Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8.

PubWeight™: 1.48‹?› | Rank: Top 5%

🔗 View Article (PMC 306600)

Published in EMBO J on August 01, 2000

Authors

M Sugahara1, T Mikawa, T Kumasaka, M Yamamoto, R Kato, K Fukuyama, Y Inoue, S Kuramitsu

Author Affiliations

1: Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Articles citing this

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc Natl Acad Sci U S A (2002) 3.33

AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res (2001) 3.16

Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. Nucleic Acids Res (2002) 1.96

Base excision repair. Cold Spring Harb Perspect Biol (2013) 1.91

Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate. EMBO J (2002) 1.87

Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step. Nucleic Acids Res (2001) 1.86

Structure of a trapped endonuclease III-DNA covalent intermediate. EMBO J (2003) 1.72

The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. Proc Natl Acad Sci U S A (2004) 1.52

Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA. EMBO J (2002) 1.38

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA. Nucleic Acids Res (2011) 1.32

Recent advances in the structural mechanisms of DNA glycosylases. Biochim Biophys Acta (2012) 1.30

The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage. Prog Mol Biol Transl Sci (2012) 1.22

Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J (2003) 1.18

Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase. Nucleic Acids Res (2005) 1.10

Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. Structure (2008) 1.07

Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase. Nucleic Acids Res (2004) 1.02

Structural characterization of a viral NEIL1 ortholog unliganded and bound to abasic site-containing DNA. J Biol Chem (2009) 1.01

8-Oxoguanine rearranges the active site of human topoisomerase I. Proc Natl Acad Sci U S A (2002) 1.00

Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus. DNA Repair (Amst) (2007) 1.00

A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD. J Mol Biol (2008) 0.99

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage. Mutat Res (2012) 0.96

Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA. J Biol Chem (2011) 0.95

Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair. Antioxid Redox Signal (2013) 0.95

Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA. Structure (2013) 0.95

DNA glycosylases search for and remove oxidized DNA bases. Environ Mol Mutagen (2013) 0.94

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts. DNA Repair (Amst) (2009) 0.93

Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility. Nucleic Acids Res (2005) 0.89

A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications. RNA Biol (2014) 0.87

Molecular simulations reveal a common binding mode for glycosylase binding of oxidatively damaged DNA lesions. J Am Chem Soc (2007) 0.86

Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM. J Biol Chem (2012) 0.86

Insights into the glycosylase search for damage from single-molecule fluorescence microscopy. DNA Repair (Amst) (2014) 0.85

Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. DNA Repair (Amst) (2012) 0.84

A novel nucleoid-associated protein specific to the actinobacteria. Nucleic Acids Res (2013) 0.83

Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair. BMC Microbiol (2009) 0.82

Insights into the DNA repair process by the formamidopyrimidine-DNA glycosylase investigated by molecular dynamics. Protein Sci (2004) 0.79

KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli. Nucleic Acids Res (2009) 0.79

Gene expression profiling of Mycobacterium avium subsp. paratuberculosis in simulated multi-stress conditions and within THP-1 cells reveals a new kind of interactive intramacrophage behaviour. BMC Microbiol (2012) 0.79

Base excision repair: NMR backbone assignments of Escherichia coli formamidopyrimidine-DNA glycosylase. J Biomol NMR (2002) 0.77

Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymes. PLoS One (2011) 0.75

Modulation of the turnover of formamidopyrimidine DNA glycosylase. Biochemistry (2006) 0.75

Articles cited by this

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47

The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88

Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28

Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63

Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature (1992) 36.50

Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74

Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr D Biol Crystallogr (1994) 17.44

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature (1991) 9.70

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature (2000) 4.62

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc Natl Acad Sci U S A (1991) 4.25

DNA glycosylases in the base excision repair of DNA. Biochem J (1997) 3.99

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry (1990) 3.94

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J (1995) 3.80

The causes and prevention of cancer. Proc Natl Acad Sci U S A (1995) 3.71

Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein. EMBO J (1987) 3.43

The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. Nucleic Acids Res (1996) 3.20

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO J (1998) 3.14

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites. J Biol Chem (1990) 3.08

Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry (1992) 3.04

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol (1998) 2.70

Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell (1998) 2.67

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase. J Biol Chem (1994) 2.67

A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry (1992) 2.65

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. Cell (1998) 2.41

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition. Cell (1995) 2.36

X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. Proc Natl Acad Sci U S A (1995) 2.30

