Published in Nat Neurosci on June 22, 2008
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci (2011) 2.12
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol Cell Neurosci (2009) 1.37
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci U S A (2008) 1.31
Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A (2008) 1.24
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol (2009) 1.09
TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury. Mol Pain (2011) 1.09
Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PLoS One (2013) 1.06
SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Sci Signal (2012) 1.05
A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. J Gen Physiol (2009) 1.05
The family of K2P channels: salient structural and functional properties. J Physiol (2015) 1.02
Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci Lett (2009) 1.01
Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool. J Neurosci (2010) 0.98
Molecular and cellular mechanisms of trigeminal chemosensation. Ann N Y Acad Sci (2009) 0.96
Chemosensory properties of the trigeminal system. ACS Chem Neurosci (2010) 0.94
Trafficking of neuronal two pore domain potassium channels. Curr Neuropharmacol (2010) 0.91
Psychophysical evaluation of a sanshool derivative (alkylamide) and the elucidation of mechanisms subserving tingle. PLoS One (2010) 0.91
A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats. J Neurophysiol (2011) 0.91
Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain (2014) 0.90
Functional analysis of a migraine-associated TRESK K+ channel mutation. J Neurosci (2013) 0.90
Functional analysis of missense variants in the TRESK (KCNK18) K channel. Sci Rep (2012) 0.90
RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors. PLoS One (2015) 0.89
TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways. J Biol Chem (2010) 0.88
PKC-dependent activation of human K(2P) 18.1 K(+) channels. Br J Pharmacol (2012) 0.87
Touch sense: functional organization and molecular determinants of mechanosensitive receptors. Channels (Austin) (2012) 0.87
A Role for K2P Channels in the Operation of Somatosensory Nociceptors. Front Mol Neurosci (2012) 0.86
Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9. Am J Physiol Gastrointest Liver Physiol (2015) 0.85
Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. J Neurophysiol (2009) 0.84
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J Physiol (2013) 0.84
Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol (2013) 0.84
The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK. Front Pharmacol (2013) 0.84
TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes. PLoS One (2011) 0.83
Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK. Pflugers Arch (2014) 0.83
Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto. Front Pharmacol (2015) 0.82
Modulation of TRESK background K+ channel by membrane stretch. PLoS One (2013) 0.82
Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels. Br J Pharmacol (2016) 0.82
Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors. PLoS One (2014) 0.82
The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem (2012) 0.82
Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain. Pflugers Arch (2014) 0.81
Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. Pflugers Arch (2012) 0.81
Molecular mechanisms of temperature adaptation. J Physiol (2015) 0.80
Intestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration. Pharmacol Res Perspect (2015) 0.79
Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons. J Neurophysiol (2014) 0.79
The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel. J Biol Chem (2014) 0.79
Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain (2013) 0.78
Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.78
A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. J Neurophysiol (2013) 0.78
Transient receptor potential channels encode volatile chemicals sensed by rat trigeminal ganglion neurons. PLoS One (2013) 0.77
Phosphoinositide signaling in somatosensory neurons. Adv Biol Regul (2015) 0.76
Food vibrations: Asian spice sets lips trembling. Proc Biol Sci (2013) 0.76
The Chemical and Genetic Characteristics of Szechuan Pepper (Zanthoxylum bungeanum and Z. armatum) Cultivars and Their Suitable Habitat. Front Plant Sci (2016) 0.76
Selective and state-dependent activation of TRESK background potassium channel by cloxyquin. Br J Pharmacol (2017) 0.75
Sanshool on The Fingertip Interferes with Vibration Detection in a Rapidly-Adapting (RA) Tactile Channel. PLoS One (2016) 0.75
Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth. J Nat Prod (2012) 0.75
Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial. PLoS One (2017) 0.75
The Effect of Pungent and Tingling Compounds from Piper nigrum L. on Background K(+) Currents. Front Pharmacol (2017) 0.75
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
Molecular mechanisms of nociception. Nature (2001) 7.75
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
The receptors and cells for mammalian taste. Nature (2006) 6.32
Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci (2005) 4.54
The Ca signal from fura-2 loaded mast cells depends strongly on the method of dye-loading. FEBS Lett (1985) 3.95
Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci (1999) 3.73
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol (2005) 3.72
Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci (2001) 3.65
TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J (1997) 3.60
Nociceptors--noxious stimulus detectors. Neuron (2007) 3.23
Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol (2000) 3.15
Comparative chemosensation from receptors to ecology. Nature (2006) 3.03
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci (2004) 2.70
TASK-3, a new member of the tandem pore K(+) channel family. J Biol Chem (2000) 2.29
TREK-1, a K+ channel involved in polymodal pain perception. EMBO J (2006) 2.02
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. Proc Natl Acad Sci U S A (2000) 2.01
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol (2006) 1.78
New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J Neurosci (2007) 1.62
Characterization of four types of background potassium channels in rat cerebellar granule neurons. J Physiol (2002) 1.54
Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. J Biol Chem (2002) 1.53
Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. J Neurosci (2005) 1.53
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J Physiol (2007) 1.51
Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. J Physiol (2004) 1.46
Opiate receptors and internal opiates. Sci Am (1977) 1.39
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. J Biol Chem (2003) 1.39
TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci (2007) 1.38
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics. Anesth Analg (2004) 1.23
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci (2007) 1.16
Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons. Brain Res (1999) 1.11
Does sumoylation control K2P1/TWIK1 background K+ channels? Cell (2007) 1.10
Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1. Biosci Biotechnol Biochem (2005) 1.04
From peppers to peppermints: natural products as probes of the pain pathway. Harvey Lect (2007) 0.99
TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol (2004) 0.95
Quantitative analysis of sanshool compounds in Japanese pepper (Xanthoxylum piperitum DC.) and their pungent characteristics. Biosci Biotechnol Biochem (2005) 0.92
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (2002) 8.94
AMPA receptor trafficking at excitatory synapses. Neuron (2003) 7.11
The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16
Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature (2013) 5.75
TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A (2006) 5.41
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A (2002) 4.77
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron (2010) 4.76
Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell (2002) 4.57
Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37
Endocannabinoid signaling in the brain. Science (2002) 4.28
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron (2006) 4.21
Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A (2005) 4.20
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron (2009) 4.18
Synaptic strength regulated by palmitate cycling on PSD-95. Cell (2002) 4.15
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature (2005) 3.88
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron (2006) 3.85
TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neurosci (2008) 3.52
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (2006) 3.52
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 3.51
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell (2006) 3.26
Single-cell optogenetic excitation drives homeostatic synaptic depression. Neuron (2010) 3.15
Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science (2004) 3.15
Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol (2003) 3.14
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol (2003) 3.14
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits. Neuron (2011) 2.82
AMPARs and synaptic plasticity: the last 25 years. Neuron (2013) 2.80
Rapid bidirectional switching of synaptic NMDA receptors. Neuron (2007) 2.72
LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature (2012) 2.59
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54
Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J Neurosci (2003) 2.53
Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Neuron (2006) 2.50
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
Metabolic control of vesicular glutamate transport and release. Neuron (2010) 2.44
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron (2005) 2.40
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins. Trends Cell Biol (2007) 2.35
Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation. J Neurosci (2007) 2.30
Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell (2012) 2.22
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes. Nature (2011) 2.18
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev (2005) 2.13
Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron (2005) 2.13
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology (2006) 2.10
TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron (2007) 2.07
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A (2010) 2.07
TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nat Neurosci (2005) 2.04
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (2004) 1.97
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature (2011) 1.84
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci (2005) 1.83
The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci (2002) 1.82
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron (2008) 1.79
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science (2007) 1.77
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73
Small-molecule activators of a proenzyme. Science (2009) 1.72
Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci (2008) 1.67
Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits. Trends Pharmacol Sci (2008) 1.63
New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J Neurosci (2007) 1.62
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
Diversity in NMDA receptor composition: many regulators, many consequences. Neuroscientist (2012) 1.55
GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci (2005) 1.52
NMDA receptors inhibit synapse unsilencing during brain development. Proc Natl Acad Sci U S A (2008) 1.52
Stargazin is an AMPA receptor auxiliary subunit. Proc Natl Acad Sci U S A (2005) 1.52
Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science (2002) 1.51
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature (2011) 1.49
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A (2010) 1.45
Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Neuron (2007) 1.43
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc Natl Acad Sci U S A (2005) 1.42
Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. J Neurosci (2002) 1.42
Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc (2007) 1.41
Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci (2011) 1.40
The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type. Neuron (2009) 1.39
Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc Natl Acad Sci U S A (2008) 1.37
Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. J Neurosci (2005) 1.35
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
Molecular constituents of neuronal AMPA receptors. J Cell Biol (2005) 1.31
Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci (2003) 1.30
The role of SAP97 in synaptic glutamate receptor dynamics. Proc Natl Acad Sci U S A (2010) 1.30
Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on. Philos Trans R Soc Lond B Biol Sci (2013) 1.30
Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron (2013) 1.29