Published in Proc Natl Acad Sci U S A on April 19, 2010
The molecular and cellular basis of bitter taste in Drosophila. Neuron (2011) 2.49
A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila. Nature (2013) 1.67
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Peripheral coding of taste. Neuron (2014) 1.51
Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour. Nature (2016) 1.42
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol (2010) 1.36
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins. Nat Commun (2014) 1.30
Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun (2013) 1.20
How we feel: ion channel partnerships that detect mechanical inputs and give rise to touch and pain perception. Neuron (2012) 1.14
Drosophila TRP channels and animal behavior. Life Sci (2012) 1.04
Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila. PLoS One (2012) 1.02
Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci (2013) 1.01
Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J Neurosci (2013) 0.99
Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain. Trends Genet (2015) 0.99
Gustatory receptors required for avoiding the insecticide L-canavanine. J Neurosci (2012) 0.97
The history of TRP channels, a commentary and reflection. Pflugers Arch (2011) 0.96
Molecular neurobiology of Drosophila taste. Curr Opin Neurobiol (2015) 0.94
Optogenetic induction of aversive taste memory. Neuroscience (2012) 0.92
Acid sensing by sweet and bitter taste neurons in Drosophila melanogaster. Nat Commun (2013) 0.92
Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons. PLoS Genet (2013) 0.90
Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception. Dev Dyn (2011) 0.88
The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila. Curr Biol (2016) 0.85
Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol (2014) 0.84
Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels. Br J Pharmacol (2016) 0.82
Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons. PLoS One (2015) 0.80
Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila. Elife (2016) 0.80
Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2011) 0.80
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Bioessays (2015) 0.80
TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae. Nat Neurosci (2016) 0.79
Drosophila Bitter Taste(s). Front Integr Neurosci (2015) 0.79
TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway. PLoS Genet (2016) 0.79
The full repertoire of Drosophila gustatory receptors for detecting an aversive compound. Nat Commun (2015) 0.79
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. PLoS One (2012) 0.78
Forcing open TRP channels: Mechanical gating as a unifying activation mechanism. Biochem Biophys Res Commun (2015) 0.77
Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps mercedesae. Open Biol (2016) 0.77
dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One (2015) 0.77
Contribution of Drosophila TRPA1-expressing neurons to circadian locomotor activity patterns. PLoS One (2013) 0.77
Differences in ion channel phenotype and function between humans and animal models. Front Biosci (Landmark Ed) (2018) 0.77
Genetic basis of triatomine behavior: lessons from available insect genomes. Mem Inst Oswaldo Cruz (2013) 0.76
H2O2-Sensitive Isoforms of Drosophila TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. Genetics (2016) 0.76
Contribution of Drosophila TRPA1 to Metabolism. PLoS One (2016) 0.76
Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature. Chem Senses (2013) 0.76
A Bitter Taste of the Sun Makes Egg-Laying Flies Run. Genetics (2017) 0.75
Genetic analysis of the electrophysiological response to salicin, a bitter substance, in a polyphagous strain of the silkworm Bombyx mori. PLoS One (2012) 0.75
A decision underlies phototaxis in an insect. Open Biol (2016) 0.75
TRPA1 Channels in Drosophila and Honey Bee Ectoparasitic Mites Share Heat Sensitivity and Temperature-Related Physiological Functions. Front Physiol (2016) 0.75
Stretching the imagination beyond muscle spindles - stretch-sensitive mechanisms in arthropods. J Anat (2015) 0.75
Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila. Biomol Ther (Seoul) (2015) 0.75
Thermotaxis, circadian rhythms, and TRP channels in Drosophila. Temperature (Austin) (2015) 0.75
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
TRP channels. Annu Rev Biochem (2007) 8.09
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature (2000) 7.66
An internal thermal sensor controlling temperature preference in Drosophila. Nature (2008) 6.52
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell (2003) 5.95
Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A (2003) 5.55
Molecular architecture of smell and taste in Drosophila. Annu Rev Neurosci (2007) 5.24
painless, a Drosophila gene essential for nociception. Cell (2003) 4.93
Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A (2005) 4.20
Taste representations in the Drosophila brain. Cell (2004) 3.95
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
A TRPV family ion channel required for hearing in Drosophila. Nature (2003) 3.53
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53
Taste perception and coding in Drosophila. Curr Biol (2004) 3.52
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 3.35
Two Gr genes underlie sugar reception in Drosophila. Neuron (2007) 3.05
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
Opposite thermosensor in fruitfly and mouse. Nature (2003) 3.04
Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr Biol (2001) 2.76
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
A taste receptor required for the caffeine response in vivo. Curr Biol (2006) 2.51
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nat Neurosci (2001) 2.45
The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell (1996) 2.41
Peripheral coding of bitter taste in Drosophila. J Neurobiol (2003) 2.28
Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19
Sugar receptors in Drosophila. Curr Biol (2007) 2.18
A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A (2007) 2.16
A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship. Curr Biol (2009) 2.10
A taste of the Drosophila gustatory receptors. Curr Opin Neurobiol (2009) 2.04
Multiple gustatory receptors required for the caffeine response in Drosophila. Proc Natl Acad Sci U S A (2009) 2.02
Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr Biol (2001) 1.99
Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol (2008) 1.89
Differentiated response to sugars among labellar chemosensilla in Drosophila. Zoolog Sci (2002) 1.88
Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1. Curr Biol (2006) 1.71
Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci (2008) 1.64
Insects as chemosensors of humans and crops. Nature (2006) 1.57
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Molecular, biochemical, and electrophysiological characterization of Drosophila norpA mutants. J Biol Chem (1996) 1.21
Drosophila TRP channels. Pflugers Arch (2005) 1.10
Contribution of different taste cells and signaling pathways to the discrimination of "bitter" taste stimuli by an insect. J Neurosci (2002) 1.01
Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol (2005) 0.98
