Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.

Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev (2009) 3.62

The structural basis for the mutagenicity of O(6)-methyl-guanine lesions. Proc Natl Acad Sci U S A (2006) 3.01

Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84

Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer (2012) 2.52

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A (2001) 2.26

Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J (2003) 2.25

Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chem Res Toxicol (2006) 2.25

Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct. Mol Cell Biol (2001) 2.23

Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15

Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics (2004) 1.76

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2004) 1.64

Response of human DNA polymerase iota to DNA lesions. Nucleic Acids Res (2001) 1.56

Role of human DNA polymerase kappa as an extender in translesion synthesis. Proc Natl Acad Sci U S A (2002) 1.51

Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev (2007) 1.47

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Mol Cell Biol (2004) 1.47

Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase process. EMBO J (2002) 1.43

Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics (2002) 1.43

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. J Biol Chem (2006) 1.32

Accuracy of lesion bypass by yeast and human DNA polymerase eta. Proc Natl Acad Sci U S A (2001) 1.32

Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics (2005) 1.28

Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanine. Mol Cell Biol (2003) 1.22

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J Biol Chem (2009) 1.21

Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate. Proc Natl Acad Sci U S A (2003) 1.12

Acidic residues critical for the activity and biological function of yeast DNA polymerase eta. Mol Cell Biol (2001) 1.12

Variations on a theme: eukaryotic Y-family DNA polymerases. Biochim Biophys Acta (2009) 1.10

Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. EMBO J (2001) 1.09

A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair. Genes Dev (2003) 1.05

The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme. Mol Cell Biol (2003) 1.01

Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. Genes Dev (2003) 0.98

Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases. Nucleic Acids Res (2010) 0.96

UV-induced T-->C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase eta in vivo. Nucleic Acids Res (2002) 0.94

Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. J Biol Chem (2010) 0.94

In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine. Chem Res Toxicol (2012) 0.90

Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. Cell Rep (2014) 0.87

Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae. Mutagenesis (2009) 0.86

DNA polymerase eta and chemotherapeutic agents. Antioxid Redox Signal (2011) 0.86

Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. Mol Cell Biol (2005) 0.84

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy. PLoS One (2013) 0.81

Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β. J Am Chem Soc (2014) 0.81

Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chem Res Toxicol (2012) 0.81

Lesion Orientation of O(4)-Alkylthymidine Influences Replication by Human DNA Polymerase η. Chem Sci (2016) 0.80

Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine. J Mol Biol (2011) 0.80

Genetic instability in budding and fission yeast-sources and mechanisms. FEMS Microbiol Rev (2015) 0.80

Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae. PLoS Biol (2014) 0.79

The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. DNA Repair (Amst) (2010) 0.79

Mutagenic bypass of the butadiene-derived 2'-deoxyuridine adducts by polymerases eta and zeta. Mutat Res (2007) 0.77

The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells. Adv Biosci Biotechnol (2015) 0.75

DNA polymerases in the mitochondria: A critical review of the evidence. Front Biosci (Landmark Ed) (2017) 0.75

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Res (2017) 0.75

Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases. Chem Res Toxicol (2016) 0.75

NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro. DNA Repair (Amst) (2017) 0.75

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature (1991) 9.70

hRAD30 mutations in the variant form of xeroderma pigmentosum. Science (1999) 7.40

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science (1999) 7.20

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell (1995) 5.54

Biochemical basis of DNA replication fidelity. Crit Rev Biochem Mol Biol (1993) 4.69

Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39

Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies. Methods Enzymol (1995) 3.65

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet (2000) 3.39

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase. J Biol Chem (1990) 3.38

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem (1997) 3.11

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci U S A (1993) 3.07

Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta. Proc Natl Acad Sci U S A (2000) 2.89

Mutagenic specificity: reversion of iso-1-cytochrome c mutants of yeast. J Mol Biol (1973) 2.88

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion site. Biochemistry (1991) 2.59

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A (1996) 2.57

Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta. J Biol Chem (1999) 2.54

The role of DNA mismatch repair in drug resistance. Clin Cancer Res (1998) 2.49

Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem (1998) 2.42

X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. Proc Natl Acad Sci U S A (1995) 2.30

Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: implication in mutagenesis and repair activity. Photochem Photobiol (1995) 2.07

NMR studies of a DNA containing 8-hydroxydeoxyguanosine. Nucleic Acids Res (1991) 2.03

Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs. Biochemistry (1994) 2.01

Thymine dimers bend DNA. Proc Natl Acad Sci U S A (1988) 1.86

Determination of pyrimidine dimer unwinding angle by measurement of DNA electrophoretic mobility. J Mol Biol (1982) 1.84

1H NMR study of the exchangeable protons of the duplex d(GCGTTGCG).d(CGCAACGC) containing a thymine photodimer. Nucleic Acids Res (1987) 1.78

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature (1981) 1.72

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature (1980) 1.71

Thermodynamic comparison of the base pairs formed by the carcinogenic lesion O6-methylguanine with reference both to Watson-Crick pairs and to mismatched pairs. Biochemistry (1989) 1.60

Site-specific effect of thymine dimer formation on dAn.dTn tract bending and its biological implications. Proc Natl Acad Sci U S A (1991) 1.43

High-resolution structure of a mutagenic lesion in DNA. Proc Natl Acad Sci U S A (1990) 1.38

