47

Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood (1991) 2.41

Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol (1996) 2.40

Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science (1992) 2.39

Effect of limited homology on gene conversion in a Saccharomyces cerevisiae plasmid recombination system. Mol Cell Biol (1988) 2.37

Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol (1993) 2.37

Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen. Cell (1982) 2.35

Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40. Proc Natl Acad Sci U S A (1975) 2.32

Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31

Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol Cell Biol (1990) 2.27

Mitotic gene conversion lengths, coconversion patterns, and the incidence of reciprocal recombination in a Saccharomyces cerevisiae plasmid system. Mol Cell Biol (1986) 2.27

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature (1998) 2.25

The subcellular localization of E2F-4 is cell-cycle dependent. Proc Natl Acad Sci U S A (1997) 2.24

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev (1998) 2.19

Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules. Proc Natl Acad Sci U S A (1975) 2.17

Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc Natl Acad Sci U S A (1987) 2.15

Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science (1992) 2.13

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell (1987) 2.13

Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues. J Exp Med (1973) 2.13

Regulation of the erythropoietin gene. Blood (1999) 2.10

Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation. Hum Mol Genet (1998) 2.06

Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus. Virology (1973) 2.05

Inheritance of the 2 micrometer m DNA plasmid from Saccharomyces. Genetics (1977) 2.01

trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Cell (1988) 1.98

The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol (1995) 1.97

Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95

Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol (1992) 1.94