Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family.

PubWeight™: 4.08‹?› | Rank: Top 1%

🔗 View Article (PMID 10827956)

Published in Science on May 26, 2000

Authors

L Ramakrishnan1, N A Federspiel, S Falkow

Author Affiliations

1: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. lalitar@cmgm.stanford.edu

Articles citing this

(truncated to the top 100)

Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A (2003) 9.15

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol (2002) 8.88

Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 7.29

Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol Microbiol (2004) 4.62

The complete genome sequence of Mycobacterium avium subspecies paratuberculosis. Proc Natl Acad Sci U S A (2005) 4.16

Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev (2003) 4.14

Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol Rev (2007) 4.13

A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2003) 3.70

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res (2008) 3.26

Tuberculosis: latency and reactivation. Infect Immun (2001) 3.15

Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol (2004) 3.12

Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun (2001) 2.98

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol Biol (2006) 2.97

Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol (2012) 2.86

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci U S A (2003) 2.60

Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med (2003) 2.30

Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis. Infect Immun (2001) 2.26

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide. Mol Cell (2015) 2.18

Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc Natl Acad Sci U S A (2001) 2.17

Mycobacterium tuberculosis genes induced during infection of human macrophages. Infect Immun (2002) 2.04

Identification of prophages in bacterial genomes by dinucleotide relative abundance difference. PLoS One (2007) 1.95

Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent. Microbiol Mol Biol Rev (2002) 1.91

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica. Proc Natl Acad Sci U S A (2002) 1.83

Drosophila melanogaster is a genetically tractable model host for Mycobacterium marinum. Infect Immun (2003) 1.73

PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response. Infect Immun (2003) 1.72

Mycobacterial mutants with defective control of phagosomal acidification. PLoS Pathog (2005) 1.71

Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci U S A (2002) 1.70

Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulcerans. J Clin Microbiol (2002) 1.67

Virulence factors of the Mycobacterium tuberculosis complex. Virulence (2012) 1.64

Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences. Infect Immun (2001) 1.63

Mycobacterial PE/PPE proteins at the host-pathogen interface. Clin Dev Immunol (2011) 1.62

Extensive repetitive DNA facilitates prokaryotic genome plasticity. Proc Natl Acad Sci U S A (2003) 1.59

Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infect Immun (2003) 1.59

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect Immun (2002) 1.54

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry (2007) 1.52

Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Antimicrob Agents Chemother (2006) 1.48

Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence. J Bacteriol (2004) 1.45

Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring niche-specific gene expression. Microbiol Mol Biol Rev (2005) 1.45

Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. PLoS One (2010) 1.44

Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect Immun (2006) 1.39

aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome. Mol Microbiol (2011) 1.33

Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas. Infect Immun (2001) 1.32

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Dis Model Mech (2011) 1.32

A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages. Infect Immun (2006) 1.31

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis. Mol Microbiol (2012) 1.30

Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. Infect Immun (2007) 1.28

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway. J Biol Chem (2011) 1.27

Sporulation in mycobacteria. Proc Natl Acad Sci U S A (2009) 1.22

Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions. Infect Immun (2002) 1.21

Isolation of acid-inducible genes of Mycobacterium tuberculosis with the use of recombinase-based in vivo expression technology. Infect Immun (2003) 1.20

DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect Immun (2002) 1.19

Clinical latency and reactivation of AIDS-related mycobacterial infections. J Virol (2004) 1.19

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Infect Immun (2006) 1.17

ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A (2008) 1.15

Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo. J Bacteriol (2006) 1.15

The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs. J Infect Dis (2010) 1.13

Immunogenicity of the Mycobacterium tuberculosis PPE55 (Rv3347c) protein during incipient and clinical tuberculosis. Infect Immun (2005) 1.13

Identification of cyclic AMP-regulated genes in Mycobacterium tuberculosis complex bacteria under low-oxygen conditions. J Bacteriol (2005) 1.12

An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep (2012) 1.11

Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J Bacteriol (2006) 1.11

Fish monocytes as a model for mycobacterial host-pathogen interactions. Infect Immun (2001) 1.11

Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses. BMC Med Genomics (2008) 1.10

