PubRank

J P Mecklin

Author PubWeight™ 143.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Clues to the pathogenesis of familial colorectal cancer. Science 1993 14.52
2 New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999 11.94
3 The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991 9.82
4 Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998 8.47
5 Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 2000 8.41
6 Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 1999 6.73
7 Genetic mapping of a locus predisposing to human colorectal cancer. Science 1993 4.12
8 Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000 3.98
9 Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 1995 3.45
10 Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994 3.25
11 Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology 2000 3.01
12 Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 1995 2.85
13 Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology 1996 2.60
14 Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med 1995 2.40
15 Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Res 2001 2.12
16 Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet 1994 2.08
17 The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol 2001 1.84
18 Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am J Hum Genet 2001 1.81
19 Clinical features of colorectal carcinoma in cancer family syndrome. Dis Colon Rectum 1986 1.79
20 DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet 1996 1.64
21 Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A 2000 1.63
22 Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms. Scand J Gastroenterol 2003 1.57
23 Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases. Br J Cancer 1984 1.56
24 Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer 2000 1.49
25 Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. Cancer 1998 1.48
26 Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. Am J Pathol 1999 1.38
27 A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden. Cancer Detect Prev 1994 1.36
28 Follow-up of patients operated on for colorectal carcinoma. Am J Surg 1990 1.33
29 Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 2000 1.27
30 Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin Cancer Res 2001 1.24
31 Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study. Int J Cancer 2001 1.23
32 Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families. Proc Natl Acad Sci U S A 1994 1.14
33 Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer. Cancer Detect Prev 2000 1.12
34 Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations. Fam Cancer 2001 1.11
35 Histopathology of colorectal carcinomas and adenomas in cancer family syndrome. Dis Colon Rectum 1986 1.11
36 No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. Cancer Res 2000 1.11
37 SMAD genes in juvenile polyposis. Genes Chromosomes Cancer 1999 1.10
38 The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med 1994 1.10
39 Cancer family syndrome. Genetic analysis of 22 Finnish kindreds. Gastroenterology 1986 1.09
40 MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. Cancer Res 2001 1.06
41 Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome. Int J Cancer 1997 1.06
42 Complete and incomplete intestinal metaplasia at the oesophagogastric junction: prevalences and associations with endoscopic erosive oesophagitis and gastritis. Gut 1999 1.04
43 Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry. Cancer 1990 1.03
44 Screening for colorectal carcinoma in cancer family syndrome kindreds. Scand J Gastroenterol 1987 1.01
45 The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer. Anticancer Res 1994 0.99
46 Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online. Hum Mutat 1998 0.98
47 Endometrial carcinoma in the cancer family syndrome. Cancer 1991 0.97
48 Surveillance in hereditary nonpolyposis colorectal cancer: an international cooperative study of 165 families. The International Collaborative Group on HNPCC. Dis Colon Rectum 1993 0.97
49 The International Collaborative Group on HNPCC. Anticancer Res 1994 0.96
50 Prognosis of colorectal cancer varies in different high-risk conditions. Ann Med 1998 0.96
51 Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds. Cancer Res 1991 0.96
52 No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer. Scand J Gastroenterol 2002 0.95
53 Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. Gastroenterology 1998 0.95
54 Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease. The Central Finland Endoscopy Study Group. Am J Gastroenterol 1999 0.95
55 Comprehension of cancer risk one and 12 months after predictive genetic testing for hereditary non-polyposis colorectal cancer. J Med Genet 2001 0.95
56 Primary gastrointestinal non-Hodgkin's lymphoma. A population based study in central Finland in 1975-1993. Acta Oncol 1997 0.94
57 Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma. Cancer Res 1992 0.91
58 Specialized columnar epithelium of the esophagogastric junction: prevalence and associations. The Central Finland Endoscopy Study Group. Am J Gastroenterol 1999 0.91
59 Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol 1998 0.91
60 The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study. Br J Cancer 1990 0.89
61 Evaluation of a counselling protocol for predictive genetic testing for hereditary non-polyposis colorectal cancer. J Med Genet 2000 0.88
62 The value of a follow-up programme after radical surgery for colorectal carcinoma. Scand J Gastroenterol 1989 0.87
63 Screening for hereditary colorectal carcinoma. Scand J Gastroenterol 1989 0.85
64 Improvements in the treatment and prognosis of colorectal carcinoma. Br J Surg 1988 0.84
65 No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer. Oncogene 2006 0.83
66 Classical Barrett esophagus contrasted with Barrett-type epithelium at normal-appearing esophagogastric junction. Central Finland Endoscopy Study Group. Scand J Gastroenterol 2000 0.83
67 Identification of cancer family syndrome. Gastroenterology 1986 0.78
68 Biofeedback therapy in rectal prolapse patients. Dis Colon Rectum 1996 0.78
69 Serum carcinoembryonic antigen and DNA ploidy in colorectal carcinoma. A prospective study. Scand J Gastroenterol 1991 0.78
70 [A breakthrough in solving the genetic background of colon cancer]. Duodecim 1993 0.78
71 Growth of human colorectal carcinoma implants in the mouse subrenal capsule assay. Ann Chir Gynaecol 1989 0.77
72 Hereditary aspects of endometrial adenocarcinoma. Int J Cancer 1995 0.75
73 [How should patients with colorectal cancer be followed?]. Duodecim 1992 0.75
74 Surgeons and cancer. Ann Chir Gynaecol 2000 0.75
75 Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. J Med Genet 2000 0.75
76 Endo-ultrasonography for preoperative staging of rectal cancer. Ann Chir Gynaecol 1988 0.75
77 [para-esophageal hernia--a poorly recognised form of hiatal hernia]. Duodecim 1995 0.75
78 Screening for gastrointestinal cancers in high-risk groups. Dig Dis 1989 0.75
79 The role of surgery in Crohn's disease: a retrospective analysis from a single hospital. Scand J Surg 2010 0.75
80 [Acetylsalicylic acid and the prevention of cancer]. Duodecim 1999 0.75
81 Ischaemic colitis--a clinical study of seven patients with special emphasis on diagnostic problems. Ann Chir Gynaecol 1991 0.75
82 [Screening for colon cancer]. Duodecim 1994 0.75
83 [Blood transfusion and prognosis of colorectal canmcer]. Duodecim 1989 0.75
84 [Glucose metabolism disorders following an acute alcoholic pancreatitis]. Duodecim 1998 0.75
85 [Prognosis and follow-up of colon and rectal carcinoma patients after surgical intervention]. Duodecim 1988 0.75
86 [A familial cancer syndrome]. Duodecim 1984 0.75