Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMC 2290314)

Published in J Physiol on May 15, 2002

Authors

Anthony N van den Pol1, Prabhat K Ghosh, Rong-Jian Liu, Ying Li, George K Aghajanian, Xiao-Bing Gao

Author Affiliations

1: Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA. anthony.vandenpol@yale.edu

Articles citing this

Control of sleep and wakefulness. Physiol Rev (2012) 3.06

Neuropeptide transmission in brain circuits. Neuron (2012) 1.69

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci (2014) 1.53

Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev (2012) 1.45

Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proc Natl Acad Sci U S A (2012) 1.41

Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome. J Neurosci (2009) 1.36

Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents. J Physiol (2010) 1.29

Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. J Neurosci (2003) 1.28

Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1. J Neurosci (2008) 1.24

Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice. Eur J Neurosci (2007) 1.17

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proc Natl Acad Sci U S A (2010) 1.10

Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice. Am J Physiol Cell Physiol (2009) 1.07

Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus. Neuroscience (2007) 1.04

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc Natl Acad Sci U S A (2013) 1.01

Brain orexin promotes obesity resistance. Ann N Y Acad Sci (2012) 0.99

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest (2014) 0.99

Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy. J Physiol (2005) 0.98

Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor. J Physiol (2012) 0.98

Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. Brain Res (2008) 0.97

Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones. J Physiol (2003) 0.93

GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture. J Appl Physiol (1985) (2008) 0.93

Orexin/hypocretin receptor signalling: a functional perspective. Br J Pharmacol (2014) 0.92

GABA excitation in mouse hilar neuropeptide Y neurons. J Physiol (2007) 0.90

Role of the locus coeruleus in enhanced orexin A-induced spontaneous physical activity in obesity-resistant rats. Am J Physiol Regul Integr Comp Physiol (2013) 0.82

GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis. Neuroreport (2010) 0.82

Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain (2013) 0.82

Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons. J Neurophysiol (2012) 0.81

Role of orexin receptors in obesity: from cellular to behavioral evidence. Int J Obes (Lond) (2012) 0.80

Functional implications of sleep development. PLoS Biol (2005) 0.80

Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets. J Neurosci (2015) 0.79

Central control of circadian phase in arousal-promoting neurons. PLoS One (2013) 0.79

The orexinergic system influences conditioned odor aversion learning in the rat: a theory on the processes and hypothesis on the circuit involved. Front Behav Neurosci (2014) 0.77

Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery. Br J Pharmacol (2014) 0.76

Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response. Pflugers Arch (2016) 0.76

Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders. Neuropharmacology (2011) 0.76

Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose 'Liking' and Intake but Scopolamine in Caudal Shell Shifts 'Liking' Toward 'Disgust' and 'Fear'. Neuropsychopharmacology (2016) 0.75

Articles cited by this

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66

Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci (1998) 9.88

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99

Hypocretin (orexin) deficiency in human narcolepsy. Lancet (2000) 7.92

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05

Reduced number of hypocretin neurons in human narcolepsy. Neuron (2000) 6.94

Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci (1981) 4.15

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06

Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A (1999) 3.42

A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal (1996) 3.18

Distribution of orexin receptor mRNA in the rat brain. FEBS Lett (1998) 2.90

The role of locus coeruleus in the regulation of cognitive performance. Science (1999) 2.89

Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annu Rev Neurosci (1979) 2.51

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci (1998) 2.45

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol (1999) 2.32

Membrane properties of rat locus coeruleus neurones. Neuroscience (1984) 2.29

Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J Neurosci (1999) 2.17

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci (2000) 2.05

Excitatory actions of GABA in developing rat hypothalamic neurones. J Physiol (1996) 1.64

Enkephalin opens potassium channels on mammalian central neurones. Nature (1982) 1.60

Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J Neurosci (1996) 1.54

Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats. J Neurosci (1989) 1.46

Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin. Neuroscience (1995) 1.39

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron (1998) 1.37

Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. J Comp Neurol (1978) 1.31

Ontogeny of monoamine neurons in the locus coeruleus, Raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J Comp Neurol (1974) 1.28

Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons. Neuroscience (1992) 1.19

Selective neuronal expression of green fluorescent protein with cytomegalovirus promoter reveals entire neuronal arbor in transgenic mice. J Neurosci (1998) 1.19

Light-microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. I. Early ontogeny. J Comp Neurol (1981) 1.16

Noradrenergic neurons from the locus ceruleus in dissociated cell culture: culture methods, morphology, and electrophysiology. J Neurosci (1986) 1.12

Pacemaker potentials of serotonergic dorsal raphe neurons: contribution of a low-threshold Ca2+ conductance. Synapse (1987) 1.08

Membrane properties and adrenergic responses in locus coeruleus neurons of young rats. J Neurosci (1987) 1.08

Molecular control of locus coeruleus neurotransmission. Biol Psychiatry (1999) 1.07

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport (2000) 1.06

Lateral hypothalamus: early developmental expression and response to hypocretin (orexin). J Comp Neurol (2001) 1.04

Dye-coupling among neurons of the rat locus coeruleus during postnatal development. Neuroscience (1993) 0.98

Narcolepsy: a neurodegenerative disease of the hypocretin system? Neuron (2000) 0.96

Development and plasticity of the locus coeruleus: a review of recent physiological and pharmacological experimentation. Prog Neurobiol (1990) 0.95

Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. J Neurosci (1993) 0.94

Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J Physiol (2002) 0.92

Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. J Neurosci (1984) 0.92

Tyrosine hydroxylase-immunoreactive neurons of the hypothalamus: a light and electron microscopic study. Neuroscience (1984) 0.91