Attenuated Mycobacterium marinum protects zebrafish against mycobacteriosis. J Fish Dis (2009) 1.10

Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: potential role in antigenic variability. J Bacteriol (2008) 1.10

Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii. J Bacteriol (2012) 1.08

RDRio Mycobacterium tuberculosis infection is associated with a higher frequency of cavitary pulmonary disease. J Clin Microbiol (2008) 1.05

Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Infect Immun (2003) 1.05

The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens. Curr Drug Targets (2011) 1.02

Statistical signals in bioinformatics. Proc Natl Acad Sci U S A (2005) 1.01

Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair. BMC Evol Biol (2006) 1.00

Comparative genomic and proteomic analyses of PE/PPE multigene family of Mycobacterium tuberculosis H₃₇Rv and H₃₇Ra reveal novel and interesting differences with implications in virulence. Nucleic Acids Res (2012) 0.99

The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. PLoS One (2013) 0.97

PPE38 modulates the innate immune response and is required for Mycobacterium marinum virulence. Infect Immun (2011) 0.97

Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts. PLoS One (2012) 0.97

Association of Mycobacterium tuberculosis PE PGRS33 polymorphism with clinical and epidemiological characteristics. Tuberculosis (Edinb) (2007) 0.97

Mapping essential domains of Mycobacterium smegmatis WhmD: insights into WhiB structure and function. J Bacteriol (2006) 0.96

Localization of proteins in the cell wall of Mycobacterium avium subsp. paratuberculosis K10 by proteomic analysis. Proteome Sci (2010) 0.95

Differential B-cell responses are induced by Mycobacterium tuberculosis PE antigens Rv1169c, Rv0978c, and Rv1818c. Clin Vaccine Immunol (2007) 0.95

Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis. Infect Immun (2005) 0.95

The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate innate immunity and mediate bacillary survival in macrophages. PLoS One (2012) 0.93

Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation? FEBS Open Bio (2014) 0.92

A mycobacterial gene involved in synthesis of an outer cell envelope lipid is a key factor in prevention of phagosome maturation. Infect Immun (2006) 0.91

Comparative genome analysis of fish and human isolates of Mycobacterium marinum. Mar Biotechnol (NY) (2013) 0.91

Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol (2010) 0.91

Sequence polymorphisms in a surface PPE protein distinguish types I, II, and III of Mycobacterium avium subsp. paratuberculosis. J Clin Microbiol (2008) 0.90

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis. J Bacteriol (2006) 0.90

The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect Immun (2009) 0.89

Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms. J Med Microbiol (2010) 0.89

Identification of two Mycobacterium marinum loci that affect interactions with macrophages. Infect Immun (2004) 0.88

Mycobacterium tuberculosis of the RDRio genotype is the predominant cause of tuberculosis and associated with multidrug resistance in Porto Alegre City, South Brazil. J Clin Microbiol (2013) 0.88

Selection of peptide entry motifs by bacterial surface display. Biochem J (2002) 0.88

Molecular and physiological effects of mycobacterial oxyR inactivation. J Bacteriol (2006) 0.88

Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides. J Bacteriol (2011) 0.86

Pyrimidine nucleoside salvage confers an advantage to Xenorhabdus nematophila in its host interactions. Appl Environ Microbiol (2005) 0.85

Strong antibody responses to Mycobacterium tuberculosis PE-PGRS62 protein are associated with latent and active tuberculosis. Infect Immun (2009) 0.84

Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. Curr Top Microbiol Immunol (2013) 0.83

Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci. Infect Immun (2008) 0.83

Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 long terminal repeat promoter. J Biol Chem (2012) 0.83

Genomic comparison of PE and PPE genes in the Mycobacterium avium complex. J Clin Microbiol (2009) 0.82

The PE16 (Rv1430) of Mycobacterium tuberculosis is an esterase belonging to serine hydrolase superfamily of proteins. PLoS One (2013) 0.82

Articles cited by this

New clues to how the TB bacillus persists. Science (2000) 4.22

Articles by these authors

(truncated to the top 100)

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87

Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid. J Bacteriol (1976) 43.93

