Published in Nature on January 31, 1991
Recent evidence for evolution of the genetic code. Microbiol Rev (1992) 4.32
Thioredoxin reductase. Biochem J (2000) 3.47
A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. EMBO J (2000) 3.40
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J (1993) 3.14
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98
Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Rep (2000) 2.74
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci U S A (1996) 2.33
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest (1996) 2.21
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity. Proc Natl Acad Sci U S A (1996) 1.85
Catalytic properties of an Escherichia coli formate dehydrogenase mutant in which sulfur replaces selenium. Proc Natl Acad Sci U S A (1991) 1.80
Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations. Nucleic Acids Res (1994) 1.77
Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Proc Natl Acad Sci U S A (1993) 1.73
SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. EMBO J (2000) 1.72
The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis. Proc Natl Acad Sci U S A (1996) 1.68
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest (2003) 1.67
Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA. Proc Natl Acad Sci U S A (1993) 1.66
Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A (1993) 1.65
Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? Proc Natl Acad Sci U S A (1996) 1.63
Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem J (1995) 1.55
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26
A protein binds the selenocysteine insertion element in the 3'-UTR of mammalian selenoprotein mRNAs. Nucleic Acids Res (1996) 1.26
In vitro and in vivo characterization of novel mRNA motifs that bind special elongation factor SelB. Proc Natl Acad Sci U S A (1997) 1.26
Functions and evolution of selenoprotein methionine sulfoxide reductases. Biochim Biophys Acta (2009) 1.25
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br J Pharmacol (2002) 1.23
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest (1995) 1.19
Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha. Proc Natl Acad Sci U S A (2001) 1.19
Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum. Genome Biol (2013) 1.18
Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA (1995) 1.18
Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. EMBO J (1998) 1.16
A thyroid hormone-regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase. Proc Natl Acad Sci U S A (1994) 1.10
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09
Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology (2011) 1.04
Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol Cell Biol (2008) 1.04
Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium. Proc Natl Acad Sci U S A (1995) 1.03
The length and the secondary structure of the D-stem of human selenocysteine tRNA are the major identity determinants for serine phosphorylation. EMBO J (1994) 1.02
Identification of the major soluble cuticular glycoprotein of lymphatic filarial nematode parasites (gp29) as a secretory homolog of glutathione peroxidase. Proc Natl Acad Sci U S A (1992) 1.00
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. J Clin Invest (1993) 0.99
The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol (2008) 0.98
Role of the 3' untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply. Biochem J (1996) 0.98
Selenoprotein gene expression in thyroid and pituitary of young pigs is not affected by dietary selenium deficiency or excess. J Nutr (2009) 0.97
Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis. Adv Nutr (2011) 0.96
The thyroid gland is a major source of circulating T3 in the rat. J Clin Invest (1993) 0.95
Interaction of selenoprotein PA and the thioredoxin system, components of the NADPH-dependent reduction of glycine in Eubacterium acidaminophilum and Clostridium litorale [corrected]. J Bacteriol (1991) 0.92
Some properties of murine selenocysteine synthase. Biochem J (1992) 0.92
The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. EMBO J (2006) 0.91
Efficient use and recycling of the micronutrient iodide in mammals. Biochimie (2010) 0.91
The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway. Dev Genes Evol (2008) 0.89
Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol (2011) 0.87
A bioassay based on recombinant DNA technology for determining selenium concentration. Appl Environ Microbiol (1994) 0.85
The proximal pathway of metabolism of the chlorinated signal molecule differentiation-inducing factor-1 (DIF-1) in the cellular slime mould Dictyostelium. Biochem J (1995) 0.85
Rapid kinetics of dehalogenation promoted by iodotyrosine deiodinase from human thyroid. Biochemistry (2015) 0.84
Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1. Biochem J (1995) 0.84
Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl (2006) 0.84
Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1. Biochem J (2003) 0.83
Selenium. Role of the essential metalloid in health. Met Ions Life Sci (2013) 0.82
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells. Endocrinology (2009) 0.80
The role of the iodothyronine deiodinases in the physiology and pathophysiology of thyroid hormone action. Eur Thyroid J (2012) 0.80
Effect of selenium deficiency on hepatic type I 5-iodothyronine deiodinase activity and hepatic thyroid hormone levels in the rat. Biochem J (1992) 0.80
Selenoprotein Gene Nomenclature. J Biol Chem (2016) 0.80
Identification of a eukaryotic reductive dechlorinase and characterization of its mechanism of action on its natural substrate. Chem Biol (2011) 0.80
Nuclease sensitive element binding protein 1 associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation. J Cell Physiol (2006) 0.79
The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology (2014) 0.78
Protein multifunctionality: principles and mechanisms. Transl Oncogenomics (2008) 0.78
Analysis of iodine and selenium trace elements in umbilical cord blood in cretinous regions in northwest China in 1999. Environ Health Prev Med (2002) 0.78
Interaction of thioamides, selenoamides, and amides with diiodine. Bioinorg Chem Appl (2006) 0.77
Concentrations of thyroid hormones in serum and activity of hepatic 5' monodeiodinase in copper-deficient rats. Z Ernahrungswiss (1996) 0.77
Thyroid hormone deiodinases revisited: insights from lungfish: a review. J Comp Physiol B (2005) 0.77
Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology (2014) 0.76
Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc (2013) 0.75
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells. Endocrinology (2009) 0.75
Ubiquitinated deiodinase: not dead yet. J Clin Invest (2003) 0.75
New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1991) 0.75
A DFT investigation of a bulky biomimetic model catalyzing the 5'-outer ring deiodination of thyroxine. J Mol Model (2016) 0.75
Coordinated expression and regulation of deiodinases and thyroid hormone receptors during metamorphosis in the Japanese flounder (Paralichthys olivaceus). Fish Physiol Biochem (2016) 0.75
Application of nuclear analytical methods in the investigation and identification of new selenoproteins. Biol Trace Elem Res (1994) 0.75
Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature (1991) 4.63
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J (1993) 3.14
Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr (1979) 3.07
Levothyroxine therapy in patients with thyroid disease. Ann Intern Med (1993) 2.96
Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev (1981) 2.78
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest (2001) 2.77
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature (1989) 2.46
Maternal and fetal thyroid function. N Engl J Med (1994) 2.43
Identification of a thyroid hormone receptor that is pituitary-specific. Science (1989) 2.37
Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med (1982) 2.12
Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med (1990) 2.03
Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (1983) 1.97
Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med (2000) 1.88
Direct immunoassay of triiodothyronine in human serum. J Clin Invest (1972) 1.87
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology (1992) 1.80
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol (1989) 1.73
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med (2000) 1.72
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science (1977) 1.61
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology (1982) 1.58
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem (1991) 1.55
Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53
The effect of diphenylhydantoin on thyroxine metabolism in man. J Clin Invest (1970) 1.47
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology (1978) 1.46
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A (1988) 1.46
Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest (1982) 1.46
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol (1989) 1.45
Neonatal thyroid function in congenital hypothyroidism. J Pediatr (1976) 1.45
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol (1980) 1.43
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology (1997) 1.41
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem (1989) 1.39
Thyroid hormone regulation of gene expression. Annu Rev Physiol (1991) 1.39
Triiodothyronine: review of recent studies of its physiology and pathophysiology in man. Metabolism (1972) 1.37
Plasma T4 and T3 levels in naturally metamorphosing Eurycea bislineata (Amphibia; Plethodontidae). Gen Comp Endocrinol (1986) 1.37
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Proc Natl Acad Sci U S A (1982) 1.37
Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA (1978) 1.35
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol (2000) 1.35
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest (1985) 1.34
Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. J Clin Invest (1979) 1.34
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology (1996) 1.33
Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. Metabolism (1971) 1.31
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. Proc Natl Acad Sci U S A (1987) 1.31
Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest (1983) 1.30
Cerebral cortex responds rapidly to thyroid hormones. Science (1981) 1.29
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology (2001) 1.27
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26
Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. Metabolism (1978) 1.25
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem (2001) 1.23
Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology (1983) 1.23
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology (2000) 1.23
Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary. J Clin Invest (1979) 1.23
Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology (1977) 1.20
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest (1995) 1.19
Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. J Clin Invest (1974) 1.19
Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest (1972) 1.18
Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology (1999) 1.16
Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA (1982) 1.16
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest (1984) 1.15
Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen (2001) 1.13
Is there a negative TRE in the luciferase reporter cDNA? Thyroid (1996) 1.12
Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics (1979) 1.11
Correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with Graves' disease and subacute thyroiditis. Metabolism (1978) 1.11
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology (2000) 1.10
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology (2000) 1.09
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07
Rapid thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat cerebral cortex and cerebellum. J Clin Invest (1980) 1.06
Total and free triiodothyronine and thyroxine in early infancy. J Clin Endocrinol Metab (1974) 1.05
Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. Metabolism (1975) 1.05
Metabolic clearance of endogenous and radioiodinated thyroglobulin in rats. Endocrinology (1978) 1.04
Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism. J Clin Invest (1982) 1.03
Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum. Metabolism (1971) 1.03
Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries. Nucleic Acids Res (1988) 1.01
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol (1992) 1.01
Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J Clin Invest (1973) 1.01
Immunoassay of thyroxine in unextracted human serum. J Clin Endocrinol Metab (1973) 1.01
Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity. J Biol Chem (1986) 1.00
Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. J Clin Invest (1973) 1.00
Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase. Endocrinology (1991) 1.00
Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol (1990) 0.99
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab (2001) 0.99
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. J Clin Invest (1993) 0.99
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol (1993) 0.99
Partial peripheral resistance to thyroid hormone. Am J Med (1981) 0.98
Triiodothyronine and thyroxine content of desiccated thyroid tablets. Metabolism (1977) 0.98
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab (1992) 0.97
Peripheral metabolism of homologous thyrotropin in euthyroid and hypothyroid rats: acute effects of thyrotropin-releasing hormone, triiodothyronine, and thyroxine. Endocrinology (1978) 0.97
Thyroxine to 3,5,3'-triiodothyronine conversion by rat anterior pituitary and liver. Metabolism (1978) 0.97
Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5'-deiodinases by thyroid hormone. Endocrinology (1984) 0.97
Thyroxine (T4) immunoassay using a filter paper blood samples for screening of neonates for hypothyroidism. Pediatr Res (1975) 0.97
Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease. N Engl J Med (1981) 0.96
Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase. FEBS Lett (1994) 0.96
Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice. Endocrinology (1995) 0.95
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. Endocrinology (1998) 0.95
Different pathways of iodothyronine 5'-deiodination in rat cerebral cortex. Biochem Biophys Res Commun (1981) 0.95
Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem (1999) 0.94
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. J Clin Endocrinol Metab (2003) 0.94