Published in Neuron on October 01, 1996
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
Diffusion in brain extracellular space. Physiol Rev (2008) 5.34
Astrocytes promote myelination in response to electrical impulses. Neuron (2006) 4.23
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J Neurosci (2006) 1.90
Oligodendrocytes: biology and pathology. Acta Neuropathol (2009) 1.81
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J Cell Biol (1999) 1.81
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
Astrocytes in multiple sclerosis: a product of their environment. Cell Mol Life Sci (2008) 1.66
Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Am J Pathol (1998) 1.65
Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Proc Natl Acad Sci U S A (2003) 1.60
A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res (2008) 1.26
A novel interaction of the Golgi complex with the vimentin intermediate filament cytoskeleton. J Cell Biol (2001) 1.24
Astrocytes from the contused spinal cord inhibit oligodendrocyte differentiation of adult oligodendrocyte precursor cells by increasing the expression of bone morphogenetic proteins. J Neurosci (2011) 1.21
Don't fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair. Restor Neurol Neurosci (2008) 1.19
Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. Am J Pathol (1998) 1.19
Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev (2009) 1.19
Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. J Neurosci (2011) 1.11
White matter astrocytes in health and disease. Neuroscience (2013) 1.07
Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. Am J Pathol (2002) 1.02
Pathogenesis and prevention of intraventricular hemorrhage. Clin Perinatol (2013) 1.00
Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function. BMC Neurosci (2011) 0.93
Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model. J Neurosci (2011) 0.92
Astrocytes are an early target in osmotic demyelination syndrome. J Am Soc Nephrol (2011) 0.91
Intermediate filaments: a historical perspective. Exp Cell Res (2007) 0.91
Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One (2010) 0.91
Astrocyte phenotypes and their relationship to myelination. J Anat (2010) 0.90
Optic neuritis in neuromyelitis optica. Prog Retin Eye Res (2013) 0.90
Recent molecular approaches to understanding astrocyte function in vivo. Front Cell Neurosci (2013) 0.88
Partial recovery of the damaged rat blood-brain barrier is mediated by adherens junction complexes, extracellular matrix remodeling and macrophage infiltration following focal astrocyte loss. Neuroscience (2013) 0.88
A novel and efficient gene transfer strategy reduces glial reactivity and improves neuronal survival and axonal growth in vitro. PLoS One (2009) 0.87
Role of GFAP in CNS injuries. Neurosci Lett (2014) 0.86
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. PLoS One (2009) 0.86
Re-evaluating the treatment of acute optic neuritis. J Neurol Neurosurg Psychiatry (2014) 0.86
Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens. Childs Nerv Syst (2013) 0.83
Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes. Glia (2010) 0.82
"Targeting astrocytes in CNS injury and disease: A translational research approach". Prog Neurobiol (2016) 0.81
Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration. Brain Res (2009) 0.81
Genomic survey of prepulse inhibition in mouse chromosome substitution strains. Genes Brain Behav (2009) 0.81
The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity. J Virol (2015) 0.80
Persistent astrocyte activation in the fragile X mouse cerebellum. Brain Behav (2015) 0.79
The multifaceted role of astrocytes in regulating myelination. Exp Neurol (2016) 0.79
Proteomic Identification of Nrf2-Mediated Phase II Enzymes Critical for Protection of Tao Hong Si Wu Decoction against Oxygen Glucose Deprivation Injury in PC12 Cells. Evid Based Complement Alternat Med (2014) 0.78
Interferons, signal transduction pathways, and the central nervous system. J Interferon Cytokine Res (2014) 0.78
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Sci Rep (2016) 0.78
Cellular basis of steroid neuroprotection in the wobbler mouse, a genetic model of motoneuron disease. Cell Mol Neurobiol (2001) 0.78
Astrocytes in Oligodendrocyte Lineage Development and White Matter Pathology. Front Cell Neurosci (2016) 0.78
HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation. J Biol Chem (2016) 0.76
A comparison of neurotoxicity in cerebellum produced by dermal application of chlorpyrifos in young and adult mice. J Neural Transm (Vienna) (2011) 0.76
Neuroimmunological Implications of AQP4 in Astrocytes. Int J Mol Sci (2016) 0.76
Sex Hormones Regulate Cytoskeletal Proteins Involved in Brain Plasticity. Front Psychiatry (2015) 0.76
Effect of type-2 astrocytes on the viability of dorsal root ganglion neurons and length of neuronal processes. Neural Regen Res (2014) 0.76
Heterogeneity of the blood-brain barrier. Tissue Barriers (2016) 0.76
Glial fibrillary acidic protein is one of the key factors underlying neuron-like elongation in PC12 cells. Exp Ther Med (2010) 0.75
Genomic and Proteomic Biomarker Discovery in Neurological Disease. Biomark Insights (2008) 0.75
The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell (2016) 0.75
Müller glia reactivity follows retinal injury despite the absence of the glial fibrillary acidic protein gene in Xenopus. Dev Biol (2016) 0.75
Astrocyte-mediated regulation of multidrug resistance p-glycoprotein in fetal and neonatal brain endothelial cells: age-dependent effects. Physiol Rep (2016) 0.75
Regrowth of transected retinal ganglion cell axons despite persistent astrogliosis in the lizard (Gallotia galloti). J Anat (2013) 0.75
Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons. Front Aging Neurosci (2016) 0.75
Tuberal hypothalamic expression of the glial intermediate filaments, glial fibrillary acidic protein and vimentin across the turkey hen (Meleagris gallopavo) reproductive cycle: Further evidence for a role of glial structural plasticity in seasonal reproduction. Gen Comp Endocrinol (2013) 0.75
Astrocyte heterogeneity across the brain and spinal cord occurs developmentally, in adulthood and in response to demyelination. PLoS One (2017) 0.75
Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation. Cell Mol Neurobiol (2016) 0.75
What's new in neuromyelitis optica? A short review for the clinical neurologist. J Neurol (2017) 0.75
MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism. Prog Neuropsychopharmacol Biol Psychiatry (2017) 0.75
JC Polyomavirus Attachment and Entry: Potential Sites for PML Therapeutics. Curr Clin Microbiol Rep (2017) 0.75
Expression pattern of NeuN and GFAP during human fetal spinal cord development. Childs Nerv Syst (2015) 0.75
Omega-3 fatty acids revert high-fat diet-induced neuroinflammation but not recognition memory impairment in rats. Metab Brain Dis (2017) 0.75
