NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

PubWeight™: 2.67‹?› | Rank: Top 1%

🔗 View Article (PMC 517812)

Published in J Clin Invest on October 01, 2000

Authors

H Kono1, I Rusyn, M Yin, E Gäbele, S Yamashina, A Dikalova, M B Kadiiska, H D Connor, R P Mason, B H Segal, B U Bradford, S M Holland, R G Thurman

Author Affiliations

1: Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599-7365, USA.

Articles citing this

(truncated to the top 100)

Liver fibrosis. J Clin Invest (2005) 17.27

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology (2012) 3.94

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Gastroenterology (2006) 3.53

Toll-like receptors as targets in chronic liver diseases. Gut (2009) 2.29

Signalling pathways in alcohol-induced liver inflammation. J Hepatol (2009) 2.29

Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol (2009) 2.26

Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology (2002) 2.18

TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest (2003) 2.16

NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90

Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology (2014) 1.73

NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One (2010) 1.69

Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59

Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J Leukoc Biol (2006) 1.56

Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol (2011) 1.52

Inflammation in alcoholic liver disease. Annu Rev Nutr (2012) 1.49

A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am J Pathol (2003) 1.41

Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol (2008) 1.37

Chronic granulomatous disease. Hematol Oncol Clin North Am (2012) 1.36

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol (2011) 1.35

NOX in liver fibrosis. Arch Biochem Biophys (2007) 1.29

Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem (2010) 1.27

Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl) (2008) 1.27

Regulation of innate immunity by NADPH oxidase. Free Radic Biol Med (2012) 1.26

Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo. Free Radic Biol Med (2008) 1.23

Mechanisms and cell signaling in alcoholic liver disease. Biol Chem (2010) 1.19

Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. Alcohol Clin Exp Res (2003) 1.18

Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Proteomics (2006) 1.16

Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicol Appl Pharmacol (2008) 1.14

Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Hepatology (2009) 1.14

Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. J Dig Dis (2012) 1.14

Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis (2010) 1.13

NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol (2011) 1.13

Kupffer cells in the liver. Compr Physiol (2013) 1.12

MicroRNA Signature in Alcoholic Liver Disease. Int J Hepatol (2012) 1.12

Rodent models of alcoholic liver disease: of mice and men. Alcohol (2012) 1.11

The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology (2005) 1.10

Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal (2014) 1.10

Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. Hepatology (2008) 1.10

Anti-inflammatory pathways and alcoholic liver disease: role of an adiponectin/interleukin-10/heme oxygenase-1 pathway. World J Gastroenterol (2010) 1.09

Alcoholic liver disease and hepatitis C: a frequently underestimated combination. World J Gastroenterol (2009) 1.08

Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin Liver Dis (2009) 1.08

Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med (2005) 1.08

Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology (2010) 1.08

NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol (2014) 1.08

Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic Biol Med (2009) 1.07

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem (2010) 1.05

Oxidative stress and inflammation: essential partners in alcoholic liver disease. Int J Hepatol (2012) 1.05

NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. J Immunol (2013) 1.04

Expression of lipopolysaccharide binding protein and its receptor CD14 in experimental alcoholic liver disease. World J Gastroenterol (2001) 1.03

Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis. J Surg Res (2009) 1.03

Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect Immun (2001) 1.02

Role of Nox2 in elimination of microorganisms. Semin Immunopathol (2008) 1.01

New role of plasminogen activator inhibitor-1 in alcohol-induced liver injury. J Gastroenterol Hepatol (2008) 1.00

Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution. AIDS (2009) 1.00

Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology (2007) 0.99

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J Gastroenterol (2014) 0.99

Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology (2009) 0.99

The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? Semin Immunopathol (2009) 0.96

Mitochondria and redox signaling in steatohepatitis. Antioxid Redox Signal (2011) 0.96

Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism. Exp Biol Med (Maywood) (2012) 0.96

CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. Int J Hepatol (2011) 0.95

Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med (2014) 0.94

Toll-like receptors in the pathogenesis of alcoholic liver disease. Gastroenterol Res Pract (2010) 0.93

Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes. Alcohol (2010) 0.93

A superoxide-hypersusceptible Salmonella enterica serovar Typhimurium mutant is attenuated but regains virulence in p47(phox-/-) mice. Infect Immun (2002) 0.93

Role of Toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol (2008) 0.93

Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease? World J Gastroenterol (2009) 0.92

CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes Nutr (2009) 0.91

PKCepsilon plays a causal role in acute ethanol-induced steatosis. Arch Biochem Biophys (2008) 0.91

Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radic Biol Med (2014) 0.90

Acute alcohol-induced liver injury. Front Physiol (2012) 0.90

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes. Gastroenterology (2016) 0.90

