Published in Am J Hum Genet on September 12, 2002
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
In hypertension, the kidney is not always the heart of the matter. J Clin Invest (2005) 1.17
Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study. Hypertension (2008) 1.10
A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. Nephrol Dial Transplant (2008) 1.08
Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island. Eur J Hum Genet (2010) 1.04
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS One (2012) 1.03
Linkage mapping of CVD risk traits in the isolated Norfolk Island population. Hum Genet (2008) 0.97
Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates. PLoS One (2013) 0.86
An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP). Hum Genet (2007) 0.84
A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18. Eur J Hum Genet (2013) 0.84
African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32. Am J Hum Genet (2003) 0.83
Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension. Small GTPases (2014) 0.82
Exploring pleiotropy using principal components. BMC Genet (2003) 0.81
Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations. BMC Med Genet (2009) 0.77
Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population. PLoS One (2013) 0.77
Genome-wide linkage and positional association study of blood pressure response to dietary sodium intervention: the GenSalt Study. Am J Epidemiol (2012) 0.76
Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study. BMC Cardiovasc Disord (2014) 0.75
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet (1999) 25.93
Faster sequential genetic linkage computations. Am J Hum Genet (1993) 18.83
Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet (1996) 17.95
The affected-pedigree-member method of linkage analysis. Am J Hum Genet (1988) 13.67
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension (1995) 10.38
Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nat Genet (1994) 10.35
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension (2000) 8.84
Avoiding recomputation in linkage analysis. Hum Hered (1994) 8.39
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
Allele frequency estimation from data on relatives. Am J Hum Genet (1991) 5.62
Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Opin Biotechnol (1998) 5.36
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29
Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping. Am J Hum Genet (1999) 4.79
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Use of population isolates for mapping complex traits. Nat Rev Genet (2000) 4.28
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet (1997) 3.51
Population choice in mapping genes for complex diseases. Nat Genet (1999) 3.36
Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP). Hypertension (2002) 3.32
Strategies for characterizing highly polymorphic markers in human gene mapping. Am J Hum Genet (1992) 3.25
Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations. Am J Hum Genet (1999) 3.16
A simple method for DNA purification from peripheral blood. Anal Biochem (1988) 2.98
Genome-wide linkage analysis of systolic and diastolic blood pressure: the Québec Family Study. Circulation (2000) 2.75
The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet (1998) 2.74
The value of isolated populations. Nat Genet (2001) 2.51
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics (2001) 2.50
Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. Am J Hum Genet (1997) 2.38
A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet (1999) 2.15
Incorrect specification of marker allele frequencies: effects on linkage analysis. Am J Hum Genet (1993) 2.10
Further evidence for the increased power of LOD scores compared with nonparametric methods. Am J Hum Genet (1999) 1.96
New target regions for human hypertension via comparative genomics. Genome Res (2000) 1.75
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet (1992) 1.55
Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet (1995) 1.50
A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet (2001) 1.49
Random search for shared chromosomal regions in four affected individuals: the assignment of a new hereditary ataxia locus. Am J Hum Genet (1995) 1.34
QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish. Circulation (2000) 1.30
Archival, demographic and genetic studies define a Sardinian sub-isolate as a suitable model for mapping complex traits. Hum Genet (2001) 1.28
Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension (2000) 1.24
Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. J Hypertens (2000) 1.19
Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension (2001) 1.16
Molecular genetics of essential hypertension: recent results and emerging strategies. Curr Opin Nephrol Hypertens (2001) 1.13
Not all isolates are equal: linkage disequilibrium analysis on Xq13.3 reveals different patterns in Sardinian sub-populations. Hum Genet (2002) 1.12
Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variation. Hum Mol Genet (1998) 1.09
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. Hypertension (1999) 1.08
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet (2000) 0.97
Genome scan for blood pressure loci in mice. Hypertension (1999) 0.97
Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus. Hypertension (1997) 0.96
Linkage of familial Alzheimer disease to chromosome 14 in two large early-onset pedigrees: effects of marker allele frequencies on lod scores. Am J Med Genet (1993) 0.88
Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18. Am J Med Genet (2001) 0.86
Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mamm Genome (1999) 0.86
Linkage of hypertension to chromosome 2q14-q23 in Chinese families. J Hypertens (2001) 0.86
Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method. Am J Hum Genet (2001) 0.85
Identification of a new candidate locus for uric acid nephrolithiasis. Am J Hum Genet (2001) 0.84
Identification of quantitative trait loci for serum cholesterol levels in stroke-prone spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol (2000) 0.82
A genome-wide search for susceptibility loci to human essential hypertension. Curr Hypertens Rep (2001) 0.77
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature (2006) 9.30
Repeatability of published microarray gene expression analyses. Nat Genet (2008) 8.24
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol (2008) 6.76
