Caffeine synthase gene from tea leaves.

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🔗 View Article (PMID 10984041)

Published in Nature on August 31, 2000

Authors

M Kato1, K Mizuno, A Crozier, T Fujimura, H Ashihara

Author Affiliations

1: Department of Biology, Faculty of Science, Ochanomizu University, Tokyo, Japan.

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Metabolism of H-Gibberellin A(1) and H-Gibberellin A(4) by Phaseolus coccineus Seedlings. Plant Physiol (1975) 2.39

STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med (1999) 2.36

Late thoracic outlet syndrome secondary to malunion of the fractured clavicle: case report and review of the literature. J Trauma (2001) 2.14

Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry. Cell Microbiol (2001) 2.12

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Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum (1996) 1.97

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Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine. J Biol Chem (1998) 1.95

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Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J Biol Chem (1995) 1.84

[Red free light magnifying photography in neuritis and some retinal vascular lesions]. Nihon Ganka Kiyo (1969) 1.81

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Serial transmission of a putative causative virus of enterically transmitted non-A, non-B hepatitis to Macaca fascicularis and Macaca mulatta. Jpn J Exp Med (1990) 1.34

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Analysis of an expression profile of genes in the human adipose tissue. Gene (1997) 1.32

Coinfection of hepatitis C virus in patients with chronic hepatitis B infection. J Hepatol (1994) 1.31

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Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta. EMBO J (1994) 1.30

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Gas6 induces mesangial cell proliferation via latent transcription factor STAT3. J Biol Chem (2001) 1.24

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Studies on bredinin. I. Isolation, characterization and biological properties. J Antibiot (Tokyo) (1974) 1.18

Case report ganglion cysts of the bilateral cruciate ligaments. Arthroscopy (1999) 1.18

Amino acid sequence of a beta chain of AII component of adult chicken haemoglobin. Nat New Biol (1973) 1.18

Monoclonal antibody specific to virulence-associated 15- to 17-kilodalton antigens of Rhodococcus equi. J Clin Microbiol (1993) 1.18

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Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. Am J Pathol (2001) 1.17

Cross-antigenicity among six species of dust mites and house dust antigens. J Allergy (1969) 1.16

Evaluation of functional deficits determined by four different hop tests in patients with anterior cruciate ligament deficiency. Knee Surg Sports Traumatol Arthrosc (1998) 1.16

Molecular analysis of the gene encoding a rice starch branching enzyme. Mol Gen Genet (1993) 1.16

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Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate. J Biol Chem (1994) 1.14

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem Biophys Res Commun (1980) 1.14

Mapping QTLs influencing rice floral morphology using recombinant inbred lines derived from a cross between Oryza sativa L. and Oryza rufipogon Griff. Theor Appl Genet (2003) 1.14

Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma. Int J Oncol (2001) 1.14

Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines. J Agric Food Chem (2000) 1.14