Published in J Biol Chem on October 18, 2000
How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. Microbiol Mol Biol Rev (2006) 6.39
Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proc Natl Acad Sci U S A (2012) 1.45
A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Mol Cell (2007) 1.43
Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation. Microbiol Mol Biol Rev (2014) 1.31
A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase. Protein Sci (2001) 1.27
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry (2010) 1.08
Evolution of bacterial phosphoglycerate mutases: non-homologous isofunctional enzymes undergoing gene losses, gains and lateral transfers. PLoS One (2010) 0.99
Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2. Biochemistry (2009) 0.92
Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. J Bacteriol (2006) 0.88
Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae. J Biol Chem (2010) 0.85
Characterization of cofactor-dependent and cofactor-independent phosphoglycerate mutases from Archaea. Extremophiles (2007) 0.84
Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis. J Biol Chem (2013) 0.79
Unliganded structure of human bisphosphoglycerate mutase reveals side-chain movements induced by ligand binding. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.79
Structure of Leishmania major cysteine synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase. J Biol Chem (2014) 0.77
Energetic Coupling between Ligand Binding and Dimerization in Escherichia coli Phosphoglycerate Mutase. Biochemistry (2016) 0.75
Purification, crystallization and preliminary X-ray crystallographic analysis of the archaeal phosphoglycerate mutase PH0037 from Pyrococcus horikoshii OT3. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis. Proc Natl Acad Sci U S A (2016) 0.75
New insights into the catalytic mechanism of histidine phosphatases revealed by a functionally essential arginine residue within the active site of the Sts phosphatases. Biochem J (2013) 0.75
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes (1999) 7.14
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Visual processing impairment and risk of motor vehicle crash among older adults. JAMA (1998) 4.49
Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J (1993) 3.80
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41
Nucleosome mobilization catalysed by the yeast SWI/SNF complex. Nature (1999) 3.28
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet (1999) 3.27
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Structure of an adenine-cytosine base pair in DNA and its implications for mismatch repair. Nature (1986) 3.00
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A (1992) 2.75
Molecular structure of the G.A base pair in DNA and its implications for the mechanism of transversion mutations. Proc Natl Acad Sci U S A (1986) 2.46
IRS-2 pathways integrate female reproduction and energy homeostasis. Nature (2000) 2.45
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol (1993) 2.44
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem (2000) 2.32
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest (1992) 2.31
The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 2.17
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci U S A (1984) 2.09
IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. Endocrinology (1993) 2.07
Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem (1995) 2.06
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05
DNA conformation is determined by economics in the hydration of phosphate groups. Nature (1987) 2.04
Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs. Biochemistry (1994) 2.01
Expression and function of IRS-1 in insulin signal transmission. J Biol Chem (1992) 1.98
Human IL6 enhances leptin action in mice. Diabetologia (2009) 1.98
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol (1995) 1.97
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem (2000) 1.95
The junction-resolving enzymes. Nat Rev Mol Cell Biol (2001) 1.89
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem (1996) 1.85
Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol (1996) 1.81
Cross-talk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci U S A (1996) 1.81
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A (1992) 1.79
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem (1988) 1.74
The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution. J Biol Chem (1987) 1.72
The IRS-signalling system during insulin and cytokine action. Bioessays (1997) 1.71
Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol Cell Biol (1996) 1.70
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem (2000) 1.67
The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta (1985) 1.64
Structure of Alba: an archaeal chromatin protein modulated by acetylation. EMBO J (2002) 1.61
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci U S A (1993) 1.58
Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus. Nucleic Acids Res (2001) 1.58
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes (1993) 1.57
Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. J Biol Chem (1984) 1.56
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem (1995) 1.56
Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol (1988) 1.55
The IRS-1 signaling system. Trends Biochem Sci (1994) 1.53
Role of IRS-1-GRB-2 complexes in insulin signaling. Mol Cell Biol (1994) 1.53
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J Biol Chem (1994) 1.52
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J Biol Chem (1992) 1.50
The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells. Anal Biochem (1981) 1.47
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. J Biol Chem (2001) 1.45
Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin. J Biol Chem (1985) 1.45
Characterization of the insulin receptor kinase purified from human placental membranes. J Biol Chem (1983) 1.45
The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins. J Mol Biol (2000) 1.44
The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA. Nature (1986) 1.43
Inosine.adenine base pairs in a B-DNA duplex. Nucleic Acids Res (1987) 1.40
Oligonucleotide structure: a decade of results from single crystal X-ray diffraction studies. Q Rev Biophys (1989) 1.40
Operative laparoscopy: removal of intra-abdominal IUD with biopsy tongs. Obstet Gynecol (1970) 1.39
The crystal structure of a class II fructose-1,6-bisphosphate aldolase shows a novel binuclear metal-binding active site embedded in a familiar fold. Structure (1996) 1.39
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem (1988) 1.39
Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem (1993) 1.38
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem (1998) 1.35
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol Endocrinol (1997) 1.34
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem (1995) 1.34
DNA-drug interactions. The crystal structure of d(CGATCG) complexed with daunomycin. J Mol Biol (1989) 1.33
Crystal and molecular structure of r(CGCGAAUUAGCG): an RNA duplex containing two G(anti).A(anti) base pairs. Structure (1994) 1.33
The crystal structure of Escherichia coli class II fructose-1, 6-bisphosphate aldolase in complex with phosphoglycolohydroxamate reveals details of mechanism and specificity. J Mol Biol (1999) 1.32
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. J Biol Chem (1985) 1.32
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem (1996) 1.31
Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem (1995) 1.31
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. J Biol Chem (1995) 1.30
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A (1993) 1.30
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem (1998) 1.29
An archaeal XPF repair endonuclease dependent on a heterotrimeric PCNA. Mol Microbiol (2003) 1.29
Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus. Proc Natl Acad Sci U S A (2001) 1.28
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors. Structure (1999) 1.28
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Nat Struct Biol (2001) 1.27
IRS proteins and beta-cell function. Diabetes (2001) 1.26
Determining significant fold differences in gene expression analysis. Pac Symp Biocomput (2001) 1.25
Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.25
Characterization of an endogenous substrate of the insulin receptor in cultured cells. J Biol Chem (1987) 1.24
Refined crystal structure of an octanucleotide duplex with G . T mismatched base-pairs. J Mol Biol (1986) 1.24
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res (1998) 1.24
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem (1995) 1.23
Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22
Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. J Biol Chem (1982) 1.22
The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett (1999) 1.20
Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin. Mol Cell Biol (1997) 1.20
M-plasty techniques. J Dermatol Surg (1976) 1.19
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells. J Cell Biol (1987) 1.19
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem (1996) 1.18
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc Natl Acad Sci U S A (1996) 1.18