Published in Nature on January 09, 1997
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell (1998) 13.56
Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci U S A (1999) 3.74
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J (2000) 2.14
Role of transcription factors in inflammatory lung diseases. Thorax (1998) 1.85
Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc Natl Acad Sci U S A (2001) 1.45
Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. EMBO J (1997) 1.31
Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. EMBO Rep (2000) 1.19
The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation. Thromb Haemost (2009) 1.18
Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13
The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells. J Exp Med (1998) 1.07
Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1. Proc Natl Acad Sci U S A (1997) 1.02
Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure (2007) 1.02
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT). Proc Natl Acad Sci U S A (2001) 1.00
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. Hum Mol Genet (2009) 0.97
The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein. Biochem J (1997) 0.96
DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers. Histochem Cell Biol (2010) 0.86
Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB. Nucleic Acids Res (2013) 0.85
Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells. J Immunol (2012) 0.81
The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain. Structure (2014) 0.79
The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. J Aging Res (2016) 0.78
Downregulation of NFAT2 promotes melanogenesis in B16 melanoma cells. Anat Cell Biol (2010) 0.78
Anti-Transcription Factor RNA Aptamers as Potential Therapeutics. Nucleic Acid Ther (2015) 0.75
The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation. Mol Cell Biol (2014) 0.75
The sequence of the human genome. Science (2001) 101.55
A whole-genome assembly of Drosophila. Science (2000) 38.48
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene (1989) 23.74
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91
Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques (1990) 13.62
The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology (1997) 13.27
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science (1998) 11.23
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell (1992) 8.51
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (1992) 8.15
The mechanism of action of cyclosporin A and FK506. Immunol Today (1992) 7.57
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature (1984) 7.37
Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering. Biochem Biophys Res Commun (1983) 7.26
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Controlling signal transduction with synthetic ligands. Science (1993) 6.70
Identification of a putative regulator of early T cell activation genes. Science (1988) 6.62
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature (1993) 6.41
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J (1996) 6.36
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature (1991) 6.30
Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev (1996) 6.01
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science (1994) 5.47
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A (1993) 5.13
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science (1991) 5.12
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell (1994) 5.00
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science (1997) 4.99
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell (1998) 4.95
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science (1989) 4.70
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature (2000) 4.62
Gene splicing by overlap extension. Methods Enzymol (1993) 4.59
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science (1987) 4.59
Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data. Biochemistry (2000) 4.52
Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol (1988) 4.33
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature (1993) 4.26
Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae. Genetics (1997) 4.21
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (1992) 4.12
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev (1990) 3.98
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem (2001) 3.89
Canalization in evolutionary genetics: a stabilizing theory? Bioessays (2000) 3.62
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56
Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol (1990) 3.55
Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol (2000) 3.39
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell (2000) 3.39
Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Structure of the NF-kappa B p50 homodimer bound to DNA. Nature (1995) 3.33
Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. J Virol (1997) 3.33
Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J Immunol (1979) 3.32
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev (1997) 3.29
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature (1999) 3.21
Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol (1996) 3.20
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance. J Mol Biol (1982) 3.05
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol (2001) 3.03
Molecular cloning and overexpression of the human FK506-binding protein FKBP. Nature (1990) 3.02
Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene (1993) 2.99
Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. J Biol Chem (1993) 2.98
NMR spectroscopy: a multifaceted approach to macromolecular structure. Q Rev Biophys (2000) 2.98
Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen. Cell (1982) 2.94
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91
Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci U S A (1988) 2.90
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature (1996) 2.90
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol (1996) 2.77
Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. Biochemistry (1991) 2.77
Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells. Mol Cell Biol (1986) 2.76
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J (1990) 2.74
Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain. J Biomol NMR (1994) 2.72
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene (2008) 2.71
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67
ATP is essential for protein translocation into Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1985) 2.65
Moving towards an integrated approach to molecular detection and identification of Toxoplasma gondii. Parasitology (2009) 2.60
Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell (1999) 2.58
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell (1998) 2.57