J F Habener

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992 7.66
2 Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997 5.47
3 Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 1988 5.29
4 Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999 5.10
5 Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 1990 5.02
6 Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 1997 4.40
7 The glucagon-like peptides. Endocr Rev 1999 3.51
8 Retracted Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J 1990 3.29
9 Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc Natl Acad Sci U S A 1974 3.24
10 Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 1996 2.98
11 Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001 2.95
12 IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 1994 2.89
13 Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A 1987 2.79
14 Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987 2.70
15 Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993 2.52
16 Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000 2.50
17 Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab 2001 2.49
18 The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 1999 2.44
19 Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A 1988 2.40
20 Pre-proparathyroid hormone: analysis of radioactive tryptic peptides and amino acid sequence. Biochemistry 1976 2.25
21 Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986 2.22
22 Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care 1992 2.21
23 Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev 1993 2.21
24 C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A 1993 2.09
25 Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Natl Acad Sci U S A 1978 2.07
26 Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996 2.06
27 Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A 1971 2.04
28 Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Natl Acad Sci U S A 1972 1.97
29 Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 1997 1.96
30 Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A 1984 1.93
31 Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem 1988 1.93
32 A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. EMBO J 1990 1.92
33 Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 1999 1.89
34 An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol 1990 1.81
35 Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. J Clin Invest 1972 1.77
36 Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem 1987 1.75
37 Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 1986 1.73
38 Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem 1976 1.67
39 Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun 1996 1.67
40 The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab 2000 1.61
41 Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes 1990 1.55
42 Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res 2001 1.54
43 Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc Natl Acad Sci U S A 1982 1.54
44 Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 1998 1.51
45 Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. J Invest Dermatol 1998 1.51
46 Structural analysis of human proparathyroid hormone by a new microsequencing approach. Nature 1974 1.50
47 Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology 2000 1.50
48 Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci 1992 1.50
49 Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes 1989 1.48
50 cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem 1999 1.47
51 Proparathyroid hormone: biosynthesis by human parathyroid adenomas. Science 1972 1.47
52 Cyclic AMP signaling and gene regulation. Annu Rev Nutr 1998 1.46
53 The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept 1994 1.46
54 Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Biochemistry 1998 1.45
55 Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem 1984 1.45
56 Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci U S A 1984 1.44
57 Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell 1985 1.44
58 CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol 1999 1.43
59 Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science 1981 1.43
60 Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest 1992 1.42
61 Biosynthesis of parathyroid hormone (second of two parts). N Engl J Med 1978 1.42
62 Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 1992 1.42
63 Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 1999 1.41
64 Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. J Biol Chem 1980 1.40
65 Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol 1999 1.38
66 Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci U S A 1999 1.37
67 Calcium-dependent intracellular degradation of parathyroid hormone: a possible mechanism for the regulation of hormone stores. Endocrinology 1975 1.37
68 Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 1999 1.37
69 Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines. J Clin Invest 1987 1.36
70 Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol 1988 1.35
71 Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem 1984 1.34
72 Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem 1985 1.33
73 The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription. J Biol Chem 1988 1.33
74 Developmental stage-specific expression of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol 1991 1.33
75 Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev 1984 1.31
