Published in Hepatology on May 01, 2000
Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol (2009) 1.81
Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma. Br J Cancer (2002) 1.62
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin. EMBO J (2002) 1.57
Prognostic importance of survivin in breast cancer. Br J Cancer (2003) 1.56
Nuclear or cytoplasmic expression of survivin: what is the significance? Int J Cancer (2005) 1.52
Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma. Br J Cancer (2003) 1.33
Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin. Mol Cancer (2011) 1.26
MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway. Sci Rep (2015) 1.23
Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene. J Virol (2009) 1.17
Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression. Proc Natl Acad Sci U S A (2004) 1.16
Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression. J Virol (2005) 1.13
Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer (2009) 1.12
The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update. Protein Cell (2014) 1.10
Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma. J Cancer Res Clin Oncol (2006) 1.08
Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients. Br J Cancer (2005) 1.05
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer (2011) 1.03
survivin messenger RNA expression is a good prognostic biomarker for oesophageal carcinoma. Br J Cancer (2002) 1.02
Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases. Viruses (2012) 0.97
Relationship between survivin expression and recurrence, and prognosis in hepatocellular carcinoma. World J Gastroenterol (2007) 0.96
Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. PLoS One (2011) 0.96
Immunohistochemical expression of nuclear and cytoplasmic survivin in gastrointestinal carcinoma. Int J Clin Exp Pathol (2013) 0.94
Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate. BMC Cancer (2010) 0.93
Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition. World J Gastroenterol (2007) 0.92
Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli. J Cell Physiol (2012) 0.92
Detection of Survivin-expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA. Clin Exp Metastasis (2006) 0.91
Polymorphisms of survivin promoter are associated with risk of esophageal squamous cell carcinoma. J Cancer Res Clin Oncol (2009) 0.90
Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth. J Cancer Res Clin Oncol (2012) 0.90
Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies. Hum Pathol (2012) 0.88
Dynamic expression of apoptosis-related genes during development of laboratory hepatocellular carcinoma and its relation to apoptosis. World J Gastroenterol (2005) 0.87
Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker. Proc Natl Acad Sci U S A (2015) 0.87
Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck. Head Neck Oncol (2010) 0.87
Survivin: A molecular biomarker in cancer. Indian J Med Res (2015) 0.86
Cellular immunotherapy for soft tissue sarcomas. Immunotherapy (2012) 0.86
Anti-cancer effects of p21WAF1/CIP1 transcriptional activation induced by dsRNAs in human hepatocellular carcinoma cell lines. Acta Pharmacol Sin (2011) 0.86
Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector. Gene Ther (2011) 0.85
Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2. World J Gastroenterol (2004) 0.85
An RGD-modified MRI-visible polymeric vector for targeted siRNA delivery to hepatocellular carcinoma in nude mice. PLoS One (2013) 0.85
Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma. Biomed Imaging Interv J (2011) 0.84
Clinicopathological indices to predict hepatocellular carcinoma molecular classification. Liver Int (2015) 0.83
Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells. World J Gastroenterol (2005) 0.83
Prognostic value of survivin in locally advanced prostate cancer: study based on RTOG 8610. Int J Radiat Oncol Biol Phys (2008) 0.83
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun (2015) 0.82
Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression. PLoS One (2013) 0.82
Delivery strategies and potential targets for siRNA in major cancer types. Adv Drug Deliv Rev (2016) 0.82
Association of polymorphisms in survivin gene with the risk of hepatocellular carcinoma in Chinese han population: a case control study. BMC Med Genet (2012) 0.81
Developmental expression of survivin during embryonic submandibular salivary gland development. BMC Dev Biol (2001) 0.81
Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells. J Korean Soc Coloproctol (2010) 0.81
Multifactorial nature of hepatocellular carcinoma drug resistance: could plant polyphenols be helpful? World J Gastroenterol (2007) 0.81
Survivin antisense oligodeoxynucleotide inhibits growth of gastric cancer cells. World J Gastroenterol (2004) 0.80
Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol. BMC Cancer (2016) 0.79
Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NF kappa B. World J Gastroenterol (2005) 0.79
Bevacizumab enhances chemosensitivity of hepatocellular carcinoma to adriamycin related to inhibition of survivin expression. J Cancer Res Clin Oncol (2010) 0.79
Knockdown of survivin gene expression by RNAi induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721. World J Gastroenterol (2005) 0.79
Survivin expression induced by doxorubicin in cholangiocarcinoma. World J Gastroenterol (2004) 0.78
KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial-Mesenchymal Transition. Invest Ophthalmol Vis Sci (2017) 0.76
Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma. Med Oncol (2012) 0.76
Survivin is not a promising serological maker for the diagnosis of hepatocellular carcinoma. Oncol Lett (2015) 0.76
A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase. Cancers (Basel) (2012) 0.76
Significance of intracellular localization of survivin in cervical squamous cell lesions: Correlation with disease progression. Oncol Lett (2014) 0.76
Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Cancer Sci (2017) 0.75
Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma. Oncol Lett (2016) 0.75
Dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy. J Transl Med (2017) 0.75
Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I. Dis Markers (2016) 0.75
Novel combination of sorafenib and biochanin-A synergistically enhances the anti-proliferative and pro-apoptotic effects on hepatocellular carcinoma cells. Sci Rep (2016) 0.75
miRNA-335 and miRNA-182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin. Oncol Lett (2016) 0.75
Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Int J Biol Sci (2015) 0.75
Understanding the role of PIN1 in hepatocellular carcinoma. World J Gastroenterol (2016) 0.75
Functional analysis of a survivin-like gene in Bombyx mori. Cytotechnology (2013) 0.75
CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin. Cancer Biol Ther (2014) 0.75
Targeting survivin using a combination of miR‑494 and survivin shRNA has synergistic effects on the suppression of prostate cancer growth. Mol Med Rep (2015) 0.75
Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med (2016) 0.75
