Regulatory evolution and the origin of the bilaterians.

Early evolution of animal cell signaling and adhesion genes. Proc Natl Acad Sci U S A (2006) 2.20

A phylogenetic analysis of myosin heavy chain type II sequences corroborates that Acoela and Nemertodermatida are basal bilaterians. Proc Natl Acad Sci U S A (2002) 1.70

The evolution of early Foraminifera. Proc Natl Acad Sci U S A (2003) 1.46

Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa). Dev Genes Evol (2006) 1.30

Isolation and characterization of two T-box genes from sponges, the phylogenetically oldest metazoan taxon. Dev Genes Evol (2003) 0.99

Life cycle evolution: was the eumetazoan ancestor a holopelagic, planktotrophic gastraea? BMC Evol Biol (2013) 0.92

Quantitative assessment of Hox complex expression in the indirect development of the polychaete annelid Chaetopterus sp. Proc Natl Acad Sci U S A (2000) 0.91

Introduction. The evolution of evo-devo biology. Proc Natl Acad Sci U S A (2000) 0.87

The molecular basis for the evolution of the metazoan bodyplan: extracellular matrix-mediated morphogenesis in marine demosponges. J Mol Evol (2003) 0.84

The manoeuvrability hypothesis to explain the maintenance of bilateral symmetry in animal evolution. Biol Direct (2012) 0.83

Conservation and co-option in developmental programmes: the importance of homology relationships. Front Zool (2005) 0.82

In silico evolution of gene cooption in pattern-forming gene networks. ScientificWorldJournal (2012) 0.80

Metamorphic remodeling of morphology and the body cavity in Phoronopsis harmeri (Lophotrochozoa, Phoronida): the evolution of the phoronid body plan and life cycle. BMC Evol Biol (2015) 0.78

Eric Davidson: Steps to a gene regulatory network for development. Dev Biol (2016) 0.75

Early mesodermal expression of Hox genes in the polychaete Alitta virens (Annelida, Lophotrochozoa). Dev Genes Evol (2016) 0.75

Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q Rev Biol (1971) 5.18

The zootype and the phylotypic stage. Nature (1993) 4.28

Hox genes in brachiopods and priapulids and protostome evolution. Nature (1999) 3.58

Analysis of Hox gene expression in the chick limb bud. Development (1996) 3.47

Patterning the vertebrate neuraxis. Science (1996) 3.20

Fossils, genes and the evolution of animal limbs. Nature (1997) 3.04

Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. Science (1999) 2.43

A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod (1997) 2.33

Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere. Genes Dev (1998) 2.22

Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol (1999) 2.07

A role of Ultrabithorax in morphological differences between Drosophila species. Nature (1998) 2.07

Ligand binding was acquired during evolution of nuclear receptors. Proc Natl Acad Sci U S A (1997) 1.94

Origin of bilaterian body plans: evolution of developmental regulatory mechanisms. Science (1995) 1.70

How embryos work: a comparative view of diverse modes of cell fate specification. Development (1990) 1.46

Precambrian animal diversity: putative phosphatized embryos from the Doushantuo Formation of China. Proc Natl Acad Sci U S A (2000) 1.44

Evaluating multiple alternative hypotheses for the origin of Bilateria: an analysis of 18S rRNA molecular evidence. Proc Natl Acad Sci U S A (1998) 1.30

The making of a feather: homeoproteins, retinoids and adhesion molecules. Bioessays (1993) 1.26

Molecular phylogeny of the ETS gene family. Oncogene (1999) 1.24

Set-aside cells in maximal indirect development: evolutionary and developmental significance. Bioessays (1997) 1.24

Ancient origins of axial patterning genes: Hox genes and ParaHox genes in the Cnidaria. Evol Dev (2001) 1.23

Spatial mechanisms of gene regulation in metazoan embryos. Development (1991) 1.20

Bilaterian origins: significance of new experimental observations. Dev Biol (2000) 1.13

araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes Dev (1996) 1.10

Homeoboxes in sea anemones and other nonbilaterian animals: implications for the evolution of the Hox cluster and the zootype. Curr Top Dev Biol (1998) 1.07

Expression of the Hox gene complex in the indirect development of a sea urchin. Proc Natl Acad Sci U S A (1998) 1.05