76 Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes 2001 1.31
77 Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. J Biol Chem 1983 1.30
78 Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest 1987 1.29
79 Nuclear translocation and DNA recognition signals colocalized within the bZIP domain of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB. Mol Endocrinol 1991 1.29
80 Sequence-dependent energetics of the B-Z transition in supercoiled DNA containing nonalternating purine-pyrimidine sequences. Proc Natl Acad Sci U S A 1985 1.27
81 Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem 1995 1.27
82 Metabolism of parathyroid hormone: physiologic and clinical significance. Am J Med 1974 1.25
83 Immunoassay for human calcitonin. II. Clinical studies. Metabolism 1971 1.24
84 Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest 1998 1.24
85 An assessment of the Z-DNA forming potential of alternating dA-dT stretches in supercoiled plasmids. Biochemistry 1986 1.24
86 Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Mol Cell Biol 1991 1.23
87 Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin. Proc Natl Acad Sci U S A 1981 1.23
88 Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Dev Biol 1999 1.22
89 Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47. J Biol Chem 1997 1.21
90 Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin. Proc Natl Acad Sci U S A 1980 1.19
91 alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. J Biol Chem 1982 1.19
92 POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Mol Cell Biol 1997 1.18
93 Immunoreactive parathyroid hormone in circulation of man. Nat New Biol 1972 1.17
94 trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene. Mol Cell Biol 1987 1.17
95 CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element. Nucleic Acids Res 2000 1.16
96 Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes 1997 1.16
97 Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells. Biochem Biophys Res Commun 2000 1.15
98 Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 2001 1.15
99 Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem 1990 1.15
100 Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 2000 1.14
101 Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors. J Biol Chem 1992 1.14
102 Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. J Biol Chem 1982 1.13
103 Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology 1996 1.13
104 DNA complementary to parathyroid mRNA directs synthesis of pre-proparathyroid hormone in a linked transcription-translation system. Nature 1977 1.12
105 cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc Natl Acad Sci U S A 1996 1.12
106 Parathyroid secretion: discovery of a major calcium-dependent protein. Science 1974 1.11
107 Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Proc Natl Acad Sci U S A 1983 1.11
108 Expression of adenylyl cyclase subtypes in pancreatic beta-cells. Biochem Biophys Res Commun 1999 1.10
109 Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J Biol Chem 1998 1.10
110 Multiple cis-acting DNA regulatory elements mediate hepatic angiotensinogen gene expression. Mol Endocrinol 1989 1.10
111 Multiple adenosine 3',5'-cyclic [corrected] monophosphate response element DNA-binding proteins generated by gene diversification and alternative exon splicing. Mol Endocrinol 1990 1.09
112 Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes 2000 1.09
113 Distinct adenosine 3',5'-monophosphate and phorbol ester-responsive signal transduction pathways converge at the level of transcriptional activation by the interactions of DNA-binding proteins. Mol Endocrinol 1989 1.09
114 Microtubules and the intracellular conversion of proparathyroid hormone to parathyroid hormone. Endocrinology 1975 1.07
115 Vasopressin mRNA in situ hybridization: localization and regulation studied with oligonucleotide cDNA probes in normal and Brattleboro rat hypothalamus. Proc Natl Acad Sci U S A 1985 1.07
116 Cellular localization of angiotensinogen gene expression in brown adipose tissue and mesentery: quantification of messenger ribonucleic acid abundance using hybridization in situ. Endocrinology 1987 1.07
117 Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology 1984 1.07
118 Glucagon gene 5'-flanking sequences promote islet cell-specific gene transcription. J Biol Chem 1987 1.07
119 Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes 1997 1.07
120 Cyclic AMP-responsive transcriptional activation domain of CREB-327 involves interdependent phosphorylated subdomains. EMBO J 1994 1.05
121 Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia 2011 1.05
122 Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. Nucleic Acids Res 1992 1.05
123 Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. J Biol Chem 1999 1.05
124 Insulinotropic hormone glucagon-like peptide 1 (GLP-1) activation of insulin gene promoter inhibited by p38 mitogen-activated protein kinase. Endocrinology 2001 1.04
125 Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene. Endocrinology 1996 1.04
126 Proglucagon processing in a rat islet cell line resembles phenotype of intestine rather than pancreas. Endocrinology 1986 1.04
127 The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. Endocrinology 1993 1.04
128 The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. J Biol Chem 1984 1.03
129 Enzymic processing of proparathyroid hormone by cell-free extracts of parathyroid glands. Biochemistry 1977 1.03
130 A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins. J Biol Chem 1990 1.03