General method for the isolation of plasmid deoxyribonucleic acid. J Bacteriol (1973) 31.68

FACS-optimized mutants of the green fluorescent protein (GFP). Gene (1996) 24.12

The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. N Engl J Med (1990) 15.92

Contribution of adhesion to bacterial persistence in the mouse urinary tract. Infect Immun (1983) 14.71

Construction and expression of recombinant plasmids encoding type 1 or D-mannose-resistant pili from a urinary tract infection Escherichia coli isolate. Infect Immun (1981) 14.05

Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis. Infect Immun (1981) 13.80

Identification of the uncultured bacillus of Whipple's disease. N Engl J Med (1992) 12.33

Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev (1976) 12.28

Polynucleotide sequence relationships among members of Enterobacteriaceae. J Bacteriol (1969) 11.27

Specific labeling and physical characterization of R-factor deoxyribonucleic acid in Escherichia coli. J Bacteriol (1970) 11.06

Coordinate regulation and sensory transduction in the control of bacterial virulence. Science (1989) 10.59

Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev (1997) 10.52

Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell (1987) 9.80

A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature (1985) 9.45

Translocation of a plasmid DNA sequence which mediates ampicillin resistance: molecular nature and specificity of insertion. Proc Natl Acad Sci U S A (1975) 9.20

The composite genome of the legume symbiont Sinorhizobium meliloti. Science (2001) 9.11

The enterotoxin plasmids of Escherichia coli. J Infect Dis (1974) 9.10

The generation of a ColE1-Apr cloning vehicle which allows detection of inserted DNA. Mol Gen Genet (1975) 8.80

Origin of the TEM-beta-lactamase gene found on plasmids. J Bacteriol (1975) 8.70

Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infect Immun (1975) 8.68

Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect Immun (1983) 8.49

Molecular nature of two nonconjugative plasmids carrying drug resistance genes. J Bacteriol (1974) 8.42

Characterization of plasmid deoxyribonucleic acid from Neisseria gonorrhoeae. Infect Immun (1974) 8.30

Detection of enterotoxigenic Escherichia coli by DNA colony hybridization. J Infect Dis (1980) 8.15

Common themes in microbial pathogenicity. Microbiol Rev (1989) 7.78

Association of hemolysin production, hemagglutination of human erythrocytes, and virulence for chicken embryos of extraintestinal Escherichia coli isolates. Infect Immun (1978) 7.28

A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains. Proc Natl Acad Sci U S A (2000) 6.85

Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells. Infect Immun (1988) 6.68

Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins. Infect Immun (1984) 6.63

The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc Natl Acad Sci U S A (1990) 6.57

Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A (1999) 6.34

Molecular epidemiology of Vibrio cholerae in the U.S. Gulf Coast. J Clin Microbiol (1982) 6.34

Plasmid-associated enterotoxin production in a strain of Escherichia coli isolated from humans. Infect Immun (1972) 6.21

Identification of enterotoxigenic Escherichia coli by colony hybridization using three enterotoxin gene probes. J Infect Dis (1982) 6.09

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin. Nature (1980) 6.04

Polynucleotide sequence relationships among plasmids of the I compatibility complex. J Gen Microbiol (1974) 5.91

Haemolysin contributes to virulence of extra-intestinal E. coli infections. Nature (1981) 5.83

Organization and expression of genes responsible for type 1 piliation in Escherichia coli. J Bacteriol (1984) 5.83

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med (1994) 5.78

Nature of R-factor replication in the presence of chloramphenicol. Proc Natl Acad Sci U S A (1975) 5.64

Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication. Biochimie (1988) 5.62

Deletions affecting the transposition of an antibiotic resistance gene. Proc Natl Acad Sci U S A (1977) 5.48

Cistrons encoding Escherichia coli heat-labile toxin. J Bacteriol (1979) 5.43

The problems of drug-resistant pathogenic bacteria. The replication of R-factor DNA in Escherichia coli K-12 following conjugation. Ann N Y Acad Sci (1971) 5.42

Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. Mol Microbiol (1998) 5.25

Use of a single-strand specific nuclease for analysis of bacterial and plasmid deoxyribonucleic acid homo- and heteroduplexes. J Bacteriol (1973) 5.23