Inhibitory adenosine A1-receptors on rat locus coeruleus neurones. An intracellular electrophysiological study. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.89

Development of the noradrenergic innervation of neocortex. Brain Res (1979) 0.88

Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. J Neurosci (1996) 0.88

Modification of postnatal development of neocortex in rat brain with experimental deprivation of locus coeruleus. Brain Res (1974) 0.85

Inhibition by ethanol of excitatory amino acid receptors in rat locus coeruleus neurons in vitro. Naunyn Schmiedebergs Arch Pharmacol (1998) 0.84

Evidence for a neurotropic role of noradrenaline neurons in the postnatal development of rat cerebral cortex. J Neurocytol (1982) 0.83

Major innervation of newborn rat cortex by monoaminergic neurons. Science (1977) 0.82

Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro. Eur J Neurosci (1996) 0.80

The effect of neonatal 6-hydroxydopamine treatment on synaptogenesis in the visual cortex of the rat. J Comp Neurol (1982) 0.79

Some in vivo electrophysiological properties of locus coeruleus neurones in fetal rats. Exp Brain Res (1987) 0.77

Articles by these authors

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science (2010) 10.97

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol (2006) 8.05

Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60

Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14

Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98

Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68

DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature (2003) 5.66

Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron (2006) 5.64

Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species. PLoS One (2010) 5.39

Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A (2006) 5.35

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell (2005) 5.10

Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature (2009) 4.98

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81

Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry (2011) 3.62

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol (2007) 3.47

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science (2006) 3.26

Synaptic dysfunction in depression: potential therapeutic targets. Science (2012) 3.15

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10

Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09

Use of ITS2 region as the universal DNA barcode for plants and animals. PLoS One (2010) 2.92

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proc Natl Acad Sci U S A (2008) 2.71

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58

Selection of aptamers for molecular recognition and characterization of cancer cells. Anal Chem (2007) 2.57

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48

Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med (2009) 2.41

Nicotine decreases food intake through activation of POMC neurons. Science (2011) 2.41

De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. BMC Genomics (2010) 2.41

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21

The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development (2005) 2.19

Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study. BMC Health Serv Res (2008) 2.17

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res (2012) 2.16

Actin homolog MreBH governs cell morphogenesis by localization of the cell wall hydrolase LytE. Dev Cell (2006) 2.14

Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr (2013) 2.11

Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging. Cell Transplant (2014) 2.09

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07

Maternal and offspring pools of osteocalcin influence brain development and functions. Cell (2013) 2.00

Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med (2015) 1.99

Utility of N-terminal pro B-type natriuretic peptide and mean platelet volume in differentiating congestive heart failure from chronic obstructive pulmonary disease. Int J Cardiol (2013) 1.99

The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99

Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro. Biol Reprod (2007) 1.94

Identification of liver cancer-specific aptamers using whole live cells. Anal Chem (2008) 1.90

Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biol Reprod (2008) 1.89

Reduction of RF-induced sample heating with a scroll coil resonator structure for solid-state NMR probes. J Magn Reson (2005) 1.89

Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology (2011) 1.85

Autophagy contributes to leaf starch degradation. Plant Cell (2013) 1.85

Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron (2004) 1.83

Serotonin regulates rhythmic whisking. Neuron (2003) 1.83

New class of potent antitumor acylhydrazone derivatives containing furan. Eur J Med Chem (2010) 1.82

Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy. Circ Arrhythm Electrophysiol (2008) 1.77

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol Psychiatry (2011) 1.77

Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex. J Neurosci (2010) 1.74

Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology (2003) 1.74

Estimation of 10-year risk of fatal and nonfatal ischemic cardiovascular diseases in Chinese adults. Circulation (2006) 1.73

Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73

Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure. Glia (2011) 1.73

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71

SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71

Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples. Clin Chem (2007) 1.69

Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Cell Metab (2005) 1.66

Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia. Arterioscler Thromb Vasc Biol (2009) 1.64

Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer (2011) 1.63

Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J Clin Invest (2009) 1.63

Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci (2002) 1.63

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology (2009) 1.62

Authentication of the family Polygonaceae in Chinese pharmacopoeia by DNA barcoding technique. J Ethnopharmacol (2009) 1.62

Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages. J Leukoc Biol (2007) 1.61

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology (2014) 1.60

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol (2012) 1.60

The whisking rhythm generator: a novel mammalian network for the generation of movement. J Neurophysiol (2007) 1.58

Restoration of hand function in a rat model of repair of brachial plexus injury. Brain (2009) 1.57

Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomain. Proc Natl Acad Sci U S A (2005) 1.55

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work. J Dermatol (2010) 1.54

Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens (2010) 1.54

Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. J Neurosci (2006) 1.51

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci (2009) 1.50

Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese. Ophthalmic Genet (2012) 1.50

The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J Pharmacol Exp Ther (2010) 1.48

Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match. Transpl Int (2011) 1.48

A decreased mean platelet volume is associated with stable and exacerbated asthma. Respiration (2014) 1.48

Hepatitis B virus reactivation in patients with multiple myeloma receiving bortezomib-containing regimens followed by autologous stem cell transplant. Leuk Lymphoma (2015) 1.47

Decreased serum bilirubin is associated with silent cerebral infarction. Arterioscler Thromb Vasc Biol (2013) 1.47

Fasting serum lipid and dehydroepiandrosterone sulfate as important metabolites for detecting isolated postchallenge diabetes: serum metabolomics via ultra-high-performance LC-MS. Clin Chem (2013) 1.46

Evidence based acupuncture practice recommendations for peripheral facial paralysis. Am J Chin Med (2009) 1.45

Baseline pulmonary function and quality of life 9 years later in a middle-aged Chinese population. Chest (2005) 1.45

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS One (2010) 1.45