Published in Genomics on January 01, 1991
Trisomy 21: association between reduced recombination and nondisjunction. Am J Hum Genet (1991) 3.08
Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet (1991) 2.16
Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region. Am J Hum Genet (1995) 1.48
Mechanisms of ring chromosome formation in 11 cases of human ring chromosome 21. Am J Hum Genet (1992) 1.38
Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res (2000) 1.10
Integration of gene maps: chromosome 21. Proc Natl Acad Sci U S A (1993) 1.10
The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol (1994) 1.05
Radiation hybrid mapping. Proc Natl Acad Sci U S A (1991) 1.05
Linkage of congenital recessive deafness (gene DFNB10) to chromosome 21q22.3. Am J Hum Genet (1996) 1.04
"Compensatory" uniparental disomy of chromosome 21 in two cases. J Med Genet (1994) 0.92
Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones. Proc Natl Acad Sci U S A (1992) 0.92
No significant effect of monosomy for distal 21q22.3 on the Down syndrome phenotype in "mirror" duplications of chromosome 21. Am J Hum Genet (1992) 0.90
Construction of a map of chromosome 16 by using radiation hybrids. Proc Natl Acad Sci U S A (1992) 0.89
A contiguous Not I restriction map of band q22.3 of human chromosome 21. Proc Natl Acad Sci U S A (1992) 0.85
Analysis of chromosome 21 yeast artificial chromosome (YAC) clones. Am J Hum Genet (1992) 0.83
Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res (1998) 0.82
Random-breakage mapping method applied to human DNA sequences. Nucleic Acids Res (1996) 0.82
A radiation hybrid map of the BRCA1 region. Am J Hum Genet (1994) 0.81
A radiation hybrid map of 15 loci on the distal long arm of chromosome 4, the region containing the gene responsible for facioscapulohumeral muscular dystrophy (FSHD). Am J Hum Genet (1993) 0.80
Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21. Proc Natl Acad Sci U S A (1992) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer (1977) 53.23
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer (1976) 22.55
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science (2001) 15.54
A gene map of the human genome. Science (1996) 14.32
Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Proc Natl Acad Sci U S A (1989) 13.66
A physical map of 30,000 human genes. Science (1998) 12.43
A physical map of the human genome. Nature (2001) 12.39
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90
Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease. Nat Genet (1997) 10.14
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science (2001) 8.73
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
A strategy to reveal high-frequency RFLPs along the human X chromosome. Am J Hum Genet (1984) 7.73
Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62
Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Proc Natl Acad Sci U S A (1980) 7.04
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Report of the Committee on the Genetic Constitution of Chromosomes 13, 14, 15 and 16. Cytogenet Cell Genet (1985) 6.87
Positive and negative effects of widespread badger culling on tuberculosis in cattle. Nature (2005) 6.64
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 5.89
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science (1990) 5.35
A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet (1999) 4.96
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 4.95
Impact of localized badger culling on tuberculosis incidence in British cattle. Nature (2003) 4.84
A human telomeric protein. Science (1995) 4.77
Regional localization on the human X of DNA segments cloned from flow sorted chromosomes. Nucleic Acids Res (1982) 4.67
SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Cell (1981) 4.64
Control of human telomere length by TRF1 and TRF2. Mol Cell Biol (2000) 4.54
Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J (1990) 4.49
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30
A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med (2000) 4.14
Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06
TB policy and the badger culling trials. Vet Rec (2006) 4.02
Specific and nonspecific NK cell activation during virus infection. Nat Immunol (2001) 4.02
A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94
Imaging membrane protein helical wheels. J Magn Reson (2000) 3.80
Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci U S A (1995) 3.79
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (1991) 3.73
TB policy and the badger culling trials. Vet Rec (2006) 3.67
An STS-based radiation hybrid map of the human genome. Genome Res (1997) 3.57
High-throughput genotyping with single nucleotide polymorphisms. Genome Res (2001) 3.55
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature (1998) 3.53
"Fluorescent timer": protein that changes color with time. Science (2000) 3.42
Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature (1996) 3.41
Methods for estimating the case fatality ratio for a novel, emerging infectious disease. Am J Epidemiol (2005) 3.40
Structural basis of the redox switch in the OxyR transcription factor. Cell (2001) 3.32
Inhibition of human immunodeficiency virus gene amplification by heparin. J Clin Microbiol (1991) 3.32
Structure of the transmembrane region of the M2 protein H(+) channel. Protein Sci (2001) 3.31
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell (1985) 3.30
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28
Bovine tuberculosis: towards a future control strategy. Vet Rec (2000) 3.27
Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell (1986) 3.22
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev (2000) 3.13
Evolutionarily conserved sequences on human chromosome 21. Genome Res (2001) 2.95
Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 2.90
Weighted-ensemble Brownian dynamics simulations for protein association reactions. Biophys J (1996) 2.87
Predicting protein diffusion coefficients. Proc Natl Acad Sci U S A (1993) 2.87
Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci U S A (1991) 2.81
Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A (1994) 2.74
Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) Science (1996) 2.73
Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res (1997) 2.72
Tankyrase promotes telomere elongation in human cells. Curr Biol (2000) 2.67
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66
Programmable matter by folding. Proc Natl Acad Sci U S A (2010) 2.65
TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64
Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activation sequence but does not require TATA sequences. Mol Cell Biol (1986) 2.63
A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat Genet (1995) 2.63
Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res (2000) 2.62
AN APPROXIMATE CELL MODEL FOR LIQUID HYDROGEN, I. Proc Natl Acad Sci U S A (1962) 2.59
Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J (2001) 2.55
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature (1996) 2.54