Published in Fam Cancer on January 01, 2001
Is surveillance of the small bowel indicated for Lynch syndrome families? Gut (2007) 2.42
Lynch syndrome genes. Fam Cancer (2005) 1.94
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. Cancer Epidemiol Biomarkers Prev (2008) 1.06
The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome. Fam Cancer (2007) 1.01
Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer. Int J Colorectal Dis (2009) 0.89
Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. World J Gastroenterol (2004) 0.88
Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients. Hered Cancer Clin Pract (2005) 0.86
Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. World J Gastroenterol (2005) 0.85
Phenotypic heterogeneity in hereditary non-polyposis colorectal cancer: identical germline mutations associated with variable tumour morphology and immunohistochemical expression. J Clin Pathol (2006) 0.85
Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer. World J Gastroenterol (2009) 0.84
Lynch syndrome: the influence of environmental factors on extracolonic cancer risk in hMLH1 c.C1528T mutation carriers and their mutation-negative sisters. Fam Cancer (2010) 0.83
Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer. World J Gastroenterol (2006) 0.83
Genetics and pathology of pancreatic cancer. HPB (Oxford) (2006) 0.82
Primary sclerosing epithelioid fibrosarcoma of the lung in a patient with Lynch syndrome. Lung (2012) 0.82
Familial pancreatic cancer. Fam Cancer (2004) 0.81
Report of a Novel Mutation in MLH1 Gene in a Hispanic Family from Puerto Rico Fulfilling Classic Amsterdam Criteria for Lynch Syndrome. Gastroenterol Res Pract (2014) 0.80
Detection of germline mutations of hMLH1 and hMSH2 based on cDNA sequencing in China. World J Gastroenterol (2005) 0.79
The role of epigenetics in Lynch syndrome. Fam Cancer (2013) 0.79
The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation. Fam Cancer (2007) 0.78
The effect of genotypes and parent of origin on cancer risk and age of cancer development in PMS2 mutation carriers. Genet Med (2015) 0.77
The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria. Hered Cancer Clin Pract (2006) 0.77
Familial Colorectal Cancer Type X in Central Iran: A New Clinicopathologic Description. Int J Hematol Oncol Stem Cell Res (2017) 0.75
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47
Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol (2000) 3.98
Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. Gastroenterology (1997) 3.97
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology (1996) 3.54
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell (1999) 2.91
Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer (1995) 2.85
Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review. Cancer (1996) 2.44
Cancer family "G" revisited: 1895-1970. Cancer (1971) 1.81
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Hum Mol Genet (1996) 1.76
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol Cell Biol (1997) 1.74
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet (1996) 1.64
Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations. Am J Hum Genet (1997) 1.63
Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer. Am J Hum Genet (1996) 1.58
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer (2000) 1.49
The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer. J Biol Chem (1999) 1.48
Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae. Nat Genet (1998) 1.33
Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls. Am J Hum Genet (1998) 1.30
Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer. Mol Cell Biol (1998) 1.25
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol (1998) 1.11
Is the mismatch repair deficient type of Muir-Torre syndrome confined to mutations in the hMSH2 gene? Hum Genet (1996) 1.04
Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. Int J Cancer (1999) 1.04
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online. Hum Mutat (1998) 0.98
Reduced frequency of extracolonic cancers in hereditary nonpolyposis colorectal cancer families with monoallelic hMLH1 expression. Am J Hum Genet (1997) 0.96
Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. Gastroenterology (1998) 0.95
Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer. Genes Chromosomes Cancer (2000) 0.94
Missense and nonsense mutations in codon 659 of MLH1 cause aberrant splicing of messenger RNA in HNPCC kindreds. Genes Chromosomes Cancer (1999) 0.94
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology (1999) 11.94
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum (1991) 9.82
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (2000) 8.41
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol (2001) 6.30
IRAK: a kinase associated with the interleukin-1 receptor. Science (1996) 5.32
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Effect of local medical opinion leaders on quality of care for acute myocardial infarction: a randomized controlled trial. JAMA (1998) 4.36
Genetic mapping of a locus predisposing to human colorectal cancer. Science (1993) 4.12
Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol (2000) 3.98
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med (1995) 3.61
HLA and AIDS: a cautionary tale. Trends Mol Med (2001) 3.51
Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (1995) 3.45
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res (1994) 3.25
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology (2000) 3.01
Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer (1995) 2.85
Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology (1996) 2.60
Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins (2005) 2.59
Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis. Obes Rev (2009) 2.49
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem (1999) 2.43
Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med (1995) 2.40
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A (1993) 2.35
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest (2000) 2.32
Delayed hospital presentation in patients who have had acute myocardial infarction. Ann Intern Med (1997) 2.30
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Res (2001) 2.12
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet (1994) 2.08
Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06
Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther (2004) 1.97
The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol (2001) 1.84
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am J Hum Genet (2001) 1.81
Clinical features of colorectal carcinoma in cancer family syndrome. Dis Colon Rectum (1986) 1.79
Methylation of thymine residues during oligonucleotide synthesis. Nucleic Acids Res (1985) 1.74
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67
Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia (2008) 1.66
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet (1996) 1.64
Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63
Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning. Neuroscience (2007) 1.61
Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms. Scand J Gastroenterol (2003) 1.57
Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases. Br J Cancer (1984) 1.56
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer (2000) 1.49
Recurrent germline mutation in MSH2 arises frequently de novo. J Med Genet (2000) 1.49
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. Cancer (1998) 1.48
The effect of comorbidity on use of thrombolysis or aspirin in patients with acute myocardial infarction eligible for treatment. J Gen Intern Med (1997) 1.46
Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA (1996) 1.44
Computer algorithms for the automated measurement of retinal arteriolar diameters. Br J Ophthalmol (2001) 1.42
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol (2001) 1.42
Structural impact of hydrodynamic injection on mouse liver. Gene Ther (2006) 1.41
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. Am J Pathol (1999) 1.38
Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc Natl Acad Sci U S A (1993) 1.36
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden. Cancer Detect Prev (1994) 1.36
Clinic-based evaluation of Clearview Chlamydia MF for detection of Chlamydia trachomatis in vaginal and cervical specimens from women at high risk in China. Sex Transm Infect (2006) 1.34
Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics (2000) 1.34
Follow-up of patients operated on for colorectal carcinoma. Am J Surg (1990) 1.33
Three-layer core/shell structure in Au-Pd bimetallic nanoparticles. Nano Lett (2007) 1.32
Immobilized Pseudomonas cepacia lipase for biodiesel fuel production from soybean oil. Bioresour Technol (2005) 1.29
Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum Gene Ther (1992) 1.28
Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion (2000) 1.27
NMR structural studies of intramolecular (Y+)n.(R+)n(Y-)nDNA triplexes in solution: imino and amino proton and nitrogen markers of G.TA base triple formation. Biochemistry (1991) 1.26
Digital light-directed synthesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis. J Comb Chem (2000) 1.25
Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin Cancer Res (2001) 1.24
Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study. Int J Cancer (2001) 1.23
Identification of two cis-acting elements that independently regulate the length of poly(A) on Xenopus albumin pre-mRNA. RNA (1998) 1.23
Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem (2001) 1.23
Analysis of the complete genome of Tembusu virus, a flavivirus isolated from ducks in China. Transbound Emerg Dis (2011) 1.23
DNA CTG triplet repeats involved in dynamic mutations of neurologically related gene sequences form stable duplexes. Nucleic Acids Res (1995) 1.20
Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo. Proc Natl Acad Sci U S A (1993) 1.20
Nitrogen export from an agriculture watershed in the Taihu Lake area, China. Environ Geochem Health (2004) 1.19
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. J Biol Chem (2001) 1.18
Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study. J Mol Biol (1996) 1.17
Consultation between cardiologists and generalists in the management of acute myocardial infarction: implications for quality of care. Arch Intern Med (1998) 1.17
Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide. J Biomol Struct Dyn (1997) 1.16
Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res (1998) 1.15
Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther (1992) 1.15
Electro-acupuncture relieves chronic visceral hyperalgesia in rats. Neurosci Lett (2004) 1.15
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. J Biol Chem (1999) 1.14
Shifting physician prescribing to a preferred histamine-2-receptor antagonist. Effects of a multifactorial intervention in a mixed-model health maintenance organization. Med Care (1998) 1.14
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families. Proc Natl Acad Sci U S A (1994) 1.14
Characterization of a Tembusu virus isolated from naturally infected house sparrows (Passer domesticus) in Northern China. Transbound Emerg Dis (2012) 1.13
Integration of data driven decision support into the HELIOS environment. Int J Biomed Comput (1994) 1.12
Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer. Cancer Detect Prev (2000) 1.12
Isolation and genetic characterization of a tembusu virus strain isolated from mosquitoes in Shandong, China. Transbound Emerg Dis (2013) 1.11
No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. Cancer Res (2000) 1.11
Histopathology of colorectal carcinomas and adenomas in cancer family syndrome. Dis Colon Rectum (1986) 1.11
Human leukocyte antigen (HLA) A1-B8-DR3 (8.1) haplotype, tumor necrosis factor (TNF) G-308A, and risk of non-Hodgkin lymphoma. Leukemia (2010) 1.11
Characterization of oligodeoxyribonucleotide synthesis on glass plates. Nucleic Acids Res (2001) 1.11
An efficient and economic site-specific deuteration strategy for NMR studies of homologous oligonucleotide repeat sequences. Nucleic Acids Res (1997) 1.10
SMAD genes in juvenile polyposis. Genes Chromosomes Cancer (1999) 1.10
Evolution of HLA class II molecules: Allelic and amino acid site variability across populations. Genetics (1999) 1.10
VEGF165 and angiopoietin-1 decreased myocardium infarct size through phosphatidylinositol-3 kinase and Bcl-2 pathways. Gene Ther (2005) 1.10
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis. Cancer Metastasis Rev (1994) 1.10
Tembusu virus in human, China. Transbound Emerg Dis (2013) 1.10
The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med (1994) 1.10