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature (2011) 1.98
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood (2009) 1.85
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68
Meta-analysis of linkage studies for Alzheimer's disease--a web resource. Neurobiol Aging (2009) 1.65
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase. Proc Natl Acad Sci U S A (2010) 1.60
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma. Nat Med (2002) 1.59
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood (2013) 1.51
Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2008) 1.48
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res (2010) 1.45
Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome-independent block of angiogenesis and matrix metalloproteinases. Int J Cancer (2011) 1.45
EDA2R is associated with androgenetic alopecia. J Invest Dermatol (2008) 1.44
Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. Am J Hum Genet (2003) 1.42
Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci. Am J Hum Genet (2006) 1.41
High resolution analysis and phylogenetic network construction using complete mtDNA sequences in sardinian genetic isolates. Mol Biol Evol (2006) 1.37
Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis. Hum Genet (2003) 1.32
Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. Haematologica (2010) 1.31
Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis (2010) 1.31
A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia. Am J Hum Genet (2004) 1.24
Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data. PLoS One (2013) 1.19
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet (2008) 1.19
A genome-wide linkage scan for age at menarche in three populations of European descent. J Clin Endocrinol Metab (2008) 1.19
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet (2012) 1.14
Not all isolates are equal: linkage disequilibrium analysis on Xq13.3 reveals different patterns in Sardinian sub-populations. Hum Genet (2002) 1.12
Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS One (2009) 1.11
Statistical tools for linkage analysis and genetic association studies. Expert Rev Mol Diagn (2005) 1.10
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. Mol Biol Cell (2006) 1.09
Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways. J Med Genet (2011) 1.09
Ocular refraction: heritability and genome-wide search for eye morphometry traits in an isolated Sardinian population. Hum Genet (2004) 1.07
High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis. PLoS One (2009) 1.06
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. Am J Hum Genet (2013) 1.06
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes (2011) 1.05
Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet (2007) 1.04
Regular cigarette smoking influences the transsulfuration pathway, endothelial function, and inflammation biomarkers in a sex-gender specific manner in healthy young humans. Am J Transl Res (2013) 1.03
GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. PLoS Genet (2013) 1.03
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet (2013) 1.02
The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women. BMC Cardiovasc Disord (2013) 1.01
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. Hum Mol Genet (2013) 1.01
Bayesian detection of expression quantitative trait loci hot spots. Genetics (2011) 1.00
Patterns of linkage disequilibrium between SNPs in a Sardinian population isolate and the selection of markers for association studies. Hum Hered (2007) 1.00
Suicide risk in multiple sclerosis: a systematic review of current literature. J Psychosom Res (2012) 0.98
PedVizApi: a Java API for the interactive, visual analysis of extended pedigrees. Bioinformatics (2007) 0.98
Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking. PLoS Genet (2013) 0.96
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia (2014) 0.96
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Res Hum Genet (2012) 0.95
Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A (2013) 0.95
Mood disorders medications: predictors of nonadherence - review of the current literature. Expert Rev Neurother (2013) 0.94
Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children. PLoS One (2013) 0.94
Genome-wide co-expression analysis in multiple tissues. PLoS One (2008) 0.93
Macrophages transmit human immunodeficiency virus type 1 products to CD4-negative cells: involvement of matrix metalloproteinase 9. J Virol (2007) 0.92
Antioxidant activity of Calendula officinalis extract: inhibitory effects on chemiluminescence of human neutrophil bursts and electron paramagnetic resonance spectroscopy. Pharmacology (2009) 0.92
Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. Eur J Hum Genet (2010) 0.92
Licorice reduces serum testosterone in healthy women. Steroids (2004) 0.92
Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci. Endocrinology (2007) 0.91
HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies. PLoS One (2012) 0.91
FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. Rheumatology (Oxford) (2011) 0.90
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring) (2011) 0.90
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. PLoS One (2012) 0.89
Oral contraceptives modify DNA methylation and monocyte-derived macrophage function. Biol Sex Differ (2012) 0.89
Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study. Arterioscler Thromb Vasc Biol (2009) 0.89
Affective temperaments and hopelessness as predictors of health and social functioning in mood disorder patients: a prospective follow-up study. J Affect Disord (2013) 0.88
ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration. Bioinformatics (2011) 0.88
Carbenoxolone induces oxidative stress in liver mitochondria, which is responsible for transition pore opening. Endocrinology (2005) 0.88
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc Res (2012) 0.87
Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method. Eur J Hum Genet (2007) 0.87
Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy. Neurosci Lett (2007) 0.87
Alteration of liver enzymes is a feature of the MYH9-related disease syndrome. PLoS One (2012) 0.87
Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates. PLoS One (2013) 0.86
Optic disc drusen, angioid streaks, and mottled fundus in various combinations in a Sicilian family. Graefes Arch Clin Exp Ophthalmol (2002) 0.86