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A (1999) 5.17

Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis. J Bacteriol (1981) 5.11

Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci U S A (1996) 5.03

Genetic analysis of phase change in Bordetella pertussis. Infect Immun (1984) 5.03

Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology (1997) 5.00

Fluorescence-based isolation of bacterial genes expressed within host cells. Science (1997) 4.98

Polynucleotide sequence divergence among strains of Escherichia coli and closely related organisms. J Bacteriol (1972) 4.87

Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proc Natl Acad Sci U S A (1989) 4.87

Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci U S A (1989) 4.78

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc Natl Acad Sci U S A (1991) 4.57

Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. Mol Microbiol (1996) 4.51

Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell (1990) 4.47

Molecular characterization of environmental and nontoxigenic strains of Vibrio cholerae. Infect Immun (1981) 4.45

Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer. J Cell Biol (1988) 4.44

Molecular relationships among the Salmonelleae. J Bacteriol (1973) 4.35

The meaning and impact of the human genome sequence for microbiology. Trends Microbiol (2001) 4.30

Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature (1993) 4.30

Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature (1999) 4.14

Isolation and nucleotide sequence determination of a gene encoding a heat-stable enterotoxin of Escherichia coli. Infect Immun (1983) 4.14

Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: independence from host rec functions and orientation of insertion. J Bacteriol (1976) 4.13

Salmonella interactions with polarized human intestinal Caco-2 epithelial cells. J Infect Dis (1990) 4.09

Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A (2001) 4.05

Genetics of digalactoside-binding adhesin from a uropathogenic Escherichia coli strain. Infect Immun (1983) 4.03

Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae. Antimicrob Agents Chemother (1977) 4.02

The construction of a cloning vector designed for gene replacement in Bordetella pertussis. Gene (1986) 4.01

Nucleotide sequence homology between the heat-labile enterotoxin gene of Escherichia coli and Vibrio cholerae deoxyribonucleic acid. J Bacteriol (1980) 3.89

Polynucleotide sequence relationships among Ent plasmids and the relationship between Ent and other plasmids. J Bacteriol (1975) 3.88

The molecular nature of R-factors. J Mol Biol (1966) 3.88

Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells. Infect Immun (1987) 3.81

Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci U S A (1992) 3.79

Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol (1977) 3.76

The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease. Infect Immun (1989) 3.75

Cloning and expression of an afimbrial adhesin (AFA-I) responsible for P blood group-independent, mannose-resistant hemagglutination from a pyelonephritic Escherichia coli strain. Infect Immun (1984) 3.75

Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli. J Bacteriol (1984) 3.73

Conjugal transfer of R plasmids in Neisseria gonorrhoeae. Nature (1977) 3.71

Analysis of sequences transposed by complementation of two classes of transposition-deficient mutants of Tn3. J Bacteriol (1978) 3.69

Detection of Shigella in feces using DNA amplification. J Infect Dis (1990) 3.61

Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell monolayer. Mol Microbiol (1988) 3.59

Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion. Science (1989) 3.55

Evidence for plasmid contribution to the virulence of fish pathogen Vibrio anguillarum. Infect Immun (1977) 3.49

Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. J Infect Dis (1984) 3.48

Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system. Nature (1989) 3.48

Genetics of the Enterobacteriaceae. C. Molecular relationships among members of the Enterobacteriaceae. Adv Genet (1971) 3.43

Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proc Natl Acad Sci U S A (1997) 3.43

Salmonellosis: host immune responses and bacterial virulence determinants. Annu Rev Immunol (1996) 3.41

Signal transduction in the mammalian cell during bacterial attachment and entry. Cell (1993) 3.41

Polynucleotide sequence relationships among some bacterial plasmids. J Bacteriol (1971) 3.38

Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia. Infect Immun (1993) 3.34

Molecular cloning and physical characterization of a chromosomal hemolysin from Escherichia coli. Infect Immun (1983) 3.30

Characterization of an Escherichia coli plasmid encoding for synthesis of heat-labile toxin: molecular cloning of the toxin determinant. Infect Immun (1978) 3.28

Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. Gene (1996) 3.20