131 Cell-free translation of the messenger RNA coding for the alpha subunit of thyroid-stimulating hormone. J Biol Chem 1978 1.02
132 Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element. J Biol Chem 1992 1.02
133 Bovine proparathyroid hormone: structural analysis of radioactive peptides formed by limited cleavage. Endocrinology 1973 1.01
134 Transcriptional activator-coactivator recognition: nascent folding of a kinase-inducible transactivation domain predicts its structure on coactivator binding. Biochemistry 1998 1.01
135 Parathyroid hormone messenger ribonucleic acid: effects of calcium on cellular regulation in vitro. Endocrinology 1983 1.00
136 Destabilized secondary structure of newly replicated HeLa DNA. J Mol Biol 1970 1.00
137 Cellular processing of pre-proparathyroid hormone involves rapid hydrolysis of the leader sequence. J Biol Chem 1979 1.00
138 Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem 1983 1.00
139 Expression of the gene encoding transcription factor cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells. Endocrinology 1995 0.99
140 Procalcitonin is a glycoprotein. J Biol Chem 1981 0.99
141 Transcriptional regulation of chorionic gonadotropin alpha- and beta-subunit gene expression by 8-bromo-adenosine 3',5'-monophosphate. Endocrinology 1986 0.98
142 Homologous desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells. Endocrinology 1991 0.98
143 Pre-prosomatostatins. Products of cell-free translations of messenger RNAs from anglerfish islets. J Biol Chem 1980 0.98
144 Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Endocrinology 2001 0.98
145 Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun 1996 0.97
146 Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology 1979 0.96
147 Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression. Trends Endocrinol Metab 2008 0.96
148 Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia. J Clin Endocrinol Metab 1998 0.96
149 Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene. J Biol Chem 1986 0.96
150 Insulinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin. J Biol Chem 1997 0.95
151 Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells. Diabetes 2000 0.95
152 The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Mol Cell Biol 1990 0.95
153 A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes 1998 0.94
154 Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc Natl Acad Sci U S A 1986 0.93
155 Parathyroid hormone biosynthesis. Correlation of conversion of biosynthetic precursors with intracellular protein migration as determined by electron microscope autoradiography. J Cell Biol 1979 0.93
156 Biosynthesis of parathyroid hormone (first of two parts). N Engl J Med 1978 0.93
157 Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway. J Biol Chem 1987 0.93
158 Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Mol Cell Biol 1990 0.93
159 Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes. FEBS Lett 1991 0.93
160 Gonadotropin and thyrotropin alpha- and beta-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes. J Clin Endocrinol Metab 1987 0.93
161 Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro. Endocrinology 1976 0.93
162 Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia 2009 0.93
163 Parathyroid hormone biosynthesis: structure and function of biosynthetic precursors. Fed Proc 1978 0.93
164 Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones. Endocrinology 1985 0.92
165 Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol Endocrinol 1988 0.92
166 Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells. Endocrinology 1994 0.92
167 CHOP/GADD153 gene expression response to cellular stresses inhibited by prior exposure to ultraviolet light wavelength band C (UVC). Inhibitory sequence mediating the UVC response localized to exon 1. J Biol Chem 2000 0.92
168 Pre-proparathyroid hormone: fidelity of the translation of parathyroid messenger RNA by extracts of wheat germ. Biochemistry 1976 0.92
169 Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins. J Biol Chem 1989 0.92
170 Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest 1987 0.91
171 Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 2000 0.91
172 Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. J Biol Chem 1996 0.91
173 Enhancer and promoter element interactions dictate cyclic adenosine monophosphate mediated and cell-specific expression of the glycoprotein hormone alpha-gene. Mol Endocrinol 1989 0.91
174 Chemical and biologic studies of proparathyroid hormone and parathyroid hormone: analysis of hormone biosynthesis and metabolism. Mt Sinai J Med 1973 0.91
175 Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians. Diabetes 1998 0.91
176 Parathyroid secretory protein: Immunocytochemical localisation within cells that contain parathyroid hormone. Lancet 1978 0.91
177 Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent nonsuppressible component of secretion. J Clin Invest 1976 0.91
178 DNA-binding and dimerization domains of adenosine 3',5'- cyclic monophosphate-responsive protein CREB reside in the carboxyl-terminal 66 amino acids. Mol Endocrinol 1990 0.91
179 Intestinal pre-prosomatostatin. Identification of mRNA coding for a precursor by cell-free translations and hybridization with a cloned islet cDNA. J Biol Chem 1981 0.90
180 Multiple immunoreactive forms of calcitonin in human plasma. Biochem Biophys Res Commun 1974 0.90
181 Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. J Biol Chem 1979 0.90
