Published in J Immunol on November 01, 2000
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A (2004) 2.42
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity. Mol Cell Biol (2002) 1.72
NF-AT5 is a critical regulator of inflammatory arthritis. Arthritis Rheum (2011) 1.68
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2004) 1.38
Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2005) 1.32
cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein. Proc Natl Acad Sci U S A (2002) 1.29
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation. Proc Natl Acad Sci U S A (2006) 1.28
Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5). Am J Physiol Cell Physiol (2011) 1.15
Mitochondrial control of cell death induced by hyperosmotic stress. Apoptosis (2007) 1.15
Role of NFAT5 in inflammatory disorders associated with osmotic stress. Curr Genomics (2010) 1.10
BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res (2010) 1.08
Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance. Proc Natl Acad Sci U S A (2004) 1.07
NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone. Nucleic Acids Res (2005) 1.06
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol Biol (2008) 1.03
Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2009) 1.01
Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation. Arterioscler Thromb Vasc Biol (2011) 0.97
Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res (2009) 0.94
Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function. PLoS One (2011) 0.94
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance. J Mol Signal (2013) 0.94
c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP. FASEB J (2010) 0.93
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem (2009) 0.92
High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. Mol Biol Cell (2011) 0.91
The betaine/GABA transporter and betaine: roles in brain, kidney, and liver. Front Physiol (2014) 0.88
Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells. Am J Physiol Renal Physiol (2011) 0.87
Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells. Am J Physiol Renal Physiol (2009) 0.87
Nuclear import of a lipid-modified transcription factor: mobilization of NFAT5 isoform a by osmotic stress. Cell Cycle (2011) 0.86
Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress. PLoS One (2009) 0.86
Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment. Oxid Med Cell Longev (2016) 0.84
Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV. PLoS One (2013) 0.84
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol (2015) 0.82
Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes. Exp Mol Med (2013) 0.82
Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc (2014) 0.82
Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP. PLoS One (2010) 0.79
Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures. Cell Death Differ (2014) 0.78
NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake. Am J Physiol Renal Physiol (2012) 0.77
Modulation of NFAT-5, an outlying member of the NFAT family, in human keratinocytes and skin. Am J Transl Res (2009) 0.77
The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. Biomed Res Int (2015) 0.77
Downregulation of the taurine transporter TauT during hypo-osmotic stress in NIH3T3 mouse fibroblasts. J Membr Biol (2012) 0.76
Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. J Neurochem (2011) 0.75
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5. Immunol Cell Biol (2016) 0.75
TonEBP and SMIT expression in human placenta. Anat Cell Biol (2012) 0.75
Osmolyte regulation by TonEBP/NFAT5 during anoxia-recovery and dehydration-rehydration stresses in the freeze-tolerant wood frog (Rana sylvatica). PeerJ (2017) 0.75
TonEBP/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet/streptozotocin-induced diabetic mice. Sci Rep (2017) 0.75
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene (1989) 23.74
Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques (1990) 13.62
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Gene splicing by overlap extension. Methods Enzymol (1993) 4.59
Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res (1993) 3.59
A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev (1996) 3.35
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev (1997) 3.29
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev (1999) 2.92
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature (1996) 2.90
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med (2016) 2.89
Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2001) 2.88
Separation of components in fenestrated and branched endovascular grafting--branch protection or a potentially new mode of failure? Eur J Vasc Endovasc Surg (2008) 2.74
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
Post-hemorrhagic shock mesenteric lymph is cytotoxic to endothelial cells and activates neutrophils. Shock (1998) 2.48
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
Architectural variations of inducible eukaryotic promoters: preset and remodeling chromatin structures. Bioessays (1994) 2.38
Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg (1998) 2.24
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl Acad Sci U S A (1996) 2.20
A lung computed tomographic assessment of positive end-expiratory pressure-induced lung overdistension. Am J Respir Crit Care Med (1998) 2.12
Inhibition of nuclear hormone receptor activity by calreticulin. Nature (1994) 2.11
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc Natl Acad Sci U S A (1983) 2.03
Topographic guidance labels in a sensory projection to the forebrain. Neuron (1998) 2.03
Lentiviral vectors for enhanced gene expression in human hematopoietic cells. Mol Ther (2000) 2.01
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells. Proc Natl Acad Sci U S A (1987) 1.81
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell (2000) 1.76
PEEP-induced changes in lung volume in acute respiratory distress syndrome. Two methods to estimate alveolar recruitment. Intensive Care Med (2011) 1.76
Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells. Nat Biotechnol (1996) 1.70
Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Curr Biol (1995) 1.67
Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos. Methods Enzymol (2000) 1.66
Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism. J Biol Chem (1987) 1.60
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci U S A (2000) 1.60
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr Biol (1996) 1.60
Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun (2008) 1.59
Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Mol Cell Biol (1984) 1.55
Reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants. Mol Gen Genet (1996) 1.51
Distribution of inhaled nitric oxide during sequential and continuous administration into the inspiratory limb of the ventilator. Intensive Care Med (1997) 1.51
Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production. Nature (1983) 1.51
AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J Biol Chem (1999) 1.49
Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets. Am J Respir Crit Care Med (2001) 1.46
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature (1997) 1.43
Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Mol Cell Neurosci (1997) 1.43
Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation. Blood (1999) 1.42
Doppler study of the effects of inhaled nitric oxide and intravenous almitrine on regional pulmonary blood flows in patients with acute lung injury. Minerva Anestesiol (2013) 1.41
A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood (1996) 1.40
Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg (1995) 1.39
Removal of feedback inhibition of delta 1-pyrroline-5-carboxylate synthetase, a bifunctional enzyme catalyzing the first two steps of proline biosynthesis in plants. J Biol Chem (1995) 1.38
Molecular cloning of an immunoglobulin kappa constant gene from NZB mouse. Gene (1981) 1.37
Increased specificity of PCR-amplified products by size-fractionation of restriction enzyme-digested template genomic DNA. Nucleic Acids Res (1988) 1.34
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J (1999) 1.33
Role of the heart in the loss of aeration characterizing lower lobes in acute respiratory distress syndrome. CT Scan ARDS Study Group. Am J Respir Crit Care Med (2000) 1.32
Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. Blood (1990) 1.30
Leptin receptor action in hepatic cells. J Biol Chem (1997) 1.29
Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood (1995) 1.28
Molecular architecture of the hsp70 promoter after deletion of the TATA box or the upstream regulation region. Mol Cell Biol (1997) 1.28
Gut-derived mesenteric lymph: a link between burn and lung injury. Arch Surg (1999) 1.28
The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription. J Clin Endocrinol Metab (1998) 1.25
Regional distribution of gas and tissue in acute respiratory distress syndrome. II. Physiological correlations and definition of an ARDS Severity Score. CT Scan ARDS Study Group. Intensive Care Med (2000) 1.24
Aromatase and COX-2 expression in human breast cancers. J Steroid Biochem Mol Biol (2001) 1.23
Rhesus monkey placental transgene expression after lentiviral gene transfer into preimplantation embryos. Proc Natl Acad Sci U S A (2001) 1.22
Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol (1990) 1.22
Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood (2000) 1.21
Low doses of diagnostic energy X-rays protect against neoplastic transformation in vitro. Int J Radiat Biol (2003) 1.21
A mapping label required for normal scale of body representation in the cortex. Nat Neurosci (2000) 1.20
The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells. Blood (2001) 1.17
Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein. J Thromb Haemost (2013) 1.17
Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheumatol (2009) 1.17
A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells. Gene Ther (1997) 1.16
Characterization of the autophosphorylation of Era, an essential Escherichia coli GTPase. Mol Microbiol (1994) 1.16
Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats--a proteomics approach. Neurochem Int (2006) 1.15
Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities. J Med Chem (1998) 1.14
Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta. J Med Chem (1998) 1.12
Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. J R Soc Interface (2011) 1.12
Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res (1995) 1.12
A scanographic assessment of pulmonary morphology in acute lung injury. Significance of the lower inflection point detected on the lung pressure-volume curve. Am J Respir Crit Care Med (1999) 1.11
The prevalence of plasmid-mediated AmpC beta-lactamases among clinical isolates of Escherichia coli and Klebsiella pneumoniae from five children's hospitals in China. Eur J Clin Microbiol Infect Dis (2008) 1.11
Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology (1996) 1.11
Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif. Nucleic Acids Res (1996) 1.10
Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells. Surgery (2001) 1.09
Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol (Noisy-le-grand) (2003) 1.07
Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. J Biol Chem (1996) 1.07
Nucleoside diphosphate kinase from Escherichia coli. J Bacteriol (1995) 1.07
Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome. Eur Respir J Suppl (2003) 1.05
Green tea and its catechins inhibit breast cancer xenografts. Nutr Cancer (2001) 1.05
Epstein-Barr virus (EBV) in enteropathy-associated T-cell lymphoma (EATL). J Pathol (1993) 1.04
Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells. Mol Cell Biol (1998) 1.04
Depression, anxiety and quality of life in parents of children with epilepsy. Acta Neurol Scand (2009) 1.03
Special feature for the Olympics: effects of exercise on the immune system: exercise-induced modulation of macrophage function. Immunol Cell Biol (2000) 1.03
Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int J Oncol (1999) 1.03
CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters. Invest Ophthalmol Vis Sci (1999) 1.03
Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes. Neuroscience (2002) 1.02
Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Vis Neurosci (2000) 1.02
Overexpression of HOX11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential. Blood (1998) 1.02
Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. Oncogene (2008) 1.01
The effect of estrogen on aromatase and vascular endothelial growth factor messenger ribonucleic acid in the normal nonhuman primate mammary gland. J Clin Endocrinol Metab (1999) 1.01
MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases. Clin Genet (2008) 1.01
Significance of VLA-4-VCAM-1 interaction and CD44 for transendothelial invasion in a bone marrow metastatic myeloma model. Clin Exp Metastasis (1999) 1.00
Effect of different promoters on expression of genes introduced into hematopoietic and marrow stromal cells by electroporation. Exp Hematol (1990) 1.00