Variations on a theme: eukaryotic Y-family DNA polymerases.

Error-prone translesion synthesis mediates acquired chemoresistance. Proc Natl Acad Sci U S A (2010) 1.85

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A (2013) 1.30

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA. Proc Natl Acad Sci U S A (2011) 1.04

PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. Subcell Biochem (2012) 1.01

Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases η and κ and Rev1 in error-prone translesion synthesis. Biochemistry (2014) 0.93

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis. J Mol Biol (2011) 0.91

Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases. Biochemistry (2014) 0.88

DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol (2012) 0.88

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ. DNA Repair (Amst) (2013) 0.83

Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein. DNA Repair (Amst) (2011) 0.82

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. Proc Natl Acad Sci U S A (2016) 0.82

The Roles of UmuD in Regulating Mutagenesis. J Nucleic Acids (2010) 0.82

Selective disruption of the DNA polymerase III α-β complex by the umuD gene products. Nucleic Acids Res (2012) 0.81

Multiple strategies for translesion synthesis in bacteria. Cells (2012) 0.80

Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80

The Many Roles of PCNA in Eukaryotic DNA Replication. Enzymes (2016) 0.79

Bypass of a psoralen DNA interstrand cross-link by DNA polymerases β, ι, and κ in vitro. Biochemistry (2012) 0.79

Architecture of y-family DNA polymerases relevant to translesion DNA synthesis as revealed in structural and molecular modeling studies. J Nucleic Acids (2010) 0.78

Polymerase manager protein UmuD directly regulates Escherichia coli DNA polymerase III α binding to ssDNA. Nucleic Acids Res (2013) 0.77

R.I.P. to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance. Bioessays (2016) 0.77

Structural model of the Y-Family DNA polymerase V/RecA mutasome. J Mol Graph Model (2012) 0.76

Synthetic nucleotides as probes of DNA polymerase specificity. J Nucleic Acids (2012) 0.75

Contiguous 2,2,4-triamino-5(2H)-oxazolone obstructs DNA synthesis by DNA polymerases α, β, η, ι, κ, REV1 and Klenow Fragment exo-, but not by DNA polymerase ζ. J Biochem (2015) 0.75

Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis. PLoS One (2016) 0.75

Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases. Genes (Basel) (2017) 0.75

Structure and functional analysis of the BRCT domain of translesion synthesis DNA polymerase Rev1. Biochemistry (2012) 0.75

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA. Biochemistry (2017) 0.75

A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases. Theor Biol Med Model (2011) 0.75

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature (1998) 10.49

hRAD30 mutations in the variant form of xeroderma pigmentosum. Science (1999) 7.40

DNA replication fidelity. Annu Rev Biochem (2000) 7.29

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science (1999) 7.20

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell (2004) 6.12

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature (2000) 5.48

Structure of the replicating complex of a pol alpha family DNA polymerase. Cell (2001) 5.26

DNA polymerases: structural diversity and common mechanisms. J Biol Chem (1999) 5.00

Deoxycytidyl transferase activity of yeast REV1 protein. Nature (1996) 4.96

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. Biochemistry (1991) 4.55

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J (2004) 4.42

Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39

DNA replication fidelity. J Biol Chem (2004) 4.28

The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics (1997) 4.04

Kinetic mechanism of DNA polymerase I (Klenow). Biochemistry (1987) 3.93

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics. Biochemistry (1991) 3.86

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60

Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev (2001) 3.59

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature (2004) 3.57

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet (2000) 3.39

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase. J Biol Chem (1990) 3.38

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol (1998) 3.31

An open and closed case for all polymerases. Structure (1999) 3.26

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15

poliota, a remarkably error-prone human DNA polymerase. Genes Dev (2000) 3.08

Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta. Proc Natl Acad Sci U S A (2000) 2.89

Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Mol Cell (2001) 2.88

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. Biochemistry (1988) 2.86

A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity. Proc Natl Acad Sci U S A (1997) 2.85

Low fidelity DNA synthesis by human DNA polymerase-eta. Nature (2000) 2.85

Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84

Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure (2003) 2.77

Structures of mismatch replication errors observed in a DNA polymerase. Cell (2004) 2.70