Homology of Hox genes and the zootype concept in early metazoan evolution. Mol Phylogenet Evol (1998) 1.04

Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina. Proc Natl Acad Sci U S A (1999) 1.02

The ets multigene family is conserved throughout the Metazoa. Nucleic Acids Res (1993) 1.02

Life stage and tissue-specific expression of the homeobox gene cnox1-Pc of the hydrozoan Podocoryne carnea. Dev Biol (1995) 0.95

Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning. Development (1998) 0.94

Homeobox genes in the Ctenophora: identification of paired-type and Hox homologues in the atentaculate ctenophore, Beroë ovata. Mol Mar Biol Biotechnol (1996) 0.94

Quantitative assessment of Hox complex expression in the indirect development of the polychaete annelid Chaetopterus sp. Proc Natl Acad Sci U S A (2000) 0.91

Origin of the integrin-mediated signal transduction. Functional studies with cell cultures from the sponge Suberites domuncula. Eur J Biochem (1999) 0.90

Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family. J Mol Evol (1998) 0.88

A hox/hom homeobox gene in sponges. Gene (1995) 0.84

Isolation, characterization, and expression of Le-msx, a maternally expressed member of the msx gene family from the glossiphoniid leech, Helobdella. Dev Dyn (1996) 0.78

Gene regulation for higher cells: a theory. Science (1969) 14.19

Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene. Science (1998) 5.66

The hardwiring of development: organization and function of genomic regulatory systems. Development (1997) 5.55

Regulation of gene expression: possible role of repetitive sequences. Science (1979) 5.34

Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q Rev Biol (1971) 5.18

Organization, transcription, and regulation in the animal genome. Q Rev Biol (1973) 3.95

Sources and evolution of human Alu repeated sequences. Proc Natl Acad Sci U S A (1988) 3.95

Structural gene sets active in embryos and adult tissues of the sea urchin. Cell (1976) 3.38

A program for least squares analysis of reassociation and hybridization data. Nucleic Acids Res (1977) 3.13

General interspersion of repetitive with non-repetitive sequence elements in the DNA of Xenopus. J Mol Biol (1973) 3.08

The single-copy DNA sequence polymorphism of the sea urchin Strongylocentrotus purpuratus. Cell (1978) 3.06

The echinoid immune system and the phylogenetic occurrence of immune mechanisms in deuterostomes. Immunol Today (1992) 2.86

Comparative aspects of DNA organization in Metazoa. Chromosoma (1975) 2.82

Insertion and/or deletion of many repeated DNA sequences in human and higher ape evolution. Proc Natl Acad Sci U S A (1986) 2.81

Studies on nucleic acid reassociation kinetics: reactivity of single-stranded tails in DNA-DNA renaturation. Proc Natl Acad Sci U S A (1975) 2.50

Very short repeats and coordinate induction of genes. Nature (1983) 2.44

Mapping of gene transcripts by nuclease protection assays and cDNA primer extension. Methods Enzymol (1987) 2.41

A measurement of the sequence complexity of polysomal messenger RNA in sea urchin embryos. Cell (1974) 2.41

Cis-regulatory logic in the endo16 gene: switching from a specification to a differentiation mode of control. Development (2001) 2.36

Structural genes adjacent to interspersed repetitive DNA sequences. Cell (1975) 2.35

Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23

Note on the control of gene expression during development. J Theor Biol (1971) 2.05

Modular cis-regulatory organization of developmentally expressed genes: two genes transcribed territorially in the sea urchin embryo, and additional examples. Proc Natl Acad Sci U S A (1996) 1.81

Sequence organization in Xenopus DNA studied by the electron microscope. J Mol Biol (1975) 1.74

Spatial expression of Hox cluster genes in the ontogeny of a sea urchin. Development (2000) 1.73

A complete second gut induced by transplanted micromeres in the sea urchin embryo. Science (1993) 1.69

Ontogenic activation of a fusion gene introduced into sea urchin eggs. Proc Natl Acad Sci U S A (1987) 1.69

Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus. J Mol Biol (1983) 1.60

Nonrepetitive DNA sequence representation in sea urchin embryo messenger RNA. Proc Natl Acad Sci U S A (1973) 1.60

