PubRank

J C Cambier

Author PubWeight™ 164.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med 1984 4.14
2 Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science 1995 3.24
3 Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science 1994 2.98
4 The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science 1992 2.41
5 B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J 1990 2.24
6 Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu Rev Immunol 1987 2.22
7 Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature 1987 1.93
8 The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell 1989 1.91
9 Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol 1996 1.90
10 The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity 2000 1.88
11 Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 1998 1.78
12 B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled. J Exp Med 1983 1.77
13 The B-cell antigen receptor complex. Immunol Today 1991 1.74
14 Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 1995 1.73
15 IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A 1991 1.67
16 B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol 1984 1.66
17 Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 1991 1.66
18 New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL) Immunol Today 1995 1.65
19 Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med 1995 1.62
20 Identification and characterization of a loss-of-function human MPYS variant. Genes Immun 2011 1.60
21 B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med 1983 1.56
22 B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol 1999 1.55
23 Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol 1983 1.54
24 Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity 2001 1.54
25 The B-cell antigen receptor complex: structure and signal transduction. Immunol Today 1994 1.53
26 Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol 1995 1.51
27 Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance. J Exp Med 1976 1.50
28 Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A 1994 1.49
29 Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med 1998 1.47
30 Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol 1986 1.45
31 Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. Mol Cell Biol 1993 1.44
32 Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol 1986 1.43
33 Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J 1994 1.43
34 Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med 2000 1.34
35 B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. J Exp Med 1977 1.32
36 Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation. Immunol Rev 1987 1.32
37 TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science 2001 1.31
38 Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol 1998 1.28
39 Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature 1987 1.25
40 Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med 1997 1.25
41 Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol 2000 1.24
42 Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene 1998 1.24
43 Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail. J Exp Med 2001 1.22
44 Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands. J Immunol 1989 1.22
45 Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol 1987 1.21
46 Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc Natl Acad Sci U S A 1989 1.21
47 B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells. J Exp Med 1977 1.21
48 B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. J Immunol 1984 1.21
49 Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med 2001 1.19
50 mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cells. J Immunol 1984 1.17
51 The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. Immunol Rev 1979 1.15
52 Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J Immunol 2001 1.12
53 Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance. J Immunol 1989 1.12
54 B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol Rev 2000 1.12
55 B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies. J Immunol 1984 1.11
56 Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity 1999 1.10
57 Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD. Proc Natl Acad Sci U S A 1978 1.10
58 Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol 1999 1.09
59 Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol 1990 1.09
60 B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgM. Eur J Immunol 1983 1.08
61 Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol 2000 1.08
62 B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1. J Immunol 1993 1.08
63 Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol 1997 1.07
64 Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation. Immunity 1997 1.07
65 Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J Exp Med 1999 1.06
66 Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem 1993 1.04
67 Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol 1991 1.04
68 Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention? J Allergy Clin Immunol 2000 1.04
69 Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J Immunol 1998 1.04
70 Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle. J Immunol Methods 1983 1.02
71 Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells. J Immunol 1990 1.01
72 Cell cycle dependence for expression of membrane associated IgD, IgM and Ia antigen on mitogen-stimulated murine B-lymphocytes. Ann N Y Acad Sci 1982 1.01
73 Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. J Exp Med 1982 1.01
74 gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J Immunol 1994 1.00
75 A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro. J Immunol 2000 1.00
76 B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol 1997 0.99
77 B cell activation. II. Receptor cross-linking by thymus-independent and thymus-dependent antigens induces a rapid decrease in the plasma membrane potential of antigen-binding B lymphocytes. J Immunol 1983 0.97
78 Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol Lett 1996 0.97
79 Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1. J Immunol 1991 0.96
80 Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol 1989 0.95
81 T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor. Immunol Today 1991 0.94
82 Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. J Immunol 1997 0.94
83 Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C. J Biol Chem 1990 0.94
84 Fc gamma RIIB activation leads to inhibition of signalling by independently ligated receptors. Biochem Soc Trans 2003 0.93
85 Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion. J Immunol 1976 0.92
86 Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immunoglobulin, CD19, CD21, and B-cell gp95. Proc Natl Acad Sci U S A 1990 0.92