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J (2003) 2.69

Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature (2004) 2.68

Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell (2001) 2.65

Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1. Proc Natl Acad Sci U S A (2005) 2.62

Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta. J Biol Chem (1999) 2.54

Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell (2007) 2.46

Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43

Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Genes Dev (2000) 2.38

Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science (2005) 2.37

Evidence for a second function for Saccharomyces cerevisiae Rev1p. Mol Microbiol (2000) 2.29

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A (2001) 2.26

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Nucleic Acids Res (2000) 2.25

Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct. Mol Cell Biol (2001) 2.23

Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15

Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem (2001) 2.15

Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site. EMBO J (2004) 2.14

The human DINB1 gene encodes the DNA polymerase Poltheta. Proc Natl Acad Sci U S A (2000) 2.12

Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. J Biol Chem (1999) 2.11

Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability. Mol Gen Genet (1998) 2.11

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity. Structure (2004) 2.10

Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota. Mol Cell Biol (2000) 2.08

Error-prone lesion bypass by human DNA polymerase eta. Nucleic Acids Res (2000) 2.07

Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J Biol Chem (2000) 2.06

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02

Replication past O(6)-methylguanine by yeast and human DNA polymerase eta. Mol Cell Biol (2000) 1.95

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94

Yeast Rev1 protein is a G template-specific DNA polymerase. J Biol Chem (2002) 1.86

The mechanism of action of T7 DNA polymerase. Curr Opin Struct Biol (1998) 1.86

Error rate and specificity of human and murine DNA polymerase eta. J Mol Biol (2001) 1.86

REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell (2006) 1.85

Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Structure (2005) 1.80

Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry (2000) 1.75

Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Structure (2008) 1.72

Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71

Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Biochemistry (2002) 1.71

Cellular functions of DNA polymerase zeta and Rev1 protein. Adv Protein Chem (2004) 1.67

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2004) 1.64

Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Cell (2001) 1.63

Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63

Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. J Biol Chem (2006) 1.62

Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions. Mol Cell Biol (2006) 1.61

trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases. J Biol Chem (2002) 1.60

Inefficient bypass of an abasic site by DNA polymerase eta. J Biol Chem (2000) 1.60

Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. Proc Natl Acad Sci U S A (2002) 1.59

Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat Struct Mol Biol (2006) 1.58

Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA. Biochemistry (2001) 1.57

Functional hydrogen-bonding map of the minor groove binding tracks of six DNA polymerases. Biochemistry (2000) 1.57

Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. EMBO J (2000) 1.56

Ubiquitination of PCNA and the polymerase switch in human cells. Cell Cycle (2004) 1.53

Role of human DNA polymerase kappa as an extender in translesion synthesis. Proc Natl Acad Sci U S A (2002) 1.51

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Mol Cell Biol (2004) 1.47

Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Biochemistry (2002) 1.47

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Proc Natl Acad Sci U S A (2002) 1.46

Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta. Proc Natl Acad Sci U S A (2003) 1.45

Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity. Nucleic Acids Res (2000) 1.41

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Nat Struct Mol Biol (2004) 1.40

Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta. J Biol Chem (2002) 1.40

A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage. J Biol Chem (2007) 1.39

Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese. J Biol Chem (2007) 1.38

Activities of human DNA polymerase kappa in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion. DNA Repair (Amst) (2002) 1.37

Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines. EMBO J (2001) 1.36

Crystal structure of the catalytic core of human DNA polymerase kappa. Structure (2004) 1.35

Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Mol Cell Biol (2005) 1.33

An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure (2006) 1.31

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA. Proc Natl Acad Sci U S A (2011) 1.04

PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. Subcell Biochem (2012) 1.01

Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases. Nucleic Acids Res (2010) 0.96

An alternative form of replication protein a prevents viral replication in vitro. J Biol Chem (2008) 0.90

Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways. J Am Chem Soc (2014) 0.80

Bradykinetic alcohol dehydrogenases make yeast fitter for growth in the presence of allyl alcohol. Chem Biol Interact (2012) 0.76