Published in J Pharmacol Exp Ther on July 01, 2000
Genes that distinguish physiological and pathological angiogenesis. Cancer Cell (2007) 3.35
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch (2003) 3.33
Impact of OATP transporters on pharmacokinetics. Br J Pharmacol (2009) 2.97
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Part Fibre Toxicol (2010) 1.89
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol (2012) 1.74
Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.71
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet (2004) 1.51
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol (2011) 1.41
Development of neuropeptide drugs that cross the blood-brain barrier. NeuroRx (2005) 1.27
Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. J Pharm Sci (2007) 1.14
The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med (2013) 1.12
Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx (2005) 1.11
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx (2005) 1.03
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier. J Pharmacol Exp Ther (2010) 1.02
Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacol Rev (2013) 1.01
Transport systems for opioid peptides in mammalian tissues. AAPS J (2005) 0.97
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One (2009) 0.96
Emerging role for drug transporters at the blood-testis barrier. Trends Pharmacol Sci (2010) 0.95
Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. Biochem J (2003) 0.94
Blood-brain barrier transporters and response to CNS-active drugs. Eur J Clin Pharmacol (2009) 0.91
Pharmacogenetics of the organic anion transporting polypeptide 1A2. Pharmacogenomics (2009) 0.90
Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE. Pharm Res (2008) 0.89
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg (2009) 0.87
The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation. J Physiol (2011) 0.87
Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: relevance to CNS drug delivery. J Cereb Blood Flow Metab (2014) 0.85
Managing drug-resistant epilepsy: challenges and solutions. Neuropsychiatr Dis Treat (2016) 0.85
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2009) 0.85
Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2. Br J Pharmacol (2011) 0.84
Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury. Brain Res (2015) 0.82
Central nervous system (CNS) delivery of glucocorticoids is fine-tuned by saturable transporters at the blood-CNS barriers and nonbarrier regions. Endocrinology (2010) 0.82
Hepatocellular transport proteins and their role in liver disease. World J Gastroenterol (2001) 0.82
Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy. Front Pharmacol (2012) 0.82
Drug delivery to the ischemic brain. Adv Pharmacol (2014) 0.82
The effect of the enkephalin DADLE on transcription does not depend on opioid receptors. Histochem Cell Biol (2006) 0.82
Role of solute carriers in response to anticancer drugs. Mol Cell Ther (2014) 0.81
Pharmacogenetics of chronic pain and its treatment. Mediators Inflamm (2013) 0.81
The role of multidrug resistance-associated protein in the blood-brain barrier and opioid analgesia. Synapse (2013) 0.81
Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders. Front Cell Neurosci (2015) 0.81
Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS. Pflugers Arch (2014) 0.80
Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2. AAPS J (2013) 0.80
Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast. Endocrinology (2012) 0.79
Volume transmission of beta-endorphin via the cerebrospinal fluid; a review. Fluids Barriers CNS (2012) 0.79
PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability. PLoS One (2014) 0.79
Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells. J Pharm Sci (2011) 0.78
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy. AAPS J (2015) 0.78
Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells. Br J Pharmacol (2015) 0.75
Efflux transporters in blood-brain interfaces of the developing brain. Front Neurosci (2015) 0.75
Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat. J Cent Nerv Syst Dis (2017) 0.75
Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance. Mol Pharmacol (2016) 0.75
Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice. Peptides (2007) 0.75
Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke. J Cent Nerv Syst Dis (2017) 0.75
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature (1995) 6.13
Molecular and neuronal substrate for the selective attenuation of anxiety. Science (2000) 5.07
The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet (1999) 4.77
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature (1999) 4.36
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
c-jun is essential for normal mouse development and hepatogenesis. Nature (1993) 3.43
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nat Neurosci (1999) 3.36
A crucial role for B cells in neuroinvasive scrapie. Nature (1998) 3.19
Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proc Natl Acad Sci U S A (2002) 2.90
Measles virus spread and pathogenesis in genetically modified mice. J Virol (1998) 2.84
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev (1992) 2.77
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Acute heart transplant rejection due to Saint John's wort. Lancet (2000) 2.71
Molecular pathogenesis of cholestasis. N Engl J Med (1998) 2.68
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta (2003) 2.53
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. EMBO J (1998) 2.48
Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. J Cell Biol (1984) 2.47
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology (2001) 2.36
Complement facilitates early prion pathogenesis. Nat Med (2001) 2.30
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet (1996) 2.20
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (1995) 2.19
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18
Post-exposure prophylaxis after accidental prion inoculation. Lancet (1997) 2.15
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (2000) 2.15
NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem (1997) 2.14
Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell (1989) 2.14
Prion research: the next frontiers. Nature (1997) 2.13
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron (2000) 2.13
Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A (1991) 2.11
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther (2001) 2.10
Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol (1995) 2.10
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature (1997) 2.08
The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med (1997) 2.07
Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proc Natl Acad Sci U S A (1996) 2.04
No propagation of prions in mice devoid of PrP. Cell (1994) 2.02
Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest (1994) 1.98
Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain (2004) 1.96
St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther (2000) 1.89
Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and Canada. Neurology (2005) 1.88
A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J (1998) 1.86
Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases) Brain Pathol (1995) 1.86
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J (2001) 1.85
Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo. Eur J Neurosci (1995) 1.83
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science (2001) 1.82
Epidemiology of drug exposure and adverse drug reactions in two swiss departments of internal medicine. Br J Clin Pharmacol (2000) 1.82
Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proc Natl Acad Sci U S A (1999) 1.81
Prion protein expression in different species: analysis with a panel of new mAbs. Proc Natl Acad Sci U S A (1998) 1.80
Fatal hepatoxicity secondary to nimesulide. Eur J Clin Pharmacol (2001) 1.72
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology (1995) 1.66
Synapse-specific localization of NMDA and GABA(A) receptor subunits revealed by antigen-retrieval immunohistochemistry. J Comp Neurol (1998) 1.65
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell (1994) 1.64
Binding of disease-associated prion protein to plasminogen. Nature (2000) 1.64
Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron (2001) 1.64
Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J (1998) 1.61
Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Nat Genet (1995) 1.60
Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc Natl Acad Sci U S A (1996) 1.60
A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A (2005) 1.60
Transient cortical blindness and bioccipital brain lesions in two patients with acute intermittent porphyria. Ann Intern Med (1995) 1.58
Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc Natl Acad Sci U S A (1992) 1.55
Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther (1995) 1.53
Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci U S A (1994) 1.51
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol (2002) 1.49
Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J Neurosci (2000) 1.48
Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes. Science (1991) 1.46
Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem (1994) 1.46
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology (2000) 1.46
Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. Am J Physiol (1999) 1.45
Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci (1998) 1.45
Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther (1999) 1.44
Safety and efficacy of repeated shockwave lithotripsy of gallstones with and without adjuvant bile acid therapy. Gastroenterology (1997) 1.41
GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur J Neurosci (1999) 1.40
7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstones. Gastroenterology (1996) 1.39
Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol (2000) 1.38
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J (1997) 1.36
Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest (1995) 1.35
Transepithelial prion transport by M cells. Nat Med (2001) 1.35
Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology (2001) 1.32
Hepatic transport of bile salts. Semin Liver Dis (2000) 1.31