Electrophysiological evidence for two transduction pathways within a bitter-sensitive taste receptor. J Neurophysiol (1997) 0.95
Specific molecular alterations in the norpA-encoded phospholipase C of Drosophila and their effects on electrophysiological responses in vivo. J Neurochem (2004) 0.92
TRP channels. Annu Rev Biochem (2007) 8.09
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J (2003) 3.35
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A (2009) 3.13
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol (2004) 2.86
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure. J Biol Chem (2004) 2.66
A taste receptor required for the caffeine response in vivo. Curr Biol (2006) 2.51
TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol (2003) 2.45
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell (2007) 2.33
A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A (2007) 2.16
Phototransduction and retinal degeneration in Drosophila. Pflugers Arch (2007) 2.15
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev (2005) 2.13
Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Neuron (2005) 2.12
A Drosophila model for LRRK2-linked parkinsonism. Proc Natl Acad Sci U S A (2008) 2.12
Function of rhodopsin in temperature discrimination in Drosophila. Science (2011) 2.11
A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship. Curr Biol (2009) 2.10
High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease. Kidney Int (2005) 2.02
Multiple gustatory receptors required for the caffeine response in Drosophila. Proc Natl Acad Sci U S A (2009) 2.02
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem (2001) 1.97
Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron (2004) 1.93
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem (2006) 1.90
Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol (2008) 1.89
WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol (2009) 1.87
Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc Natl Acad Sci U S A (2003) 1.87
The molecular basis for attractive salt-taste coding in Drosophila. Science (2013) 1.78
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (2010) 1.78
Avoiding DEET through insect gustatory receptors. Neuron (2010) 1.75
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell (2008) 1.69
PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (2002) 1.65
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. J Biol Chem (2005) 1.64
Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci (2008) 1.64
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol (2003) 1.56
Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype. Histopathology (2012) 1.53
Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron (2003) 1.48
The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron (2008) 1.48
Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochem Biophys Res Commun (2005) 1.44
A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum Gene Ther (2002) 1.40
Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. Am J Respir Cell Mol Biol (2006) 1.39
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J (2004) 1.39
Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron (2005) 1.37
Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. Hum Gene Ther (2003) 1.36
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol (2010) 1.36
Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem (2002) 1.35
Histamine and its receptors modulate temperature-preference behaviors in Drosophila. J Neurosci (2006) 1.27
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Eng Des Sel (2010) 1.26
Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL. J Biol Chem (2003) 1.17
PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci U S A (2006) 1.16
Functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector. Hum Gene Ther (2004) 1.16
Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach. J Biol Chem (2006) 1.15
Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics. J Gen Physiol (2010) 1.15
Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance. Biophys J (2007) 1.15
Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships. Hum Mutat (2008) 1.15
Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell (2010) 1.14
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. Hum Mol Genet (2011) 1.13
Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol (2002) 1.12
Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol (2007) 1.11
Requirement for an enzymatic visual cycle in Drosophila. Curr Biol (2009) 1.11
An odorant-binding protein required for suppression of sweet taste by bitter chemicals. Neuron (2013) 1.11
Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. J Neurosci (2002) 1.09
Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci (2010) 1.09
Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization. Proc Natl Acad Sci U S A (2004) 1.07
ClC-5: role in endocytosis in the proximal tubule. Am J Physiol Renal Physiol (2005) 1.07
Drosophila TRPML is required for TORC1 activation. Curr Biol (2012) 1.06
Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem (2004) 1.06
Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. J Gen Physiol (2010) 1.06
Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation. J Biol Chem (2002) 1.06
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci U S A (2013) 1.05
Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. J Biol Chem (2004) 1.04
Drosophila TRP channels and animal behavior. Life Sci (2012) 1.04
A phosphoinositide synthase required for a sustained light response. J Neurosci (2006) 1.04
Chloride channels in the kidney: lessons learned from knockout animals. Am J Physiol Renal Physiol (2002) 1.04
The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland. Endocrinology (2005) 1.02
Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics (2004) 1.02
Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Mol Ther (2009) 1.01
Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1. PLoS One (2010) 1.01
Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci (2013) 1.01
In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel. J Neurosci (2007) 1.01
Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques. Mol Ther (2002) 1.00
Protein microarray platforms for clinical proteomics. Proteomics Clin Appl (2007) 1.00
De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells. Mol Cell Proteomics (2006) 1.00
A phase I trial of intranasal Moli1901 for cystic fibrosis. Chest (2004) 1.00
Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J Neurosci (2013) 0.99
Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol (2005) 0.98
Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing. J Biol Chem (2008) 0.97
Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines. J Biol Chem (2003) 0.97
Gustatory receptors required for avoiding the insecticide L-canavanine. J Neurosci (2012) 0.97
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation. Proc Natl Acad Sci U S A (2005) 0.97
Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease. J Biol Chem (2009) 0.96
Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates. Mol Ther (2007) 0.96
Hypoxia-induced mitogenic factor/FIZZ1 induces intracellular calcium release through the PLC-IP(3) pathway. Am J Physiol Lung Cell Mol Physiol (2009) 0.95