Published in Biochem Pharmacol on June 15, 1979
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A (1993) 4.82
Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci U S A (1986) 3.78
Mechanism of action of some inhibitors of endothelium-derived relaxing factor. Proc Natl Acad Sci U S A (1986) 2.03
Bradykinin-stimulated electrolyte secretion in rabbit and guinea pig intestine. Involvement of arachidonic acid metabolites. J Clin Invest (1983) 1.45
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. Gut (1983) 1.37
The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. Br J Pharmacol (1981) 1.25
Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores. Biochem J (1991) 1.24
TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite. EMBO J (1991) 1.19
The effect of anti-inflammatory drugs on eicosanoid formation in a chronic model of inflammatory bowel disease in the rat. Br J Pharmacol (1988) 1.18
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. Br J Pharmacol (1993) 1.13
2-substituted indazolinones: orally active and selective 5-lipoxygenase inhibitors with anti-inflammatory activity. Br J Pharmacol (1990) 1.11
Adventures in vascular biology: a tale of two mediators. Philos Trans R Soc Lond B Biol Sci (2006) 1.10
Pharmacological characterization of polycation-induced rat hind-paw oedema. Br J Pharmacol (1990) 1.10
The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action. Drugs (1987) 1.07
Dual effect of (-)-N6-phenylisopropyl adenosine on guinea-pig trachea. Br J Pharmacol (1984) 1.04
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses. Br J Pharmacol (1988) 1.04
Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression. Am J Pathol (1984) 1.01
Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation. Br J Pharmacol (1988) 1.00
Role of lipoxygenase products in murine pulmonary granuloma formation. J Clin Invest (1984) 0.99
Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anaesthetized guinea-pigs. Br J Pharmacol (1982) 0.97
Induction of zymosan-air-pouch inflammation in rats and its characterization with reference to the effects of anticomplementary and anti-inflammatory agents. Br J Pharmacol (1983) 0.96
Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages. Br J Pharmacol (1980) 0.96
Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts. Br J Pharmacol (1984) 0.92
12-lipoxygenase: a potential target for novel anti-platelet therapeutics. Cardiovasc Hematol Agents Med Chem (2011) 0.92
The anti-inflammatory effect of glucocorticoid-induced phospholipase inhibitory proteins. Agents Actions (1985) 0.92
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis. Biochem J (1984) 0.90
Different patterns of release of endothelium-derived relaxing factor and prostacyclin. Br J Pharmacol (1992) 0.90
Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice. Br J Pharmacol (1990) 0.89
Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid. Br J Pharmacol (1985) 0.89
Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis. Br J Pharmacol (1983) 0.88
The effect of mixed inhibitors of cyclo-oxygenase and lipoxygenase on the indomethacin-induced hyper-reactivity in the isolated trachea of the pig. Br J Pharmacol (1982) 0.87
The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclo-oxygenase inhibitors. Br J Pharmacol (1983) 0.87
Increased leukotriene B4 synthesis in immune injured rat glomeruli. J Clin Invest (1988) 0.86
Phospholipase A2 inhibition prevents mucosal damage associated with small intestinal ischaemia in rats. Gut (1988) 0.83
Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. Br J Pharmacol (1987) 0.82
Stimulation and inhibition of prostacyclin formation in the gastric mucosa and ileum in vitro by anti-inflammatory agents. Br J Pharmacol (1983) 0.82
Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187. Br J Pharmacol (1985) 0.81
Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs. Br J Pharmacol (1989) 0.81
Interdependence of contractile responses of rat small mesenteric arteries on nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid. Br J Pharmacol (1994) 0.81
Pharmacological studies into cyclo-oxygenase, lipoxygenase and phospholipase in smooth muscle contraction in the isolated trachea. Br J Pharmacol (1984) 0.81
Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. Immunology (1985) 0.80
A major role for phospholipase A2 in antigen-induced arachidonic acid release in rat mast cells. Biochem J (1987) 0.80
Platelet release reaction and aggregation induced by canatoxin, a convulsant protein: evidence for the involvement of the platelet lipoxygenase pathway. Br J Pharmacol (1985) 0.80
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals. Ann Rheum Dis (1988) 0.80
Effects of antiinflammatory agents on chronic Salmonella typhimurium infection in a mouse model. Infect Immun (1983) 0.79
Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C. Proc Natl Acad Sci U S A (1984) 0.79
Calcium ionophore A23187 induces release of chemokinetic and aggregating factors from polymorphonuclear leucocytes. Br J Pharmacol (1980) 0.79
High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase. Biochem J (1988) 0.79
Relative roles of nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid in the contractile responses of rat renal arcuate arteries. Br J Pharmacol (1994) 0.78
Effect of synthetic PAF-acether on human neutrophil function. Agents Actions (1981) 0.78
Corneal reepithelialization and anti-inflammatory agents. Trans Am Ophthalmol Soc (1982) 0.78
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride. Am J Pathol (1991) 0.77
Proceedings of the British Pharmacological Society. 17th-19th December, 1979: University of London (Institute of Education). Br J Pharmacol (1980) 0.75
Proceedings of the British Pharmacological Society, University of Cambridge, 6th-8th April, 1983. Abstracts. Br J Pharmacol (1983) 0.75
The effects of arachidonic acid and non-steroidal anti-inflammatory drugs on intrapulmonary airways of the guinea-pig. Br J Pharmacol (1984) 0.75
Proceedings of the British Pharmacological Society. 9th-11th September 1985. Abstracts. Br J Pharmacol (1985) 0.75
Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride. Proc Natl Acad Sci U S A (1986) 0.75
Influence of niridazole and chloroquine on arterial and myometrial prostacyclin synthesis. Br J Pharmacol (1987) 0.75
A neutrophil-derived cytochrome P450-dependent metabolite of arachidonic acid modulates neutrophil behavior. Am J Pathol (1987) 0.75
Examination of chemotactic properties of bovine mammary macrophages. Can J Vet Res (1991) 0.75
Dissociation between the effects of zymosan on the systemic and pulmonary vessels of the rat. Br J Pharmacol (1991) 0.75
Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC. Evid Based Complement Alternat Med (2017) 0.75
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol (1971) 37.53
Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature (1969) 13.60