Myelin damage due to local quantitative abnormalities in normal prion levels: evidence from subacute combined degeneration and multiple sclerosis. J Neurol (2013) 0.75
Homocysteine induces hypophosphorylation of intermediate filaments and reorganization of actin cytoskeleton in C6 glioma cells. Cell Mol Neurobiol (2009) 0.75
Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system. Neural Regen Res (2017) 0.75
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem (2001) 7.03
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet (1996) 5.15
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet (1997) 5.11
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell (1977) 4.34
Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes. Cell (1983) 4.26
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med (1999) 3.66
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol (1988) 3.63
A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell (1992) 3.50
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A (1994) 3.33
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell (1998) 3.33
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med (2000) 3.20
Meiotic pachytene arrest in MLH1-deficient mice. Cell (1996) 3.18
Identification of two human beta-tubulin isotypes. Mol Cell Biol (1983) 3.15
Evidence that a human beta-tubulin pseudogene is derived from its corresponding mRNA. Nature (1982) 3.08
Sequence of an expressed human beta-tubulin gene containing ten Alu family members. Nucleic Acids Res (1984) 3.08
Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein. Science (1988) 3.04
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science (1994) 3.00
Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science (1983) 2.91
Observations on viral demyelinating encephalomyelitis. Canine distemper. Lab Invest (1972) 2.88
Adrenoleukodystrophy. A clinical and pathological study of 17 cases. Arch Neurol (1975) 2.86
Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol (1983) 2.85
Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet (1997) 2.85
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature (1992) 2.82
Making and reading microarrays. Nat Genet (1999) 2.81
Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1. J Immunol (1991) 2.80
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry (2007) 2.70
Lewy bodies of Parkinson's disease contain neurofilament antigens. Science (1983) 2.70
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med (1994) 2.70
Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem (2001) 2.62
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet (1999) 2.62
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med (1999) 2.61
The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol (1995) 2.57
Pathway leading to correctly folded beta-tubulin. Cell (1996) 2.55
Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med (1997) 2.51
Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A (1984) 2.51
Sequence homology requirements for intermolecular recombination in mammalian cells. Proc Natl Acad Sci U S A (1986) 2.50
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau. J Cell Sci (1992) 2.42
Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36
The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau. J Cell Biol (1989) 2.34
Late complications of immune deviation therapy in a nonhuman primate. Science (1996) 2.30
Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin. J Cell Biol (1993) 2.28
Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis. Nature (1988) 2.27
Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol (2001) 2.27
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. Mol Cell Biol (1985) 2.22
Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe. J Cell Biol (1985) 2.20
The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A (1995) 2.18
Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau. Nature (1989) 2.15
Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: detection of inactive light-chain messenger RNA. J Mol Biol (1974) 2.14
Electron microscopic observations on the cerebellar cortex in kuru. J Neurol Sci (1969) 2.14
Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin. Mol Cell Biol (1993) 2.11
Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol (1986) 2.07
Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest (1990) 2.03
Free intermingling of mammalian beta-tubulin isotypes among functionally distinct microtubules. Cell (1987) 2.02
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest (1991) 2.01
The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol (1986) 1.97
Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. J Cell Biol (1997) 1.97
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev (1999) 1.95
Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature (1984) 1.95
Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study. Lab Invest (1970) 1.93
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. Ann Neurol (1995) 1.91
Diverse mechanisms in the generation of human beta-tubulin pseudogenes. Science (1982) 1.87
Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol (1985) 1.85
Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol (1991) 1.84
Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab Invest (1984) 1.83
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med (2000) 1.82
The cytoskeleton of primary astrocytes in culture contains actin, glial fibrillary acidic protein, and the fibroblast-type filament protein, vimentin. J Neurochem (1981) 1.79
Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Ann Neurol (2001) 1.78
ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. J Cell Biol (2000) 1.76
Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J Immunol (1995) 1.76
Quantitative aspects of reactive gliosis: a review. Neurochem Res (1992) 1.74
An ultrastructural study of experimental demyelination and remyelination. I. Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest (1969) 1.73
Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell (1978) 1.73
Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol (1991) 1.73
Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Eur Respir J (1995) 1.72
Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. J Cell Biol (1999) 1.72
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest (2000) 1.72
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol (1990) 1.71
Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry (1996) 1.71
The alpha- and beta-tubulin folding pathways. Trends Cell Biol (1997) 1.70
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res (2000) 1.68
Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci U S A (1991) 1.65
Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res (1999) 1.60