Published in J Neurosci on August 01, 1988
Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc Natl Acad Sci U S A (1992) 2.45
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci U S A (1990) 2.35
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol (1993) 1.80
A voltage-dependent persistent sodium current in mammalian hippocampal neurons. J Gen Physiol (1990) 1.73
A mutation in the pore of the sodium channel alters gating. Biophys J (1995) 1.34
Membrane stretch affects gating modes of a skeletal muscle sodium channel. Biophys J (1999) 1.18
Gating of skeletal and cardiac muscle sodium channels in mammalian cells. J Physiol (1999) 1.16
Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel. J Physiol (1998) 1.09
Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons. Biophys J (1993) 1.08
Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis. Biophys J (1997) 1.02
Transient and persistent sodium currents in normal and denervated mammalian skeletal muscle. J Physiol (1989) 1.01
Two transient outward currents in histamine neurones of the rat hypothalamus in vitro. J Physiol (1990) 0.97
Regulatory Role of Voltage-Gated Na Channel β Subunits in Sensory Neurons. Front Pharmacol (2011) 0.95
Expression of cardiac Na channels with appropriate physiological and pharmacological properties in Xenopus oocytes. Proc Natl Acad Sci U S A (1991) 0.94
Inactivation of batrachotoxin-modified Na+ channels in GH3 cells. Characterization and pharmacological modification. J Gen Physiol (1992) 0.89
Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. J Clin Invest (1989) 0.82
Kinetics of renaturation of DNA. J Mol Biol (1968) 25.41
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis. Anal Biochem (1976) 21.07
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors. J Mol Biol (1972) 19.88
Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide. Nucleic Acids Res (1977) 15.92
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. J Mol Biol (1973) 11.40
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
A physical study by electron microscopy of the terminally reptitious, circularly permuted DNA from the coliphage particles of Escherichia coli 15. J Mol Biol (1970) 6.63
The actin genes of Drosophila: a dispersed multigene family. Cell (1980) 5.91
Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner. Cell (1983) 5.44
Electron microscope heteroduplex studies of sequence relations among bacterial plasmids: identification and mapping of the insertion sequences IS1 and IS2 in F and R plasmids. J Bacteriol (1975) 5.44
The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell (1981) 5.27
Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J Mol Biol (1976) 4.65
Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules. Cell (1976) 4.41
Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature (1994) 4.34
The naming of voltage-gated calcium channels. Neuron (1994) 4.31
IS2, a genetic element for turn-off and turn-on of gene activity in E. coli. Mol Gen Genet (1974) 4.16
Interspersion of repetitive and nonrepetitive DNA sequences in the Drosophila melanogaster genome. Cell (1975) 4.13
Hydrodynamic shear breakage of DNA. Biopolymers (1972) 4.12
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
The inducible lac operator-repressor system is functional in mammalian cells. Cell (1987) 3.80
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Improved methods for the formation and stabilization of R-loops. Nucleic Acids Res (1979) 3.73
Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts. Cell (1983) 3.69
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol (1997) 3.61
Expression of the mitochondrial genome in HeLa cells. VI. Size determination of mitochondrial ribosomal RNA by electron microscopy. J Mol Biol (1971) 3.57
Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits. J Cell Biol (1993) 3.54
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes. Cell (1982) 3.48
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Electron-microscopic visualization of deletion mutations. Proc Natl Acad Sci U S A (1968) 3.35
Sequence arrangement of the rDNA of Drosophila melanogaster. Cell (1977) 3.35
Intercellular Communication: Renal, Urinary Bladder, Sensory, and Salivary Gland Cells. Science (1965) 3.28
The inward rectifier potassium channel family. Curr Opin Neurobiol (1995) 3.23
RD-114, baboon, and woolly monkey viral RNA's compared in size and structure. Cell (1976) 3.20
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron (1993) 3.10
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (1995) 3.06
An electron microscope study of Sindbis virus RNA. Cold Spring Harb Symp Quant Biol (1974) 2.99
A heteroduplex study of the sequence relationships between the RNAs of M-MSV and M-MLV. Cell (1977) 2.96
High-molecular-weight RNAs of AKR, NZB, and wild mouse viruses and avian reticuloendotheliosis virus all have similar dimer structures. J Virol (1978) 2.96
A new method of in situ hybridization. Chromosoma (1975) 2.94
Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations. J Gen Physiol (1977) 2.86
Electron microscope heteroduplex study of sequence relations of T2, T4, and T6 bacteriophage DNAs. Virology (1974) 2.82
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol (2001) 2.81
Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol (1978) 2.79
Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci (2000) 2.72
Electron microscope heteroduplex study of the heterogeneity of Mu phage and prophage DNA. Virology (1974) 2.72
Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels. J Neurosci (1995) 2.68
Structure, subunit composition, and molecular weight of RD-114 RNA. J Virol (1975) 2.66
Selective dissociation of histones from calf thymus nucleoprotein. J Mol Biol (1967) 2.65
Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Ann Oncol (2010) 2.64
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci (1999) 2.63
Electron microscopic heteroduplex studies of sequence relations among plasmids of Escherichia coli: structure of F13 and related F-primes. J Bacteriol (1975) 2.60
Heteroduplex analysis of avian RNA tumor viruses. Proc Natl Acad Sci U S A (1977) 2.59
Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha1 subunit. Nature (1997) 2.55
Heteroduplex structures of bacteriophage Mu DNA. Virology (1973) 2.52
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (1982) 2.48
RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1997) 2.43
Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease. BMJ (1996) 2.43
Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflugers Arch (1994) 2.40
Effect of DNA length on the free energy of binding of an unwinding ligand to a supercoiled DNA. J Mol Biol (1972) 2.40
Structure and functional expression of a member of the low voltage-activated calcium channel family. Science (1993) 2.38
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci U S A (1990) 2.35
Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (1988) 2.31
An open randomised trial of second-line endocrine therapy in advanced breast cancer. comparison of the aromatase inhibitors letrozole and anastrozole. Eur J Cancer (2003) 2.31
Electron microscope studies of tumor virus RNA. Cold Spring Harb Symp Quant Biol (1975) 2.30
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Science (1995) 2.30
Electron microscope studies of heteroduplex DNA from a deletion mutant of bacteriophage phiX-174. Proc Natl Acad Sci U S A (1972) 2.29
A-type potassium channels expressed from Shaker locus cDNA. Proc Natl Acad Sci U S A (1988) 2.26
Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels. Nucleic Acids Res (1978) 2.24
Developmentally regulated transcription from Drosophila melanogaster chromosomal site 67B. Dev Biol (1982) 2.24
Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc Natl Acad Sci U S A (1994) 2.23
Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE study. Ann Oncol (2008) 2.23
Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci (2001) 2.23
Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron (1992) 2.22
Analysis of a drosophila tRNA gene cluster: two tRNALeu genes contain intervening sequences. Cell (1981) 2.20
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. J Gen Physiol (1975) 2.19
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. VII. Mapping the ribosomal RNA genes of plasmid F14. J Mol Biol (1974) 2.18
Sequence arrangement and biological activity of cloned feline leukemia virus proviruses from a virus-productive human cell line. J Virol (1981) 2.17
An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cells mitochondrial DNA. Cell (1976) 2.17
Numerical reconstruction of the quantal event at nicotinic synapses. Biophys J (1979) 2.17
Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results. Ann Oncol (2012) 2.16
In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. Methods Enzymol (1998) 2.15
Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol (2000) 2.13
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. IV. The F sequences in F14. J Mol Biol (1974) 2.11
Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci (1999) 2.10
Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci U S A (1994) 2.10