Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.

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Published in Nat Nanotechnol on October 23, 2011

Authors

H Cabral1, Y Matsumoto, K Mizuno, Q Chen, M Murakami, M Kimura, Y Terada, M R Kano, K Miyazono, M Uesaka, N Nishiyama, K Kataoka

Author Affiliations

1: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Japan.

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A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75

A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53

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A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20

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Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72

The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56

Preliminary criteria for classification of adult Still's disease. J Rheumatol (1992) 7.53

Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature (2001) 7.31

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature (1998) 7.30

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The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80

Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat Genet (1996) 6.43

Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38

Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22

A novel integron-like element carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1995) 6.00

The probability of consanguineous marriages. Genetics (1966) 5.85

Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (2000) 5.62

Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32

On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16

Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06

On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97

Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83

The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science (1999) 4.69

LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med (2000) 4.68

Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65

On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J (1997) 4.48

The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44

Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37

Smad6 inhibits signalling by the TGF-beta superfamily. Nature (1997) 4.34

The basal ganglia and adaptive motor control. Science (1994) 4.27

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem (2001) 4.22

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature (1994) 4.20

Reciprocal subsidies: dynamic interdependence between terrestrial and aquatic food webs. Proc Natl Acad Sci U S A (2001) 4.13

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08

Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00

ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell (1998) 3.98

Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol (1989) 3.89

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57

Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51

Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1979) 3.51

The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44

Effect of overall phenotypic selection on genetic change at individual loci. Proc Natl Acad Sci U S A (1978) 3.41

In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic. Antimicrob Agents Chemother (1984) 3.35

The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat Genet (1996) 3.35

Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32

Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99

Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94

Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev (1995) 2.92

Mutation and evolution at the molecular level. Genetics (1973) 2.79

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem (1996) 2.77

BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nat Genet (1996) 2.75

Gallbladder muscle dysfunction in patients with chronic acalculous disease. Gastroenterology (2001) 2.73

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res (1998) 2.63

Do rehabilitative nursing homes improve the outcomes of care? J Am Geriatr Soc (1996) 2.63

Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev (1998) 2.56

Polymicrogyria is an uncommon manifestation in 22q11.2 deletion syndrome. Am J Med Genet (2000) 2.54

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol (1992) 2.53

Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol (2001) 2.51

Role of nonimmune IgG bound to PfEMP1 in placental malaria. Science (2001) 2.50

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest (1999) 2.50

Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem (2000) 2.47

TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell (1990) 2.46

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem (1999) 2.44

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem (1996) 2.43

Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development (2001) 2.42

BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol (2000) 2.40

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J (1990) 2.38

STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med (1999) 2.36

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36

Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology (2005) 2.33

The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet (2004) 2.33

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem (1999) 2.32

The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland. J Clin Endocrinol Metab (1995) 2.32

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol (2000) 2.32

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A (2000) 2.31

Spectral response curves of single cones in the carp. Vision Res (1967) 2.30