Published in J Clin Invest on September 01, 2000
Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest (2003) 2.18
Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update. Hum Mutat (2010) 1.81
Carney complex (CNC). Orphanet J Rare Dis (2006) 1.64
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. Nat Genet (2014) 1.63
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A (2004) 1.56
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (2010) 1.36
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A (2003) 1.33
The differential diagnosis of familial lentiginosis syndromes. Fam Cancer (2011) 1.12
Carney complex and other conditions associated with micronodular adrenal hyperplasias. Best Pract Res Clin Endocrinol Metab (2010) 1.11
Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice. PLoS Genet (2010) 1.09
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. Proc Natl Acad Sci U S A (2007) 1.07
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol (2009) 1.03
Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A. Mol Endocrinol (2007) 1.03
The variations in the immunologic features and interleukin-6 levels for the surgical treatment of cardiac myxomas. Surg Today (2007) 1.02
Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men. Mol Endocrinol (2006) 1.00
Familial micronodular adrenocortical disease, Cushing syndrome, and mutations of the gene encoding phosphodiesterase 11A4 (PDE11A). Am J Surg Pathol (2010) 0.97
Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes. Acta Neuropathol (2011) 0.95
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. Cancer Res (2008) 0.95
Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics. Mol Cell Endocrinol (2013) 0.95
A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations. Clin Endocrinol (Oxf) (2008) 0.91
Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design. Biochemistry (2014) 0.91
Cell-type specific expression of a dominant negative PKA mutation in mice. PLoS One (2011) 0.91
The transcriptome that mediates increased cyclic adenosine monophosphate signaling in PRKAR1A defects and other settings. Endocr Pract (2011) 0.88
Thyroid cancer: current molecular perspectives. J Oncol (2010) 0.87
Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association. J Clin Endocrinol Metab (2011) 0.87
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem (2006) 0.87
Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278). Biochem Biophys Res Commun (2009) 0.86
Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice. Cell Death Differ (2014) 0.84
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD). Hum Mol Genet (2014) 0.80
Unraveling the molecular basis of micronodular adrenal hyperplasia. Curr Opin Endocrinol Diabetes Obes (2008) 0.80
An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology (2013) 0.80
The role of genetic and epigenetic changes in pituitary tumorigenesis. Neurol Med Chir (Tokyo) (2014) 0.78
The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention. Acta Biochim Biophys Sin (Shanghai) (2015) 0.77
Isolated familial somatotropinomas: clinical and genetic considerations. Trans Am Clin Climatol Assoc (2003) 0.77
Multiple cerebral cavernous malformations associated with extracranial mesenchymal anomalies. Neurosurg Rev (2007) 0.77
Insights from systems pharmacology into cardiovascular drug discovery and therapy. BMC Syst Biol (2014) 0.76
Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters. Hum Mol Genet (2013) 0.76
Novel PRKAR1A gene mutations in Carney Complex. Int J Clin Exp Pathol (2010) 0.76
D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci (2014) 0.76
Mouse model for bilateral adrenal hyperplasia. Ann Endocrinol (Paris) (2009) 0.75
Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. PLoS One (2014) 0.75
GenBank. Nucleic Acids Res (2000) 36.75
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet (1998) 19.35
Cardiac myxomas. N Engl J Med (1995) 14.96
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet (1998) 7.36
Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet (1999) 6.90
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem (1990) 5.02
The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine (Baltimore) (1985) 4.64
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
Mouse tumor model for neurofibromatosis type 1. Science (1999) 2.89
Cardiac myxoma. A clinicopathologic study. Am J Clin Pathol (1993) 2.49
Identification of a novel genetic locus for familial cardiac myxomas and Carney complex. Circulation (1998) 2.21
Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest (1998) 2.00
Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest (1996) 1.94
Structural features of cardiac myxomas. Histology, histochemistry, and electron microscopy. Hum Pathol (1973) 1.90
Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice. J Biol Chem (1997) 1.80
mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci (1999) 1.78
Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy. Cancer Res (1990) 1.60
The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell (1991) 1.59
Differences between nonfamilial and familial cardiac myxoma. Am J Surg Pathol (1985) 1.47
Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. Cell (1991) 1.28
Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1997) 1.28
Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nat Med (1997) 1.24
Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1. Proc Natl Acad Sci U S A (1988) 1.11
Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins. J Biol Chem (1999) 1.11
Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha. J Cell Biol (1996) 1.07
Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue. J Biol Chem (1999) 1.01
Interleukin-6 and cardiac myxoma. Am J Cardiol (1994) 1.01
TSH Receptor Mutations and Thyroid Disease. Trends Endocrinol Metab (2008) 0.96
A dual role for the cAMP-dependent protein kinase in tyrosine hydroxylase gene expression. Proc Natl Acad Sci U S A (1993) 0.90
Adenosine regulates the production of interleukin-6 by human gingival fibroblasts via cyclic AMP/protein kinase A pathway. J Periodontal Res (2000) 0.85
Molecular genetic diagnosis of the familial myxoma syndrome (Carney complex). Am J Med Genet (1999) 0.84
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene. Hum Genet (1996) 0.84
The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids. Endocrinology (1997) 0.83
Regulation of Schwann cell proliferation in cultured segments of the adult rat sciatic nerve. J Neurosci Res (1998) 0.83
Cell cycle control in the terminally differentiated myocyte. A platform for myocardial repair? Cardiol Clin (1998) 0.79
Gs protein mutations and the pathogenesis and function of pituitary tumors. Metabolism (1996) 0.79
A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. Genes Chromosomes Cancer (2000) 0.79