The Value of Survivin Gene and Proliferation of Hepatocytes in Screening for Hepatocellular Carcinoma. Gastroenterology Res (2009) 0.75
Arsenic trioxide treatment of rabbit liver VX-2 carcinoma via hepatic arterial cannulation-induced apoptosis and decreased levels of survivin in the tumor tissue. Croat Med J (2013) 0.75
Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells. J Immunol (2016) 0.75
Survivin downregulation using siRNA nanoliposomes inhibits cell proliferation and promotes the apoptosis of MHCC-97H hepatic cancer cells: An in vitro and in vivo study. Oncol Lett (2017) 0.75
Magnetic Cationic Amylose Nanoparticles Used to Deliver Survivin-Small Interfering RNA for Gene Therapy of Hepatocellular Carcinoma In Vitro. Nanomaterials (Basel) (2017) 0.75
Alcohol-dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma. PLoS One (2017) 0.75
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51
Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet (1988) 8.76
Localization of brain electrical activity via linearly constrained minimum variance spatial filtering. IEEE Trans Biomed Eng (1997) 7.41
Nucleotide sequence of bacteriophage fd DNA. Nucleic Acids Res (1978) 7.25
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem (2001) 7.21
Laparoscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc (1994) 6.86
Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains. Proc Natl Acad Sci U S A (1968) 6.82
The coagulation cascade: initiation, maintenance, and regulation. Biochemistry (1991) 6.29
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84
G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell (1990) 5.55
Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry (1992) 5.48
The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr (1994) 5.47
Studies on bacteriophage fd DNA. IV. The sequence of messenger RNA for the major coat protein gene. J Mol Biol (1977) 5.34
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt: a Bayesian coalescent approach. Mol Biol Evol (2003) 4.99
A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell (1991) 4.90
Nucleotide sequence of Escherichia coli K-12 replication origin. Proc Natl Acad Sci U S A (1979) 4.85
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science (1993) 4.64
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62
Nucleotide sequence of small ColE1 derivatives: structure of the regions essential for autonomous replication and colicin E1 immunity. Mol Gen Genet (1979) 4.30
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev (1995) 4.23
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol (1998) 4.14
Retrotransposons of rice involved in mutations induced by tissue culture. Proc Natl Acad Sci U S A (1996) 4.00
Replication origin of the Escherichia coli K-12 chromosome: the size and structure of the minimum DNA segment carrying the information for autonomous replication. Mol Gen Genet (1980) 3.99
Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) (1990) 3.97
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes Dev (1992) 3.83
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics (1995) 3.60
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem (1999) 3.55
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med (2000) 3.44
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob Agents Chemother (2002) 3.17
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science (2001) 3.13
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci U S A (1994) 3.09
MOR1 is essential for organizing cortical microtubules in plants. Nature (2001) 3.07
Some properties of purified skeletal muscle alpha-actinin. J Biol Chem (1976) 3.06
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem (2001) 3.02
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology (1995) 2.99
Columns for visual features of objects in monkey inferotemporal cortex. Nature (1992) 2.93
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. Science (1999) 2.84
A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet (1999) 2.83
Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron (2005) 2.82
Sequence of promoter for coat protein gene of bacteriophage fd. Nature (1976) 2.82
Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol (1982) 2.80
Complications of pedicle screw fixation in reconstructive surgery of the cervical spine. Spine (Phila Pa 1976) (2000) 2.77
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem (1996) 2.77
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Improvement in visual sensitivity by changes in local context: parallel studies in human observers and in V1 of alert monkeys. Neuron (1995) 2.74
Amino acid sequence of human von Willebrand factor. Biochemistry (1986) 2.73
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein. Proc Natl Acad Sci U S A (1987) 2.70
Studies on purified -actinin. I. Effect of temperature and tropomyosin on the -actinin-F-actin interaction. J Mol Biol (1972) 2.66
Electrical behaviour of the motoneurone membrane during intracellularly applied current steps. J Physiol (1965) 2.60
Role of Ahch in gonadal development and gametogenesis. Nat Genet (1998) 2.60
Choice behavior of rats in a concurrent-chains schedule: Amount and delay of reinforcement. J Exp Anal Behav (1982) 2.59
Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells. J Bacteriol (1988) 2.59
Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol (1989) 2.58
A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J Clin Oncol (1992) 2.58
Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil (1998) 2.53
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol (2001) 2.51
Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 2.49
Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med (1989) 2.49
Frequency of choroidal abnormalities in neurofibromatosis type 1. Lancet (2000) 2.48
PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet (1997) 2.44
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem (1996) 2.43
Retained asymptomatic third molars and risk for second molar pathology. J Dent Res (2013) 2.43
Predictive value of microalbuminuria in medical ICU patients: results of a pilot study. Chest (2001) 2.43
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene (2006) 2.42
Nucleotide sequence of the asnA gene coding for asparagine synthetase of E. coli K-12. Nucleic Acids Res (1981) 2.42
Periodic emission from the gamma-ray binary 1FGL J1018.6-5856. Science (2012) 2.40
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood (2001) 2.39
Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. J Pathol (2008) 2.37
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci (2000) 2.36
Synthesis of DNA during meiosis. Proc Natl Acad Sci U S A (1966) 2.33
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis (2000) 2.32
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol (1990) 2.30
The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J (2001) 2.28
Interactions between endogenous gamma interferon and tumor necrosis factor in host resistance against primary and secondary Listeria monocytogenes infections. Infect Immun (1989) 2.28
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells (1999) 2.28