The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis. Alcohol Clin Exp Res (2012) 0.90

Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice. Am J Pathol (2004) 0.90

Hepatic stellate cells and innate immunity in alcoholic liver disease. World J Gastroenterol (2011) 0.89

Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma. Life Sci (2012) 0.89

Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells. Iran J Basic Med Sci (2015) 0.89

Peroxynitrite and opiate antinociceptive tolerance: a painful reality. Arch Biochem Biophys (2008) 0.86

NADPH Oxidases in Chronic Liver Diseases. Adv Hepatol (2014) 0.86

Lipid-derived free radical production in superantigen-induced interstitial pneumonia. Free Radic Biol Med (2009) 0.85

Relationship between liver function and brain shrinkage in patients with alcohol dependence. Alcohol Clin Exp Res (2011) 0.85

Targeting the redox balance in inflammatory skin conditions. Int J Mol Sci (2013) 0.84

A simple method to systematically study oxidatively modified proteins in biological samples and its applications. Methods Enzymol (2010) 0.83

Genetic resistance to liver fibrosis on A/J mouse chromosome 17. Alcohol Clin Exp Res (2013) 0.83

Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues. Free Radic Biol Med (2011) 0.83

Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model. Inflammation (2003) 0.82

Hypertension and chronic ethanol consumption: What do we know after a century of study? World J Cardiol (2014) 0.82

Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc Natl Acad Sci U S A (2015) 0.82

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease. World J Gastroenterol (2014) 0.82

Signaling mechanisms in alcoholic liver injury: role of transcription factors, kinases and heat shock proteins. World J Gastroenterol (2007) 0.82

Targeting Hepatic Fibrosis in Autoimmune Hepatitis. Dig Dis Sci (2016) 0.81

Macrophages an£1 Alcohol-Related Liver Inflammation. Alcohol Res (2015) 0.80

Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol. Nutr Res Pract (2011) 0.80

Chronic ethanol feeding modulates inflammatory mediators, activation of nuclear factor-κB, and responsiveness to endotoxin in murine Kupffer cells and circulating leukocytes. Mediators Inflamm (2014) 0.80

Synthesis of endotoxin receptor CD14 protein in Kupffer cells and its role in alcohol-induced liver disease. World J Gastroenterol (2003) 0.80

Focus on: Alcohol and the liver. Alcohol Res Health (2010) 0.80

Screening for stress-resistance mutations in the mouse. Front Genet (2014) 0.80

Analysis of nucleoside-binding proteins by ligand-specific elution from dye resin: application to Mycobacterium tuberculosis aldehyde dehydrogenases. J Struct Funct Genomics (2009) 0.80

Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2012) 0.80

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Actual causes of death in the United States. JAMA (1993) 28.34

The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30

Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A (1987) 10.43

Active oxygen species and the functions of phagocytic leukocytes. Annu Rev Biochem (1980) 5.86

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol (1988) 5.68

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev (1989) 5.61

The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med (1995) 4.25

Oxidants as stimulators of signal transduction. Free Radic Biol Med (1997) 3.43

Oxygen radicals and signaling. Curr Opin Cell Biol (1998) 3.33

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology (1999) 3.24

Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. Neuron (1997) 3.19

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition. J Biol Chem (1991) 2.80

II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol (1998) 2.76

Simulation of multiple isotropic spin-trap EPR spectra. J Magn Reson B (1994) 2.69

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. Proc Natl Acad Sci U S A (1990) 2.63

Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology (1994) 2.37

Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology (1997) 2.35

Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res (1989) 2.18

Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology (1999) 1.47

CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol (1999) 1.29

Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology (1990) 1.28

Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol (1997) 1.21

Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol (1984) 1.15

Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats. Lipids (1978) 1.09

Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1. Proc Soc Exp Biol Med (1994) 1.08

Allopurinol prevents early alcohol-induced liver injury in rats. J Pharmacol Exp Ther (2000) 1.03

Differential inhibition of prostaglandin and superoxide production by dexamethasone in primary cultures of rat Kupffer cells. Eur J Biochem (1986) 1.01

In vivo formation of a free radical metabolite of ethanol. Mol Pharmacol (1990) 0.99

Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. Am J Physiol (1997) 0.97

Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation during acute iron poisoning. Mol Pharmacol (1993) 0.96

WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes. Carcinogenesis (1998) 0.91

Role of Kupffer cells in the ethanol-induced oxidative stress in the liver. Front Biosci (1999) 0.89

Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Mol Pharmacol (1995) 0.88

Articles by these authors

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46

Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13

Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore) (2000) 7.17

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. N Engl J Med (1999) 5.82

Effects of sampling standardization on estimates of Phanerozoic marine diversification. Proc Natl Acad Sci U S A (2001) 5.27

Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet (1995) 4.46

Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) (2000) 4.45

The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med (1995) 4.25

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet (2001) 3.86

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology (1999) 3.24

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet (1999) 3.12

Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem (1972) 3.11

p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest (2001) 3.02

Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. N Engl J Med (2001) 2.75

Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology (2001) 2.72

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest (1998) 2.67

Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet (1999) 2.63

Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology (1995) 2.58

Burkholderia pseudomallei infection in a Puerto Rican patient with chronic granulomatous disease: case report and review of occurrences in the Americas. Clin Infect Dis (1998) 2.53

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science (2001) 2.52

Infectious cell entry mechanism of influenza virus. J Virol (1982) 2.41

Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology (1994) 2.37

Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology (1997) 2.35

Interferon-gamma and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev (2000) 2.29

The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood (2000) 2.24

Fibroblast growth factor 2 control of vascular tone. Nat Med (1998) 2.21

Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14

Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology (1997) 2.14

Quantifying amyloid by congo red spectral shift assay. Methods Enzymol (1999) 2.09

Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. J Biol Chem (1979) 2.03

Aspergillus nidulans infection in chronic granulomatous disease. Medicine (Baltimore) (1998) 2.03

Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br J Cancer (1995) 1.96

Viral infections in interferon-gamma receptor deficiency. J Pediatr (1999) 1.91

Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice. Infect Immun (2000) 1.87

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci U S A (1995) 1.81

Metabolic effects of ethanol in perfused rat liver. J Biol Chem (1969) 1.73

Flavin and pyridine nucleotide oxidation-reduction changes in perfused rat liver. I. Anoxia and subcellular localization of fluorescent flavoproteins. J Biol Chem (1969) 1.73

The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69

In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem Res Toxicol (1997) 1.68

Interferon-gamma in the management of infectious diseases. Ann Intern Med (1995) 1.68

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem (1998) 1.67

The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates. J Biol Chem (1982) 1.66

Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine. Am J Physiol Gastrointest Liver Physiol (2001) 1.64

Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol (2001) 1.64

Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol (1997) 1.63

Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases. Clin Infect Dis (1995) 1.63

Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. Transpl Infect Dis (2007) 1.61

Ischemic preconditioning of rat livers against cold storage-reperfusion injury: role of nonparenchymal cells and the phenomenon of heterologous preconditioning. Liver Transpl (2001) 1.59

Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance. Antimicrob Agents Chemother (2000) 1.58

Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements. Free Radic Biol Med (1999) 1.58

Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology (1998) 1.58

Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol Sci (2001) 1.56

Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Anal Biochem (1999) 1.55

The many facets of reperfusion injury. Gastroenterology (1995) 1.53

Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol (1992) 1.52

Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept. J Membr Biol (1995) 1.52

Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity (1997) 1.50

The influence of sulfide on solid-phase mercury bioavailability for methylation by pure cultures of Desulfobulbus propionicus (1pr3). Environ Sci Technol (2001) 1.50

Reduced early alcohol-induced liver injury in CD14-deficient mice. J Immunol (2001) 1.50

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci (1995) 1.50

Improved method for post-embedding cytochemistry using reduced osmium and LR white resin. J Histochem Cytochem (1994) 1.50

Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease. Proc Natl Acad Sci U S A (1997) 1.48

Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase. Circulation (2000) 1.48

The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohort. Transfusion (2010) 1.45

Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology (1997) 1.45

Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. J Exp Med (1999) 1.44

Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res (2001) 1.44

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase. Biochem Biophys Res Commun (1975) 1.43

561del4 defines a novel small deletion hotspot in the interferon-gamma receptor 1 chain. Clin Immunol (2002) 1.43

Fatal excited delirium following cocaine use: epidemiologic findings provide new evidence for mechanisms of cocaine toxicity. J Forensic Sci (1997) 1.43

Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42

The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol (1998) 1.40

Parallel studies of clonogenic leukaemia cells and the leukaemia cell population as a whole in acute myelogenous leukaemia. Eur J Cancer (1994) 1.39

Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation. J Immunol (1996) 1.39

The involvement of Kupffer cells in carbon tetrachloride toxicity. Toxicol Appl Pharmacol (1993) 1.38

Inhibition of glucagon effects in perfused rat liver by (+)decanoylcarnitine. J Biol Chem (1969) 1.37

The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. Biochemistry (1975) 1.36

Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver. Eur J Biochem (1973) 1.36

Detection of intracellular phosphorylated STAT-1 by flow cytometry. Clin Immunol (1999) 1.34