Published in J Biol Chem on October 31, 2000
WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79
Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci U S A (2002) 1.80
WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene (2004) 1.47
Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci U S A (2002) 1.41
WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res (2003) 1.28
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem (2009) 1.28
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol (2007) 1.26
Hyaluronan and hyaluronidase in genitourinary tumors. Front Biosci (2008) 1.24
Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. J Biol Chem (2014) 1.19
WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol (2010) 1.16
Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. PLoS One (2009) 1.05
Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy. Cell Death Dis (2013) 1.02
Hyalurondiase: both a tumor promoter and suppressor. Semin Cancer Biol (2008) 1.02
WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear. Int J Oncol (2005) 0.99
Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget (2015) 0.98
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer. Prostaglandins Other Lipid Mediat (2007) 0.98
Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One (2009) 0.98
Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. Hum Mol Genet (2010) 0.98
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. Biochim Biophys Acta (2014) 0.98
Zfra is a small wizard in the mitochondrial apoptosis. Aging (Albany NY) (2010) 0.97
WW domain-containing oxidoreductase in neuronal injury and neurological diseases. Oncotarget (2014) 0.96
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. BMC Cancer (2009) 0.96
Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia. Genes Cancer (2011) 0.96
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease. Cell Death Dis (2010) 0.95
Common fragile site tumor suppressor genes and corresponding mouse models of cancer. J Biomed Biotechnol (2010) 0.93
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. BMC Cancer (2010) 0.90
Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo. Oncotarget (2015) 0.89
The fragile site WWOX gene and the developing brain. Exp Biol Med (Maywood) (2014) 0.88
Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q. Hum Genet (2005) 0.88
Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma. BMC Med Genomics (2013) 0.88
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death. Cell Death Dis (2012) 0.88
WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase. Cell Cycle (2015) 0.87
The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX. J Hepatol (2008) 0.87
Image-based assessment of growth and signaling changes in cancer cells mediated by direct cell-cell contact. PLoS One (2009) 0.87
Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas. Front Oncol (2013) 0.86
Structure and apoptotic function of p73. BMB Rep (2015) 0.85
UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget (2015) 0.85
Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts. BMC Cell Biol (2002) 0.85
Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk. Oncotarget (2016) 0.82
Expanding the genetic basis of copy number variation in familial breast cancer. Hered Cancer Clin Pract (2014) 0.81
Introduction to a thematic issue for WWOX. Exp Biol Med (Maywood) (2015) 0.81
Oncosuppressor proteins of fragile sites are reduced in cervical cancer. Cancer Lett (2009) 0.81
Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp Biol Med (Maywood) (2015) 0.80
WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis. Cell Death Discov (2015) 0.80
WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer. Exp Biol Med (Maywood) (2015) 0.79
Role of WWOX and NF-κB in lung cancer progression. Transl Respir Med (2013) 0.79
Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors. Int J Mol Sci (2017) 0.78
Bubbling cell death: A hot air balloon released from the nucleus in the cold. Exp Biol Med (Maywood) (2016) 0.78
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. PLoS One (2015) 0.78
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Hum Mol Genet (2013) 0.77
Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase. Exp Biol Med (Maywood) (2014) 0.77
HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response. Front Cell Dev Biol (2016) 0.76
Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem (2016) 0.76
Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells. Exp Biol Med (Maywood) (2015) 0.76
Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PLoS One (2015) 0.75
Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. Saudi J Biol Sci (2017) 0.75
Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response. PLoS Genet (2016) 0.75
Expression of WW domain-containing oxidoreductase WWOX in pterygium. Mol Vis (2015) 0.75
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget (2016) 0.75
Zfra induction of memory anticancer response via a novel immune cell. Oncoimmunology (2016) 0.75
WWOX inhibits the invasion of lung cancer cells by downregulating RUNX2. Cancer Gene Ther (2016) 0.75
Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma. Exp Biol Med (Maywood) (2014) 0.75
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