182 Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription. Mol Endocrinol 1990 0.90
183 Early events in the cellular formation of proparathyroid hormone. J Cell Biol 1980 0.90
184 Radioimmunoassay for bovine calcitonin. J Lab Clin Med 1972 0.90
185 Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Comp Biochem Physiol B Biochem Mol Biol 1998 0.89
186 Regulation by thyroxine of the mRNA encoding the alpha subunit of mouse thyrotropin. J Biol Chem 1983 0.89
187 Thyroid-stimulating hormone biosynthesis. Cellular processing, assembly, and release of subunits. J Biol Chem 1981 0.89
188 Peripheral metabolism of bovine parathyroid hormone in the dog. Metabolism 1975 0.89
189 Pre - proparathyroid hormone identified by cell - free translation of messenger RNA from hyperplastic human parathyroid tissue. J Clin Invest 1975 0.89
190 Parathyroid mRNA directs the synthesis of pre-proparathyroid hormone and proparathyroid hormone in the Krebs ascites cell-free system. Biochem Biophys Res Commun 1975 0.89
191 Effect of aging and diabetes on the enteroinsular axis. J Gerontol A Biol Sci Med Sci 2001 0.89
192 Inactivation of calcitonin by specific organs. Nat New Biol 1972 0.88
193 Provasopressin-neurophysin II processing is cell-specific in heterologous cell lines expressing a metallothionein-vasopressin fusion gene. J Biol Chem 1987 0.88
194 Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology 1998 0.88
195 Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett 1991 0.88
196 Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM. FEBS Lett 1995 0.88
197 The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Mol Endocrinol 1991 0.88
198 Impaired cyclic AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line. Mol Cell Biol 1995 0.88
199 GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes. Horm Metab Res 2010 0.87
200 Pancreatic pre-proglucagons are encoded by two separate mRNAs. J Biol Chem 1981 0.87
201 Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line. Mol Cell Biol 1987 0.87
202 Explanation for unusual potency of salmon calcitonin. Nat New Biol 1971 0.87
203 Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes Care 2001 0.87
204 Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice. Diabetes Obes Metab 2011 0.87
205 Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science 1986 0.87
206 Calcitonin precursor identified by cell-free translation of mRNA. J Biol Chem 1979 0.86
207 Differentiation-specific element: a cis-acting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Mol Endocrinol 1993 0.86
208 An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. Proc Natl Acad Sci U S A 1994 0.86
209 Changes in the sedimentation properties of HeLa cell DNA and nucleoprotein during replication. Biochim Biophys Acta 1969 0.86
210 Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 2001 0.86
211 Biosynthesis of parathyroid hormone. Recent Prog Horm Res 1976 0.85
212 New concepts in the formation, regulation of release, and metabolism of parathyroid hormone. Ciba Found Symp 1976 0.85
213 Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells. J Biol Chem 1989 0.85
214 Prosomatostatin-specific antigen in rat brain: localization by immunocytochemical staining with an antiserum to a synthetic sequence of preprosomatostatin. Proc Natl Acad Sci U S A 1983 0.85
215 Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. Mol Cell Biol 1993 0.85
216 Effects of calcium ionophores on the synthesis and release of parathyroid hormone. Endocrinology 1977 0.85
217 Subcellular distributions of parathyroid hormone, hormonal precursors, and parathyroid secretory protein. Endocrinology 1979 0.85
218 Parathyroid hormone radioimmunoassay. Ann Intern Med 1979 0.84
219 Technique for the identification of a biosynthetic precursor to parathyroid hormone. Methods Enzymol 1975 0.84
220 RNA processing and the control of spermatogenesis. Front Horm Res 1999 0.84
221 Regulation of parathyroid hormone secretion and biosynthesis. Annu Rev Physiol 1981 0.84
222 Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells. Endocrinology 1995 0.84
223 Cell type-specific regulation of CREB gene expression: mutational analysis of CREB promoter activity. J Neurochem 1998 0.84
224 CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun 1999 0.84
225 Cell-free translation of messenger RNA coding for a precursor of human calcitonin. Biochem Biophys Res Commun 1979 0.84
226 Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response. Mol Cell Endocrinol 1990 0.83
227 Luteinizing and follicle-stimulating hormones. Cell-free translations of messenger RNAs coding for subunit precursors. J Biol Chem 1980 0.83
228 Distinct adjacent protein-binding domains in the glycoprotein hormone alpha gene interact independently with a cAMP-responsive enhancer. J Biol Chem 1989 0.83
229 Developmental expression of the rat somatostatin gene. Endocrinology 1984 0.83
230 Insulinotropic glucagonlike peptide-I(7-37)/(7-36)amide A new incretin hormone. Trends Endocrinol Metab 1992 0.83
231 Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells. J Neurochem 1996 0.82
232 Glucagon precursors identified by immunoprecipitation of products of cell-free translation of messenger RNA. Diabetes 1980 0.82
233 Immunological stability of calcitonin in plasma. Endocrinology 1972 0.82
234 Novel expression of the angiotensinogen gene in a rat pancreatic islet cell line. Transcriptional regulation by glucocorticoids. J Biol Chem 1986 0.81
235 Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA 1986 0.81
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