87 Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle. J Immunol 1986 0.92
88 Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor. J Immunol 1994 0.91
89 The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling. Immunol Lett 1996 0.91
90 Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. Immunol Rev 1997 0.91
91 Desferoxamine blocks IL 2 receptor expression on human T lymphocytes. J Immunol 1986 0.91
92 Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes. J Immunol 1986 0.90
93 B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression. J Immunol 1986 0.90
94 Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis. J Immunol 1988 0.89
95 Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling. J Immunol 2000 0.89
96 Signal transmission pathways and lymphocyte function. Immunol Today 1990 0.89
97 Abortive activation of B lymphocytes by monoclonal anti-immunoglobulin antibodies. J Immunol 1986 0.89
98 Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP. Immunol Rev 2000 0.88
99 Enrichment of viable lymphocytes in defined cycle phases by sorting on the basis of pulse width of axial light extinction. Cytometry 1982 0.87
100 Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells. J Immunol 2001 0.87
101 Delivery of B cell receptor-internalized antigen to endosomes and class II vesicles. J Exp Med 1997 0.87
102 Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor. J Immunol 1994 0.87
103 Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules. J Exp Med 1994 0.87
104 Improved method for measuring intracellular Ca++ with fluo-3. Cytometry 1990 0.86
105 CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes. Eur J Immunol 1992 0.86
106 Role of alterations in Ca(2+)-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J Toxicol Environ Health 1995 0.86
107 Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol 1985 0.86
108 Structural compartmentalization of MHC class II signaling function. Immunol Today 1993 0.85
109 Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation. Mol Immunol 2003 0.85
110 Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. J Immunol 2000 0.84
111 Constitutive production of a factor supporting B lymphocyte differentiation by a T cell hybridoma. J Immunol 1983 0.83
112 B lymphocyte activation. Transmembrane signal transduction by membrane immunoglobulin in isolated cell membranes. J Immunol 1987 0.83
113 pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton. J Immunol 1998 0.82
114 Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis. Immunol Lett 1999 0.82
115 Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP. Bioorg Med Chem Lett 1998 0.82
116 B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg. J Immunol 1985 0.82
117 Isolated phosphorylcholine binding lymphocytes. I. Use of a cleavable crosslinking reagent for solid-phase adsorbent isolation of functional antigen binding cells. J Immunol Methods 1982 0.82
118 Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes. J Exp Med 1995 0.82
119 Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate. Mol Immunol 1995 0.82
120 Qualitatively distinct signaling through T cell antigen receptor subunits. Eur J Immunol 1997 0.82
121 The effect of second signals on the induction of B cell tolerance: failure of helper T cells to block tolerance induction. Eur J Immunol 1981 0.81
122 Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor. Eur J Immunol 1996 0.81
123 Identification and characterization of a hapten-modifiable TEPC 15 cross-reactive idiotype in swine. Mol Immunol 1985 0.81
124 A rapid method for the purification of immunoglobulin M (IgM) from the sera of certain mammalian species. Prep Biochem 1974 0.80
125 Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy. J Allergy Clin Immunol 2001 0.80
126 Human pre-B and B cell membrane mu-chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene. J Immunol 1992 0.80
127 The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene. J Immunol 1993 0.80
128 Molecular targets of CD45 in B cell antigen receptor signal transduction. J Immunol 1997 0.79
129 Bacterial superantigens induce V beta-specific T cell receptor internalization. Mol Immunol 1996 0.79
130 B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation. J Immunol 1998 0.79
131 B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro. Immunology 1992 0.78
132 Inactivation of antigen-responsive clones with antisera specific for IgM or IgD. J Immunol 1978 0.78
133 FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. Biochem Soc Trans 2001 0.78
134 Induction of clonally restricted thymus-dependent antibody responses in vitro using phosphorylcholine derivatized sheep erythrocytes. J Immunol Methods 1980 0.78
135 Flow cytometry as an analytic and preparative tool for studies of neuroendocrine function. Methods Enzymol 1983 0.77
136 B cell tolerance. I. Analysis of hapten-specific unresponsiveness induced in vitro in adult and neonatal murine spleen cell populations. J Immunol 1977 0.77
137 CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase. Eur J Immunol 1998 0.76
138 Interleukin-4 overcomes the negative influence of cyclic AMP accumulation on antigen receptor stimulated B lymphocytes. Mol Immunol 1998 0.76
139 Quantitative assay of paravaccinia virus based on enumeration of inclusion-containing cells. Appl Microbiol 1972 0.75
140 Modulation of in vitro murine B-lymphocyte response by curcumin. Phytomedicine 2009 0.75
141 Increase in the intracellular free calcium concentration is not an obligatory early event in lipopeptide-induced B-cell activation. Immunology 1991 0.75
142 The dynamics and relationship of K+ efflux and Ca++ influx in B lymphocytes after antigen-receptor cross-linking. Soc Gen Physiol Ser 1988 0.75
143 Measurement of phosphoinositide hydrolysis in isolated cell membrane preparations. Methods Enzymol 1989 0.75
144 Identification of a brain theta-positive, secretory cell from hematopoietic tissues. J Immunol 1981 0.75
145 Coupling of B cell surface Ig, Ia and BSF1 receptors to intracellular "second messengers". Adv Exp Med Biol 1987 0.75
146 Inhibitory receptors and their modes of action. Cold Spring Harb Symp Quant Biol 1999 0.75
147 Differential transmembrane signaling in B lymphocyte activation. Ann N Y Acad Sci 1987 0.75
148 Neither interleukin 2 nor gamma interferon directly promote growth or differentiation of mouse B cells. Scand J Immunol 1987 0.75
149 Evaluation of methods for the isolation of plasma membranes displaying guanosine 5'-triphosphate-dependence for the regulation of adenylate cyclase activity: potential application to the study of other guanosine 5'-triphosphate-dependent transduction systems. Anal Biochem 1988 0.75
150 Seeing the way to B-cell growth. Nature 1986 0.75