Molecular and functional characterization of a family of rat brain T-type calcium channels.

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Published in J Biol Chem on November 09, 2000

Authors

J E McRory1, C M Santi, K S Hamming, J Mezeyova, K G Sutton, D L Baillie, A Stea, T P Snutch

Author Affiliations

1: Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels. Biophys J (1996) 1.25

The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. J Neurosci (1996) 1.24

Properties of chromatin subunits from developing trout testis. J Biol Chem (1975) 1.24

Voltage-dependent facilitation of a neuronal alpha 1C L-type calcium channel. EMBO J (1994) 1.20

Aspects of calcium-activated chloride currents: a neuronal perspective. Pharmacol Ther (1995) 1.18

Alterations in the pattern of gene expression following heat shock in the nematode Caenorhabditis elegans. Can J Biochem Cell Biol (1983) 1.15

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Genetic organization of the unc-60 region in Caenorhabditis elegans. Genetics (1988) 1.13

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Cloning within the unc-43 to unc-31 interval (linkage group IV) of the Caenorhabditis elegans genome using Tc1 linkage selection. Can J Genet Cytol (1985) 1.12

The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans. Development (1997) 1.10

The subunit structure of chromatin: characteristics of nucleohistone and nucleoprotamine from developing trout testis. FEBS Lett (1974) 1.10

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Identification of an integration center for cross-talk between protein kinase C and G protein modulation of N-type calcium channels. J Biol Chem (1999) 1.09

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Interactions of polyamines with neuronal ion channels. Trends Neurosci (1993) 1.08

Potassium channels in C. elegans. WormBook (2005) 1.07

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Genetic balancers. Methods Cell Biol (1995) 1.06

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