High sequence diversity in the RNA synthesized at the lampbrush stage of oögenesis. Proc Natl Acad Sci U S A (1969) 1.60

Sea urchin embryo mRNA sequences expressed in the nuclear RNA of adult tissues. Cell (1978) 1.59

The A/P axis in echinoderm ontogeny and evolution: evidence from fossils and molecules. Evol Dev (2001) 1.58

Studies on nucleic acid reassociation kinetics: empirical equations describing DNA reassociation. Proc Natl Acad Sci U S A (1976) 1.57

Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo. Genes Dev (1988) 1.56

Persistence in early amphibian embryos of informational RNA's from the lampbrush chromosome stage of oögenesis. Proc Natl Acad Sci U S A (1967) 1.55

Organization and expression of multiple actin genes in the sea urchin. Mol Cell Biol (1981) 1.52

Persistence and integration of cloned DNA in postembryonic sea urchins. Dev Biol (1985) 1.50

Message sequences and short repetitive sequences are interspersed in sea urchin egg poly(A)+ RNAs. Nature (1980) 1.49

Calculation of sequence divergence from the thermal stability of DNA heteroduplexes. J Mol Evol (1992) 1.47

Precambrian animal diversity: putative phosphatized embryos from the Doushantuo Formation of China. Proc Natl Acad Sci U S A (2000) 1.44

The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes. Proc Natl Acad Sci U S A (1968) 1.41

Activation of sea urchin actin genes during embryogenesis. Measurement of transcript accumulation from five different genes in Strongylocentrotus purpuratus. J Mol Biol (1986) 1.41

Repetitive sequence transcripts in development. Nature (1982) 1.41

Studies on nucleic acid reassociation kinetics: rate of hybridization of excess RNA with DNA, compared to the rate of DNA renaturation. Proc Natl Acad Sci U S A (1977) 1.36

Gene regulatory factors of the sea urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein. Development (1991) 1.34

Contrasting patterns of DNA sequence arrangement in Apis mellifera (honeybee) and Musca domestica (housefly). Chromosoma (1976) 1.32

Significance of rare m RNA sequences in liver. Arch Biochem Biophys (1977) 1.32

Arrangement and characterization of repetitive sequence elements in animal DNAs. Cold Spring Harb Symp Quant Biol (1974) 1.31

Sea urchin actin gene subtypes. Gene number, linkage and evolution. J Mol Biol (1984) 1.30

Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript. Dev Biol (1977) 1.29

Messenger RNA prevalence in sea urchin embryos measured with cloned cDNAs. Proc Natl Acad Sci U S A (1980) 1.29

Sequence of mRNA coding for bindin, a species-specific sea urchin sperm protein required for fertilization. Proc Natl Acad Sci U S A (1986) 1.27

Appearance and persistence of maternal RNA sequences in sea urchin development. Dev Biol (1977) 1.26

Molecular biology of the sea urchin embryo. Science (1982) 1.25

Regulation of cytoplasmic mRNA prevalence in sea urchin embryos. Rates of appearance and turnover for specific sequences. J Mol Biol (1984) 1.25

Cell lineage-specific programs of expression of multiple actin genes during sea urchin embryogenesis. J Mol Biol (1986) 1.24

Set-aside cells in maximal indirect development: evolutionary and developmental significance. Bioessays (1997) 1.24

Evolutionary divergence and length of repetitive sequences in sea urchin DNA. J Mol Evol (1976) 1.24

Differential expression of the actin gene family of Strongylocentrotus purpuratus. Dev Biol (1984) 1.23

Micromeres are required for normal vegetal plate specification in sea urchin embryos. Development (1995) 1.22

Specific representation of cloned repetitive DNA sequences in sea urchin RNAs. Cell (1978) 1.22

Activation of RNA synthesis associated with gastrulation. Proc Natl Acad Sci U S A (1966) 1.22

Modular cis-regulatory organization of Endo16, a gut-specific gene of the sea urchin embryo. Development (1996) 1.21

Repetitive and non-repetitive sequence in sea urchin heterogeneous nuclear RNA. J Mol Biol (1974) 1.21

Developmental expression of two cloned sequences coding for rare sea urchin embryo messages. Dev Biol (1980) 1.21