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage. Mol Carcinog (1990) 2.24

Structural basis for the excision repair of alkylation-damaged DNA. Cell (1996) 2.23

Isolation and characterization of endonuclease VIII from Escherichia coli. Biochemistry (1994) 2.09

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA. J Biol Chem (1994) 2.03

DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA. EMBO J (2000) 2.01

Characterization of Escherichia coli endonuclease VIII. J Biol Chem (1997) 1.80

Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on gamma-irradiation in aqueous solution. Biochemistry (1985) 1.78

Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc Natl Acad Sci U S A (1989) 1.73

Mechanism of action of Escherichia coli endonuclease III. Biochemistry (1987) 1.54

NH2-terminal proline acts as a nucleophile in the glycosylase/AP-lyase reaction catalyzed by Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg) protein. J Biol Chem (1997) 1.51

Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell (1996) 1.43

The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site. J Biol Chem (1995) 1.24

3'- and 5'-strand cleavage reactions catalyzed by the Fpg protein from Escherichia coli occur via successive beta- and delta-elimination mechanisms, respectively. Biochemistry (1996) 1.23

Function of the zinc finger in Escherichia coli Fpg protein. J Biol Chem (1993) 1.21

DNA containing a chemically reduced apurinic site is a high affinity ligand for the E. coli formamidopyrimidine-DNA glycosylase. Nucleic Acids Res (1992) 1.18

Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. J Biol Chem (1993) 1.15

Repair of oxidative DNA damage in gram-positive bacteria: the Lactococcus lactis Fpg protein. Microbiology (1995) 1.07

Mechanism of action of base release by Escherichia coli Fpg protein: role of lysine 155 in catalysis. Biochemistry (1997) 1.07

Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology (1997) 1.04

Role of lysine-57 in the catalytic activities of Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg protein). Nucleic Acids Res (1998) 0.98

Reductive methylation of the amino terminus of endonuclease V eradicates catalytic activities. Evidence for an essential role of the amino terminus in the chemical mechanisms of catalysis. J Biol Chem (1991) 0.98

AP site structural determinants for Fpg specific recognition. Nucleic Acids Res (1999) 0.94

Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product. Mol Gen Genet (1998) 0.94

Trichromatic Concept at SPring-8 RIKEN Beamline I. J Synchrotron Radiat (1998) 0.92

Prokaryotic 5'-3' exonucleases share a common core structure with gamma-delta resolvase. Nucleic Acids Res (1997) 0.91

Nucleotide sequence of a gene from alkaliphilic Bacillus firmus RAB that is homologous to the fpg gene of Escherichia coli. Nucleic Acids Res (1990) 0.90

DNA polymerase beta in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry (1997) 0.89

A common mechanism of action for the N-glycosylase activity of DNA N-glycosylase/AP lyases from E. coli and T4. Mutat Res (1996) 0.83

Thermostable repair enzyme for oxidative DNA damage from extremely thermophilic bacterium, Thermus thermophilus HB8. Nucleic Acids Res (1998) 0.81

Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds. Mutat Res (1997) 0.79

Co-transcription of a homologue of the formamidopyrimidine-DNA glycosylase (fpg) and lysophosphatidic acid acyltransferase (nlaA) in Neisseria meningitidis. FEMS Microbiol Lett (1995) 0.79

Crystallization and preliminary X-ray crystallographic studies of Thermus thermophilus HB8 MutM protein involved in repairs of oxidative DNA damage. J Biochem (2000) 0.77

Articles by these authors

Crystal structure of rhodopsin: A G protein-coupled receptor. Science (2000) 28.60

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun (1997) 14.09

Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43

Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells. Biophys J (1993) 9.35

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A (2001) 6.78

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature (2000) 6.58

Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol (2001) 6.05

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75

Detection of calcium binding proteins by 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresis. J Biochem (1984) 4.69

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature (1994) 4.20

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci (2001) 4.02

Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling. Nature (2001) 3.92

Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol (2000) 3.75

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol (1996) 3.72

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60

The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol (2001) 3.58

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res (2001) 3.57

Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Cell (1986) 3.54

Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev (1991) 3.26

Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med (2000) 3.25

Genetic organization of the bacterial conjugative transposon Tn916. J Bacteriol (1988) 3.18