Structural studies of the O6meG.C interaction in the d(C-G-C-G-A-A-T-T-C-O6meG-C-G) duplex. Biochemistry (1986) 1.36

O6-benzylguanine and its role in chemotherapy. Clin Cancer Res (1997) 1.36

Structural studies of the O6meG.T interaction in the d(C-G-T-G-A-A-T-T-C-O6meG-C-G) duplex. Biochemistry (1986) 1.28

Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences. Biochemistry (1991) 1.26

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes. Proc Natl Acad Sci U S A (1989) 1.24

Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine. Proc Natl Acad Sci U S A (1987) 1.19

The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level. Cancer Invest (1997) 1.16

Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication. Nucleic Acids Res (1997) 0.98

Kinetic analysis of the coding properties of O6-methylguanine in DNA: the crucial role of the conformation of the phosphodiester bond. Biochemistry (1994) 0.96

O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.C pairing in dodecanucleotide duplexes. Biochemistry (1989) 0.90

Replication across O6-methylguanine by human DNA polymerase beta in vitro. Insights into the futile cytotoxic repair and mutagenesis of O6-methylguanine. J Biol Chem (1996) 0.88

O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.T pairing in dodecanucleotide duplexes. Biochemistry (1989) 0.86

O6-methylguanine-induced replication blocks. Carcinogenesis (1995) 0.86

Human tumor cell strains defective in the repair of alkylation damage. Carcinogenesis (1980) 0.82

Enhanced cell killing and mutagenesis by ethylnitrosourea in xeroderma pigmentosum cells. Carcinogenesis (1981) 0.78

A molecular approach to the study of genic heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura. Genetics (1969) 16.51

A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila. Proc Natl Acad Sci U S A (1968) 8.98

hRAD30 mutations in the variant form of xeroderma pigmentosum. Science (1999) 7.40

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science (1999) 7.20

The Y-family of DNA polymerases. Mol Cell (2001) 6.49

Effects of the RAD52 Gene on Recombination in SACCHAROMYCES CEREVISIAE. Genetics (1980) 6.07

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature (2000) 5.48

Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res (1999) 5.35

Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast (1990) 5.00

Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39

Chromosome interactions in Drosophila robusta. Genetics (1967) 3.75

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev (1994) 3.61

Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev (2001) 3.59

Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of Saccharomyces cerevisiae. J Bacteriol (1981) 3.45

Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP. EMBO J (1988) 3.43

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet (2000) 3.39

ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal. Mol Cell (2001) 3.36

Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations. Mol Gen Genet (1981) 3.31

RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination. Mol Cell Biol (1988) 3.27

Genic variation in a natural population of Drosophila persimilis. Proc Natl Acad Sci U S A (1969) 3.22

Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. Mol Cell Biol (1992) 3.12

Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem (1997) 3.11

RAD3 protein of Saccharomyces cerevisiae is a DNA helicase. Proc Natl Acad Sci U S A (1987) 2.97

Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta. Proc Natl Acad Sci U S A (2000) 2.89

Mutagenic specificity: reversion of iso-1-cytochrome c mutants of yeast. J Mol Biol (1973) 2.88

Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Mol Cell (2001) 2.88

Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84

Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics (1977) 2.83

DNA repair genes and proteins of Saccharomyces cerevisiae. Annu Rev Genet (1993) 2.81

RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcription. Nature (1994) 2.73

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J Biol Chem (1996) 2.72

The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity. Genes Dev (1988) 2.71

Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell (2001) 2.65

Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH. J Biol Chem (1995) 2.65

Origin of reproductive isolation in the absence of apparent genic differentiation in a geographic isolate of Drosophila pseudoobscura. Genetics (1972) 2.60

Nucleotide excision repair in yeast. Mutat Res (2000) 2.54

Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta. J Biol Chem (1999) 2.54

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc Natl Acad Sci U S A (1991) 2.53

Lack of chemically induced mutation in repair-deficient mutants of yeast. Genetics (1974) 2.51

The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function. Mol Cell Biol (1993) 2.50

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA. Science (1995) 2.49

Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase. Mol Cell Biol (1985) 2.48

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev (1998) 2.46

RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination. Mol Cell Biol (1990) 2.45

Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage. Mol Cell Biol (1989) 2.43

Isolation and characterization of the RAD3 gene of Saccharomyces cerevisiae and inviability of rad3 deletion mutants. Proc Natl Acad Sci U S A (1983) 2.38

RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates. Proc Natl Acad Sci U S A (1985) 2.32

Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts. Mol Cell Biol (2001) 2.28

Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease. Nature (1993) 2.27

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A (2001) 2.26

Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature (1993) 2.25

Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems. J Biol Chem (1995) 2.23

Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct. Mol Cell Biol (2001) 2.23

The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway. Genetics (1990) 2.19

The nucleotide sequence of the RAD3 gene of Saccharomyces cerevisiae: a potential adenine nucleotide binding amino acid sequence and a nonessential acidic carboxyl terminal region. Nucleic Acids Res (1985) 2.18

Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem (2001) 2.15

Gene differences between third-chromosome inversions of Drosophila pseudobscura. Genetics (1976) 2.15

The human DINB1 gene encodes the DNA polymerase Poltheta. Proc Natl Acad Sci U S A (2000) 2.12

Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. J Biol Chem (1999) 2.11

Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair. J Biol Chem (1996) 2.10