Evolution of sea urchin non-repetitive DNA. J Mol Evol (1980) 1.19

Sequence organization of the poly(A) RNA synthesized and accumulated in lampbrush chromosome stage Xenopus laevis oocytes. J Mol Biol (1982) 1.19

Synthesis and turnover of polysomal mRNAs in sea urchin embryos. Cell (1977) 1.19

Whole mount in situ hybridization shows Endo 16 to be a marker for the vegetal plate territory in sea urchin embryos. Mech Dev (1993) 1.19

Lineage and fate of each blastomere of the eight-cell sea urchin embryo. Genes Dev (1987) 1.18

Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes. Immunogenetics (1999) 1.18

Sequence complexity of heterogeneous nuclear RNA in sea urchin embryos. Cell (1975) 1.17

Characteristics of individual repetitive sequence families in the sea urchin genome studied with cloned repeats. Cell (1978) 1.16

SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos. Dev Biol (1996) 1.15

Differential stability of expression of similarly specified endogenous and exogenous genes in the sea urchin embryo. Development (1991) 1.15

Distribution of repetitive and nonrepetivite sequence transcripts in HeLa mRNA. Proc Natl Acad Sci U S A (1974) 1.14

Absence of short period interspersion of repetitive and non-repetitive sequences in the DNA of Drosophila melanogaster. Chromosoma (1976) 1.14

Complexity of RNA in eggs of Drosophila melanogaster and Musca domestica. Genetics (1980) 1.13

Bilaterian origins: significance of new experimental observations. Dev Biol (2000) 1.13

Macromere cell fates during sea urchin development. Development (1991) 1.11

Repetitive sequences of the sea urchin genome. III. Nucleotide sequences of cloned repeat elements. J Mol Biol (1981) 1.11

A sea urchin genome project: sequence scan, virtual map, and additional resources. Proc Natl Acad Sci U S A (2000) 1.10

Inducible expression of a cloned heat shock fusion gene in sea urchin embryos. Proc Natl Acad Sci U S A (1984) 1.10

Gene regulatory factors of the sea urchin embryo. II. Two dissimilar proteins, P3A1 and P3A2, bind to the same target sites that are required for early territorial gene expression. Development (1991) 1.10

Repetitive sequences of the sea urchin genome. Distribution of members of specific repetitive families. J Mol Biol (1981) 1.10

A multimerizing transcription factor of sea urchin embryos capable of looping DNA. Proc Natl Acad Sci U S A (1995) 1.09

Recovery of developmentally defined gene sets from high-density cDNA macroarrays. Dev Biol (2000) 1.09

Genetic information in oocyte RNA. J Mol Biol (1971) 1.09

Gypsy/Ty3-class retrotransposons integrated in the DNA of herring, tunicate, and echinoderms. J Mol Evol (1995) 1.08

Accumulation of individual histone mRNAs during embryogenesis of the sea urchin Strongylocentrotus purpuratus. Dev Biol (1982) 1.08

DNA sequence organization in the genomes of five marine invertebrates. Chromosoma (1975) 1.07

A comparative molecular approach to mesodermal patterning in basal deuterostomes: the expression pattern of Brachyury in the enteropneust hemichordate Ptychodera flava. Development (1999) 1.07

Spatial and temporal information processing in the sea urchin embryo: modular and intramodular organization of the CyIIIa gene cis-regulatory system. Development (1996) 1.05

Evidence for the appearance of novel gene products during amphibian blastulation. Proc Natl Acad Sci U S A (1968) 1.05

A lineage-specific gene encoding a major matrix protein of the sea urchin embryo spicule. II. Structure of the gene and derived sequence of the protein. Dev Biol (1987) 1.05

Expression of the Hox gene complex in the indirect development of a sea urchin. Proc Natl Acad Sci U S A (1998) 1.05

Oral-aboral axis specification in the sea urchin embryo. I. Axis entrainment by respiratory asymmetry. Dev Biol (2001) 1.04

Retroviral-like element in a marine invertebrate. Proc Natl Acad Sci U S A (1991) 1.04

Single copy DNA and structural gene sequence relationships among four sea urchin species. Chromosoma (1976) 1.03