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04

Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant. J Bacteriol (1987) 3.04

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature (1995) 2.91

Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol (1991) 2.88

Spred is a Sprouty-related suppressor of Ras signalling. Nature (2001) 2.87

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol (1995) 2.87

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol Cell Biol (1995) 2.84

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M. Nat Genet (1996) 2.77

Sequential alterations in the nuclear chromatin region during mitosis of the fission yeast Schizosaccharomyces pombe: video fluorescence microscopy of synchronously growing wild-type and cold-sensitive cdc mutants by using a DNA-binding fluorescent probe. J Cell Sci (1981) 2.75

The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J (1988) 2.74

Qualitative comparison of carbon dioxide-induced change in cerebral near-infrared spectroscopy versus jugular venous oxygen saturation in adults with acute brain disease. Crit Care Med (1995) 2.74

Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med (1998) 2.69

Negative control for the initiation of meiosis in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1985) 2.69

Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr (1975) 2.66

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron (1988) 2.66

Gelsolin, a multifunctional actin regulatory protein. J Biol Chem (1999) 2.64

Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62

Doppler ultrasound examination of multiple sclerosis patients and control participants: inter-observer agreement and association with disease. Eur J Vasc Endovasc Surg (2013) 2.62

Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa. J Neurosurg (1997) 2.60

S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell (1994) 2.57

De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology (2009) 2.53

Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis. Gut (1999) 2.51

Mapping of a cluster of genes for components of the transcriptional and translational machineries of Escherichia coli. J Mol Biol (1977) 2.50

Clinicopathological study of fatal myocardial sarcoidosis. Ann N Y Acad Sci (1976) 2.47

Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett (1989) 2.43

Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe. J Cell Biol (1997) 2.43

Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep (2001) 2.43

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int (2010) 2.40

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol (2001) 2.40

Structural genomics projects in Japan. Nat Struct Biol (2000) 2.40

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40

Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev (1992) 2.36

Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis. Nucleic Acids Res (2000) 2.35

Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res (2003) 2.32

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32

Contranscription of genes for RNA polymerase subunits beta and beta' with genes for ribosomal proteins in Escherichia coli. Proc Natl Acad Sci U S A (1978) 2.30

The world according to Maf. Nucleic Acids Res (1997) 2.30

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol (1996) 2.30

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem (2001) 2.29

Combined transcriptome and proteome analysis as a powerful approach to study genes under glucose repression in Bacillus subtilis. Nucleic Acids Res (2001) 2.28

Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell (1995) 2.25

Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature (1993) 2.25

Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity. J Biol Chem (1975) 2.23

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell (2001) 2.15

An updatable holographic three-dimensional display. Nature (2008) 2.14

PETT VI: a positron emission tomograph utilizing cesium fluoride scintillation detectors. J Comput Assist Tomogr (1982) 2.14

A new photosystem II reaction center component (4.8 kDa protein) encoded by chloroplast genome. FEBS Lett (1988) 2.13

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J (1998) 2.13

Homologous activators of ras in fission and budding yeast. Nature (1990) 2.11

Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport (1992) 2.11

Protection of recurrent laryngeal nerve during neck surgery: a new combination of neutracer, laryngeal mask airway, and fiberoptic bronchoscope. Anesthesiology (1991) 2.10

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med (2001) 2.10

Estimates of the cost-effectiveness of a single course of interferon-alpha 2b in patients with histologically mild chronic hepatitis C. Ann Intern Med (1997) 2.09

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem (1999) 2.09

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07

Lymphatic manifestations of lymphangioleiomyomatosis. Lymphology (2014) 2.06

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06

Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J Biol Chem (1997) 2.05

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res (2000) 2.03

Analysis of the acid-base titration curve of hen lysozyme. J Biochem (1980) 2.02

Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem (1999) 2.00

Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J Bacteriol (1998) 1.98

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem (1997) 1.98

Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways. Proc Natl Acad Sci U S A (1991) 1.98

The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. J Cell Biol (1993) 1.97

Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1990) 1.97

Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J Biol Chem (1994) 1.97

The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain. Mol Cell Biol (1998) 1.97

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Mol Cell Biol (1995) 1.97

Organization of genes for transcription and translation in the rif region of the Escherichia coli chromosome. J Bacteriol (1979) 1.96

Purification and properties of beta-lactamase from Proteus morganii. J Bacteriol (1977) 1.96