Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMID 11075806)

Published in Mol Endocrinol on November 01, 2000

Authors

B Gereben1, C Goncalves, J W Harney, P R Larsen, A C Bianco

Author Affiliations

1: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98

Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77

Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest (2006) 2.56

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest (2005) 1.81

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest (2003) 1.67

The human selenoproteome: recent insights into functions and regulation. Cell Mol Life Sci (2009) 1.50

American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41

Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol (2007) 1.17

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol (2009) 1.09

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells. J Clin Invest (2011) 1.06

Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology (2011) 1.04

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest (2015) 1.03

Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta (2012) 0.98

Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol Cell Biol (2011) 0.98

Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf) (2014) 0.97

Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues. J Endocrinol (2014) 0.93

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis. Ann Rheum Dis (2014) 0.92

Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol (2011) 0.87

AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders. Thyroid Res (2011) 0.85

The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol (2013) 0.84

Thyroid hormone and the neuroglia: both source and target. J Thyroid Res (2011) 0.84

Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol (2015) 0.82

Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol (2011) 0.82

Physiological role and regulation of iodothyronine deiodinases: a 2011 update. J Endocrinol Invest (2011) 0.80

Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells. Endocrinology (2009) 0.80

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population. Eur Radiol (2016) 0.77

Membrane Protein Quantity Control at the Endoplasmic Reticulum. J Membr Biol (2016) 0.75

Ubiquitinated deiodinase: not dead yet. J Clin Invest (2003) 0.75

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation. J Endocrinol (2012) 0.75

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice. PLoS One (2016) 0.75

The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance. PLoS One (2014) 0.75

Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc (2013) 0.75

Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera. J Clin Immunol (2007) 0.75

Articles by these authors

Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature (1991) 4.63

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J (1993) 3.14

Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr (1979) 3.07

Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature (1991) 3.06

Levothyroxine therapy in patients with thyroid disease. Ann Intern Med (1993) 2.96

Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev (1981) 2.78

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest (2001) 2.77

Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Rep (2000) 2.74

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature (1989) 2.46

Maternal and fetal thyroid function. N Engl J Med (1994) 2.43

Identification of a thyroid hormone receptor that is pituitary-specific. Science (1989) 2.37

Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med (1982) 2.12

Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes. RNA (1999) 2.06

Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med (1990) 2.03

Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (1983) 1.97

Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. J Biol Chem (1995) 1.96

Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute inhibition of thyroid-stimulating hormone release. J Clin Invest (1978) 1.88

Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med (2000) 1.88

Direct immunoassay of triiodothyronine in human serum. J Clin Invest (1972) 1.87

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology (1992) 1.80

Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations. Nucleic Acids Res (1994) 1.77

American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. The Committee on Nomenclature of the American Thyroid Association. Clin Chem (1991) 1.74

Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol (1989) 1.73

Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med (2000) 1.72

SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. EMBO J (2000) 1.72

Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest (1987) 1.67

Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Mol Cell Biol (2001) 1.66

Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science (1977) 1.61

An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology (1982) 1.58

The Caenorhabditis elegans homologue of thioredoxin reductase contains a selenocysteine insertion sequence (SECIS) element that differs from mammalian SECIS elements but directs selenocysteine incorporation. J Biol Chem (1999) 1.56

Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem (1991) 1.55

Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest (2001) 1.54

Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53

The effect of diphenylhydantoin on thyroxine metabolism in man. J Clin Invest (1970) 1.47

Selenocysteine incorporation in eukaryotes: insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element. RNA (1996) 1.47

The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology (1978) 1.46

Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A (1988) 1.46

Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest (1982) 1.46

Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol (1989) 1.45

Neonatal thyroid function in congenital hypothyroidism. J Pediatr (1976) 1.45

Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol (1980) 1.43

Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology (1997) 1.41

Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem (1989) 1.39

Thyroid hormone regulation of gene expression. Annu Rev Physiol (1991) 1.39

Triiodothyronine: review of recent studies of its physiology and pathophysiology in man. Metabolism (1972) 1.37

Plasma T4 and T3 levels in naturally metamorphosing Eurycea bislineata (Amphibia; Plethodontidae). Gen Comp Endocrinol (1986) 1.37

Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Proc Natl Acad Sci U S A (1982) 1.37

Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA (1978) 1.35

Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. J Clin Invest (1979) 1.34

Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest (1985) 1.34

Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology (1996) 1.33

Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. Metabolism (1971) 1.31

Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide. RNA (1998) 1.31

Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. Proc Natl Acad Sci U S A (1987) 1.31

Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest (1983) 1.30

Regulation of human thioredoxin reductase expression and activity by 3'-untranslated region selenocysteine insertion sequence and mRNA instability elements. J Biol Chem (1999) 1.30

Cerebral cortex responds rapidly to thyroid hormones. Science (1981) 1.29

Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology (2001) 1.27

Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26

Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. Metabolism (1978) 1.25

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem (2001) 1.23

Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology (1983) 1.23

Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology (2000) 1.23

Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary. J Clin Invest (1979) 1.23

Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology (1977) 1.20

Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest (1995) 1.19

Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. J Clin Invest (1974) 1.19

Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest (1972) 1.18

Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA (1982) 1.16

Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology (1999) 1.16

Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest (1984) 1.15

Selenocysteine incorporation directed from the 3'UTR: characterization of eukaryotic EFsec and mechanistic implications. Biofactors (2001) 1.14

Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen (2001) 1.13

Is there a negative TRE in the luciferase reporter cDNA? Thyroid (1996) 1.12

Correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with Graves' disease and subacute thyroiditis. Metabolism (1978) 1.11

Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics (1979) 1.11

Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology (2000) 1.10

Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology (2000) 1.09

A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09