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) (2008) 9.45
Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA (1999) 9.18
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05
Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science (1998) 5.98
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet (1996) 5.15
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet (1997) 5.11
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab (2001) 4.53
Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell (1977) 4.34
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science (1982) 4.05
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet (1999) 3.73
Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (1985) (2000) 3.54
Seeing the herpesvirus capsid at 8.5 A. Science (2000) 3.35
Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA (1997) 3.27
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Structural variants of human T200 glycoprotein (leukocyte-common antigen). EMBO J (1987) 3.19
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
Chromogenic cephalosporin spot test to detect beta-lactamase in clinically significant bacteria. J Clin Microbiol (1979) 3.17
Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. Science (1998) 3.00
Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia (2003) 3.00
The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A (1987) 2.91
Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet (1997) 2.85
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. Science (1998) 2.84
Making and reading microarrays. Nat Genet (1999) 2.81
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry (2007) 2.70
Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. Proc Natl Acad Sci U S A (1999) 2.70
Localization of gelsolin proximal to ABL on chromosome 9. Am J Hum Genet (1988) 2.64
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet (1999) 2.62
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med (1999) 2.61
Complete genome sequence of the shrimp white spot bacilliform virus. J Virol (2001) 2.58
Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med (1993) 2.55
Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids. Nat Struct Biol (1995) 2.51
Sequence homology requirements for intermolecular recombination in mammalian cells. Proc Natl Acad Sci U S A (1986) 2.50
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48
Spinal cord stimulation facilitates functional walking in a chronic, incomplete spinal cord injured. Spinal Cord (2002) 2.47
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension (2001) 2.42
Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science (1998) 2.42
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci U S A (1986) 2.42
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. Mol Cell Biol (1985) 2.22
Identification of a novel genetic locus for familial cardiac myxomas and Carney complex. Circulation (1998) 2.21
The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A (1995) 2.18
Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell (1995) 2.15
Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J Med Genet (2002) 2.11
Legume consumption and risk of coronary heart disease in US men and women: NHANES I Epidemiologic Follow-up Study. Arch Intern Med (2001) 2.08
Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J Clin Invest (1996) 2.07
Electron correlation effects in resonant inelastic X-ray scattering of NaV2O5. Phys Rev Lett (2002) 2.06
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol (1993) 2.05
Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet (1998) 2.04
Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol (2001) 2.03
Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med (1991) 1.99
Minimal residual disease detection in childhood precursor-B-cell acute lymphoblastic leukemia: relation to other risk factors. A Children's Oncology Group study. Leukemia (2003) 1.97
Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol (2001) 1.96
Long-term absolute benefit of lowering blood pressure in hypertensive patients according to the JNC VI risk stratification. Hypertension (2000) 1.96
p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res (1995) 1.95
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev (1999) 1.95
A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32. J Immunol (1987) 1.94
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron (1996) 1.91
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol (1995) 1.86
An acute ischemic stroke classification instrument that includes CT or MR angiography: the Boston Acute Stroke Imaging Scale. AJNR Am J Neuroradiol (2008) 1.80
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J Exp Med (1993) 1.75
Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Genomics (1994) 1.73
The impact of the first world war on civilian health in Britain. Econ Hist Rev (1977) 1.72
Prevalence, awareness, treatment and control of hypertension in North America, North Africa and Asia. J Hum Hypertens (2004) 1.71
Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry (1996) 1.71
Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant (2009) 1.69
Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14. Circulation (2001) 1.69
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res (2000) 1.68
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell (2001) 1.68
Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Hum Mol Genet (2001) 1.68
Human gamma-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7. Nature (1985) 1.66
The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science (1984) 1.66
The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J Exp Med (1989) 1.64
Localization of the beta-globin gene by chromosomal in situ hybridization. Am J Hum Genet (1984) 1.64
Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Dev Dyn (1998) 1.63
Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. J Clin Endocrinol Metab (1998) 1.63
Medical causes of seizures. Lancet (1998) 1.62
Hodgkin's disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone. N Engl J Med (1992) 1.61
The AIDS-related experiences and practices of primary care physicians in Los Angeles: 1984-89. Am J Public Health (1990) 1.61
Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res (1999) 1.60
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Oncogene (2011) 1.59
Dyspepsia and irritable bowel syndrome in China: a population-based endoscopy study of prevalence and impact. Aliment Pharmacol Ther (2010) 1.59
Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med (1999) 1.58
Tonotopic organization of auditory cortical fields delineated by parvalbumin immunoreactivity in macaque monkeys. J Comp Neurol (1997) 1.57
Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology (2009) 1.56