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (1976) 13.19
Prostaglandins: their disappearance from and release into the circulation. Nature (1967) 8.66
The release and fate of vaso-active hormones in the circulation. Br J Pharmacol (1969) 7.90
Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev (1974) 7.76
Prostaglandins released by the spleen. Nature (1968) 7.61
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A (1999) 5.96
Indomethacin and aspirin abolish prostaglandin release from the spleen. Nat New Biol (1971) 5.62
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A (1993) 4.82
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A (1988) 4.77
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev (1978) 4.66
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54
Inactivation of prostaglandins by the lungs. Nature (1970) 4.47
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins (1976) 4.44
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature (1979) 4.41
Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature (1980) 4.29
Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet (1977) 4.11
The importance of phospholipase-A2 in prostaglandin biosynthesis. Biochem Pharmacol (1976) 3.88
Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci U S A (1986) 3.78
Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. Prostaglandins (1977) 3.74
Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet (1978) 3.74
The chemical structure of prostaglandin X (prostacyclin). Prostaglandins (1976) 3.63
Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nat New Biol (1972) 3.54
Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (1972) 3.30
Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med (1979) 3.29
Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res (1977) 3.28
Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (1973) 3.20
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled. Proc Natl Acad Sci U S A (1988) 2.84
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83
Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature (1991) 2.82
A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis. Br J Pharmacol (1975) 2.79
Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins (1977) 2.67
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci U S A (1990) 2.63
Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species. Prostaglandins (1980) 2.59
Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro. Br J Pharmacol (1972) 2.53
Pharmacokinetic function of the pulmonary circulation. Physiol Rev (1974) 2.52
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br J Pharmacol (1972) 2.52
Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull (1978) 2.51
Prostaglandins, oxygen tension and smooth muscle tone. Br J Pharmacol (1972) 2.51
Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther (1973) 2.48
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Br J Pharmacol Chemother (1967) 2.44
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br J Pharmacol (1973) 2.42
Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids. Br J Pharmacol (1978) 2.41
Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle. Prostaglandins (1973) 2.39
The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure. Proc Natl Acad Sci U S A (1995) 2.36
The contribution of prostaglandin production to contractions of the isolated uterus of the rat. Br J Pharmacol (1973) 2.33
Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol (1993) 2.32
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins (1976) 2.28
Conversion of angiotensin I to angiotensin II. Nature (1967) 2.26
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature (1980) 2.24
Release of prostaglandin E-1 from the rat stomach. Nature (1967) 2.13
Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci U S A (1989) 2.08
Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br J Pharmacol (1973) 2.07
The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings]. Br J Pharmacol (1976) 2.06
The release of catechol amines from the adrenal medulla by histamine. Br J Pharmacol Chemother (1965) 2.00
Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol (1999) 1.99
Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci U S A (1993) 1.96
Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nat Med (1996) 1.96
Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat. Eur J Pharmacol (1989) 1.95
Fate of angiotensin I in the circulation. Nature (1968) 1.94
Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochem Biophys Res Commun (1990) 1.94
Anti-phospholipase proteins. Prostaglandins (1984) 1.93
Metabolism of the angiotensins in isolated perfused tissues. Nature (1969) 1.91
5-hydroxytryptamine in the circulation of the dog. Nature (1967) 1.88
Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone. Lancet (1990) 1.88
The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. Br J Pharmacol (1977) 1.87
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. Prostaglandins (1978) 1.85
Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1alpha with those of prostaglandin E2 in rats and rabbits. Br J Pharmacol (1978) 1.85
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. Proc Natl Acad Sci U S A (1989) 1.82
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol (1994) 1.82
Proceedings: Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum. Br J Pharmacol (1972) 1.80
The detection and estimation of bradykinin in the circulating blood. Br J Pharmacol Chemother (1967) 1.80
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci U S A (1987) 1.80
Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br J Pharmacol (1982) 1.74
Inflammatory effects of prostaglandin D2 in rat and human skin. Br J Pharmacol (1976) 1.69
The electronic aggregometer: a novel device for assessing platelet behavior in blood. J Pharmacol Methods (1980) 1.66
The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. J Physiol (1966) 1.66
Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids. Nature (1976) 1.65
Inhibition of phospholipase. Br Med Bull (1983) 1.65
The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins. Br J Pharmacol (1972) 1.65
Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol (1995) 1.63
Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung. Nature (1987) 1.63
Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A (1998) 1.60
Prostacyclin is a circulating hormone. Nature (1978) 1.60
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol (2000) 1.57
Synthesis of 6-keto-PGF1alpha by ram seminal vesicle microsomes. Prostaglandins (1977) 1.57
Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. J Immunol (1993) 1.57
Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition. Prostaglandins (1976) 1.56
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci U S A (1997) 1.52